Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A.

abstract：:We investigated the role of single nucleotide polymorphisms in genes encoding for drug-metabolizing enzymes in 209 newly diagnosed multiple myeloma patients included in a clinical trial comparing single with double intensive therapy. We observed no significant association between polymorphisms in CYP3A4, CYP3A5, MDR1,...

journal_title：Haematologica

authors： Schilthuizen C,Broyl A,van der Holt B,de Knegt Y,Lokhorst H,Sonneveld P

更新日期：2007-02-01 00:00:00

abstract：:Elucidating the regulation mechanism of integrin αIIbβ3 is key to understand platelet biology and thrombotic diseases. Previous in vitro studies have implicated a role of migfilin in the support of platelet αIIbβ3 activation, however, contribution of migfilin to thrombosis and hemostasis in vivo and a detailed mechani...

journal_title：Haematologica

authors： Zhou Y,Hu M,Chen X,Wang S,Li J,Sa L,Li L,Huang J,Cheng H,Hu H

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acquired red cell aplasia (RCA) is a rare disorder and can be either idiopathic or associated with certain diseases, pregnancy, or drugs. In exceptionally rare cases, it has been reported to co-exist with other autoimmune cytopenias. We report a high incidence of RCA and autoimmune hemolytic a...

journal_title：Haematologica

authors： Elimelakh M,Dayton V,Park KS,Gruessner AC,Sutherland D,Howe RB,Reding MT,Eastlund T,van Burik JA,Singleton TP,Gruessner RW,Key NS

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The differential diagnosis between multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) may be uncertain in some cases; this problem is reflected by discrepancies between different classification systems with an accordance in only 2/3 of cases. We studied whether...

journal_title：Haematologica

authors： Sezer O,Heider U,Zavrski I,Possinger K

更新日期：2001-08-01 00:00:00

abstract：:A case of acute adult T-cell leukemia-lymphoma (ATLL) was observed in northeast Italy, presenting with fever, lymphadenomegaly, splenomegaly, hypercalcemia and renal failure. Leukaemic cells were morphologically typical, expressed a T-cell CD4+ phenotype, did not display any helper functions, and grew in vitro under s...

journal_title：Haematologica

authors： Fanin R,Minutillo S,D'Agaro P,Raspadori D,Tassinari A,Tazzari P,Testoni N,Damiani D,Gallizia C,Michieli M

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:There is variability in the outcome of patients with chronic lymphocytic leukemia with apparently the same stage of disease. Identifying genetic variants that influence patients' outcome and response to treatment may provide important insights into the biology of the disease. DESIGN AND METHODS:We investiga...

journal_title：Haematologica

authors： Wade R,Di Bernardo MC,Richards S,Rossi D,Crowther-Swanepoel D,Gaidano G,Oscier DG,Catovsky D,Houlston RS

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor mobilized peripheral blood stem cells are increasingly used instead of bone marrow as a stem cell source for transplantation. Whereas this change is almost complete for autologous transplantation, there are some concerns when considering allogeneic transplants. DESIGN A...

journal_title：Haematologica

authors： Gallardo D,de la Cámara R,Nieto JB,Espigado I,Iriondo A,Jiménez-Velasco A,Vallejo C,Martín C,Caballero D,Brunet S,Serrano D,Solano C,Ribera JM,de la Rubia J,Carreras E

更新日期：2009-09-01 00:00:00

abstract：:We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. The study population consisted of 784 adults with acute myeloid leukemia in remission or myelodysplastic syndromes undergoi...

journal_title：Haematologica

authors： Artz AS,Logan B,Zhu X,Akpek G,Bufarull RM,Gupta V,Lazarus HM,Litzow M,Loren A,Majhail NS,Maziarz RT,McCarthy P,Popat U,Saber W,Spellman S,Ringden O,Wickrema A,Pasquini MC,Cooke KR,from the Center for International B

更新日期：2016-11-01 00:00:00

abstract：:JAK2 V617F, identified in the majority of patients with myeloproliferative neoplasms, tyrosine phosphorylates SOCS3 and escapes its inhibition. Here, we demonstrate that the JAK2 exon 12 mutants described in a subset of V617F-negative MPN cases, also stabilize tyrosine phosphorylated SOCS3. SOCS3 tyrosine phosphorylat...

journal_title：Haematologica

authors： Elliott J,Suessmuth Y,Scott LM,Nahlik K,McMullin MF,Constantinescu SN,Green AR,Johnston JA

更新日期：2009-04-01 00:00:00

abstract：:The success story of hemophilia care first began in the 1970s, when the availability of plasma-derived concentrates of coagulation factor VIII (FVIII) and factor IX (FIX) provided efficacious treatment of bleeding in patients with hemophilia A and B. This positive scenario was consolidated in terms of greater safety a...

journal_title：Haematologica

authors： Mannucci PM

更新日期：2020-03-01 00:00:00

abstract：:We evaluate the long-term results of a prospective clinical study enrolling more than 100 adult patients with Burkitt lymphoma/leukemia. Depending on extent of disease, treatment consisted of six to eight rituximab infusions and four to six courses of intensive chemotherapy (attenuated in patients aged >55 years) with...

journal_title：Haematologica

authors： Intermesoli T,Rambaldi A,Rossi G,Delaini F,Romani C,Pogliani EM,Pagani C,Angelucci E,Terruzzi E,Levis A,Cassibba V,Mattei D,Gianfaldoni G,Scattolin AM,Di Bona E,Oldani E,Parolini M,Gökbuget N,Bassan R

更新日期：2013-11-01 00:00:00

abstract：:Relapsed/refractory multiple myeloma represents a major challenge in multiple myeloma therapy. For patients with relapsed/refractory multiple myeloma, we developed a treatment schema of metronomically scheduled drug therapy. We identified 186 patients who had been treated with metronomic therapy between March 2004 and...

journal_title：Haematologica

authors： Papanikolaou X,Szymonifka J,Rosenthal A,Heuck CJ,Mitchell A,Johann D Jr,Keller J,Waheed S,Usmani SZ,Van Rhee F,Bailey C,Petty N,Hoering A,Crowley J,Barlogie B

更新日期：2013-07-01 00:00:00

abstract：:Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear ...

journal_title：Haematologica

authors： Heringer-Walther S,Eckert K,Schumacher SM,Uharek L,Wulf-Goldenberg A,Gembardt F,Fichtner I,Schultheiss HP,Rodgers K,Walther T

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Children with Down syndrome have an increased risk of developing acute lymphoblastic leukemia and a poor tolerance of methotrexate. This latter problem is assumed to be caused by a higher cellular sensitivity of tissues in children with Down syndrome. However, whether differences in pharmacokinetics play a r...

journal_title：Haematologica

authors： Buitenkamp TD,Mathôt RA,de Haas V,Pieters R,Zwaan CM

更新日期：2010-07-01 00:00:00

abstract：:We describe the case of a 12-year old boy with Hoyeraal-Hreidarsson Syndrome (HHS). This syndrome includes intrauterine growth retardation, microcephaly, mental retardation, cerebellar malformation, and pancytopenia. HHS is a severe multisystem disorder associated with premature mortality, due to bone marrow failure. ...

journal_title：Haematologica

authors： Ozdemir MA,Karakukcu M,Kose M,Kumandas S,Gumus H

更新日期：2004-09-01 00:00:00

abstract：:In patients with low and intermediate risk myelodysplastic syndrome and deletion 5q (del(5q)) treated with lenalidomide, monitoring of cytogenetic response is mandatory, since patients without cytogenetic response have a significantly increased risk of progression. Therefore, we have reviewed cytogenetic data of 302 p...

journal_title：Haematologica

authors： Göhring G,Giagounidis A,Büsche G,Hofmann W,Kreipe HH,Fenaux P,Hellström-Lindberg E,Schlegelberger B

更新日期：2011-02-01 00:00:00

abstract：:Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the evidence for stand-alone intrathecal prophylaxis has been perfor...

journal_title：Haematologica

authors： Eyre TA,Djebbari F,Kirkwood AA,Collins GP

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:beta-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate beta-globin chain production. The excessive unbound alpha-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis. DESIGN AND METHODS:I...

journal_title：Haematologica

authors： Srinoun K,Svasti S,Chumworathayee W,Vadolas J,Vattanaviboon P,Fucharoen S,Winichagoon P

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Increased levels of microparticles exposing tissue factor circulate in the blood of patients with coronary heart disease, possibly disseminating their pro-thrombotic and pro-inflammatory potential. Because diets rich in n-3 (polyunsaturated) fatty acids have been associated with reduced incidence of coronary...

journal_title：Haematologica

authors： Del Turco S,Basta G,Lazzerini G,Evangelista M,Rainaldi G,Tanganelli P,Christensen JH,Schmidt EB,De Caterina R

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mantle cell lymphoma (MCL) is a separate histological and clinical entity recently recognized in the new revised European-American Lymphoma Classification. Little information exists regarding its therapy. We report the results of a retrospective study of 27 patients affected by MCL evaluating t...

journal_title：Haematologica

authors： Bertini M,Rus C,Freilone R,Botto B,Calvi R,Novero D,Orsucci L,Vitolo U,Palestro G,Resegotti L

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The outcome of patients with severe aplastic anemia (SAA) has improved considerably over the last decades. Bone marrow transplantation (BMT) is the treatment of choice in young patients who have an HLA-identical sibling donor. This study analyzes the outcome and factors related to survival in p...

journal_title：Haematologica

authors： Hernández-Boluda JC,Marín P,Carreras E,Aguilar JL,Grañena A,Rozman C,Montserrat E

更新日期：1999-01-01 00:00:00

abstract：:One hundred thirty-three febrile episodes in 115 neutropenic patients with hematologic malignancies were empirically treated with ceftriaxone and amikacin in a single daily dose. An indwelling central venous catheter (CVC) was present in 44 cases. Septicemia was documented in 18 (41%) patients with CVC (13 gram-positi...

journal_title：Haematologica

authors： Martino P,Girmenia C,Raccah R,Micozzi A,Cimino G,Mandelli F

更新日期：1990-01-01 00:00:00

abstract：:Systemic AL amyloidosis, a disease with improving outcomes using novel therapies, is increasingly recognized in the elderly but treatment and outcomes have not been systematically studied in this group of patients in whom comorbidities and frailty may compound morbidity and mortality. We report the outcomes of 295 pat...

journal_title：Haematologica

authors： Sachchithanantham S,Offer M,Venner C,Mahmood SA,Foard D,Rannigan L,Lane T,Gillmore JD,Lachmann HJ,Hawkins PN,Wechalekar AD

更新日期：2015-11-01 00:00:00

abstract：:Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of yo...

journal_title：Haematologica

authors： Papaioannou D,Nicolet D,Volinia S,Mrózek K,Yan P,Bundschuh R,Carroll AJ,Kohlschmidt J,Blum W,Powell BL,Uy GL,Kolitz JE,Wang ES,Eisfeld AK,Orwick SJ,Lucas DM,Caligiuri MA,Stone RM,Byrd JC,Garzon R,Bloomfield CD

更新日期：2017-08-01 00:00:00

abstract：:Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to gran...

journal_title：Haematologica

authors： Drouet M,Delaunay C,Grenier N,Garrigou P,Mayol JF,Hérodin F

更新日期：2008-03-01 00:00:00

abstract：:The occurrence of immunoglobulin heavy chain (IgH) and/or T-cell receptor (TcR) gene rearrangements has been reported in some cases of acute non lymphoid leukemia (ANLL), and variously interpreted as reflecting "aberrant gene expression" or "lineage promiscuity" of the leukemic cell. In an attempt to verify the incide...

journal_title：Haematologica

authors： Leone R,Lo Coco F,De Rossi G,Diverio D,Frontani M,Spadea A,Testi AM,Cordone I,Mandelli F

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell dep...

journal_title：Haematologica

authors： Ayuk F,Perez-Simon JA,Shimoni A,Sureda A,Zabelina T,Schwerdtfeger R,Martino R,Sayer HG,Alegre A,Lahuerta JJ,Atanackovic D,Wolschke C,Nagler A,Zander AR,San Miguel JF,Kröger N

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to evaluate the tolerability and effectiveness of a non-myeloablative conditioning regimen followed by autologous hematopoietic stem cell infusion for the treatment of severe autoimmune diseases. DESIGN AND METHODS:From 1996 patients with severe autoimmune disease no...

journal_title：Haematologica

authors： Rabusin M,Andolina M,Maximova N,Lepore L,Parco S,Tuveri G,Jankovic G

更新日期：2000-11-01 00:00:00

abstract：:Peripheral cytopenia has been reported in a number of patients with the acquired immunodeficiency syndrome (AIDS), but the mechanism of bone marrow (BM) failure is unclear. We have examined the BM morphology and cytokinetics of 16 untreated HIV-positive patients whose clinical condition ranged from asymptomatic (stage...

journal_title：Haematologica

authors： Danova M,Riccardi A,Brugnatelli S,Maserati R,Comolli G,Mazzini G,Castello A,Ascari E,Rondanelli EG

更新日期：1989-07-01 00:00:00

abstract：:A new, sensitive method combining seminested polymerase chain reaction (PCR) and heteroduplex analysis was used to detect follicular lymphoma (FL) cells in peripheral blood. Based on the detection of IgH rearrangement in DNA from peripheral blood leukocytes, the method demonstrated the presence of monoclonal B cells i...

journal_title：Haematologica

authors： Oehadian A,Koide N,Mu MM,Hassan F,Yoshida T,Yokochi T

更新日期：2004-10-01 00:00:00