Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients.

abstract：:The objective of this study was to create a bioclinical model, based on clinical and molecular predictors of event-free and overall survival for relapsed/refractory diffuse large B-cell lymphoma patients treated on the Canadian Cancer Trials Group (CCTG) LY12 prospective study. In 91 cases, sufficient histologic mater...

journal_title：Haematologica

authors： Bosch M,Akhter A,Chen BE,Mansoor A,Lebrun D,Good D,Crump M,Shepherd L,Scott DW,Stewart DA

更新日期：2018-02-01 00:00:00

abstract：:As in other malignancies, peripheral blood progenitor cells (PBPC) have almost completely replaced bone marrow as the source of stem cells for autologous transplantation in multiple myeloma. PBPC collection could be optimized either by reducing contamination by the malignant clone or by increasing hematopoietic qualit...

journal_title：Haematologica

authors： Harousseau JL

更新日期：1999-06-01 00:00:00

abstract：:The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric transferrin. As this molecule influences the production of the iron regulatory hormone hepcidin, we hypothesized that erythropoiesis-driven changes in diferric transf...

journal_title：Haematologica

authors： Mirciov CSG,Wilkins SJ,Hung GCC,Helman SL,Anderson GJ,Frazer DM

更新日期：2018-10-01 00:00:00

abstract：:Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with loss-of-function mutations in the SBDS gene, implicated in ribosome biogenesis, but the cellular and molecular events driving cell specific phenotypes in ribosomopathies rem...

journal_title：Haematologica

authors： Zambetti NA,Bindels EM,Van Strien PM,Valkhof MG,Adisty MN,Hoogenboezem RM,Sanders MA,Rommens JM,Touw IP,Raaijmakers MH

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:There is little published information on the everyday clinical management of myelodysplastic syndromes in real world practice. DESIGN AND METHODS:We conducted a cross-sectional study of all patients with myelodysplastic syndromes attending 74 French centers in a 1-week period for inpatient admission, day-ho...

journal_title：Haematologica

authors： Kelaidi C,Stamatoullas A,Beyne-Rauzy O,Raffoux E,Quesnel B,Guerci A,Dreyfus F,Brechignac S,Berthou C,Prebet T,Hicheri Y,Hacini M,Delaunay J,Gourin MP,Camo JM,Zerazhi H,Taksin AL,Legros L,Choufi B,Fenaux P,Groupe F

更新日期：2010-06-01 00:00:00

abstract：:Three cases of hepatic and/or splenic mycosis in children with acute leukemia are reported. Patients presented with fever not responding to broad spectrum antibiotics during or after prolonged and profound neutropenia. Noteworthy, in 1 case no abnormality in liver function tests was detectable at diagnosis. CT scan sh...

journal_title：Haematologica

authors： Moroni C,Castagnola E,Callea F,Lanino E,Rizzo A,Savioli C,Taccone A,Tomà P,Viscoli C

更新日期：1991-07-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome is a rare genetic disorder characterized by defective FAS-mediated apoptosis, autoimmune disease, accumulation of mature T-cell receptor alpha/beta positive, CD4 and CD8 double-negative T cells and increased risk of lymphoma. Despite frequent hematologic abnormalities, literatur...

journal_title：Haematologica

authors： Xie Y,Pittaluga S,Price S,Raffeld M,Hahn J,Jaffe ES,Rao VK,Maric I

更新日期：2017-02-01 00:00:00

abstract：:A case of acute adult T-cell leukemia-lymphoma (ATLL) was observed in northeast Italy, presenting with fever, lymphadenomegaly, splenomegaly, hypercalcemia and renal failure. Leukaemic cells were morphologically typical, expressed a T-cell CD4+ phenotype, did not display any helper functions, and grew in vitro under s...

journal_title：Haematologica

authors： Fanin R,Minutillo S,D'Agaro P,Raspadori D,Tassinari A,Tazzari P,Testoni N,Damiani D,Gallizia C,Michieli M

更新日期：1990-07-01 00:00:00

abstract：:Effects of concurrent inhibition of mTORC1/2 and Bcl-2/Bcl-xL in human acute myeloid leukemia cells were examined. Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo. Moreover, INK128 co-administered with ...

journal_title：Haematologica

authors： Rahmani M,Aust MM,Hawkins E,Parker RE,Ross M,Kmieciak M,Reshko LB,Rizzo KA,Dumur CI,Ferreira-Gonzalez A,Grant S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The degree of globin chain imbalance and tissue hypoxia are important determinants of clinical severity in thalassemia syndromes. Thus phenotypic expression may be modified by interaction of alpha- and beta-thalassemia defects, level and type of hemoglobin synthesized and oxygen release to the...

journal_title：Haematologica

authors： Traeger-Synodinos J,Papassotiriou I,Vrettou C,Skarmoutsou C,Stamoulakatou A,Kanavakis E

更新日期：2001-04-01 00:00:00

abstract：:Mucormycosis is an emerging cause of infectious morbidity and mortality in patients with hematologic malignancies. However, there are no recommendations to guide diagnosis and management. The European Conference on Infections in Leukemia assigned experts in hematology and infectious diseases to develop evidence-based ...

journal_title：Haematologica

authors： Skiada A,Lanternier F,Groll AH,Pagano L,Zimmerli S,Herbrecht R,Lortholary O,Petrikkos GL,European Conference on Infections in Leukemia.

更新日期：2013-04-01 00:00:00

abstract：:Krüppel-like factor 4 is a transcription factor with anti-proliferative effects in differentiated cells, but with the ability to reprogram adult cells into cell-cycling pluripotent cells. In cancer, Krüppel-like factor 4 acts as either an anti-oncogene or an oncogene. We analyzed Krüppel-like factor 4 gene expression ...

journal_title：Haematologica

authors： Schoenhals M,Kassambara A,Veyrune JL,Moreaux J,Goldschmidt H,Hose D,Klein B

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The clinical and immunologic activities of interleukin-2 (IL-2) in cancer patients have been extensively studied and described; however, in most of these studies, IL-2 was administered by intravenous bolus or continuous infusion, while the immunologic effects of IL-2 given by the subcutaneous (...

journal_title：Haematologica

authors： Moroni M,Porta C,De Amici M,Quaglini S,Cattabiani MA,Buzio C

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Drug-resistant leukemia cells may exhibit cross-resistance towards immunological effector mechanisms by alterations of apoptosis pathways. This is particularly relevant in allogeneic bone marrow transplantation for leukemia, where the graft-versus-leukemia effect acts on cells pretreated with ...

journal_title：Haematologica

authors： Classen CF,Falk CS,Friesen C,Fulda S,Herr I,Debatin KM

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with chronic renal failure show signs of accelerated atherosclerosis and high cardiovascular morbidity and mortality. Recent investigations indicate that uremia is associated with endothelial dysfunction and a microinflammatory state. We assessed changes in the expression of adhesion ...

journal_title：Haematologica

authors： Serradell M,Díaz-Ricart M,Cases A,Zurbano MJ,López-Pedret J,Arranz O,Ordinas A,Escolar G

更新日期：2002-10-01 00:00:00

abstract：:We performed a dose-escalation study of bendamustine in 31 patients with multiple myeloma that had progressed after high-dose chemotherapy. Bendamustine 100 mg/m2 on days 1 and 2 per cycle was found to be the maximal tolerated dose. The overall response rate was 55% with a median progression-free survival of 26 (0-61)...

journal_title：Haematologica

authors： Knop S,Straka C,Haen M,Schwedes R,Hebart H,Einsele H

更新日期：2005-09-01 00:00:00

abstract：:Transient pancytopenia preceding childhood acute lymphoblastic leukemia (ALL) is an unfrequent but well-known event. The association of this preleukemic syndrome with hepatitis is extremely rare, with only two such cases having been published in the literature. We report the case of a 16-year-old boy who was diagnosed...

journal_title：Haematologica

authors： Rafel M,Cobo F,Cervantes F,Bosch F,Campo E,Montserrat E

更新日期：1998-06-01 00:00:00

abstract：:To date, few mutations associated with a dominant quantitative deficiency of von Willebrand factor (VWF) and a high penetrance have been reported. This phenotype was confirmed in seven unrelated families of several patients diagnosed with von Willebrand's disease out of 70 who requested genetic studies of the VWF gene...

journal_title：Haematologica

authors： Casaña P,Cabrera N,Haya S,Cid AR,Aznar JA

更新日期：2006-08-01 00:00:00

abstract：:BACKGROUND. Hypofibrinogenemia and increased fibrin(ogen) degradation products in acute leukemia have been attributed to intravascular thrombin generation triggered by leukemic cells. However, the strict relationship between fibrinogen catabolism and turnover of fibrinopeptide A (FPA), which is a sensitive and specifi...

journal_title：Haematologica

authors： Castaman G,Galloni E,Dri AV,Rodeghiero F

更新日期：1993-11-01 00:00:00

abstract：:Our preliminary results suggest the existence of quantitative and qualitative differences in immune cells and type1 and type2 cytokines between granulocyte colony-stimulating factor (G-CSF) primed bone marrow (G-BM) and G-CSF-mobilized peripheral blood grafts (G-PB). Our findings suggest that lower T-cell hyporesponsi...

journal_title：Haematologica

authors： Jun HX,Jun CY,Yu ZX

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Either low molecular weight heparin (LMWH) or unfractionated heparin (UH) may be used for the prophylaxis of post-operative venous thromboembolic disease (VTD) in elective hip replacement. This study was aimed at assessing the cost-effectiveness of LMWH over UH from the society perspective, whi...

journal_title：Haematologica

authors： Marchetti M,Liberato NL,Ruperto N,Barosi G

更新日期：1999-08-01 00:00:00

abstract：:The immunomodulatory drugs, lenalidomide and pomalidomide yield high response rates in multiple myeloma patients, but are associated with a high rate of thrombocytopenia and increased risk of secondary hematologic malignancies. Here, we demonstrate that the immunomodulatory drugs induce self-renewal of hematopoietic p...

journal_title：Haematologica

authors： Liu A,Li S,Donnenberg V,Fu J,Gollin SM,Ma H,Lu C,Stolz DB,Mapara MY,Monaghan SA,Lentzsch S

更新日期：2018-10-01 00:00:00

abstract：:Previous studies identified the Ser/Thr protein kinase, AKT, as a therapeutic target in thrombo-inflammatory diseases. Here we report that specific inhibition of AKT with ARQ 092, an orally-available AKT inhibitor currently in phase Ib clinical trials as an anti-cancer drug, attenuates the adhesive function of neutrop...

journal_title：Haematologica

authors： Kim K,Li J,Barazia A,Tseng A,Youn SW,Abbadessa G,Yu Y,Schwartz B,Andrews RK,Gordeuk VR,Cho J

更新日期：2017-02-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) levels have been tested in patients with chronic relative polycythemia (RP), polycythemia vera, and in healthy subjects in order to find a possible underlying pathophysiological mechanism for relative polycythemia. No difference in statistical significance has been found between the me...

journal_title：Haematologica

authors： Cohen AM,Gelvan A,Winaver J,Kahna L,Floru S,Djaldetti M

更新日期：1989-07-01 00:00:00

abstract：:CLLU1, located at chromosome 12q22, encodes a transcript specific to chronic lymphocytic leukemia and has potential prognostic value. We assessed the value of CLLU1 expression in the LRF CLL4 randomized trial. Samples from 515 patients with chronic lymphocytic leukemia were collected immediately before the start of tr...

journal_title：Haematologica

authors： Gonzalez D,Else M,Wren D,Usai M,Buhl AM,Parker A,Oscier D,Morgan G,Catovsky D

更新日期：2013-02-01 00:00:00

abstract：:Since HA-1-specific T cells have been shown to make a significant contribution to the clinical responses in patients with relapsed leukemia, we investigated the feasibility of adoptive transfer of in vitro induced HA-1-specific CD8 positive T cells to patients with relapsed leukemia after allogeneic stem cell transpla...

journal_title：Haematologica

authors： Meij P,Jedema I,van der Hoorn MA,Bongaerts R,Cox L,Wafelman AR,Marijt EW,Willemze R,Falkenburg JH

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell dep...

journal_title：Haematologica

authors： Ayuk F,Perez-Simon JA,Shimoni A,Sureda A,Zabelina T,Schwerdtfeger R,Martino R,Sayer HG,Alegre A,Lahuerta JJ,Atanackovic D,Wolschke C,Nagler A,Zander AR,San Miguel JF,Kröger N

更新日期：2008-09-01 00:00:00

abstract：:In a case of acute myeloid leukemia we report molecular cytogenetic findings of a t(3;11)(q12;p15), characterized as a new NUP98 translocation rearranging with LOC348801 at chromosome 3. NUP98 involvement was detected by fluorescence in situ hybridization. 3'-RACE-PCR showed nucleotide 1718 (exon 13) of NUP98 was fuse...

journal_title：Haematologica

authors： Gorello P,Brandimarte L,La Starza R,Pierini V,Bury L,Rosati R,Martelli MF,Vandenberghe P,Wlodarska I,Mecucci C

更新日期：2008-09-01 00:00:00

abstract：:We quantified Wilm's tumor gene (WT1) using a real time quantitative polymerase chain reaction in 20 adult patients with acute lymphoblastic leukemia at presentation. A WT1 level greater than 906 (median value for the whole series) was a significant predictor of a poor disease-free and overall survival in uni- and mul...

journal_title：Haematologica

authors： Chiusa L,Francia di Celle P,Campisi P,Ceretto C,Marmont F,Pich A

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The efficacy and safety of added dexamethasone were assessed in patients with relapsed and/or refractory multiple myeloma who had a suboptimal response to bortezomib alone. DESIGN AND METHODS:In two previously reported, open-label, multicenter phase 2 studies, bortezomib 1.0 or 1.3 mg/m2 was ...

journal_title：Haematologica

authors： Jagannath S,Richardson PG,Barlogie B,Berenson JR,Singhal S,Irwin D,Srkalovic G,Schenkein DP,Esseltine DL,Anderson KC,SUMMIT\/CREST Investigators.

更新日期：2006-07-01 00:00:00