The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy.

abstract：:Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the evidence for stand-alone intrathecal prophylaxis has been perfor...

journal_title：Haematologica

authors： Eyre TA,Djebbari F,Kirkwood AA,Collins GP

更新日期：2020-07-01 00:00:00

abstract：:Three cases of hepatic and/or splenic mycosis in children with acute leukemia are reported. Patients presented with fever not responding to broad spectrum antibiotics during or after prolonged and profound neutropenia. Noteworthy, in 1 case no abnormality in liver function tests was detectable at diagnosis. CT scan sh...

journal_title：Haematologica

authors： Moroni C,Castagnola E,Callea F,Lanino E,Rizzo A,Savioli C,Taccone A,Tomà P,Viscoli C

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The clinical and immunologic activities of interleukin-2 (IL-2) in cancer patients have been extensively studied and described; however, in most of these studies, IL-2 was administered by intravenous bolus or continuous infusion, while the immunologic effects of IL-2 given by the subcutaneous (...

journal_title：Haematologica

authors： Moroni M,Porta C,De Amici M,Quaglini S,Cattabiani MA,Buzio C

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:CD20 has been proposed as a novel suicide gene system for the treatment of graft-versus-host disease (GVHD), a fatal complication of allogeneic bone marrow transplantation: indeed expression of the human non-immunogenic exogenous CD20 protein allows positive immunoselection of transduced cells...

journal_title：Haematologica

authors： Serafini M,Bonamino M,Golay J,Introna M

更新日期：2004-01-01 00:00:00

abstract：:Seventy-four patients over 60 years of age with new cases of ANLL diagnosed between January, 1980 and December, 1986 were retrospectively evaluated. Twenty-nine (median age 63, range 60-70) received aggressive induction polychemotherapy: 15 achieved CR (52%), 10 were resistant (34.5%) and 4 died during induction (13.5...

journal_title：Haematologica

authors： Latagliata R,Sgadari C,Pisani F,Falconi M,Spadea A,Vegna ML,Petti MC

更新日期：1989-03-01 00:00:00

abstract：:Daily intravenous arsenic trioxide administered with all-trans retinoid acid, the standard-of-care for acute promyelocytic leukemia, is costly and challenging to administer. ORH-2014 is a novel, oral arsenic trioxide formulation, consisting of micron-size drug particles with rapid dissolution and high bioavailability....

journal_title：Haematologica

authors： Ravandi F,Koumenis I,Johri A,Tallman M,Roboz GJ,Strickland S,Garcia-Manero G,Borthakur G,Naqvi K,Meyer M,Pudipeddi M,Nidarmarthy S,Vaddi K,Kantarjian H

更新日期：2020-06-01 00:00:00

abstract：:The objective of this study was to create a bioclinical model, based on clinical and molecular predictors of event-free and overall survival for relapsed/refractory diffuse large B-cell lymphoma patients treated on the Canadian Cancer Trials Group (CCTG) LY12 prospective study. In 91 cases, sufficient histologic mater...

journal_title：Haematologica

authors： Bosch M,Akhter A,Chen BE,Mansoor A,Lebrun D,Good D,Crump M,Shepherd L,Scott DW,Stewart DA

更新日期：2018-02-01 00:00:00

abstract：:Differentiation of erythroblasts to mature red blood cells involves dynamic changes of the membrane and cytoskeleton networks that are not fully characterized. Using a mouse fetal liver erythroblast culture system and a targeted shRNA functional screening strategy, we identified a critical role of pleckstrin-2 in acti...

journal_title：Haematologica

authors： Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

更新日期：2014-07-01 00:00:00

abstract：:Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of yo...

journal_title：Haematologica

authors： Papaioannou D,Nicolet D,Volinia S,Mrózek K,Yan P,Bundschuh R,Carroll AJ,Kohlschmidt J,Blum W,Powell BL,Uy GL,Kolitz JE,Wang ES,Eisfeld AK,Orwick SJ,Lucas DM,Caligiuri MA,Stone RM,Byrd JC,Garzon R,Bloomfield CD

更新日期：2017-08-01 00:00:00

abstract：:Successful expansion of hematopoietic stem cells would benefit the use of hematopoietic stem cell transplants in the clinic. Several angiopoietin-like proteins, including angiopoietin-like 7, can support the activity of hematopoietic stem cells. However, effects of ANGPTL7 on human hematopoietic stem cells and the dow...

journal_title：Haematologica

authors： Xiao Y,Jiang Z,Li Y,Ye W,Jia B,Zhang M,Xu Y,Wu D,Lai L,Chen Y,Chang Y,Huang X,Liu H,Qing G,Liu P,Li Y,Xu B,Zhong M,Yao Y,Pei D,Li P

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mantle cell lymphoma (MCL) is a separate histological and clinical entity recently recognized in the new revised European-American Lymphoma Classification. Little information exists regarding its therapy. We report the results of a retrospective study of 27 patients affected by MCL evaluating t...

journal_title：Haematologica

authors： Bertini M,Rus C,Freilone R,Botto B,Calvi R,Novero D,Orsucci L,Vitolo U,Palestro G,Resegotti L

更新日期：1998-04-01 00:00:00

abstract：:Spontaneous Rh blood group changes are a striking sign, reported to occur mainly in patients with hematologic disorders. Upon routine blood grouping, 2 unrelated individuals showed unexplained mixed red cell phenotype regarding the highly immunogenic c antigen (RH4), clinically relevant for blood transfusion and fetom...

journal_title：Haematologica

authors： Dauber EM,Mayr WR,Hustinx H,Schönbacher M,Budde H,Legler TJ,König M,Haas OA,Fritsch G,Körmöczi GF

更新日期：2019-03-01 00:00:00

abstract：:Thrombosis occurs in 20 to 30% of patients with Behçet's disease (BD), but the precise pathogenic mechanism underlying the thrombotic tendency in these patients is not well known. Venous thromboses are commonly located in the lower extremities, but right intracardiac thrombi are extremely rare. We report for the first...

journal_title：Haematologica

authors： Vayá A,Forner MJ,Estellés A,Villa P,Mira Y,Ferrando F,García Fuster JM,Oliver V,Aznar J

更新日期：2000-04-01 00:00:00

abstract：:As the defective genes for more and more genetic disorders become unravelled, it is clear that patients with apparently identical genotypes can have many different clinical conditions even in simple monogenic disorders. Beta thalassemia occurs when there is a deficiency in the synthesis of beta globin chains. The clin...

journal_title：Haematologica

authors： Thein SL

更新日期：2005-05-01 00:00:00

abstract：:Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated b...

journal_title：Haematologica

authors： Al-Sharea A,Lee MKS,Whillas A,Michell DL,Shihata WA,Nicholls AJ,Cooney OD,Kraakman MJ,Veiga CB,Jefferis AM,Jackson K,Nagareddy PR,Lambert G,Wong CHY,Andrews KL,Head GA,Chin-Dusting J,Murphy AJ

更新日期：2019-03-01 00:00:00

abstract：:The coexistence of chronic myeloid leukemia (CML) and B-cell chronic lymphocytic leukemia (CLL) in the same patient is rare. A 71-year-old woman developed a B-lineage lymphoid blast crisis at 18 months after diagnosis of Ph-positive CML. At this time, a lymphoid cell population with morphologic and immunophenotypic fe...

journal_title：Haematologica

authors： Esteve J,Cervantes F,Rives S,Rozman M,Zarco MA,Montserrat E

更新日期：1997-09-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the leukemic stem cells responsible for disease maintenance and relapse upon drug cessation. Herein, we p...

journal_title：Haematologica

authors： Landberg N,von Palffy S,Askmyr M,Lilljebjörn H,Sandén C,Rissler M,Mustjoki S,Hjorth-Hansen H,Richter J,Ågerstam H,Järås M,Fioretos T

更新日期：2018-03-01 00:00:00

abstract：:We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. The study population consisted of 784 adults with acute myeloid leukemia in remission or myelodysplastic syndromes undergoi...

journal_title：Haematologica

authors： Artz AS,Logan B,Zhu X,Akpek G,Bufarull RM,Gupta V,Lazarus HM,Litzow M,Loren A,Majhail NS,Maziarz RT,McCarthy P,Popat U,Saber W,Spellman S,Ringden O,Wickrema A,Pasquini MC,Cooke KR,from the Center for International B

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell disorders with a high propensity to transform into acute myeloid leukemia. Heterozygous missense mutations in IDH1 at position R132 and in IDH2 at positions R140 and R172 have recently been reported in acute myeloid leukemia. Howe...

journal_title：Haematologica

authors： Thol F,Weissinger EM,Krauter J,Wagner K,Damm F,Wichmann M,Göhring G,Schumann C,Bug G,Ottmann O,Hofmann WK,Schlegelberger B,Ganser A,Heuser M

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:An effective second-line treatment for intermediate and high grade non-Hodgkin's lymphoma is greatly needed since 30% of patients do not achieved complete remission (CR) and another 20% to 30% of the CRs will eventually relapse. METHODS:A four-drug combination with Mitoxantrone, Etoposide, Cisplatin and Dex...

journal_title：Haematologica

authors： Vitolo U,Orsucci L,Bertini M,Cavallero G,Gallamini A,Ghio R,Levis A,Rota-Scalabrini D,Resegotti L

更新日期：1991-01-01 00:00:00

abstract：:Recently, the principles of density gradient cell separation have been transferred to the marrow fractionation, and the Ficoll technique by using a COBE 2991 blood cell processor has been developed and widely employed as well. This method is particularly useful in view of a chemical antineoplastic purging intended for...

journal_title：Haematologica

authors： Iacone A,Quaglietta AM,D'Antonio D,Accorsi P,Dragani A,Angrilli F,Berardi A,Angelini A,Di Bartolomeo P,Di Bartolomeo G

更新日期：1991-03-01 00:00:00

abstract：:Patients with chronic lymphocytic leukemia and unmutated immunoglobulin heavy-chain variable region gene (IGHV) have inferior survival from time of treatment in clinical studies. We assessed real-world outcomes based on mutational status and treatment regimen in a nationwide population-based cohort, comprising all 4,1...

journal_title：Haematologica

authors： Rotbain EC,Frederiksen H,Hjalgrim H,Rostgaard K,Egholm GJ,Zahedi B,Poulsen CB,Enggard L,da Cunha-Bang C,Niemann CU

更新日期：2020-06-01 00:00:00

abstract：:VAD is the most active regimen in refractory myeloma patients; however, the role of vincristine and doxorubicin remains unclear. Relatively high doses of cyclophosphamide (3.6 g/sqm) increased the response rate and survival in resistant MM. Cyclophosphamide and dexamethasone were administered to 28 patients with advan...

journal_title：Haematologica

authors： Celesti L,Clavio M,Poggi A,Casciaro S,Vallebella E,Gobbi M

更新日期：1997-05-01 00:00:00

abstract：:Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal. Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase. Sequential inhibition of ribonu...

journal_title：Haematologica

authors： Zeidner JF,Karp JE,Blackford AL,Smith BD,Gojo I,Gore SD,Levis MJ,Carraway HE,Greer JM,Ivy SP,Pratz KW,McDevitt MA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Hepatic toxicity directly related to the drugs administered in cyclic chemotherapy (CT), although sometimes serious, does not limit the treatment of non-Hodgkin's lymphoma (NHL). Nevertheless, reports of reactivation of viral hepatitis in NHL patients with B virus (HBV) infection are becoming m...

journal_title：Haematologica

authors： Faggioli P,De Paschale M,Tocci A,Luoni M,Fava S,De Paoli A,Tosi A,Cassi E

更新日期：1997-01-01 00:00:00

abstract：:Systemic anaplastic large cell lymphoma is a category of T-cell non-Hodgkin's lymphoma which can be further subdivided into two distinct entities (ALK(+) and ALK(-)) based on the presence or absence of ALK gene rearrangements. Among several pathways triggered by ALK signaling, constitutive activation of STAT3 is stric...

journal_title：Haematologica

authors： Spaccarotella E,Pellegrino E,Ferracin M,Ferreri C,Cuccuru G,Liu C,Iqbal J,Cantarella D,Taulli R,Provero P,Di Cunto F,Medico E,Negrini M,Chan WC,Inghirami G,Piva R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dendritic cells (DC) pulsed with multiple myeloma (MM) patient-specific idiotype (Id) protein can induce MM-specific T-cell responses. DESIGN AND METHODS:We established serum-free culture conditions to generate monocyte-derived DC for clinical use to circumvent anti-xenogenic immune responses...

journal_title：Haematologica

authors： Reichardt VL,Milazzo C,Brugger W,Einsele H,Kanz L,Brossart P

更新日期：2003-10-01 00:00:00

abstract：:Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearranged leukemia by CRISPR-Cas9 mediated deletion of MN1. MN1 was require...

journal_title：Haematologica

authors： Sharma A,Jyotsana N,Gabdoulline R,Heckl D,Kuchenbauer F,Slany RK,Ganser A,Heuser M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The objective of this study was to evaluate the risk of Gram-negative bacterial infections in febrile neutropenic patients and to develop a specific risk score. DESIGN AND METHODS:This prospective study included 513 consecutive febrile neutropenic, evaluable patients. Forty-five per cent of t...

journal_title：Haematologica

authors： Cordonnier C,Herbrecht R,Buzyn A,Leverger G,Leclercq R,Nitenberg G,Bastuji-Garin S,Club de Réflexion sur les Infections en Onco-Hématologie group.

更新日期：2005-08-01 00:00:00

abstract：:Circulating stem cells (CSC) are well documented in animals and humans. Though their function in normal conditions remains obscure, autologous CSC seem capable of restoring hemopoiesis after myeloablative treatment. With cell separators CSC may be harvested in adequate number, and collection may be further improved gi...

journal_title：Haematologica

authors： Majolino I,Scimé R,Indovina A

更新日期：1990-11-01 00:00:00