Oral arsenic trioxide ORH-2014 pharmacokinetic and safety profile in patients with advanced hematologic disorders.

abstract：BACKGROUND:Polycythemia vera is a clonal hematopoietic stem cell disorder in which the JAK2 V617F mutation is observed in >95% of patients, but an as yet unidentified process appears to initiate the clonal expansion of hematopoiesis. Because microRNA regulate hematopoietic differentiation, we hypothesized that dysregul...

journal_title：Haematologica

authors： Bruchova H,Merkerova M,Prchal JT

更新日期：2008-07-01 00:00:00

abstract：:Multiple myeloma management has undergone profound changes in the past thanks to advances in our understanding of the disease biology and improvements in treatment and supportive care approaches. This article presents recommendations of the European Myeloma Network for newly diagnosed patients based on the GRADE syste...

journal_title：Haematologica

authors： Engelhardt M,Terpos E,Kleber M,Gay F,Wäsch R,Morgan G,Cavo M,van de Donk N,Beilhack A,Bruno B,Johnsen HE,Hajek R,Driessen C,Ludwig H,Beksac M,Boccadoro M,Straka C,Brighen S,Gramatzki M,Larocca A,Lokhorst H,Magar

更新日期：2014-02-01 00:00:00

abstract：:Plasma levels of several soluble factors were assayed in 31 untreated patients with high-grade non-Hodgkin's lymphomas (NHL). The results showed statistically significant higher average levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-2 receptor (IL-2r) and transferrin receptor (...

journal_title：Haematologica

authors： Stasi R,Conforti M,Del Poeta G,Simone MD,Coppetelli U,Tribalto M,Cantonetti M,Perrotti A,Venditti A,Papa G

更新日期：1992-11-01 00:00:00

abstract：:The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of patients with acute myeloid leukemia (AML). Because of the poor prognosis associated with FLT3-internal tandem duplication mutated AML, allogeneic hematopoietic stem-cell transplantation (SCT) was commonly performed in first complete remission. Remarka...

journal_title：Haematologica

authors： Bazarbachi A,Bug G,Baron F,Brissot E,Ciceri F,Dalle IA,Döhner H,Esteve J,Floisand Y,Giebel S,Gilleece M,Gorin NC,Jabbour E,Aljurf M,Kantarjian H,Kharfan-Dabaja M,Labopin M,Lanza F,Malard F,Peric Z,Prebet T,Ravan

更新日期：2020-06-01 00:00:00

abstract：:Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with loss-of-function mutations in the SBDS gene, implicated in ribosome biogenesis, but the cellular and molecular events driving cell specific phenotypes in ribosomopathies rem...

journal_title：Haematologica

authors： Zambetti NA,Bindels EM,Van Strien PM,Valkhof MG,Adisty MN,Hoogenboezem RM,Sanders MA,Rommens JM,Touw IP,Raaijmakers MH

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The differential diagnosis between multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) may be uncertain in some cases; this problem is reflected by discrepancies between different classification systems with an accordance in only 2/3 of cases. We studied whether...

journal_title：Haematologica

authors： Sezer O,Heider U,Zavrski I,Possinger K

更新日期：2001-08-01 00:00:00

abstract：:The mammalian target of rapamycin plays an important role in multiple myeloma. The allosteric mammalian target of rapamycin inhibitor everolimus has long been approved for immunosuppression and has shown activity in certain cancers. This investigator-initiated phase I trial explored the use of everolimus in relapsed a...

journal_title：Haematologica

authors： Günther A,Baumann P,Burger R,Kellner C,Klapper W,Schmidmaier R,Gramatzki M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A phase II study was conducted to investigate the effects of a therapeutic program based on the combination of fludarabine and cytarabine (ARA-C) administered as a sequential continuous infusion in untreated elderly patients with acute myeloid leukemia (AML). DESIGN AND METHODS:Sixty-three pa...

journal_title：Haematologica

authors： Ferrara F,D'Arco AM,De Simone M,Mele G,Califano C,Pocali B,Danise P,Palmieri S

更新日期：2005-06-01 00:00:00

abstract：:A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point s...

journal_title：Haematologica

authors： Gallamini A,Barrington SF,Biggi A,Chauvie S,Kostakoglu L,Gregianin M,Meignan M,Mikhaeel GN,Loft A,Zaucha JM,Seymour JF,Hofman MS,Rigacci L,Pulsoni A,Coleman M,Dann EJ,Trentin L,Casasnovas O,Rusconi C,Brice P,Bolis

更新日期：2014-06-01 00:00:00

abstract：:Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to macrophages independently of this receptor under static conditions, suggesting the existence ...

journal_title：Haematologica

authors： Wohner N,Muczynski V,Mohamadi A,Legendre P,Proulle V,Aymé G,Christophe OD,Lenting PJ,Denis CV,Casari C

更新日期：2018-04-01 00:00:00

abstract：:The transferability of the T2* technique for measurement of tissue iron between magnetic resonance (MR) scanners is unknown. Heart and liver multi-breath-hold T2* sequences were installed on MR scanners at six different sites. T2* was assessed locally in five or more patients with thalassemia major (n=39), and subject...

journal_title：Haematologica

authors： Tanner MA,He T,Westwood MA,Firmin DN,Pennell DJ,Thalassemia International Federation Heart T2* Investigators.

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:There is variability in the outcome of patients with chronic lymphocytic leukemia with apparently the same stage of disease. Identifying genetic variants that influence patients' outcome and response to treatment may provide important insights into the biology of the disease. DESIGN AND METHODS:We investiga...

journal_title：Haematologica

authors： Wade R,Di Bernardo MC,Richards S,Rossi D,Crowther-Swanepoel D,Gaidano G,Oscier DG,Catovsky D,Houlston RS

更新日期：2011-10-01 00:00:00

abstract：:Chronic graft-versus-host disease is a serious complication in long-term survivors of allogeneic hematopoietic stem cell transplantation, with several organ systems affected. Chronic graft-versus-host disease is an important cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation. This a...

journal_title：Haematologica

authors： Kapur R,Ebeling S,Hagenbeek A

更新日期：2008-11-01 00:00:00

abstract：:We report a novel alpha2-globin gene allele with the mutation cod 117 TTC>TCC or alpha 117(GH5)Phe>Ser detected in three carriers with alpha-thalassemia phenotype. The mutated mRNA was present in the reticulocytes in the same amount as the normal one, but no chain or hemoglobin variant were detected. Most likely the a...

journal_title：Haematologica

authors： Lacerra G,Scarano C,Musollino G,Flagiello A,Pucci P,Carestia C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Diamond-Blackfan anemia is a rare, clinically heterogeneous, congenital red cell aplasia: 40% of patients have congenital abnormalities. Recent studies have shown that in western countries, the disease is associated with heterozygous mutations in the ribosomal protein (RP) genes in about 50% of patients. The...

journal_title：Haematologica

authors： Konno Y,Toki T,Tandai S,Xu G,Wang R,Terui K,Ohga S,Hara T,Hama A,Kojima S,Hasegawa D,Kosaka Y,Yanagisawa R,Koike K,Kanai R,Imai T,Hongo T,Park MJ,Sugita K,Ito E

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Autologous transplantation is a better treatment for multiple myeloma (MM) than chemotherapy, but uncertainty remains about patient selection, optimal timing of autograft, conditioning regimen, need for a second autograft, and role of maintenance. To provide partial answers to these questions w...

journal_title：Haematologica

authors： Majolino I,Vignetti M,Meloni G,Vegna ML,Scimè R,Tringali S,Amaddii G,Coser P,Tribalto M,Raimondi R,Bergonzi C,Sajeva MR,Sica S,Ferrando F,Messina G,Mandelli F

更新日期：1999-09-01 00:00:00

abstract：:Here we critically evaluate the role of elevated hematocrit as the principal determinant of thrombotic risk in polycythemia and erythrocytosis, defined by an expansion of red cell mass. Since red cell volume determination is no longer readily available, in clinical practice, polycythemia and erythrocytosis are defined...

journal_title：Haematologica

authors： Gordeuk VR,Key NS,Prchal JT

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Oxidant damage is an important contributor to the premature destruction of erythrocytes and anemia in thalassemias. To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of huma...

journal_title：Haematologica

authors： de Franceschi L,Turrini F,Honczarenko M,Ayi K,Rivera A,Fleming MD,Law T,Mannu F,Kuypers FA,Bast A,van der Vijgh WJ,Brugnara C

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Novel therapies capable of targeting drug resistant clonogenic MM cells are required for more effective treatment of multiple myeloma. This study investigates the cytotoxicity of natural killer cell lines against bulk and clonogenic multiple myeloma and evaluates the tumor burden after NK cell therapy in a b...

journal_title：Haematologica

authors： Swift BE,Williams BA,Kosaka Y,Wang XH,Medin JA,Viswanathan S,Martinez-Lopez J,Keating A

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T)...

journal_title：Haematologica

authors： Kracht T,Schrappe M,Strehl S,Reiter A,Elsner HA,Trka J,Cario G,Viehmann S,Harbott J,Borkhardt A,Metzler M,Langer T,Repp R,Marschalek R,Welte K,Haas OA,Stanulla M

更新日期：2004-12-01 00:00:00

abstract：:Clinical and hematologic characteristics of beta(β)-thalassemia are determined by several factors resulting in a wide spectrum of severity. Phenotype modulators are: HBB mutations, HBA defects and fetal hemoglobin production modulators (HBG2:g.-158C>T polymorphism, HBS1L-MYB intergenic region and the BCL11A). We chara...

journal_title：Haematologica

authors： Danjou F,Francavilla M,Anni F,Satta S,Demartis FR,Perseu L,Manca M,Sollaino MC,Manunza L,Mereu E,Marceddu G,Pissard S,Joly P,Thuret I,Origa R,Borg J,Forni GL,Piga A,Lai ME,Badens C,Moi P,Galanello R

更新日期：2015-04-01 00:00:00

abstract：:Despite improvements in standard therapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone for patients with untreated, diffuse large B-cell lymphoma, up to 40% of these patients relapse. Lenalidomide alone or in combination with rituximab has been shown to be active in relapsed/refractory aggr...

journal_title：Haematologica

authors： Chiappella A,Tucci A,Castellino A,Pavone V,Baldi I,Carella AM,Orsucci L,Zanni M,Salvi F,Liberati AM,Gaidano G,Bottelli C,Rossini B,Perticone S,De Masi P,Ladetto M,Ciccone G,Palumbo A,Rossi G,Vitolo U,Fondazione It

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Specific tumor cell recognition is required for optimal tumor directed therapy. Lymphokine activated killer (LAK) cells are able to recognize tumor targets specifically because LAK cells can distinguish between normal and tumor cells. This study was aimed at analyzing receptor molecules on tumor cells and th...

journal_title：Haematologica

authors： Lefterova P,Negrin R,Neubauer A,Huhn D,Blume K,Schmidt-Wolf I

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chromosome 5 and/or 7 abnormalities are cytogenetic findings indicative of a poor prognosis in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The only potential cure for such patients is allogeneic stem cell transplantation (SCT). As data on allogeneic SCT in thi...

journal_title：Haematologica

authors： van der Straaten HM,van Biezen A,Brand R,Schattenberg AV,Egeler RM,Barge RM,Cornelissen JJ,Schouten HC,Ossenkoppele GJ,Verdonck LF,Netherlands Stem Cell Transplant Registry \TYPHON\.

更新日期：2005-10-01 00:00:00

abstract：:In the present work we investigated HDL-C and its subfractions HDL2 and HDL3 as well as total cholesterol (TC), triglycerides (TG), LDL-C, VLDL-C, apolipoproteins A1 (ApoA1) and B (ApoB) and lipoprotein (a) (Lp(a) in 25 patients with newly diagnosed acute lymphocytic leukemia (ALL) before and after induction treatment...

journal_title：Haematologica

authors： Scribano D,Baroni S,Pagano L,Zuppi C,Leone G,Giardina B

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The mdr-1 gene, which codes for a 170-kd transmembrane glycoprotein (P170), is frequently overexpressed in multidrug resistant (MDR) tumor cell lines and in spontaneous tumors, including leukemia and lymphoma. However, it is also constitutively expressed as a normal gene in normal tissues. METHODS:We used h...

journal_title：Haematologica

authors： Damiani D,Michieli M,Michelutti A,Geromin A,Raspadori D,Fanin R,Savignano C,Giacca M,Pileri S,Mallardi F

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear. DESIGN AND METHODS:Hepcidin expression, SMAD and extracellular signa...

journal_title：Haematologica

authors： Poli M,Luscieti S,Gandini V,Maccarinelli F,Finazzi D,Silvestri L,Roetto A,Arosio P

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:There is little published information on the everyday clinical management of myelodysplastic syndromes in real world practice. DESIGN AND METHODS:We conducted a cross-sectional study of all patients with myelodysplastic syndromes attending 74 French centers in a 1-week period for inpatient admission, day-ho...

journal_title：Haematologica

authors： Kelaidi C,Stamatoullas A,Beyne-Rauzy O,Raffoux E,Quesnel B,Guerci A,Dreyfus F,Brechignac S,Berthou C,Prebet T,Hicheri Y,Hacini M,Delaunay J,Gourin MP,Camo JM,Zerazhi H,Taksin AL,Legros L,Choufi B,Fenaux P,Groupe F

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce l...

journal_title：Haematologica

authors： Bousquet M,Nguyen D,Chen C,Shields L,Lodish HF

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Folate deficiency in the general population is associated with a risk of cardiovascular disease and various cancers. The aim of this study was to evaluate folate status in Italian blood donors and its relationship with gender and smoking habit. DESIGN AND METHODS:A prospective study of 201 fi...

journal_title：Haematologica

authors： Cafolla A,Dragoni F,Girelli G,Tosti ME,Costante A,Pastorelli D,Bedogni G,Scott S

更新日期：2000-07-01 00:00:00