Intracardiac thrombosis in a case of Behcet's disease associated with the prothrombin 20210G-A mutation.

Abstract:

:Thrombosis occurs in 20 to 30% of patients with Behçet's disease (BD), but the precise pathogenic mechanism underlying the thrombotic tendency in these patients is not well known. Venous thromboses are commonly located in the lower extremities, but right intracardiac thrombi are extremely rare. We report for the first time on a young patient with BD associated the 20210G-A prothrombin gene mutation and right intracardiac thrombosis. We suggest that the association of BD with this newly recognized prothrombotic genetic mutation may have contributed to the development of the thrombotic event in this patient.

journal_name

Haematologica

journal_title

Haematologica

authors

Vayá A,Forner MJ,Estellés A,Villa P,Mira Y,Ferrando F,García Fuster JM,Oliver V,Aznar J

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

425-8

issue

4

eissn

0390-6078

issn

1592-8721

journal_volume

85

pub_type

杂志文章
  • Clinical features and laboratory patterns in a cohort of consecutive Argentinian patients with von Willebrand's disease.

    abstract:BACKGROUND AND OBJECTIVES:von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. DESIGN AND METHODS:The types and subtypes, blood group frequency and its relevance, bleeding sites, response to...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Woods AI,Meschengieser SS,Blanco AN,Salviú MJ,Farías CE,Kempfer AC,Lazzari MA

    更新日期:2001-04-01 00:00:00

  • Beta-, delta beta-thalassemia and Hb lepore among Yugoslav, Bulgarian, Turkish and Albanian.

    abstract::Over the past 20 years we have studied 1781 patients with beta-thalassemia syndromes of which 1481 Yugoslav, 166 Bulgarian, 102 Turkish and 32 Albanian. In this paper we summarize the data on the heterogeneity and molecular basis of beta-thal, delta beta-thal and Lepore hemoglobinopathy in these four nationalities liv...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Efremov GD

    更新日期:1990-09-01 00:00:00

  • Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow.

    abstract:BACKGROUND AND OBJECTIVES:Detection of minimal residual disease (MRD) by multiparameter flow cytometry is an emerging prognostic factor in patients with acute myeloid leukemia (AML). The present analysis aimed at improving the applicability of this approach to more patients with AML. DESIGN AND METHODS:Bone marrow sam...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Kern W,Danhauser-Riedl S,Ratei R,Schnittger S,Schoch C,Kolb HJ,Ludwig WD,Hiddemann W,Haferlach T

    更新日期:2003-06-01 00:00:00

  • Interferon-alpha 2b is not effective in the treatment of refractory immune thrombocytopenic purpura.

    abstract::About 25-30% of patients with immune thrombocytopenic purpura (ITP) are refractory to corticosteroids, splenectomy and other treatments. It has been suggested that interferon-alpha 2b (IFN-alpha 2b) may be useful in the treatment of chronic refractory ITP patients. We treated 9 chronic refractory ITP patients with IFN...

    journal_title:Haematologica

    pub_type: 信件

    doi:

    authors: Vianelli N,Tazzari PL,Baravelli S,Ricci F,Valdrè L,Tura S

    更新日期:1998-08-01 00:00:00

  • Fibrinogen survival and fibrinopeptide A in acute leukemia.

    abstract::BACKGROUND. Hypofibrinogenemia and increased fibrin(ogen) degradation products in acute leukemia have been attributed to intravascular thrombin generation triggered by leukemic cells. However, the strict relationship between fibrinogen catabolism and turnover of fibrinopeptide A (FPA), which is a sensitive and specifi...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Castaman G,Galloni E,Dri AV,Rodeghiero F

    更新日期:1993-11-01 00:00:00

  • Targeting CD47/TNFAIP8 by miR-155 overcomes drug resistance and inhibits tumor growth through induction of phagocytosis and apoptosis in multiple myeloma.

    abstract::The mechanisms of drug resistance in multiple myeloma are poorly understood. Here we show that CD47, an integrin-associated receptor, is significantly upregulated in drug resistant myeloma cells in comparison with parental cells, and that high expression of CD47 detected by immunohistochemistry is associated with shor...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.227579

    authors: Rastgoo N,Wu J,Liu A,Pourabdollah M,Atenafu EG,Reece D,Chen W,Chang H

    更新日期:2020-12-01 00:00:00

  • Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes.

    abstract:BACKGROUND:Polymorphic differences between donor and recipient human leukocyte antigen class I molecules can result in graft-versus-host disease due to distinct peptide presentation. As part of the peptide-loading complex, tapasin plays an important role in selecting peptides from the pool of potential ligands. Class I...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2011.046037

    authors: Badrinath S,Saunders P,Huyton T,Aufderbeck S,Hiller O,Blasczyk R,Bade-Doeding C

    更新日期:2012-01-01 00:00:00

  • Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity.

    abstract::Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular pathologies such as atherosclerosis and thrombosis. Here, we sought ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2017.183087

    authors: Kurakula K,Koenis DS,Herzik MA Jr,Liu Y,Craft JW Jr,van Loenen PB,Vos M,Tran MK,Versteeg HH,Goumans MTH,Ruf W,de Vries CJM,Şen M

    更新日期:2018-06-01 00:00:00

  • Cutaneous T-cell lymphomas (including rare subtypes). Current concepts. II.

    abstract:BACKGROUND:Cutaneous T-cell lymphomas (CTCL) represent about the 80% of skin lymphomas and comprise a heterogeneous group of diseases with respect to clinical presentation, outcome, histologic and immunophenotypic features. In the recent years, data have been accumulated indicating that clinical and biological differen...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Paulli M,Berti E

    更新日期:2004-11-01 00:00:00

  • Optimizing diagnostic biomarkers of iron deficiency anemia in community-dwelling Indian women and preschool children.

    abstract::The detection of iron deficiency anemia is challenged by the paucity of diagnostic tests demonstrating high sensitivity and specificity. Using two biomarkers, zinc-protoporphyrin/heme and hepcidin, we established the diagnostic cut-off values for iron deficiency anemia in preschool children and women. We randomly sele...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.193243

    authors: Kanuri G,Chichula D,Sawhney R,Kuriakose K,De'Souza S,Pais F,Arumugam K,Shet AS

    更新日期:2018-12-01 00:00:00

  • The role of lactadherin in the phagocytosis of phosphatidylserine-expressing sickle red blood cells by macrophages.

    abstract::Lactadherin is a phosphatidylserine-binding glycoprotein secreted by macrophages. Less than 0.5% of normal circulating red cells showed any binding to lactadherin. However, the red cells from patients with sickle cell disease showed 2 to 10-fold increases in lactadherin binding. Further, lactadherin stimulated the pha...

    journal_title:Haematologica

    pub_type: 信件

    doi:

    authors: Dasgupta SK,Thiagarajan P

    更新日期:2005-09-01 00:00:00

  • Fludarabine and cytarabine as continuous sequential infusion for elderly patients with acute myeloid leukemia.

    abstract:BACKGROUND AND OBJECTIVES:A phase II study was conducted to investigate the effects of a therapeutic program based on the combination of fludarabine and cytarabine (ARA-C) administered as a sequential continuous infusion in untreated elderly patients with acute myeloid leukemia (AML). DESIGN AND METHODS:Sixty-three pa...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Ferrara F,D'Arco AM,De Simone M,Mele G,Califano C,Pocali B,Danise P,Palmieri S

    更新日期:2005-06-01 00:00:00

  • Clonazepam prophylaxis and busulfan-related myoclonic epilepsy in autografted acute leukemia patients.

    abstract::A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neu...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Meloni G,Nasta L,Pinto RM,Spalice A,Raucci U,Iannetti P

    更新日期:1995-11-01 00:00:00

  • Hematocrit and risk of venous thromboembolism in a general population. The Tromso study.

    abstract:BACKGROUND:Hematocrit above the normal range for the population, such as in primary or secondary erythrocytosis, predisposes to both arterial and venous thrombosis. However, little is known about the association between hematocrit and risk of venous thromboembolism in a general population. DESIGN AND METHODS:Hematocri...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2009.008417

    authors: Braekkan SK,Mathiesen EB,Njølstad I,Wilsgaard T,Hansen JB

    更新日期:2010-02-01 00:00:00

  • Long-term follow up of tandem autologous-allogeneic hematopoietic cell transplantation for multiple myeloma.

    abstract::We previously reported initial results in 102 multiple myeloma (MM) patients treated with sequential high-dose melphalan and autologous hematopoietic cell transplantation followed by 200 cGy total body irradiation with or without fludarabine 90 mg/m2 and allogeneic hematopoietic cell transplantation. Here we present l...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.200253

    authors: Maffini E,Storer BE,Sandmaier BM,Bruno B,Sahebi F,Shizuru JA,Chauncey TR,Hari P,Lange T,Pulsipher MA,McSweeney PA,Holmberg L,Becker PS,Green DJ,Mielcarek M,Maloney DG,Storb R

    更新日期:2019-02-01 00:00:00

  • Collection of peripheral blood stem cells by apheresis with continuous flow blood cell separator Dideco Vivacell.

    abstract::In S. Camillo Hospital, Rome, the Apheresis Center (CNTS-CRI) and the Haematological Division, Authors treated 17 patients affected by haematologic malignances and solid tumours with leukoapheresis procedures for PBSC collection. Nine patients were treated with continuous-flow cell separator Dideco Vivacell, performin...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Del Monte C,Basso P,Consoli P,Cossutta M,Morara R,Pescarollo A,Lanti T

    更新日期:1990-01-01 00:00:00

  • Combined semi-nested polymerase chain reaction and heteroduplex analysis for detecting monoclonality of IgH rearrangement in patients with follicular lymphoma.

    abstract::A new, sensitive method combining seminested polymerase chain reaction (PCR) and heteroduplex analysis was used to detect follicular lymphoma (FL) cells in peripheral blood. Based on the detection of IgH rearrangement in DNA from peripheral blood leukocytes, the method demonstrated the presence of monoclonal B cells i...

    journal_title:Haematologica

    pub_type: 信件

    doi:

    authors: Oehadian A,Koide N,Mu MM,Hassan F,Yoshida T,Yokochi T

    更新日期:2004-10-01 00:00:00

  • Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells.

    abstract:BACKGROUND:The nucleoside analogue fludarabine is used in the treatment of chronic lymphocytic leukemia. It triggers p53-mediated apoptosis, although the mutational status of p53 does not fully account for heterogeneity in responsiveness to treatment. The aim of this study was to identify new genes implicated in fludar...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.13186

    authors: López-Guerra M,Trigueros-Motos L,Molina-Arcas M,Villamor N,Casado FJ,Montserrat E,Campo E,Colomer D,Pastor-Anglada M

    更新日期:2008-12-01 00:00:00

  • Influence of two different Escherichia coli asparaginase preparations on fibrinolytic proteins in childhood ALL.

    abstract:BACKGROUND:Alterations in hemostasis have frequently been observed in patients with leukemia, and thrombotic events are well documented in patients receiving L-asparaginase (ASP) as a single agent or in combination with vincristine, prednisone (sometimes complemented by an anthracycline). The present study was designed...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Nowak-Göttl U,Werber G,Ziemann D,Ahlke E,Boos J

    更新日期:1996-03-01 00:00:00

  • Association of severity of organ involvement with mortality and recurrent malignancy in patients with chronic graft-versus-host disease.

    abstract::The National Institutes of Health global score for chronic graft-versus-host disease was devised by experts but was not based on empirical data. We hypothesized that analysis of prospectively collected data would enable derivation of a more accurate model for estimating mortality risk. We analyzed 574 adult patients w...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:10.3324/haematol.2014.109611

    authors: Inamoto Y,Martin PJ,Storer BE,Palmer J,Weisdorf DJ,Pidala J,Flowers ME,Arora M,Jagasia M,Arai S,Chai X,Pavletic SZ,Vogelsang GB,Lee SJ,Chronic GVHD Consortium.

    更新日期:2014-10-01 00:00:00

  • Long-term cost-effectiveness of low molecular weight heparin versus unfractionated heparin for the prophylaxis of venous thromboembolism in elective hip replacement.

    abstract:BACKGROUND AND OBJECTIVE:Either low molecular weight heparin (LMWH) or unfractionated heparin (UH) may be used for the prophylaxis of post-operative venous thromboembolic disease (VTD) in elective hip replacement. This study was aimed at assessing the cost-effectiveness of LMWH over UH from the society perspective, whi...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Marchetti M,Liberato NL,Ruperto N,Barosi G

    更新日期:1999-08-01 00:00:00

  • Molecular monitoring of childhood acute lymphoblastic leukemia using antigen receptor gene rearrangements and quantitative polymerase chain reaction technology.

    abstract::The use of minimal residual disease (MRD) measurement as a surrogate marker of molecular response to treatment can potentially improve the evaluation of treatment response and enable estimates of the residual leukemic cell burden during clinical remission, thereby improving the selection of therapeutic strategies and,...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Cazzaniga G,Biondi A

    更新日期:2005-03-01 00:00:00

  • Cell type specific novel lncRNAs and circRNAs in the BLUEPRINT haematopoietic transcriptomes atlas.

    abstract::Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the developmental stages of the hematopoietic system and the molecular bases of malignant and non-malignant blood diseases for the past three decades. Previously, only the genes targeted by expression microarrays could be profiled g...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.238147

    authors: Grassi L,Izuogu OG,Jorge NA,Seyres D,Bustamante M,Burden F,Farrow S,Farahi N,Martin FJ,Frankish A,Mudge JM,Kostadima M,Petersen R,Lambourne JJ,Rowlston S,Martin-Rendon E,Clarke L,Downes K,Estivill X,Flicek P,Marte

    更新日期:2020-07-23 00:00:00

  • Idarubicin in low-grade non-Hodgkin's lymphomas.

    abstract::The majority of responses produced in patients with low-grade lymphomas are unique among non-Hodgkin's lymphomas (NHL), and even with a more intensive chemotherapy regimen, they are only partial; the very few complete responses which are induced are usually of short duration and do not influence overall survival. Ther...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Zinzani PL

    更新日期:1997-09-01 00:00:00

  • Discrepant sensitivity of thromboplastin reagents to clotting factor levels explored by the prothrombin time in patients on stable oral anticoagulant treatment: impact on the international normalized ratio system.

    abstract:BACKGROUND AND OBJECTIVES:We tested the principle of local International Normalized Ratio (INR) calibration using INR calibrator plasmas (PT Calibration Plasma Kit, Behring), two thomboplastin reagents (Neoplastin plus, rabbit brain, Stago, and Recombiplastin, recombinant human tissue factor, Ortho Diagnostics) and the...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Testa S,Morstabilini G,Fattorini A,Galli L,Denti N,D'Angelo A

    更新日期:2002-12-01 00:00:00

  • HLA-DRB1*15 and pediatric aplastic anemia.

    abstract::We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in...

    journal_title:Haematologica

    pub_type: 信件

    doi:

    authors: Oguz FS,Yalman N,Diler AS,Oguz R,Anak S,Dorak MT

    更新日期:2002-07-01 00:00:00

  • Multi-center validation of the transferability of the magnetic resonance T2* technique for the quantification of tissue iron.

    abstract::The transferability of the T2* technique for measurement of tissue iron between magnetic resonance (MR) scanners is unknown. Heart and liver multi-breath-hold T2* sequences were installed on MR scanners at six different sites. T2* was assessed locally in five or more patients with thalassemia major (n=39), and subject...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Tanner MA,He T,Westwood MA,Firmin DN,Pennell DJ,Thalassemia International Federation Heart T2* Investigators.

    更新日期:2006-10-01 00:00:00

  • Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6.

    abstract::Multipotent stromal cells have immunomodulatory capacities and have been used in transplantation and autoimmune diseases. One of the effects of multipotent stromal cells involves the inhibition of dendritic cell differentiation. Since interleukin-6 and interleukin-10 are known to play a role in inhibiting immature den...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2012.078055

    authors: Melief SM,Geutskens SB,Fibbe WE,Roelofs H

    更新日期:2013-06-01 00:00:00

  • Diagnostic approach to lymph node enlargement.

    abstract:BACKGROUND AND OBJECTIVE:How to reach the correct diagnosis of a lymph node enlargement is still a problem which strongly challenges the knowledge and experience of the clinician. Organized and specifically oriented literature on the right sequential steps and the logical criteria that should guide this diagnostic appr...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Ghirardelli ML,Jemos V,Gobbi PG

    更新日期:1999-03-01 00:00:00

  • NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms.

    abstract:BACKGROUND AND OBJECTIVES:NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T)...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Kracht T,Schrappe M,Strehl S,Reiter A,Elsner HA,Trka J,Cario G,Viehmann S,Harbott J,Borkhardt A,Metzler M,Langer T,Repp R,Marschalek R,Welte K,Haas OA,Stanulla M

    更新日期:2004-12-01 00:00:00