Abstract:
:A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neurological examination and EEG were performed prior to and soon after completion of BU treatment and were repeated two months later. No tonic-clonic and/or myoclonic convulsions were observed. In two patients, comparison of EEG recorded before and upon completion of BU administration revealed modification of features. EEG re-evaluated two months after BU showed normalization in one of the two patients. BU may trigger both generalized and myoclonic seizures together with EEG abnormalities; PB combined with CLZ may be useful prophylactic treatment.
journal_name
Haematologicajournal_title
Haematologicaauthors
Meloni G,Nasta L,Pinto RM,Spalice A,Raucci U,Iannetti Psubject
Has Abstractpub_date
1995-11-01 00:00:00pages
532-4issue
6eissn
0390-6078issn
1592-8721journal_volume
80pub_type
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