Abstract:
:We report on the likely mechanism of an exacerbation of neurological symptoms developed during immune reconstitution after autologous non-myeloablative hematopoietic stem cell transplantation in a 33-year-old man with systemic lupus erythematosus- associated recurrent transverse myelitis. Cerebrospinal fluid examination revealed prominent neutrophilic pleocytosis and no evidence of infection or of reactivation of lupus. Following a course of corticosteroid treatment the exacerbation resolved completely and the patient's neurological function continued to improve, resulting in net gain above pre-treatment for over 1 year follow-up without maintenance immunosuppression. Granulocytic invasion of the central nervous system represents a novel and possibly preventable cause of neurological complications during haematologic reconstitution.
journal_name
Haematologicajournal_title
Haematologicaauthors
Muraro PA,Nikolov NP,Butman JA,Abati A,Gea-Banacloche J,Gress R,Lipsky P,Illei G,Pavletic Ssubject
Has Abstractpub_date
2006-06-01 00:00:00pages
ECR21issue
6 Suppleissn
0390-6078issn
1592-8721journal_volume
91pub_type
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