Fludarabine and cytarabine as continuous sequential infusion for elderly patients with acute myeloid leukemia.

abstract：:Treatment of primary breast lymphoma (PBL) remains unsatisfactory. We assess a clinical study to evaluate efficacy and toxicity of a dose dense regimen (CEOP-14) and rituximab in 32 previously untreated female patients with PBL in early stage. There was no difference in complete response rate (87%), event free-surviva...

journal_title：Haematologica

authors： Avilés A,Castañeda C,Neri N,Cleto S,Nambo MJ

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic cell transplantation is a potentially curative treatment for patients with acute lymphoblastic leukemia. However, the majority of older adults with acute lymphoblastic leukemia are not candidates for myeloablative conditioning regimens. A non-myeloablative preparative regimen is a re...

journal_title：Haematologica

authors： Ram R,Storb R,Sandmaier BM,Maloney DG,Woolfrey A,Flowers ME,Maris MB,Laport GG,Chauncey TR,Lange T,Langston AA,Storer B,Georges GE

更新日期：2011-08-01 00:00:00

abstract：:A significant proportion of hematopoietic stem cell transplants are performed with ABO-mismatched donors. The impact of ABO mismatch on outcome following transplantation remains controversial and there are no published data regarding the impact of ABO mismatch in acute myeloid leukemia patients receiving haploidentica...

journal_title：Haematologica

authors： Canaani J,Savani BN,Labopin M,Huang XJ,Ciceri F,Arcese W,Tischer J,Koc Y,Bruno B,Gülbas Z,Blaise D,Maertens J,Ehninger G,Mohty M,Nagler A

更新日期：2017-06-01 00:00:00

abstract：:Fludarabine (FLU) is a new antimetabolite chemotherapeutic agent with promising activity in lymphoproliferative disorders and, in particular, in low-grade non-Hodgkin's lymphoma (LG-NHL). Recently, a few reports have described interesting results using FLU in polychemotherapy regimens. In order to evaluate FLU in comb...

journal_title：Haematologica

authors： Zinzani PL,Bendandi M,Gherlinzoni F,Merla E,Gozzetti A,Tura S

更新日期：1996-03-01 00:00:00

abstract：:Myeloproliferative neoplasms are uncommon disorders in children, for which we have limited understanding of the pathogenesis and optimal management. JAK2 and MPL mutations, while common drivers of myeloproliferative neoplasms in adult patients, are not clearly linked to pediatric disease. Management and clinical outco...

journal_title：Haematologica

authors： Kucine N,Chastain KM,Mahler MB,Bussel JB

更新日期：2014-04-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：:Cough mixture abuse has been reported to cause severe folate deficiency and neurological defects. We carried out a prospective case-controlled survey to confirm this association and define the incidence and severity of the problem. A total of 57 cough mixture abusers and 47 other substance abusers (controls) were stud...

journal_title：Haematologica

authors： Au WY,Tsang SK,Cheung BK,Siu TS,Ma ES,Tam S

更新日期：2007-04-01 00:00:00

abstract：:CLLU1, located at chromosome 12q22, encodes a transcript specific to chronic lymphocytic leukemia and has potential prognostic value. We assessed the value of CLLU1 expression in the LRF CLL4 randomized trial. Samples from 515 patients with chronic lymphocytic leukemia were collected immediately before the start of tr...

journal_title：Haematologica

authors： Gonzalez D,Else M,Wren D,Usai M,Buhl AM,Parker A,Oscier D,Morgan G,Catovsky D

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The myeloproliferative neoplasms, essential thrombocytosis, polycythemia vera and primary myelofibrosis, share the same acquired genetic lesion, but the concept of JAK2 V617F serving as the sole lesion responsible for these neoplasms is under question, and there has been interest in identifying additional mu...

journal_title：Haematologica

authors： Stein BL,Williams DM,O'Keefe C,Rogers O,Ingersoll RG,Spivak JL,Verma A,Maciejewski JP,McDevitt MA,Moliterno AR

更新日期：2011-10-01 00:00:00

abstract：:Sixteen autologous stem cell transplant recipients received three vaccinations with conjugated haemophilus influenzae type b vaccine. Quantitative and qualitative aspects of the antibody response were studied. The vaccination schedule resulted in high antibody response rates and functional maturation of antibodies, as...

journal_title：Haematologica

authors： van der Velden AM,Claessen AM,van Velzen-Blad H,Biesma DH,Rijker GT

更新日期：2005-11-01 00:00:00

abstract：:The use of minimal residual disease (MRD) measurement as a surrogate marker of molecular response to treatment can potentially improve the evaluation of treatment response and enable estimates of the residual leukemic cell burden during clinical remission, thereby improving the selection of therapeutic strategies and,...

journal_title：Haematologica

authors： Cazzaniga G,Biondi A

更新日期：2005-03-01 00:00:00

abstract：:Overhydrated hereditary stomatocytosis, clinically characterized by hemolytic anemia, is a rare disorder of the erythrocyte membrane permeability to monovalent cations, associated with mutations in the Rh-associated glycoprotein gene. We assessed the red blood cell metabolome of 4 patients with this disorder and showe...

journal_title：Haematologica

authors： Darghouth D,Koehl B,Heilier JF,Madalinski G,Bovee P,Bosman G,Delaunay J,Junot C,Roméo PH

更新日期：2011-12-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) can be administered after a peripheral blood stem cell transplantation with the aim of accelerating neutrophil recovery. In a randomized, single-blind study we studied a new administration schedule of G-CSF in this context. ...

journal_title：Haematologica

authors： Piccirillo N,De Matteis S,Sorà F,d'Onofrio G,Leone G,Sica S

更新日期：2004-09-01 00:00:00

abstract：:Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder which is due to a mutation in the gene encoding for platelet glycoprotein Ibalpha (GPIbalpha) resulting in enhanced affinity for von Willebrand factor (VWF). PT-VWD is often mistakenly diagnosed as type 2B VWD for the similari...

journal_title：Haematologica

authors： Giannini S,Cecchetti L,Mezzasoma AM,Gresele P

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Transcription factors play essential roles in both normal and malignant hematopoiesis. This is the case for the growth factor independent 1b (GFI1B) transcription factor, which is required for erythroid and megakaryocytic differentiation and over-expressed in leukemic patients and cell lines. DESIGN AND MET...

journal_title：Haematologica

authors： Anguita E,Villegas A,Iborra F,Hernández A

更新日期：2010-01-01 00:00:00

abstract：:Diffuse large B-cell lymphoma can be classified by gene expression profiling into germinal center and activated B-cell subtypes with different prognoses after rituximab-CHOP. The importance of previously recognized prognostic markers, such as Bcl-2 protein expression and BCL2 gene abnormalities, has been questioned in...

journal_title：Haematologica

authors： Visco C,Tzankov A,Xu-Monette ZY,Miranda RN,Tai YC,Li Y,Liu WM,d'Amore ES,Li Y,Montes-Moreno S,Dybkær K,Chiu A,Orazi A,Zu Y,Bhagat G,Wang HY,Dunphy CH,His ED,Zhao XF,Choi WW,Zhao X,van Krieken JH,Huang Q,Ai W

更新日期：2013-02-01 00:00:00

abstract：:In the eighties there has been an enormous increase in our knowledge about erythropoietin, previously defined as "an elusive hormone". In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the ...

journal_title：Haematologica

authors： Liberato NL,Costa A,Barosi G

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...

journal_title：Haematologica

authors： Origa R,Galanello R,Ganz T,Giagu N,Maccioni L,Faa G,Nemeth E

更新日期：2007-05-01 00:00:00

abstract：:Interleukin-10 failed to modify either the percentage of bcl-2+ cells or the number of bcl-2 molecules, or to reduce 2-chlorodeoxyadenosine- and fludarabine-induced apoptosis. The cytokine at 0.1 ng/mL induced an increase of cell survival both in the absence or in the presence of 2-chlorodeoxyadenosine, while no diffe...

journal_title：Haematologica

authors： Morabito F,Filangeri M,Sculli G,Oliva B

更新日期：1998-11-01 00:00:00

abstract：:We report on a patient with relapsed chronic lymphocytic leukemia (CLL) treated with the novel mTOR inhibitor RAD001 within a phase II clinical trial. Although the patient initially responded to therapy, RAD001 was discontinued after 32 weeks due to progression and fludarabine-based chemotherapy was started. The patie...

journal_title：Haematologica

authors： Götze KS,Hoffmann D,Schätzl HM,Peschel C,Fend F,Decker T

更新日期：2007-09-01 00:00:00

abstract：:ALOX5 is implicated in chronic myeloid leukemia development in mouse leukemic stem cells, but its importance in human chronic myeloid leukemia is unknown. Functional ALOX5 was assessed using an LTB4 ELISA and ALOX5, and LTB4R1 mRNA expression was determined via a TaqMan gene expression assay. LTB4R1 and 5-LOX protein ...

journal_title：Haematologica

authors： Lucas CM,Harris RJ,Giannoudis A,McDonald E,Clark RE

更新日期：2014-11-01 00:00:00

abstract：:Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular pathologies such as atherosclerosis and thrombosis. Here, we sought ...

journal_title：Haematologica

authors： Kurakula K,Koenis DS,Herzik MA Jr,Liu Y,Craft JW Jr,van Loenen PB,Vos M,Tran MK,Versteeg HH,Goumans MTH,Ruf W,de Vries CJM,Şen M

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear. DESIGN AND METHODS:Hepcidin expression, SMAD and extracellular signa...

journal_title：Haematologica

authors： Poli M,Luscieti S,Gandini V,Maccarinelli F,Finazzi D,Silvestri L,Roetto A,Arosio P

更新日期：2010-11-01 00:00:00

abstract：:Five patients with lymphoid blastic transformation of chronic myeloid leukemia have been treated with IL2 associated with Vincristine (VCR) plus Prednisone (PDN). Our study indicates that IL2 may be employed in the management of this disease without excessive toxicity at the higher doses in hospitalized patients and a...

journal_title：Haematologica

authors： Meloni G,Foà R,Tosti S,Vignetti M,Gavosto F,Mandelli F

更新日期：1990-11-01 00:00:00

abstract：:n patients with Kasabach-Merritt syndrome (KMS), local activation of coagulation commonly results in disseminated intravascular coagulation (DIC). Progress of DIC is associated with 30-40% mortality as a result of uncontrollable hemorrhage. A 39-year-old woman with an enlarging giant liver hemangioma was diagnosed as ...

journal_title：Haematologica

authors： Ontachi Y,Asakura H,Omote M,Yoshida T,Matsui O,Nakao S

更新日期：2005-11-01 00:00:00

abstract：:One hundred thirty-three febrile episodes in 115 neutropenic patients with hematologic malignancies were empirically treated with ceftriaxone and amikacin in a single daily dose. An indwelling central venous catheter (CVC) was present in 44 cases. Septicemia was documented in 18 (41%) patients with CVC (13 gram-positi...

journal_title：Haematologica

authors： Martino P,Girmenia C,Raccah R,Micozzi A,Cimino G,Mandelli F

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Identification of early megakaryocyte (MK) precursors is difficult and conflicting. The prevalence of leukemias with a megakaryocytic component may be underestimated when conventional techniques are utilized. The recent development of immuno-ultrastructural procedures for simultaneous detection of platelet p...

journal_title：Haematologica

authors： Tomasi P,Tallarico A,Vasi V,Scapoli G,Castoldi G

更新日期：1993-03-01 00:00:00

abstract：:By combining the polymerase chain reaction (PCR) of the gamma globin gene promoters with synthetic oligonucleotide analysis we have diagnosed the -196 C----T and the -117 G----A substitutions in heterozygous carriers of non deletional A gamma HPFH from two unrelated Italian families. The identification of the beta-tha...

journal_title：Haematologica

authors： Gottardi E,Alfarano A,Serra A,Sciarratta G,Bertero MT,Saglio G,Camaschella C

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Cord blood (CB) is a valuable source of stem cells. Most CB units are still cryopreserved in single bags in the world's CB banks. Thawing a single CB unit, dividing it into two parts, expanding the smaller one and refreezing the other would optimize ex vivo expansion of CB progenitors prior to...

journal_title：Haematologica

authors： Timeus F,Crescenzio N,Saracco P,Doria A,Fazio L,Albiani R,Cordero Di Montezemolo L,Perugini L,Incarbone E

更新日期：2003-01-01 00:00:00

abstract：:Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. In nonanemic Taiwanese women (n=79, 44 TT variant, 35 CC variant), we administered standardized rice-based test meals containing 4 mg of labeled 57Fe or 58Fe a...

journal_title：Haematologica

authors： Buerkli S,Pei SN,Hsiao SC,Lee CT,Zeder C,Zimmermann MB,Moretti D

更新日期：2020-10-05 00:00:00