Abstract:
:We report on a patient with relapsed chronic lymphocytic leukemia (CLL) treated with the novel mTOR inhibitor RAD001 within a phase II clinical trial. Although the patient initially responded to therapy, RAD001 was discontinued after 32 weeks due to progression and fludarabine-based chemotherapy was started. The patient subsequently developed a rapidly fatal Epstein-Barr-virus-associated lymphoproliferative disorder, clonally unrelated to the CLL. The clinical course suggests caution when using newer immunosuppressive drugs for treatment of CLL, especially in the context of additional purine analog therapy.
journal_name
Haematologicajournal_title
Haematologicaauthors
Götze KS,Hoffmann D,Schätzl HM,Peschel C,Fend F,Decker Tdoi
10.3324/haematol.11155subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1282-3issue
9eissn
0390-6078issn
1592-8721journal_volume
92pub_type
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