Abstract:
BACKGROUND:Light chain amyloidosis is a rare plasma cell dyscrasia. Interphase fluorescence in situ hybridization (FISH) coupled to cytoplasmic staining of specific Ig (cIg-FISH) on bone marrow plasma cells has become well established in the initial evaluation of multiple myeloma, a related disorder. Little, however, is known about cytogenetic abnormalities in patients with light chain amyloidosis. DESIGN AND METHODS:We reviewed 56 patients with light chain amyloidosis who had cIg-FISH performed as part of their routine clinical testing using the standard screening panel employed in multiple myeloma at our institution. RESULTS:Seventy percent of patients had abnormal cIg-FISH, with the most common abnormalities being IgH translocations [48%]--including t(11;14) [39%], and t(14;16) [2%]--and del13/del13q [30%]. No t(4;14) or deletions of 17p (p53) were observed. Patients with t(11;14) had the lowest levels of clonal plasma cells, and those with del13 had the highest. The risk of death for patients harboring the t(11;14) translocation was 2.1 (CI 1.04-6.4), which on multivariate analysis was independent of therapy. CONCLUSIONS:Although preliminary, our data would suggest that cIg-FISH testing is important in patients with light chain amyloidosis and that t(11;14) is an adverse prognostic factor in these patients.
journal_name
Haematologicajournal_title
Haematologicaauthors
Bryce AH,Ketterling RP,Gertz MA,Lacy M,Knudson RA,Zeldenrust S,Kumar S,Hayman S,Buadi F,Kyle RA,Greipp PR,Lust JA,Russell S,Rajkumar SV,Fonseca R,Dispenzieri Adoi
10.3324/haematol.13369subject
Has Abstractpub_date
2009-03-01 00:00:00pages
380-6issue
3eissn
0390-6078issn
1592-8721pii
haematol.13369journal_volume
94pub_type
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