Return to normal values of lipid pattern after effective chemotherapy in acute lymphoblastic leukemia.

abstract：BACKGROUND:Resistance to imatinib is an important clinical issue in the treatment of Philadelphia chromosome-positive leukemias which is being tackled by the development of new, more potent drugs, such as the dual Src/Abl tyrosine kinase inhibitors dasatinib and bosutinib and the imatinib analog nilotinib. In the curre...

journal_title：Haematologica

authors： Puttini M,Redaelli S,Moretti L,Brussolo S,Gunby RH,Mologni L,Marchesi E,Cleris L,Donella-Deana A,Drueckes P,Sala E,Lucchini V,Kubbutat M,Formelli F,Zambon A,Scapozza L,Gambacorti-Passerini C

更新日期：2008-05-01 00:00:00

abstract：:Double umbilical cord blood transplantation is increasingly applied in the treatment of adult patients with high-risk hematological malignancies and has been associated with improved engraftment as compared to that provided by single unit cord blood transplantation. The mechanism of improved engraftment is, however, s...

journal_title：Haematologica

authors： Somers JA,Braakman E,van der Holt B,Petersen EJ,Marijt EW,Huisman C,Sintnicolaas K,Oudshoorn M,Groenendijk-Sijnke ME,Brand A,Cornelissen JJ

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...

journal_title：Haematologica

authors： Origa R,Galanello R,Ganz T,Giagu N,Maccioni L,Faa G,Nemeth E

更新日期：2007-05-01 00:00:00

abstract：:Recently, the principles of density gradient cell separation have been transferred to the marrow fractionation, and the Ficoll technique by using a COBE 2991 blood cell processor has been developed and widely employed as well. This method is particularly useful in view of a chemical antineoplastic purging intended for...

journal_title：Haematologica

authors： Iacone A,Quaglietta AM,D'Antonio D,Accorsi P,Dragani A,Angrilli F,Berardi A,Angelini A,Di Bartolomeo P,Di Bartolomeo G

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22, creating the fusion gene BCR-ABL. The clinical significance of the type of BCR-ABL transcript in newly diagnosed patients in chronic phase treated with imatinib 400 mg from initial diagnosis remains unknown....

journal_title：Haematologica

authors： Lucas CM,Harris RJ,Giannoudis A,Davies A,Knight K,Watmough SJ,Wang L,Clark RE

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). DESIGN AND METHODS:Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusi...

journal_title：Haematologica

authors： Cesana C,Nosari AM,Klersy C,Miqueleiz S,Rossi V,Ferrando P,Valentini M,Barbarano L,Morra E

更新日期：2003-09-01 00:00:00

abstract：:β-thalassemia and sickle cell disease are widespread fatal genetic diseases. None of the existing clinical treatments provides a solution for all patients. Two main strategies for treatment are currently being investigated: (i) gene transfer of a normal β-globin gene; (ii) reactivation of the endogenous γ-globin gene....

journal_title：Haematologica

authors： Manchinu MF,Marongiu MF,Poddie D,Casu C,Latini V,Simbula M,Galanello R,Moi P,Cao A,Porcu S,Ristaldi MS

更新日期：2014-01-01 00:00:00

abstract：:The clinical heterogeneity among first relapses of childhood ETV6/RUNX1-positive acute lymphoblastic leukemia indicates that further genetic alterations in leukemic cells might affect the course of salvage therapy and be of prognostic relevance. To assess the incidence and prognostic relevance of additional copy numbe...

journal_title：Haematologica

authors： Bokemeyer A,Eckert C,Meyr F,Koerner G,von Stackelberg A,Ullmann R,Türkmen S,Henze G,Seeger K

更新日期：2014-04-01 00:00:00

abstract：:We conducted a phase I/II multicenter trial using 6 cycles of brentuximab vedotin (BV) in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for treatment of patients with CD30-positive (+) B-cell lymphomas. Thirty-one patients were evaluable for toxicity and 29 for efficacy including 22...

journal_title：Haematologica

authors： Svoboda J,Bair SM,Landsburg DJ,Nasta SD,Nagle SJ,Barta SK,Khan N,Filicko-O'Hara J,Gaballa S,Strelec L,Chong E,Mitnick S,Waite TS,King C,Ballard H,Youngman M,Gerson J,Plastaras JP,Maity A,Bogusz AM,Hung SS,Nakamu

更新日期：2020-05-15 00:00:00

abstract：:We performed a dose-escalation study of bendamustine in 31 patients with multiple myeloma that had progressed after high-dose chemotherapy. Bendamustine 100 mg/m2 on days 1 and 2 per cycle was found to be the maximal tolerated dose. The overall response rate was 55% with a median progression-free survival of 26 (0-61)...

journal_title：Haematologica

authors： Knop S,Straka C,Haen M,Schwedes R,Hebart H,Einsele H

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transplant-related mortality (TRM) following allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be related to disease stage, duratiion of disease and type of donor. Furthermore, the outcome of transplants performed in the 1990s appears to be better than that of tran...

journal_title：Haematologica

authors： Bacigalupo A,Sormani MP,Lamparelli T,Gualandi F,Occhini D,Bregante S,Raiola AM,di Grazia C,Dominietto A,Tedone E,Piaggio G,Podesta M,Bruno B,Oneto R,Lombardi A,Frassoni F,Rolla D,Rollandi G,Viscoli C,Ferro C,Garba

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Mesenchymal stem cells (MSC) are progenitor cells that are capable of differentiating into mesenchymal tissues. Fetal and adult MSC have similar morphology but differ in proliferative, differentiating and immunosuppressive properties. Further exploring their differences could help in choosing ...

journal_title：Haematologica

authors： Götherström C,West A,Liden J,Uzunel M,Lahesmaa R,Le Blanc K

更新日期：2005-08-01 00:00:00

abstract：:We studied the impact of comorbidities on survival and evaluated the prognostic utility of comorbidity scores in MDS patients, who received best supportive care and were assessable according to the Charlson Comorbidity Index (CCI) and the Hematopoietic Stem Cell Transplantation Comorbidity Index (HCTCI): 171 patients ...

journal_title：Haematologica

authors： Zipperer E,Pelz D,Nachtkamp K,Kuendgen A,Strupp C,Gattermann N,Haas R,Germing U

更新日期：2009-05-01 00:00:00

abstract：:Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deformability and there is marked heterogeneity in disease severity among patients. To ...

journal_title：Haematologica

authors： Huisjes R,Makhro A,Llaudet-Planas E,Hertz L,Petkova-Kirova P,Verhagen LP,Pignatelli S,Rab MAE,Schiffelers RM,Seiler E,van Solinge WW,Corrons JV,Kaestner L,Mañú-Pereira M,Bogdanova A,van Wijk R

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We tested the principle of local International Normalized Ratio (INR) calibration using INR calibrator plasmas (PT Calibration Plasma Kit, Behring), two thomboplastin reagents (Neoplastin plus, rabbit brain, Stago, and Recombiplastin, recombinant human tissue factor, Ortho Diagnostics) and the...

journal_title：Haematologica

authors： Testa S,Morstabilini G,Fattorini A,Galli L,Denti N,D'Angelo A

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T)...

journal_title：Haematologica

authors： Kracht T,Schrappe M,Strehl S,Reiter A,Elsner HA,Trka J,Cario G,Viehmann S,Harbott J,Borkhardt A,Metzler M,Langer T,Repp R,Marschalek R,Welte K,Haas OA,Stanulla M

更新日期：2004-12-01 00:00:00

abstract：:The dic(9;20)(p11-13;q11) is a recurrent chromosomal abnormality in patients with acute lymphoblastic leukemia. Although it results in loss of material from 9p and 20q, the molecular targets on both chromosomes have not been fully elucidated. From an initial cohort of 58 with acute lymphoblastic leukemia patients with...

journal_title：Haematologica

authors： An Q,Wright SL,Moorman AV,Parker H,Griffiths M,Ross FM,Davies T,Harrison CJ,Strefford JC

更新日期：2009-08-01 00:00:00

abstract：:In childhood B-cell precursor acute lymphoblastic leukemia, cytogenetics is important in diagnosis and as an indicator of response to therapy, thus playing a key role in risk stratification of patients for treatment. Little is known of the relationship between different cytogenetic subtypes in B-cell precursor acute l...

journal_title：Haematologica

authors： Schwab CJ,Chilton L,Morrison H,Jones L,Al-Shehhi H,Erhorn A,Russell LJ,Moorman AV,Harrison CJ

更新日期：2013-07-01 00:00:00

abstract：:BCL11A was the focus of recent studies on its inhibiting effect when bound onto the β-globin cluster in the mechanism of hemoglobin switching and HbF downregulation. We examined a cohort of 10 patients displaying different HbF levels and short deletions within the γβ-δ intergenic region to find a possible correlation ...

journal_title：Haematologica

authors： Ghedira ES,Lecerf L,Faubert E,Costes B,Moradkhani K,Bachir D,Galactéros F,Pissard S

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:In normal platelets, insulin inhibits agonist-induced Ca(2+) mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca(2+) mobilization, aggregation and procoagulant activity. We searched for the cause of this insulin resistance. DESIGN AN...

journal_title：Haematologica

authors： Gerrits AJ,Gitz E,Koekman CA,Visseren FL,van Haeften TW,Akkerman JW

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Diamond-Blackfan anemia is a fatal congenital anemia characterized by a specific disruption in erythroid progenitor cell development. Approximately 25% of patients have mutations in the ribosomal protein RPS19 suggesting that Diamond-Blackfan anemia may be caused by a defect in ribosome biogenesis and transl...

journal_title：Haematologica

authors： Rey MA,Duffy SP,Brown JK,Kennedy JA,Dick JE,Dror Y,Tailor CS

更新日期：2008-11-01 00:00:00

abstract：:We report a case of adult-type Gaucher's disease associated with monoclonal gammapathy of undetermined significance. Bone marrow infiltration by Gaucher's cells and spleen infiltration by Gaucher cells and plasma cells was observed on cytohistologic examination. Splenectomy induced complete recovery of cytopenias and ...

journal_title：Haematologica

authors： Airò R,Gabusi G,Guindani M

更新日期：1993-03-01 00:00:00

abstract：:There is emerging consensus that a pro-inflammatory condition contributes to the vaso-occlusive complications of sickle cell disease (SCD). We evaluated the potential value of inflammatory mediators as early markers of severity of painful vaso-occlusive crises (VOC) in SCD. We assayed the plasma levels of cytokines, s...

journal_title：Haematologica

authors： Etienne-Julan M,Belloy MS,Decastel M,Dougaparsad S,Ravion S,Hardy-Dessources MD

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Chronic graft-versus-host disease is a common late complication of allogeneic hematopoietic stem cell transplantation. Corticosteroids are the standard initial treatment. Second-line treatment has not been well defined. We evaluated the effectiveness and safety of low doses of alemtuzumab plus low doses of r...

journal_title：Haematologica

authors： Gutiérrez-Aguirre CH,Cantú-Rodríguez OG,Borjas-Almaguer OD,González-Llano O,Jaime-Pérez JC,Solano-Genesta M,Gómez-Guijosa M,Mancias-Guerra C,Tarin L,Gómez-Almaguer D

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acquired red cell aplasia (RCA) is a rare disorder and can be either idiopathic or associated with certain diseases, pregnancy, or drugs. In exceptionally rare cases, it has been reported to co-exist with other autoimmune cytopenias. We report a high incidence of RCA and autoimmune hemolytic a...

journal_title：Haematologica

authors： Elimelakh M,Dayton V,Park KS,Gruessner AC,Sutherland D,Howe RB,Reding MT,Eastlund T,van Burik JA,Singleton TP,Gruessner RW,Key NS

更新日期：2007-08-01 00:00:00

abstract：:Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). The aim of this study was to define the prevalence and clinical characteristics of pediatric thrombosis in subjects with inherite...

journal_title：Haematologica

authors： de la Morena-Barrio B,Orlando C,de la Morena-Barrio ME,Vicente V,Jochmans K,Corral J

更新日期：2019-12-01 00:00:00

abstract：:Twenty-five adult patients with resistant or early relapsing Hodgkin's disease have been treated with CAV combination chemotherapy (CCNU, melphalan and etoposide). All patients had previously received both MOPP and ABVD regimens (23 patients as primary therapy and two as first salvage). High-energy radiotherapy had be...

journal_title：Haematologica

authors： Brusamolino E,Castelli G,Pagnucco G,Orlandi E,Malagó D,Lazzarino M,Bernasconi C

更新日期：1990-07-01 00:00:00

abstract：:Autoimmune lymphoproliferative disorders, including autoimmune lymphoproliferative syndrome (ALPS) and Dianzani autoimmune lymphoproliferative disease (DALD), are inherited defects of the Fas apoptotic pathway characterized by lymphoid accumulation and autoimmune manifestations. We report the molecular, clinical, immu...

journal_title：Haematologica

authors： Campagnoli MF,Garbarini L,Quarello P,Garelli E,Carando A,Baravalle V,Doria A,Biava A,Chiocchetti A,Rosolen A,Dufour C,Dianzani U,Ramenghi U

更新日期：2006-04-01 00:00:00

abstract：:Decidual natural killer cells accumulate at the fetal-maternal interface and play a key role in a successful pregnancy. However, their origin is still unknown. Do they derive from peripheral natural killer cells recruited in decidua or do they represent a distinct population that originates in situ? Here, we identifie...

journal_title：Haematologica

authors： Chiossone L,Vacca P,Orecchia P,Croxatto D,Damonte P,Astigiano S,Barbieri O,Bottino C,Moretta L,Mingari MC

更新日期：2014-03-01 00:00:00

abstract：UNLABELLED:BACKGROUND Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34(+) stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem cells has previously been impractical because of the sca...

journal_title：Haematologica

authors： Fischer U,Ruckert C,Hubner B,Eckermann O,Binder V,Bakchoul T,Schuster FR,Merk S,Klein HU,Führer M,Dugas M,Borkhardt A

更新日期：2012-09-01 00:00:00