Abstract:
:There is emerging consensus that a pro-inflammatory condition contributes to the vaso-occlusive complications of sickle cell disease (SCD). We evaluated the potential value of inflammatory mediators as early markers of severity of painful vaso-occlusive crises (VOC) in SCD. We assayed the plasma levels of cytokines, soluble vascular cell adhesion molecule-1, acute phase proteins, secretory phospholipase and standard hematologic indices.
journal_name
Haematologicajournal_title
Haematologicaauthors
Etienne-Julan M,Belloy MS,Decastel M,Dougaparsad S,Ravion S,Hardy-Dessources MDkeywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
863-4issue
7eissn
0390-6078issn
1592-8721journal_volume
89pub_type
信件相关文献
HAEMATOLOGICA文献大全abstract::This study aimed at evaluating the effectiveness of alpha interferon (IFN) in chronic myelomonocytic leukemia, a disease for which therapeutic options are still unsatisfactory. Fourteen sequential unselected patients received recombinant alpha-2b IFN (Intron-A, Schering-Essex) 3 megaU/day, progressively elevated to 10...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many physiological processes. Indeed, t...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2019.236901
更新日期:2020-01-31 00:00:00
abstract::Transient pancytopenia preceding childhood acute lymphoblastic leukemia (ALL) is an unfrequent but well-known event. The association of this preleukemic syndrome with hepatitis is extremely rare, with only two such cases having been published in the literature. We report the case of a 16-year-old boy who was diagnosed...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.008508
更新日期:2009-10-01 00:00:00
abstract::Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact in the general population are rare. Furthermore, discussions on the optimal definition of anemia have n...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.195552
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The threshold for prophylactic platelet transfusions has been classically established at 20,000/microL. In 48 patients with de novo acute myeloblastic leukemia (AML) we analyzed the effect of reducing the threshold for prophylactic platelet transfusion from 20,000/microL (group A) to 10,000/mic...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Chronic myeloid leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22, creating the fusion gene BCR-ABL. The clinical significance of the type of BCR-ABL transcript in newly diagnosed patients in chronic phase treated with imatinib 400 mg from initial diagnosis remains unknown....
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:10.3324/haematol.2009.009134
更新日期:2009-10-01 00:00:00
abstract::Although myelodysplastic syndromes are heterogeneous disorders comprising a benign subset of bone marrow failure similar to aplastic anemia, no laboratory test has been established to distinguish it from bone marrow failures that can evolve into acute myeloid leukemia. Plasma thrombopoietin levels were measured in 120...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2012.066217
更新日期:2013-06-01 00:00:00
abstract::Children with immune thrombocytopenia for ≥6 months completing a romiplostim study received weekly subcutaneous romiplostim (1-10 μg/kg targeting platelet counts of 50-200×109/L) in this extension to examine romiplostim's long-term safety and efficacy. Sixty-five children received romiplostim for a median of 2.6 years...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.202283
更新日期:2019-11-01 00:00:00
abstract::Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2006-05-01 00:00:00
abstract::e tested whether polymorphic variations in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and interleukin-1 (IL-1beta and IL-1RN) genes confer susceptibility to mucosa-associated lymphoid tissue lymphomas (MALT) in a Chinese population. The rates of GSTM1, GSTP1, IL-1beta and IL-1RN genotypes did not differ bet...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T)...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:
更新日期:2004-12-01 00:00:00
abstract::It is well known that allo-reactive T cells play a crucial role in graft-versus-leukemia and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (alloSCT). Allo-reactive CD4(+) T cells can mediate direct cytolysis, but may also stimulate production of IgG antibodies as helper cells. Immu...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:10.3324/haematol.2013.086652
更新日期:2014-02-01 00:00:00
abstract::We report results of a phase II trial of combination of melphalan, lenalidomide, and dexamethasone for the treatment of immunoglobulin light chain (AL) amyloidosis. The primary objectives were tolerability and hematologic response rate; secondary objectives were organ responses and survival. Treatment protocol consist...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2012.075192
更新日期:2013-05-01 00:00:00
abstract::Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deformability and there is marked heterogeneity in disease severity among patients. To ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.188151
更新日期:2020-01-31 00:00:00
abstract::By combining the polymerase chain reaction (PCR) of the gamma globin gene promoters with synthetic oligonucleotide analysis we have diagnosed the -196 C----T and the -117 G----A substitutions in heterozygous carriers of non deletional A gamma HPFH from two unrelated Italian families. The identification of the beta-tha...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neu...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::Since HA-1-specific T cells have been shown to make a significant contribution to the clinical responses in patients with relapsed leukemia, we investigated the feasibility of adoptive transfer of in vitro induced HA-1-specific CD8 positive T cells to patients with relapsed leukemia after allogeneic stem cell transpla...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2011.053371
更新日期:2012-08-01 00:00:00
abstract::Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to gran...
journal_title:Haematologica
pub_type: 信件
doi:10.3324/haematol.12183
更新日期:2008-03-01 00:00:00
abstract::About 25-30% of patients with immune thrombocytopenic purpura (ITP) are refractory to corticosteroids, splenectomy and other treatments. It has been suggested that interferon-alpha 2b (IFN-alpha 2b) may be useful in the treatment of chronic refractory ITP patients. We treated 9 chronic refractory ITP patients with IFN...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:1998-08-01 00:00:00
abstract::New drugs are needed for the treatment of relapsed acute lymphoblastic leukemia and preclinical evaluation of the MEK inhibitor, selumetinib, has shown that this drug has excellent activity in those leukemias with RAS pathway mutations. The proapoptotic protein, BIM is pivotal in the induction of cell death by both se...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.185975
更新日期:2019-09-01 00:00:00
abstract::Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the stre...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.177972
更新日期:2018-03-01 00:00:00
abstract::The coexistence of chronic myeloid leukemia (CML) and B-cell chronic lymphocytic leukemia (CLL) in the same patient is rare. A 71-year-old woman developed a B-lineage lymphoid blast crisis at 18 months after diagnosis of Ph-positive CML. At this time, a lymphoid cell population with morphologic and immunophenotypic fe...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
abstract::Our preliminary results suggest the existence of quantitative and qualitative differences in immune cells and type1 and type2 cytokines between granulocyte colony-stimulating factor (G-CSF) primed bone marrow (G-BM) and G-CSF-mobilized peripheral blood grafts (G-PB). Our findings suggest that lower T-cell hyporesponsi...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2005-05-01 00:00:00
abstract::The causes of myeloproliferative neoplasm (MPN) are unknown. We conducted a large population-based study including 11,039 myeloproliferative neoplasm patients and 43,550 matched controls with the aim of assessing the associations between a personal history of a broad span of autoimmune diseases and subsequent risk of ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.020412
更新日期:2010-07-01 00:00:00
abstract::In the eighties there has been an enormous increase in our knowledge about erythropoietin, previously defined as "an elusive hormone". In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the ...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Myelodysplastic syndromes (MDS) comprise a group of heterogeneous hematologic disorders with risk of leukemic evolution (LE). The French-American-British (FAB) co-operative group classifies them into five morphologic entities and the International Prognostic Scoring System (IPSS) proposes four...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The clinical and immunologic activities of interleukin-2 (IL-2) in cancer patients have been extensively studied and described; however, in most of these studies, IL-2 was administered by intravenous bolus or continuous infusion, while the immunologic effects of IL-2 given by the subcutaneous (...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::As the defective genes for more and more genetic disorders become unravelled, it is clear that patients with apparently identical genotypes can have many different clinical conditions even in simple monogenic disorders. Beta thalassemia occurs when there is a deficiency in the synthesis of beta globin chains. The clin...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The c-Met signaling pathway regulates a variety of biological processes, including proliferation, survival and migration. Deregulated c-Met activation has been implicated in the pathogenesis and prognosis of many human malignancies. We studied the function and prognostic significance of c-Met and hepatocyte ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2011.056101
更新日期:2012-04-01 00:00:00