Expression of the c-Met oncogene by tumor cells predicts a favorable outcome in classical Hodgkin's lymphoma.

abstract：:Arecent source data meta-analysis of randomized trials in adults assessing the immunoconjugate gemtuzumab ozogamicin combined with standard chemotherapy in acute myeloid leukemia showed a significant survival benefit in patients without an adverse karyotype. It is not clear whether the optimal dose should be 3 mg/m(2)...

journal_title：Haematologica

authors： Burnett A,Cavenagh J,Russell N,Hills R,Kell J,Jones G,Nielsen OJ,Khwaja A,Thomas I,Clark R,UK NCRI AML Study Group.

更新日期：2016-06-01 00:00:00

abstract：:Thromboembolism is a serious complication of induction therapy for childhood acute lymphoblastic leukemia. We prospectively compared the efficacy and safety of antithrombotic interventions in the consecutive leukemia trials ALL-BFM 2000 and AIEOP-BFM ALL 2009. Patients with newly diagnosed acute lymphoblastic leukemia...

journal_title：Haematologica

authors： Greiner J,Schrappe M,Claviez A,Zimmermann M,Niemeyer C,Kolb R,Eberl W,Berthold F,Bergsträsser E,Gnekow A,Lassay E,Vorwerk P,Lauten M,Sauerbrey A,Rischewski J,Beilken A,Henze G,Korte W,Möricke A,THROMBOTECT Study Inv

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Increased levels of microparticles exposing tissue factor circulate in the blood of patients with coronary heart disease, possibly disseminating their pro-thrombotic and pro-inflammatory potential. Because diets rich in n-3 (polyunsaturated) fatty acids have been associated with reduced incidence of coronary...

journal_title：Haematologica

authors： Del Turco S,Basta G,Lazzerini G,Evangelista M,Rainaldi G,Tanganelli P,Christensen JH,Schmidt EB,De Caterina R

更新日期：2008-06-01 00:00:00

abstract：:Cough mixture abuse has been reported to cause severe folate deficiency and neurological defects. We carried out a prospective case-controlled survey to confirm this association and define the incidence and severity of the problem. A total of 57 cough mixture abusers and 47 other substance abusers (controls) were stud...

journal_title：Haematologica

authors： Au WY,Tsang SK,Cheung BK,Siu TS,Ma ES,Tam S

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Whether human mesenchymal stem cells (MSC) can be transplanted is controversial and their presence in peripheral blood is not fully accepted. In the present study we have analyzed whether, within the allogeneic transplantation setting, MSC are of host or donor origin. DESIGN AND METHODS:Bone ...

journal_title：Haematologica

authors： Villaron EM,Almeida J,López-Holgado N,Alcoceba M,Sánchez-Abarca LI,Sanchez-Guijo FM,Alberca M,Pérez-Simon JA,San Miguel JF,Del Cañizo MC

更新日期：2004-12-01 00:00:00

abstract：:In this article we summarize the clinical outcome of unrelated placental/umbilical cord blood (CB) transplantation, discuss the biological characteristics of CB hematopoietic progenitor/stem cells (HPC) and balance the relative advantages and disadvantages of this therapy as compared with transplantation of other HPC ...

journal_title：Haematologica

authors： Sirchia G,Rebulla P

更新日期：1999-08-01 00:00:00

abstract：:To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (...

journal_title：Haematologica

authors： Czibere A,Bruns I,Junge B,Singh R,Kobbe G,Haas R,Germing U

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The rate of post-operative asymptomatic deep-vein thrombosis in Asian patients remains uncertain. The aim of this study was to estimate the rate of venous thromboembolism, including asymptomatic deep-vein thrombosis, undergoing hip or knee surgery and not receiving pharmacological thromboproph...

journal_title：Haematologica

authors： Leizorovicz A,SMART Venography Study Steering Committee.

更新日期：2007-09-01 00:00:00

abstract：:Thrombosis occurs in 20 to 30% of patients with Behçet's disease (BD), but the precise pathogenic mechanism underlying the thrombotic tendency in these patients is not well known. Venous thromboses are commonly located in the lower extremities, but right intracardiac thrombi are extremely rare. We report for the first...

journal_title：Haematologica

authors： Vayá A,Forner MJ,Estellés A,Villa P,Mira Y,Ferrando F,García Fuster JM,Oliver V,Aznar J

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Most secreted proteins, including coagulation factor X (FX), are synthesized with a signal peptide, which is necessary for targeting the nascent polypeptide into the endoplasmic reticulum. Characterization of naturally occurring mutations may provide insights into the functional roles of the a...

journal_title：Haematologica

authors： Wang WB,Fu QH,Yin J,Wu WM,Ding QL,Zhou RF,Hu YQ,Wang XF,Wang ZY,Wang HL

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Chromosome 5 and/or 7 abnormalities are cytogenetic findings indicative of a poor prognosis in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The only potential cure for such patients is allogeneic stem cell transplantation (SCT). As data on allogeneic SCT in thi...

journal_title：Haematologica

authors： van der Straaten HM,van Biezen A,Brand R,Schattenberg AV,Egeler RM,Barge RM,Cornelissen JJ,Schouten HC,Ossenkoppele GJ,Verdonck LF,Netherlands Stem Cell Transplant Registry \TYPHON\.

更新日期：2005-10-01 00:00:00

abstract：:Forty-six patients with chronic myeloid leukemia receiving imatinib mesylate (39 in chronic phase, one in accelerated phase, and six in blastic crisis), were studied for a 20-62 month follow-up period by cytogenetics and fluorescence in situ hybridization using dual-color, dual-fusion BCR and ABL probes. This approach...

journal_title：Haematologica

authors： Calabrese G,Fantasia D,Di Gianfilippo R,Stuppia L,Di Lorenzo R,Palka G

更新日期：2006-07-01 00:00:00

abstract：:In this open label pilot safety study 80 children over 3 months old with deep venous thrombosis were treated with enoxaparin with a target 4 h anti-factor Xa activity between 0.5-0.8 IU/mL. The children were stratified to receive once daily or twice daily doses. The study end-points were post-thrombotic syndrome, re-t...

journal_title：Haematologica

authors： Schobess R,Düring C,Bidlingmaier C,Heinecke A,Merkel N,Nowak-Göttl U

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Detection of minimal residual disease (MRD) by multiparameter flow cytometry is an emerging prognostic factor in patients with acute myeloid leukemia (AML). The present analysis aimed at improving the applicability of this approach to more patients with AML. DESIGN AND METHODS:Bone marrow sam...

journal_title：Haematologica

authors： Kern W,Danhauser-Riedl S,Ratei R,Schnittger S,Schoch C,Kolb HJ,Ludwig WD,Hiddemann W,Haferlach T

更新日期：2003-06-01 00:00:00

abstract：:To identify factors associated with relapse-free survival (RFS), 80 patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia, enrolled in a phase II study of imatinib-combined chemotherapy, were analyzed. The median follow-up of surviving patients was 26.7 months (maximum, 52.5 month...

journal_title：Haematologica

authors： Yanada M,Takeuchi J,Sugiura I,Akiyama H,Usui N,Yagasaki F,Nishii K,Ueda Y,Takeuchi M,Miyawaki S,Maruta A,Narimatsu H,Miyazaki Y,Ohtake S,Jinnai I,Matsuo K,Naoe T,Ohno R,Japan Adult Leukemia Study Group.

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To assess the efficacy and the toxic profile of gemcitabine, a novel pyrimidine antimetabolite active against several solid tumors, we carried out a study in heavily pretreated Hodgkin's disease (HD) patients. DESIGN AND METHODS:From May 1997 to January 1999, 14 pretreated patients (10 relaps...

journal_title：Haematologica

authors： Zinzani PL,Bendandi M,Stefoni V,Albertini P,Gherlinzoni F,Tani M,Piccaluga PP,Tura S

更新日期：2000-09-01 00:00:00

abstract：:Recent advances in unrelated cord blood transplantation have increased chances and options available in allogeneic stem cell transplantation. The effect of HLA disparity on outcomes after cord blood transplantation was studied recently in mainly pediatric populations. Results showed that HLA matching in combination wi...

journal_title：Haematologica

authors： Atsuta Y,Kanda J,Takanashi M,Morishima Y,Taniguchi S,Takahashi S,Ogawa H,Ohashi K,Ohno Y,Onishi Y,Aotsuka N,Nagamura-Inoue T,Kato K,Kanda Y,HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation.

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The hemangioblast is a bi-potential precursor cell with the capacity to differentiate into hematopoietic and vascular cells. In mouse E7.0-7.5 embryos, the hemangioblast can be identified by a clonal blast colony-forming cell (BL-CFC) assay or single cell OP9 co-culture. However, the ontogeny of the hemangio...

journal_title：Haematologica

authors： He WY,Lan Y,Yao HY,Li Z,Wang XY,Li XS,Zhang JY,Zhang Y,Liu B,Mao N

更新日期：2010-06-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose immunophenotype remains incompletely characterized, particularly in terms of distinction from reactive plasmacytoid dendritic cells (PDCs). This limitation complicates detection of low-level involvement by BPDCN as well as mini...

journal_title：Haematologica

authors： Wang W,Khoury JD,Miranda RN,Jorgensen JL,Xu J,Loghavi S,Li S,Pemmaraju N,Nguyen T,Medeiros LJ,Wang SA

更新日期：2020-04-02 00:00:00

abstract：BACKGROUND:Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell dep...

journal_title：Haematologica

authors： Ayuk F,Perez-Simon JA,Shimoni A,Sureda A,Zabelina T,Schwerdtfeger R,Martino R,Sayer HG,Alegre A,Lahuerta JJ,Atanackovic D,Wolschke C,Nagler A,Zander AR,San Miguel JF,Kröger N

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:In recent years many therapeutic regimens have been designed in order to improve response rate and response duration in non-Hodgkin's lymphoma (NHL). In 1991 the Italian Lymphoma Study Group (GISL) started a prospective randomized trial on treatment of aggressive and advanced NHL, focused on the efficacy of ...

journal_title：Haematologica

authors： Brugiatelli M,Federico M,Gobbi PG,Avanzini P,Callea V,Cavanna L,De Pasquale A,Di Prisco AU,Di Rienzo N,Silingardi V

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:With the development and refinement of guidance modalities for percutaneous biopsies, many investigators have reported studies supporting the role of guided core needle biopsy in the diagnosis of mediastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core need...

journal_title：Haematologica

authors： Zinzani PL,Corneli G,Cancellieri A,Magagnoli M,Lacava N,Gherlinzoni F,Bendandi M,Albertini P,Baruzzi G,Tura S,Boaron M

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce l...

journal_title：Haematologica

authors： Bousquet M,Nguyen D,Chen C,Shields L,Lodish HF

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS:We studied 23 patients with PNH, before and after five and 11 weeks of treatment with eculizumab. We examined markers of thrombin generation and reactional fibrinolysis...

journal_title：Haematologica

authors： Helley D,de Latour RP,Porcher R,Rodrigues CA,Galy-Fauroux I,Matheron J,Duval A,Schved JF,Fischer AM,Socié G,French Society of Hematology.

更新日期：2010-04-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is a disease with heterogeneous clinical and biological characteristics. Differences in Ca2+ levels among cases, both basal and upon B-cell receptor (BCR) stimulation, may reflect heterogeneity in the pathogenesis due to cell-intrinsic factors. Our aim was to elucidate cell-intrinsic...

journal_title：Haematologica

authors： Meijers RWJ,Muggen AF,Leon LG,de Bie M,van Dongen JJM,Hendriks RW,Langerak AW

更新日期：2020-01-01 00:00:00

abstract：:We report a case of adult-type Gaucher's disease associated with monoclonal gammapathy of undetermined significance. Bone marrow infiltration by Gaucher's cells and spleen infiltration by Gaucher cells and plasma cells was observed on cytohistologic examination. Splenectomy induced complete recovery of cytopenias and ...

journal_title：Haematologica

authors： Airò R,Gabusi G,Guindani M

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD). DESIGN AND METHODS:Eight patients from three unrelated families with this mutation were included in the present study who had distinct VWF abnormalities, not descr...

journal_title：Haematologica

authors： Pérez-Rodríguez A,García-Rivero A,Lourés E,López-Fernández MF,Rodríguez-Trillo A,Batlle J

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:LMO2 is highly expressed at the most immature stages of lymphopoiesis. In T-lymphocytes, aberrant LMO2 expression beyond those stages leads to T-cell acute lymphoblastic leukemia, while in B cells LMO2 is also expressed in germinal center lymphocytes and diffuse large B-cell lymphomas, where it predicts bett...

journal_title：Haematologica

authors： Malumbres R,Fresquet V,Roman-Gomez J,Bobadilla M,Robles EF,Altobelli GG,Calasanz MJ,Smeland EB,Aznar MA,Agirre X,Martin-Palanco V,Prosper F,Lossos IS,Martinez-Climent JA

更新日期：2011-07-01 00:00:00

abstract：:Since its first description in Hodgkin's disease, alcohol-induced pain has subsequently been described both in other neoplasms and in various non-malignant conditions. There seems little doubt that ethyl alcohol itself is responsible, although the mechanism for producing pain remains elusive. We report a case of alcoh...

journal_title：Haematologica

authors： Custodi P,Cerutti A,Bagnato R,Cassani P

更新日期：1993-11-01 00:00:00

abstract：:The long-term repopulating capacity of mobilized peripheral blood (MPB) CD34+ cells can be abrogated during ex vivo expansion due to cell-cycle related changes. In this study, we traced cell cycle kinetic and quiescent status of CD34+ cells during ex vivo expansion with exogenous cytokines. The addition of interleukin...

journal_title：Haematologica

authors： Sanchez-Garcia J,Torres A,Herrera C,Alvarez MA

更新日期：2006-01-01 00:00:00