Abstract:
:Since HA-1-specific T cells have been shown to make a significant contribution to the clinical responses in patients with relapsed leukemia, we investigated the feasibility of adoptive transfer of in vitro induced HA-1-specific CD8 positive T cells to patients with relapsed leukemia after allogeneic stem cell transplantation. The in vitro generation of clinical grade HA-1-specific T-cell lines from HA-1 negative donors was seen to be feasible and 3 patients were treated with HA-1-specific T-cell lines. No toxicity after infusion was observed. Although in one patient, during a period of stable disease, HA-1-specific T cells could be detected in the peripheral blood and bone marrow, these patients had no clear clinical response.
journal_name
Haematologicajournal_title
Haematologicaauthors
Meij P,Jedema I,van der Hoorn MA,Bongaerts R,Cox L,Wafelman AR,Marijt EW,Willemze R,Falkenburg JHdoi
10.3324/haematol.2011.053371subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1205-8issue
8eissn
0390-6078issn
1592-8721pii
haematol.2011.053371journal_volume
97pub_type
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