Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.

abstract：BACKGROUND:In normal platelets, insulin inhibits agonist-induced Ca(2+) mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca(2+) mobilization, aggregation and procoagulant activity. We searched for the cause of this insulin resistance. DESIGN AN...

journal_title：Haematologica

authors： Gerrits AJ,Gitz E,Koekman CA,Visseren FL,van Haeften TW,Akkerman JW

更新日期：2012-08-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-autonomous process, which is the focus of another review in the same issue of Haematologica However, studies on the microenvironment that maintains and regulates HSC (HSC niche) over the past 20 years have suggested that microenvironme...

journal_title：Haematologica

authors： Ho YH,Méndez-Ferrer S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22, creating the fusion gene BCR-ABL. The clinical significance of the type of BCR-ABL transcript in newly diagnosed patients in chronic phase treated with imatinib 400 mg from initial diagnosis remains unknown....

journal_title：Haematologica

authors： Lucas CM,Harris RJ,Giannoudis A,Davies A,Knight K,Watmough SJ,Wang L,Clark RE

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall survival when applied ...

journal_title：Haematologica

authors： Buyse M,Michiels S,Squifflet P,Lucchesi KJ,Hellstrand K,Brune ML,Castaigne S,Rowe JM

更新日期：2011-08-01 00:00:00

abstract：:To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (...

journal_title：Haematologica

authors： Czibere A,Bruns I,Junge B,Singh R,Kobbe G,Haas R,Germing U

更新日期：2009-10-01 00:00:00

abstract：:The regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique combining electron paramagnetic resonance spectroscopy and turbidimetry, which has been utilized...

journal_title：Haematologica

authors： Vara D,Cifuentes-Pagano E,Pagano PJ,Pula G

更新日期：2019-09-01 00:00:00

abstract：:Normal and clonal hematopoietic progenitor cells have been demonstrated to coexist in chronic-phase chronic myelogenous leukemia (CML), but few data are available on the presence of non neoplastic hematopoiesis during the blastic transformation phase. We used reverse transcription-polymerase chain reaction (RT-PCR) to...

journal_title：Haematologica

authors： Martinelli G,Lemoli RM,Farabegoli P,Zaccaria A,Testoni N,Buzzi M,Fogli M,Visani G,Tosi P,Motta MR

更新日期：1994-09-01 00:00:00

abstract：:Factor V Leiden (FVL) and prothrombin G20210A mutation (PTM) are the two most common genetic polymorphisms known to predispose to a first episode of venous thromboembolism (VTE). However, whether these thrombophilic abnormalities are also risk factors for recurrent VTE is unclear. We conducted a systematic review of p...

journal_title：Haematologica

authors： Marchiori A,Mosena L,Prins MH,Prandoni P

更新日期：2007-08-01 00:00:00

abstract：:To investigate the role of oral contraceptives and their interaction with thrombophilia in ischemic stroke, a case-control study on women with a first ischemic stroke when younger than 45 years was carried out. Oral contraceptives doubled the risk of ischemic stroke in the first 6-18 months of use and hyperhomocystein...

journal_title：Haematologica

authors： Martinelli I,Battaglioli T,Burgo I,Di Domenico S,Mannucci PM

更新日期：2006-06-01 00:00:00

abstract：UNLABELLED:Ruxolitinib, a JAK1/JAK2 inhibitor, is currently the only pharmacological agent approved for the treatment of myelofibrosis. Approval was based on findings from two phase 3 trials comparing ruxolitinib with placebo (COMFORT-I) and with best available therapy (COMFORT-II) for the treatment of primary or secon...

journal_title：Haematologica

authors： Wilkins BS,Radia D,Woodley C,Farhi SE,Keohane C,Harrison CN

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Familial aggregation has been recognized in patients with several lymphoid neoplasms, but the genetic basis for this familial clustering is not known. Germ-line mutations in the ataxia-telangiectasia mutated (ATM) and CHK2 genes have been detected in patients with mantle cell lymphoma (MCL), s...

journal_title：Haematologica

authors： Tort F,Camacho E,Bosch F,Harris NL,Montserrat E,Campo E

更新日期：2004-03-01 00:00:00

abstract：:We report a family with type I and type III protein S (PS) deficiency, which showed to be phenotypic variants of the same genetic disease. Direct sequencing analysis of the PROS1 gene was performed to establish the genotype. The ratio of protein C antigen and total PS antigen levels (protein C/S ratio) was used to cla...

journal_title：Haematologica

authors： ten Kate MK,Mulder R,Platteel M,Brouwer JL,van der Steege G,van der Meer J

更新日期：2006-08-01 00:00:00

abstract：:We reviewed cardiac T2* assessments from 77 thalassemia major patients between the ages of 2.5 and 18 years to study optimal timing of cardiac iron screening by magnetic resonance imaging. No patient under 9.5 years of age showed detectable cardiac iron in contrast to 36% of patients between the ages of 15-18 years ol...

journal_title：Haematologica

authors： Wood JC,Origa R,Agus A,Matta G,Coates TD,Galanello R

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Most minimal residual disease-directed treatment interventions in current treatment protocols for acute lymphoblastic leukemia are based on bone marrow testing, which is a consequence of previous studies showing the superiority of bone marrow over peripheral blood as an investigational material. Those studie...

journal_title：Haematologica

authors： Volejnikova J,Mejstrikova E,Valova T,Reznickova L,Hodonska L,Mihal V,Sterba J,Jabali Y,Prochazkova D,Blazek B,Hak J,Cerna Z,Hrusak O,Stary J,Trka J,Fronkova E

更新日期：2011-12-01 00:00:00

abstract：:In patients with low and intermediate risk myelodysplastic syndrome and deletion 5q (del(5q)) treated with lenalidomide, monitoring of cytogenetic response is mandatory, since patients without cytogenetic response have a significantly increased risk of progression. Therefore, we have reviewed cytogenetic data of 302 p...

journal_title：Haematologica

authors： Göhring G,Giagounidis A,Büsche G,Hofmann W,Kreipe HH,Fenaux P,Hellström-Lindberg E,Schlegelberger B

更新日期：2011-02-01 00:00:00

abstract：:Adoptive transfer of ex vivo expanded CD4(+)CD25(+)FOXP3(+) regulatory T cells is a successful therapy for autoimmune diseases and transplant rejection in experimental models. In man, equivalent manipulations in bone marrow transplant recipients appear safe, but questions regarding the stability of the transferred reg...

journal_title：Haematologica

authors： Scottà C,Esposito M,Fazekasova H,Fanelli G,Edozie FC,Ali N,Xiao F,Peakman M,Afzali B,Sagoo P,Lechler RI,Lombardi G

更新日期：2013-08-01 00:00:00

abstract：:Interleukin-10 failed to modify either the percentage of bcl-2+ cells or the number of bcl-2 molecules, or to reduce 2-chlorodeoxyadenosine- and fludarabine-induced apoptosis. The cytokine at 0.1 ng/mL induced an increase of cell survival both in the absence or in the presence of 2-chlorodeoxyadenosine, while no diffe...

journal_title：Haematologica

authors： Morabito F,Filangeri M,Sculli G,Oliva B

更新日期：1998-11-01 00:00:00

abstract：:Lenalidomide is a very active drug in myelodysplastic syndrome with del (5q). We report such a patient treated with this drug who developed unusual complex cytogenetic abnormalities, which were elucidated by multi-FISH and FISH analysis as jumping translocations involving the long arm of chromosome 5, that resulted in...

journal_title：Haematologica

authors： Eclache V,Da Rocha A,Le Roux G,Fenaux P

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The purpose of our cooperative trial was to investigate whether epirubicin (EPI) at 90 mg/m2 in a CHOP-like combination (called CEOP) could increase complete response (CR) and survival rates in non-Hodgkin lymphoma (NHL) patients while maintaining a tolerable degree of toxicity. METHODS:Between September 19...

journal_title：Haematologica

authors： Lambertenghi Deliliers G,Butti C,Baldini L,Ceriani A,Lombardi F,Luoni M,Montalbetti L,Pavia G,Pinotti G,Pogliani E

更新日期：1995-07-01 00:00:00

abstract：:The aim of this study was to identify new pathogenic variations of the UGT1A1 gene in 11 patients diagnosed with neonatal unconjugated hyperbilirubinemia. We describe two cases in which clinically unapparent heterozygotic mutations in the UGT1A1 gene may become evident in combination with certain environmental conditi...

journal_title：Haematologica

authors： D'Apolito M,Marrone A,Servedio V,Vajro P,De Falco L,Iolascon A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Routine electrophoretic analysis fails to detect a monoclonal component (MC) in a considerable portion of AL amyloidosis patients. We investigated whether the combination of immunofixation (IF) on agarose gel electrophoresis and bone marrow plasma cell (BMPC) light chain kappa/lambda ratio analysis could con...

journal_title：Haematologica

authors： Perfetti V,Garini P,Vignarelli MC,Marinone MG,Zorzoli I,Merlini G

更新日期：1995-09-01 00:00:00

abstract：:We report on the data collected in the Italian Registry of acquired haemophilia (AH) in 2001. Recombinant activated factor VII (rFVIIa) was selected as first-line therapy in 19 bleeding episodes because of their severity and as salvage in one case. Bleeding was controlled in 90% of the episodes, indicating the efficac...

journal_title：Haematologica

authors： Baudo F,de Cataldo F,Gaidano G,Italian registry of acquired hemophilia.

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce l...

journal_title：Haematologica

authors： Bousquet M,Nguyen D,Chen C,Shields L,Lodish HF

更新日期：2012-11-01 00:00:00

abstract：:A case of thrombotic thrombocytopenic purpura (TTP) in a 40-year-old bisexual man unaware of being HIV positive is reported. The hematologic syndrome represented the first clinical manifestation of this viral infection. The clinical picture, characterized by severe hemolytic microangiopathic anemia, thrombocytopenia, ...

journal_title：Haematologica

authors： Cruccu V,Parisio E,Pedretti D,Villa A,Confalonieri F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Myeloid leukemia of Down's syndrome (ML-DS) has characteristic biological features (e.g. expression of the truncated GATA1s), which are different from those of non-DS childhood acute myeloid leukemias (AML). The objective of this study was to investigate factors predisposing to the development...

journal_title：Haematologica

authors： Langebrake C,Klusmann JH,Wortmann K,Kolar M,Puhlmann U,Reinhardt D

更新日期：2006-11-01 00:00:00

abstract：:The assessment of clinical probability represents an important step in the diagnostic strategy of patients with suspected deep vein thrombosis. The recently derived LEFt clinical prediction rule for pregnant women combines three variables: symptoms in the left leg (L), calf circumference difference of 2 centimeters or...

journal_title：Haematologica

authors： Righini M,Jobic C,Boehlen F,Broussaud J,Becker F,Jaffrelot M,Blondon M,Guias B,Le Gal G,EDVIGE study group.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pathogen-derived molecules are danger signals and are able to activate innate immunity that in turn controls and regulates generation of adaptive immune responses. Mycobacterium tuberculosis heat shock protein 70 (myc HSP70) has been shown to exert a potent adjuvant effect in vaccination again...

journal_title：Haematologica

authors： Liso A,Benedetti R,Fagioli M,Mariano A,Falini B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Most secreted proteins, including coagulation factor X (FX), are synthesized with a signal peptide, which is necessary for targeting the nascent polypeptide into the endoplasmic reticulum. Characterization of naturally occurring mutations may provide insights into the functional roles of the a...

journal_title：Haematologica

authors： Wang WB,Fu QH,Yin J,Wu WM,Ding QL,Zhou RF,Hu YQ,Wang XF,Wang ZY,Wang HL

更新日期：2005-12-01 00:00:00

abstract：:Rituximab use in severe auto-immune diseases has recently increased. Scattered reports of opportunistic infections were the only reported serious side effects related to rituximab in pediatric patients .Here, we report transient severe acute thrombocytopenia and neutropenia respectively a few days after rituximab infu...

journal_title：Haematologica

authors： Larrar S,Guitton C,Willems M,Bader-Meunier B

更新日期：2006-08-01 00:00:00

abstract：:The development of inhibitors is currently one of the most serious complications in the treatment of hemophilic children. Prospective studies of previously untreated patients (PUP) showed that up to 52% of patients with severe hemophilia A developed inhibitors during the first 50 exposure days (ED) (>100 for outliers)...

journal_title：Haematologica

authors： Kreuz W,Ettingshausen CE,Auerswald G,Saguer IM,Becker S,Funk M,Heller C,Klarmann D,Klingebiel T,GTH PUP Study Group.

更新日期：2003-06-01 00:00:00