Abstract:
:Lenalidomide is a very active drug in myelodysplastic syndrome with del (5q). We report such a patient treated with this drug who developed unusual complex cytogenetic abnormalities, which were elucidated by multi-FISH and FISH analysis as jumping translocations involving the long arm of chromosome 5, that resulted in an increase of 5q copies. This unusual findings is discussed in the context of resistance to lenalidomide observed in this patient.
journal_name
Haematologicajournal_title
Haematologicaauthors
Eclache V,Da Rocha A,Le Roux G,Fenaux Pdoi
10.3324/haematol.11917subject
Has Abstractpub_date
2008-02-01 00:00:00pages
315-6issue
2eissn
0390-6078issn
1592-8721pii
93/2/315journal_volume
93pub_type
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