Abstract:
:Myeloproliferative neoplasms are uncommon disorders in children, for which we have limited understanding of the pathogenesis and optimal management. JAK2 and MPL mutations, while common drivers of myeloproliferative neoplasms in adult patients, are not clearly linked to pediatric disease. Management and clinical outcomes in adults have been well delineated with defined recommendations for risk stratification and treatment. This is not the case for pediatric patients, for whom there is neither a standard approach to workup nor any consensus regarding management. This review will discuss thrombocytosis in children, including causes of thrombocytosis in children, the limited knowledge we have regarding pediatric primary thrombocytosis, and our thoughts on potential risk stratification and management, and future questions to be answered by laboratory research and collaborative clinical study.
journal_name
Haematologicajournal_title
Haematologicaauthors
Kucine N,Chastain KM,Mahler MB,Bussel JBdoi
10.3324/haematol.2013.092684subject
Has Abstractpub_date
2014-04-01 00:00:00pages
620-8issue
4eissn
0390-6078issn
1592-8721pii
haematol.2013.092684journal_volume
99pub_type
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