Idarubicin in low-grade non-Hodgkin's lymphomas.

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN. However, it is not clear whether NOTCH1 mutations associate with decreased PTEN expression in primary T-ALL. Here, we compared patients with or wi...

journal_title：Haematologica

authors： Silva A,Jotta PY,Silveira AB,Ribeiro D,Brandalise SR,Yunes JA,Barata JT

更新日期：2010-04-01 00:00:00

abstract：:In 2004, we reported the short-term results of a multicentric, phase 2 study of imatinib 400 mg daily and pegylated interferon-alpha in the treatment of 76 early chronic phase Philadelphia-positive chronic myeloid leukemia patients. In this report, we update the results with an observation time of five years. After tw...

journal_title：Haematologica

authors： Palandri F,Iacobucci I,Castagnetti F,Testoni N,Poerio A,Amabile M,Breccia M,Intermesoli T,Iuliano F,Rege-Cambrin G,Tiribelli M,Miglino M,Pane F,Saglio G,Martinelli G,Rosti G,Baccarani M,GIMEMA Working Party on CML.

更新日期：2008-05-01 00:00:00

abstract：:We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent...

journal_title：Haematologica

authors： Jácomo RH,Melo RA,Souto FR,de Mattos ER,de Oliveira CT,Fagundes EM,Bittencourt HN,Bittencourt RI,Bortolheiro TC,Paton EJ,Bendlin R,Ismael S,Chauffaille Mde L,Silva D,Pagnano KB,Ribeiro R,Rego EM

更新日期：2007-10-01 00:00:00

abstract：:Older chronic lymphocytic leukemia patients have poor outcomes with standard treatments and are underrepresented in clinical trials. We retrospectively reviewed outcomes of refractory chronic lymphocytic leukemia patients in two age categories (≥70 and <70 years) treated with single-agent flavopiridol, a drug active i...

journal_title：Haematologica

authors： Stephens DM,Ruppert AS,Blum K,Jones J,Flynn JM,Johnson AJ,Ji J,Phelps MA,Grever MR,Byrd JC

更新日期：2012-03-01 00:00:00

abstract：:Epstein-Barr virus-related post-transplant lymphoproliferative disorders are recognized as a significant cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation. To better define current understanding of post-transplant lymphoproliferative disorders in stem cell transplant patie...

journal_title：Haematologica

authors： Styczynski J,van der Velden W,Fox CP,Engelhard D,de la Camara R,Cordonnier C,Ljungman P,Sixth European Conference on Infections in Leukemia, a joint venture of the Infectious Diseases Working Party of the European Society of Blood and Marr

更新日期：2016-07-01 00:00:00

abstract：:The assessment of clinical probability represents an important step in the diagnostic strategy of patients with suspected deep vein thrombosis. The recently derived LEFt clinical prediction rule for pregnant women combines three variables: symptoms in the left leg (L), calf circumference difference of 2 centimeters or...

journal_title：Haematologica

authors： Righini M,Jobic C,Boehlen F,Broussaud J,Becker F,Jaffrelot M,Blondon M,Guias B,Le Gal G,EDVIGE study group.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. DESIGN AND METHODS:We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based ...

journal_title：Haematologica

authors： Barragán E,Montesinos P,Camos M,González M,Calasanz MJ,Román-Gómez J,Gómez-Casares MT,Ayala R,López J,Fuster Ó,Colomer D,Chillón C,Larrayoz MJ,Sánchez-Godoy P,González-Campos J,Manso F,Amador ML,Vellenga E,Lowenberg B

更新日期：2011-10-01 00:00:00

abstract：:Acquired aplastic anemia, the prototypical bone marrow failure disease, is characterized by pancytopenia and marrow hypoplasia. Most aplastic anemia patients respond to immunosuppressive therapy, usually with anti-thymocyte globulin and cyclosporine, but some relapse on cyclosporine withdrawal or require long-term adm...

journal_title：Haematologica

authors： Feng X,Lin Z,Sun W,Hollinger MK,Desierto MJ,Keyvanfar K,Malide D,Muranski P,Chen J,Young NS

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Oxidant damage is an important contributor to the premature destruction of erythrocytes and anemia in thalassemias. To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of huma...

journal_title：Haematologica

authors： de Franceschi L,Turrini F,Honczarenko M,Ayi K,Rivera A,Fleming MD,Law T,Mannu F,Kuypers FA,Bast A,van der Vijgh WJ,Brugnara C

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The outcome of patients with severe aplastic anemia (SAA) has improved considerably over the last decades. Bone marrow transplantation (BMT) is the treatment of choice in young patients who have an HLA-identical sibling donor. This study analyzes the outcome and factors related to survival in p...

journal_title：Haematologica

authors： Hernández-Boluda JC,Marín P,Carreras E,Aguilar JL,Grañena A,Rozman C,Montserrat E

更新日期：1999-01-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：:Fludarabine (FLU) is a new antimetabolite chemotherapeutic agent with promising activity in lymphoproliferative disorders and, in particular, in low-grade non-Hodgkin's lymphoma (LG-NHL). Recently, a few reports have described interesting results using FLU in polychemotherapy regimens. In order to evaluate FLU in comb...

journal_title：Haematologica

authors： Zinzani PL,Bendandi M,Gherlinzoni F,Merla E,Gozzetti A,Tura S

更新日期：1996-03-01 00:00:00

abstract：:Lactadherin is a phosphatidylserine-binding glycoprotein secreted by macrophages. Less than 0.5% of normal circulating red cells showed any binding to lactadherin. However, the red cells from patients with sickle cell disease showed 2 to 10-fold increases in lactadherin binding. Further, lactadherin stimulated the pha...

journal_title：Haematologica

authors： Dasgupta SK,Thiagarajan P

更新日期：2005-09-01 00:00:00

abstract：:Aplastic anemia is usually treated with immunosuppression or allogeneic transplant, depending on patient and disease characteristics. Syngeneic transplant offers a rare treatment opportunity with minimal transplant-related mortality, and offers an insight into disease mechanisms. We present here a retrospective analys...

journal_title：Haematologica

authors： Gerull S,Stern M,Apperley J,Beelen D,Brinch L,Bunjes D,Butler A,Ganser A,Ghavamzadeh A,Koh MB,Komarnicki M,Kröger N,Maertens J,Maschan A,Peters C,Rovira M,Sengeløv H,Socié G,Tischer J,Oneto R,Passweg J,Marsh J

更新日期：2013-11-01 00:00:00

abstract：:Interactions between chronic lymphocytic leukemia (CLL) B cells and the bone marrow (BM) microenvironment play a major function in the physiopathology of CLL. Extracellular vesicles (EVs), which are composed of exosomes and microparticles, play an important role in cell communication. However, little is known about th...

journal_title：Haematologica

authors： Crompot E,Van Damme M,Pieters K,Vermeersch M,Perez-Morga D,Mineur P,Maerevoet M,Meuleman N,Bron D,Lagneaux L,Stamatopoulos B

更新日期：2017-09-01 00:00:00

abstract：:Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understanding of the mutational patterns and the prognostic impact of molecular ...

journal_title：Haematologica

authors： Bill M,Nicolet D,Kohlschmidt J,Walker CJ,Mrózek K,Eisfeld AK,Papaioannou D,Rong-Mullins X,Brannan Z,Kolitz JE,Powell BL,Archer KJ,Dorrance AM,Carroll AJ,Stone RM,Byrd JC,Garzon R,Bloomfield CD

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Polycythemia vera (PV) is a myeloproliferative disorder, characterized by the expansion of the red cell mass. Our purpose was to evaluate the efficacy of pipobroman (PB) in the long-term control of PV and to assess early and late events. DESIGN AND METHODS:From June 1975 to December 1997, 163...

journal_title：Haematologica

authors： Passamonti F,Brusamolino E,Lazzarino M,Baraté C,Klersy C,Orlandi E,Canevari A,Castelli G,Merante S,Bernasconi C

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data. This is also true for immunohistochemical classifiers that are thought to reflect the cell-of-origin subclassification of gene expression stu...

journal_title：Haematologica

authors： Bernd HW,Ziepert M,Thorns C,Klapper W,Wacker HH,Hummel M,Stein H,Hansmann ML,Ott G,Rosenwald A,Müller-Hermelink HK,Barth TF,Möller P,Cogliatti SB,Pfreundschuh M,Schmitz N,Trümper L,Höller S,Löffler M,Feller AC,Ger

更新日期：2009-11-01 00:00:00

abstract：:Monitoring minimal residual disease is an important way to identify patients with acute myeloid leukemia at high risk of relapse. In this study we investigated the prognostic potential of minimal residual disease monitoring by quantitative real-time polymerase chain reaction analysis of NPM1 mutations in patients trea...

journal_title：Haematologica

authors： Hubmann M,Köhnke T,Hoster E,Schneider S,Dufour A,Zellmeier E,Fiegl M,Braess J,Bohlander SK,Subklewe M,Sauerland MC,Berdel WE,Büchner T,Wörmann B,Hiddemann W,Spiekermann K

更新日期：2014-08-01 00:00:00

abstract：:Hodgkin's lymphoma (HL) simulating acute cholestatic hepatitis is a very unusual clinical picture. Massive liver infiltration with conspicuous acute cholestatic symptoms, in fact, suggests more aggressive systemic diseases such as non Hodgkin's lymphomas or acute leukemias. Nevertheless, we observed two cases of mixed...

journal_title：Haematologica

authors： Marinone G,Lazzari R,Pellizzari F,Marinone MG

更新日期：1989-05-01 00:00:00

abstract：:The role of reduced intensity allogeneic stem cell transplantation for the treatment of relapsed/refractory Hodgkin's lymphoma remains controversial. We retrospectively analyzed 191 patients who underwent reduced intensity allogeneic stem cell transplantation between 1998 and 2008 for relapsed or refractory Hodgkin's ...

journal_title：Haematologica

authors： Marcais A,Porcher R,Robin M,Mohty M,Michalet M,Blaise D,Tabrizi R,Clement L,Ceballos P,Daguindau E,Bilger K,Dhedin N,Lapusan S,Bay JO,Pautas C,Garban F,Ifrah N,Guillerm G,Contentin N,Bourhis JH,Yakoub Agha I,Ber

更新日期：2013-09-01 00:00:00

abstract：:Acquired aplastic anemia is an autoimmune-mediated bone marrow failure syndrome. The mechanism by which such an autoimmune reaction is initiated is unknown. Whether and how the genetic lesions detected in patients cause autoimmune bone marrow failure have not yet been determined. We found that mice with spontaneous de...

journal_title：Haematologica

authors： Xin J,Breslin P,Wei W,Li J,Gutierrez R,Cannova J,Ni A,Ng G,Schmidt R,Chen H,Parini V,Kuo PC,Kini AR,Stiff P,Zhu J,Zhang J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Relapsing primary central nervous system lymphoma carries a poor prognosis when treated with conventional chemotherapy with a one-year overall survival of 25-40%. Encouraging results have been shown with intensive chemotherapy followed by autologous hematopoietic stem cell rescue. We report the results of a ...

journal_title：Haematologica

authors： Soussain C,Choquet S,Fourme E,Delgadillo D,Bouabdallah K,Ghesquières H,Damaj G,Dupriez B,Vargaftig J,Gonzalez A,Houillier C,Taillandier L,Hoang-Xuan K,Leblond V

更新日期：2012-11-01 00:00:00

abstract：:This study aimed at evaluating the effectiveness of alpha interferon (IFN) in chronic myelomonocytic leukemia, a disease for which therapeutic options are still unsatisfactory. Fourteen sequential unselected patients received recombinant alpha-2b IFN (Intron-A, Schering-Essex) 3 megaU/day, progressively elevated to 10...

journal_title：Haematologica

authors： Catalano L,Majolino I,Musto P,Fragrasso A,Molica S,Cirincione S,Selleri C,Luciano L,De Renzo A,Vecchione R

更新日期：1989-11-01 00:00:00

abstract：:Macaques are emerging as a critical animal model in transfusion medicine, because of their evolutionary similarity to humans and perceived utility in discovery and translational science. However, little is known about the metabolism of Rhesus macaque red blood cells (RBC) and how this compares to human RBC metabolism ...

journal_title：Haematologica

authors： Stefanoni D,Shin HKH,Baek JH,Champagne DP,Nemkov T,Thomas T,Francis RO,Zimring JC,Yoshida T,Reisz JA,Spitalnik SL,Buehler PW,D'Alessandro A

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The diagnosis of myelodysplastic syndromes (MDS) is essentially morphological and based on the presence of dysplastic features in the peripheral blood and bone marrow. The French-American-British (FAB) Cooperative Group proposed a classification based on easily obtainable laboratory information...

journal_title：Haematologica

authors： Vallespí T,Imbert M,Mecucci C,Preudhomme C,Fenaux P

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Usefulness of iron chelation therapy in myelodysplastic patients is still under debate but many authors suggest its possible role in improving survival of low-risk myelodysplastic patients. Several reports have described an unexpected effect of iron chelators, such as an improvement in hemoglobin levels, in ...

journal_title：Haematologica

authors： Messa E,Carturan S,Maffè C,Pautasso M,Bracco E,Roetto A,Messa F,Arruga F,Defilippi I,Rosso V,Zanone C,Rotolo A,Greco E,Pellegrino RM,Alberti D,Saglio G,Cilloni D

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There are no widely accepted criteria for the definition of hematopoietic stem cell transplant -associated microangiopathy (TAM). An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM. DESIGN AND METHODS:The particip...

journal_title：Haematologica

authors： Ruutu T,Barosi G,Benjamin RJ,Clark RE,George JN,Gratwohl A,Holler E,Iacobelli M,Kentouche K,Lämmle B,Moake JL,Richardson P,Socié G,Zeigler Z,Niederwieser D,Barbui T,European Group for Blood and Marrow Transplantation.,E

更新日期：2007-01-01 00:00:00

abstract：:The bone marrow microenvironment regulates normal and malignant hematopoiesis, but the underlying molecular mechanisms remain poorly defined. Using a chimeric mice model, we demonstrate that Twist1 deletion in the bone marrow microenvironment results in alteration of multiple niche cells as well as downregulated expre...

journal_title：Haematologica

authors： Liu X,Ma Y,Li R,Guo D,Wang N,Zhao Y,Yin J,Ren Q,Lin Y,Ma X

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In recent years, two predictive equations to estimate median expected survival at diagnosis for patients affected with Hodgkin's disease have been developed at the University of Pavia Medical School. The present retrospective work was aimed at testing correlation between mean survival estimated...

journal_title：Haematologica

authors： Bettini R,Tonolini M,Maccianti E

更新日期：1997-05-01 00:00:00