Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy.

abstract：:Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with loss-of-function mutations in the SBDS gene, implicated in ribosome biogenesis, but the cellular and molecular events driving cell specific phenotypes in ribosomopathies rem...

journal_title：Haematologica

authors： Zambetti NA,Bindels EM,Van Strien PM,Valkhof MG,Adisty MN,Hoogenboezem RM,Sanders MA,Rommens JM,Touw IP,Raaijmakers MH

更新日期：2015-10-01 00:00:00

abstract：:It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy...

journal_title：Haematologica

authors： Yoshimi A,Baumann I,Führer M,Bergsträsser E,Göbel U,Sykora KW,Klingebiel T,Gross-Wieltsch U,van den Heuvel-Eibrink MM,Fischer A,Nöllke P,Niemeyer C

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is a clonal hematopoietic malignant disease; about 45-50% of cases do not have detectable chromosomal abnormalities. Here, we identified hidden genomic alterations and novel disease-related regions in normal karyotype acute myeloid leukemia/myelodysplastic syndrome samples. DESIGN AND...

journal_title：Haematologica

authors： Akagi T,Ogawa S,Dugas M,Kawamata N,Yamamoto G,Nannya Y,Sanada M,Miller CW,Yung A,Schnittger S,Haferlach T,Haferlach C,Koeffler HP

更新日期：2009-02-01 00:00:00

abstract：:Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To date, the role played by T-cell receptor in the oncogenic transformation of developing T cells remains unclear. Here we...

journal_title：Haematologica

authors： Gon S,Loosveld M,Crouzet T,Potier D,Bonnet M,Morin SO,Michel G,Vey N,Nunès JA,Malissen B,Roncagalli R,Nadel B,Payet-Bornet D

更新日期：2018-06-01 00:00:00

abstract：:It is well known that thalassemic patients exhibit an increased frequency of thrombotic events. Most individuals with resistance to activated protein C (APCR) are the result of a point mutation replacing Arg 506 with Gln in the factor V aminoacidic sequence (factor V Leiden). Recently APCR has been shown to account fo...

journal_title：Haematologica

authors： Giordano P,Sabato V,Schettini F,De Mattia D,Iolascon A

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Occult hepatitis B virus (HBV) infection might allow the release of viremic units into the blood supply network if blood is tested only for hepatitis B surface antigen (HBsAg). The aim of our study was to evaluate the actual prevalence, viral load and genotype of occult HBV infections among fi...

journal_title：Haematologica

authors： Manzini P,Girotto M,Borsotti R,Giachino O,Guaschino R,Lanteri M,Testa D,Ghiazza P,Vacchini M,Danielle F,Pizzi A,Valpreda C,Castagno F,Curti F,Magistroni P,Abate ML,Smedile A,Rizzetto M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The modulation of disease severity in hemophilia A (HA) patients may be related to the co-inheritance of mutations in genes with a known thrombotic effect such as factor V Leiden (FVL) and prothrombin. In the Spanish population, the prothrombin 20210A (PT20210A) allele is the most prevalent ge...

journal_title：Haematologica

authors： Tizzano EF,Soria JM,Coll I,Guzmán B,Cornet M,Altisent C,Martorell M,Domenech M,del Río E,Fontcuberta J,Baiget M

更新日期：2002-03-01 00:00:00

abstract：:We conducted a phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with relapsed, refractory myeloid leukemias. Twenty-eight patients received the construct intravenously at four dose levels (12, 18, 28 and 40 mg/m(2) per course) i...

journal_title：Haematologica

authors： Borthakur G,Rosenblum MG,Talpaz M,Daver N,Ravandi F,Faderl S,Freireich EJ,Kadia T,Garcia-Manero G,Kantarjian H,Cortes JE

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We previously found a high-level amplification in chromosomal region 21q22 in two children with acute lymphoblastic leukemia (ALL) using comparative genomic hybridization. The same region harbors the AML1 gene. The aim of the present study was to investigate whether AML1 is a target gene in the...

journal_title：Haematologica

authors： Niini T,Kanerva J,Vettenranta K,Saarinen-Pihkala UM,Knuutila S

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Continuous erythropoietin receptor activator (C.E.R.A.) is an innovative agent with unique erythropoietin receptor activity and a prolonged half-life, which has the potential for administration at extended dosing intervals. The objectives of this dose-finding study were to evaluate the hemoglo...

journal_title：Haematologica

authors： Dmoszynska A,Kloczko J,Rokicka M,Hellmann A,Spicka I,Eid JE

更新日期：2007-04-01 00:00:00

abstract：:Granulocyte transfusions are used to treat neutropenic patients with life-threatening bacterial or fungal infections that do not respond to anti-microbial drugs. Donor neutrophils that have been mobilized with granulocyte-colony stimulating factor (G-CSF) and dexamethasone are functional in terms of antibacterial acti...

journal_title：Haematologica

authors： Gazendam RP,van de Geer A,van Hamme JL,Tool AT,van Rees DJ,Aarts CE,van den Biggelaar M,van Alphen F,Verkuijlen P,Meijer AB,Janssen H,Roos D,van den Berg TK,Kuijpers TW

更新日期：2016-05-01 00:00:00

abstract：:Perforin gene (PRF1) mutations cause the primary form of hemophagocytic lymphohistiocytosis (HLH). We report a genetic defect of PRF1 in a 62-year-old Japanese man with recurrent episodes of HLH. Sequencing of PRF1 from both peripheral blood mononuclear cells and nail clippings showed compound heterozygous mutation, i...

journal_title：Haematologica

authors： Nagafuji K,Nonami A,Kumano T,Kikushige Y,Yoshimoto G,Takenaka K,Shimoda K,Ohga S,Yasukawa M,Horiuchi H,Ishii E,Harada M

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The diagnosis of myelodysplastic syndromes (MDS) is essentially morphological and based on the presence of dysplastic features in the peripheral blood and bone marrow. The French-American-British (FAB) Cooperative Group proposed a classification based on easily obtainable laboratory information...

journal_title：Haematologica

authors： Vallespí T,Imbert M,Mecucci C,Preudhomme C,Fenaux P

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The efficacy of antithymocyte globulin (ATG) in the treatment of graft-versus-host disease (GvHD) is controversial. In the present study we report on the use of low dose ATG (thymoglobuline, Sangstat) and steroids in 28 patients with moderate to severe acute GvHD. DESIGN AND METHODS:Fifteen p...

journal_title：Haematologica

authors： Graziani F,Van Lint MT,Dominietto A,Raiola AM,Di Grazia C,Lamparelli T,Gualandi F,Bregante S,Fiorone M,Bruno B,Bacigalupo A

更新日期：2002-09-01 00:00:00

abstract：:A pilot study, testing two different chemotherapeutic schedules in CML patients, was carried out in order to verify the possibility of Ph1 clone disappearance. Both therapeutic regimens, though able to induce severe marrow aplasia, determined only a reduction of Ph1 positive metaphases in two patients, while in one ca...

journal_title：Haematologica

authors： Centurioni R,Leoni P,Russo D,Brianzoni MF,Montillo M,Baccarani M,Tura S

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In multiple myeloma (MM), the mechanisms used by plasma cells to invade locally and metastasize are thought to be similar to those developed by solid tumors and include cell proliferation and secretion of extracellular matrix (ECM) degrading enzymes following adhesion to ECM proteins. We studi...

journal_title：Haematologica

authors： Ria R,Vacca A,Ribatti D,Di Raimondo F,Merchionne F,Dammacco F

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Diamond-Blackfan anemia is a fatal congenital anemia characterized by a specific disruption in erythroid progenitor cell development. Approximately 25% of patients have mutations in the ribosomal protein RPS19 suggesting that Diamond-Blackfan anemia may be caused by a defect in ribosome biogenesis and transl...

journal_title：Haematologica

authors： Rey MA,Duffy SP,Brown JK,Kennedy JA,Dick JE,Dror Y,Tailor CS

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with chronic renal failure show signs of accelerated atherosclerosis and high cardiovascular morbidity and mortality. Recent investigations indicate that uremia is associated with endothelial dysfunction and a microinflammatory state. We assessed changes in the expression of adhesion ...

journal_title：Haematologica

authors： Serradell M,Díaz-Ricart M,Cases A,Zurbano MJ,López-Pedret J,Arranz O,Ordinas A,Escolar G

更新日期：2002-10-01 00:00:00

abstract：:As in other malignancies, peripheral blood progenitor cells (PBPC) have almost completely replaced bone marrow as the source of stem cells for autologous transplantation in multiple myeloma. PBPC collection could be optimized either by reducing contamination by the malignant clone or by increasing hematopoietic qualit...

journal_title：Haematologica

authors： Harousseau JL

更新日期：1999-06-01 00:00:00

abstract：:A case of cholesterol embolism of bone marrow, concerning the pelvis and lumbar region and clinically masquerading as systemic disease or metastatic tumor, is reported in an 82-year-old man hospitalized for acute onset of reddish purple nodules on the legs and toes, intense myalgia and dorsal vertebral bone pain. The ...

journal_title：Haematologica

authors： Muretto P,Carnevali A,Ansini AL

更新日期：1991-05-01 00:00:00

abstract：:LBH589 is a novel cinnamic hydroxamic acid analog (HAA) pan-histone deacetylase inhibitor (HDACi) currently in early phase clinical development. ...

journal_title：Haematologica

authors： Kalff A,Shortt J,Farr J,McLennan R,Lui A,Scott J,Spencer A

更新日期：2008-01-01 00:00:00

abstract：:We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in...

journal_title：Haematologica

authors： Oguz FS,Yalman N,Diler AS,Oguz R,Anak S,Dorak MT

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Oxidant damage is an important contributor to the premature destruction of erythrocytes and anemia in thalassemias. To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of huma...

journal_title：Haematologica

authors： de Franceschi L,Turrini F,Honczarenko M,Ayi K,Rivera A,Fleming MD,Law T,Mannu F,Kuypers FA,Bast A,van der Vijgh WJ,Brugnara C

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Assays to evaluate platelet function are often interchangeably used to assess "resistance" to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin. DESIGN AND METHODS:Platelet function was evaluated in 162 subjects, 85 of whom were not being treated with any ...

journal_title：Haematologica

authors： Renda G,Zurro M,Malatesta G,Ruggieri B,De Caterina R

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The incidence of primary gastric non-Hodgkin's lymphoma (NHL) appears to have increased worldwide in recent years, and this seems to be confirmed by large-sample population studies. METHODS AND RESULTS:We derived our data from the Lombardy Cancer Registry, which provides the incidence of cancer in the provi...

journal_title：Haematologica

authors： Pinotti G,Novario R,Berrino F,Bianchi P,Comi MA,Gamba MC,Venco A

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Somatic hypermutation of the BCL6 gene and its expression in lymphoma represent specific markers for B-cell transit through the germinal center. Thus, analysis of BCL6 may aid in clarifying the relationship between primary mediastinal B-cell lymphoma (PMBL) and other non-thymic diffuse large c...

journal_title：Haematologica

authors： Malpeli G,Barbi S,Moore PS,Scardoni M,Chilosi M,Scarpa A,Menestrina F

更新日期：2004-09-01 00:00:00

abstract：:Reduced intensity conditioning followed by allogeneic SCT (RIC-SCT) has recently emerged as promising new salvage option for children suffering from Langerhans cell histiocytosis (LCH) with risk organ involvement and failure to conventional therapy. We report on the posttransplant course of female toddler with high-ri...

journal_title：Haematologica

authors： Steiner M,Matthes-Martin S,Attarbaschi A,Lawitschka A,Minkov M,Mittheisz E,Fritsch G,Lion T,Zoubek A,Gadner H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:A magnetic resonance (MR) signal shows an inverse correlation with bone marrow cellularity. In this study, we investigated the possibility of estimating the degree of bone marrow cellularity by means of this non-invasive technique. METHODS:In 25 patients with different hematological disorders ...

journal_title：Haematologica

authors： Rozman M,Mercader JM,Aguilar JL,Montserrat E,Rozman C

更新日期：1997-03-01 00:00:00

abstract：:The detection of iron deficiency anemia is challenged by the paucity of diagnostic tests demonstrating high sensitivity and specificity. Using two biomarkers, zinc-protoporphyrin/heme and hepcidin, we established the diagnostic cut-off values for iron deficiency anemia in preschool children and women. We randomly sele...

journal_title：Haematologica

authors： Kanuri G,Chichula D,Sawhney R,Kuriakose K,De'Souza S,Pais F,Arumugam K,Shet AS

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The relative efficacy of high-dose chemotherapy (HDC) compared to standard treatment for high-risk primary (HRPBC) or metastatic breast cancer (MBC) constitutes an area of intense controversy among the medical oncology community. A number of randomized trials have been conducted to address this issue. In mos...

journal_title：Haematologica

authors： Nieto Y

更新日期：2003-02-01 00:00:00