Abstract:
:Hodgkin's lymphoma (HL) simulating acute cholestatic hepatitis is a very unusual clinical picture. Massive liver infiltration with conspicuous acute cholestatic symptoms, in fact, suggests more aggressive systemic diseases such as non Hodgkin's lymphomas or acute leukemias. Nevertheless, we observed two cases of mixed cellularity H.L. showing all the symptoms of acute cholestatic hepatitis, without systemic lymph nodes involvement. Diagnosis was achieved by liver biopsy. Hepatic histology showed extensive portal and periportal Hodgkin's infiltrations, loss of periportal liver cells and variable damage to small bile ducts. In both cases bone marrow biopsy showed granulomatous infiltrations. Liver failure appeared to be the most frequent terminal complication of cholestatic H.L. The course of the disease was rapid, and cytostatic therapy scarcely effective. In our opinion, the cholestatic variety of H.L. should be considered in the differential diagnosis of all cases of acute or chronic cholestatic hepatitis, irrespectively of the presence of systemic lymph nodes enlargement.
journal_name
Haematologicajournal_title
Haematologicaauthors
Marinone G,Lazzari R,Pellizzari F,Marinone MGsubject
Has Abstractpub_date
1989-05-01 00:00:00pages
293-6issue
3eissn
0390-6078issn
1592-8721journal_volume
74pub_type
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