Leukemia-free survival as a surrogate end point for overall survival in the evaluation of maintenance therapy for patients with acute myeloid leukemia in complete remission.

abstract：BACKGROUND:Assays to evaluate platelet function are often interchangeably used to assess "resistance" to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin. DESIGN AND METHODS:Platelet function was evaluated in 162 subjects, 85 of whom were not being treated with any ...

journal_title：Haematologica

authors： Renda G,Zurro M,Malatesta G,Ruggieri B,De Caterina R

更新日期：2010-12-01 00:00:00

abstract：:To investigate the role of oral contraceptives and their interaction with thrombophilia in ischemic stroke, a case-control study on women with a first ischemic stroke when younger than 45 years was carried out. Oral contraceptives doubled the risk of ischemic stroke in the first 6-18 months of use and hyperhomocystein...

journal_title：Haematologica

authors： Martinelli I,Battaglioli T,Burgo I,Di Domenico S,Mannucci PM

更新日期：2006-06-01 00:00:00

abstract：:The characteristics of 14 HIV-seropositive patients with NHL consecutively observed between 1984 and 1988 at our Institution are described. Patients belonged to a known population of 1242 HIV-seropositive individuals in whom the incidence of NHL was 1.13%, significantly higher than in age-matched controls (P less than...

journal_title：Haematologica

authors： Rossi G,Cadeo G,Stellini R,Zorzi F,Favret M,Sueri L,Carosi G,Mariano M,Marinone G

更新日期：1990-05-01 00:00:00

abstract：:We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 de...

journal_title：Haematologica

authors： Morkbak AL,Hvas AM,Milman N,Nexo E

更新日期：2007-12-01 00:00:00

abstract：:Survival of myeloma patients has greatly improved with the use of autologous stem cell transplantation and novel agents, such as proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies. Compared to bortezomib- and lenalidomide-based regimens alone, the addition of high-dose melphalan followed by autolo...

journal_title：Haematologica

authors： Gay F,Engelhardt M,Terpos E,Wäsch R,Giaccone L,Auner HW,Caers J,Gramatzki M,van de Donk N,Oliva S,Zamagni E,Garderet L,Straka C,Hajek R,Ludwig H,Einsele H,Dimopoulos M,Boccadoro M,Kröger N,Cavo M,Goldschmidt H,B

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Although acquired aplastic anemia is usually a chronic disorder, a small proportion of patients with aplastic anemia was reported to recover spontaneously without specific therapy such as allogeneic bone marrow transplantation or immunosuppressive treatment. We attempted to determine the rate ...

journal_title：Haematologica

authors： Lee JH,Lee JH,Shin YR,Lee JS,Kim WK,Chi HS,Park CJ,Lee KH

更新日期：2001-09-01 00:00:00

abstract：:The main purpose of this work is to give methodologic details and further verification regarding the predictive system recently elaborated for Hodgkin's disease (HD) patients, by which, under standard accuracy and conventional treatment, patient survival can be directly estimated (within a given confidence interval) w...

journal_title：Haematologica

authors： Gobbi PG,Gobbi PG,Mazza P,Zinzani PL

更新日期：1989-01-01 00:00:00

abstract：:The role of reduced intensity allogeneic stem cell transplantation for the treatment of relapsed/refractory Hodgkin's lymphoma remains controversial. We retrospectively analyzed 191 patients who underwent reduced intensity allogeneic stem cell transplantation between 1998 and 2008 for relapsed or refractory Hodgkin's ...

journal_title：Haematologica

authors： Marcais A,Porcher R,Robin M,Mohty M,Michalet M,Blaise D,Tabrizi R,Clement L,Ceballos P,Daguindau E,Bilger K,Dhedin N,Lapusan S,Bay JO,Pautas C,Garban F,Ifrah N,Guillerm G,Contentin N,Bourhis JH,Yakoub Agha I,Ber

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients affected by hereditary bleeding disorders and treated with non-virus inactivated clotting factor concentrates during the 1970s. INFORMATION SOURCES:In this review, we briefly report the present know...

journal_title：Haematologica

authors： Franchini M,Capra F,Tagliaferri A,Rossetti G,De Gironcoli M,Rocca P,Aprili G,Gandini G

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Graft-versus-host disease (GVHD) presents an important complication of allogeneic bone marrow transplantation. A method to predict GVHD might be the analysis of cytotoxic T lymphocyte precursors, but the technique requires the use of radioactive elements not suitable in all laboratories. DESIG...

journal_title：Haematologica

authors： Maiocchi MA,Nano R,Capelli E,Bonfichi M,Alessandrino EP,Bernasconi P

更新日期：1998-08-01 00:00:00

abstract：:Here we critically evaluate the role of elevated hematocrit as the principal determinant of thrombotic risk in polycythemia and erythrocytosis, defined by an expansion of red cell mass. Since red cell volume determination is no longer readily available, in clinical practice, polycythemia and erythrocytosis are defined...

journal_title：Haematologica

authors： Gordeuk VR,Key NS,Prchal JT

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Children with Down syndrome have an increased risk of developing acute lymphoblastic leukemia and a poor tolerance of methotrexate. This latter problem is assumed to be caused by a higher cellular sensitivity of tissues in children with Down syndrome. However, whether differences in pharmacokinetics play a r...

journal_title：Haematologica

authors： Buitenkamp TD,Mathôt RA,de Haas V,Pieters R,Zwaan CM

更新日期：2010-07-01 00:00:00

abstract：:A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neu...

journal_title：Haematologica

authors： Meloni G,Nasta L,Pinto RM,Spalice A,Raucci U,Iannetti P

更新日期：1995-11-01 00:00:00

abstract：:We performed a dose-escalation study of bendamustine in 31 patients with multiple myeloma that had progressed after high-dose chemotherapy. Bendamustine 100 mg/m2 on days 1 and 2 per cycle was found to be the maximal tolerated dose. The overall response rate was 55% with a median progression-free survival of 26 (0-61)...

journal_title：Haematologica

authors： Knop S,Straka C,Haen M,Schwedes R,Hebart H,Einsele H

更新日期：2005-09-01 00:00:00

abstract：:Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our resu...

journal_title：Haematologica

authors： Bazrgar M,Karimi M,Peiravian F,Fathzadeh M

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The diagnosis of T-cell neoplasia requires the use of immunohistochemistry on tumor sections or molecular genetic analysis of T-cell receptor (TCR) clonality. Multiplex polymerase chain reactions (PCR) offer a sensitive and expeditious approach to determining clonality early in the diagnostic ...

journal_title：Haematologica

authors： Dictor M,Warenholt J,Isinger A

更新日期：2005-11-01 00:00:00

abstract：:Suspicion of myelodysplastic syndromes (MDS) is one of the commonest reasons for bone marrow aspirate in elderly patients presenting with persistent peripheral blood (PB) cytopenia of unclear etiology. A PB assay that accurately rules out MDS would have major benefits. The diagnostic accuracy of the intra-individual r...

journal_title：Haematologica

authors： Raskovalova T,Berger MG,Jacob MC,Park S,Campos L,Aanei CM,Kasprzak J,Pereira B,Labarère J,Cesbron JY,Veyrat-Masson R

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS:We studied 23 patients with PNH, before and after five and 11 weeks of treatment with eculizumab. We examined markers of thrombin generation and reactional fibrinolysis...

journal_title：Haematologica

authors： Helley D,de Latour RP,Porcher R,Rodrigues CA,Galy-Fauroux I,Matheron J,Duval A,Schved JF,Fischer AM,Socié G,French Society of Hematology.

更新日期：2010-04-01 00:00:00

abstract：:Treatment of adults with acute myeloblastic leukemia has changed substantially over the past two decades. Currently available estimates of survival do not reflect results from present state-of-the-art treatment due to a lag between the availability of new treatments and data concerning their effect on survival on the ...

journal_title：Haematologica

authors： Pulte D,Gondos A,Brenner H

更新日期：2008-04-01 00:00:00

abstract：:This review deals with the chronic lymphoproliferative disease of large granular lymphocytes endowed with T and natural killer cell characteristics. The disease is sufficiently characterized to allow its distinction from other lymphoproliferative disorders of the T cell type. The heterogeneous clinical course and labo...

journal_title：Haematologica

authors： Bassan R,Rambaldi A,Barbui T

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acquired red cell aplasia (RCA) is a rare disorder and can be either idiopathic or associated with certain diseases, pregnancy, or drugs. In exceptionally rare cases, it has been reported to co-exist with other autoimmune cytopenias. We report a high incidence of RCA and autoimmune hemolytic a...

journal_title：Haematologica

authors： Elimelakh M,Dayton V,Park KS,Gruessner AC,Sutherland D,Howe RB,Reding MT,Eastlund T,van Burik JA,Singleton TP,Gruessner RW,Key NS

更新日期：2007-08-01 00:00:00

abstract：:Diabetes insipidus and thrombocytosis were presenting symptoms in a case of adult ANLL-M1. Cytogenetic investigations revealed a typical 3q rearrangement, i.e. inv(3)(q21q26). A subclone with monosomy 7 was also found and documented by FISH analysis. Correlations between clinical/hematological features and cytogenetic...

journal_title：Haematologica

authors： La Starza R,Falzetti D,Fania C,Tabilio A,Martelli MF,Mecucci C

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Our objective was to improve the outcome of cord blood (CB) transplantation in adults, by overcoming the limitations imposed by the low number of stem cells present in CB units. DESIGN AND METHODS:We combined single CB units and co-infusion of third party donor (TPD)-derived peripheral blood ...

journal_title：Haematologica

authors： Magro E,Regidor C,Cabrera R,Sanjuán I,Forès R,Garcia-Marco JA,Ruiz E,Gil S,Bautista G,Millán I,Madrigal A,Fernandez MN

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Parvovirus B19 has a marked tropism for erythroid progenitor cells and this may lead to chronic anemia in predisposed individuals. It was the purpose of the present study to investigate prospectively the frequency of parvovirus B19 infections in patients with a diagnosis of chronic anemia. MET...

journal_title：Haematologica

authors： Heegaard ED,Myhre J,Hornsleth A,Gundestrup M,Boye H

更新日期：1997-07-01 00:00:00

abstract：:Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder which is due to a mutation in the gene encoding for platelet glycoprotein Ibalpha (GPIbalpha) resulting in enhanced affinity for von Willebrand factor (VWF). PT-VWD is often mistakenly diagnosed as type 2B VWD for the similari...

journal_title：Haematologica

authors： Giannini S,Cecchetti L,Mezzasoma AM,Gresele P

更新日期：2010-06-01 00:00:00

abstract：:We report a case of adult-type Gaucher's disease associated with monoclonal gammapathy of undetermined significance. Bone marrow infiltration by Gaucher's cells and spleen infiltration by Gaucher cells and plasma cells was observed on cytohistologic examination. Splenectomy induced complete recovery of cytopenias and ...

journal_title：Haematologica

authors： Airò R,Gabusi G,Guindani M

更新日期：1993-03-01 00:00:00

abstract：:Twice-weekly carfilzomib is approved at 27 and 56 mg/m2 to treat relapsed multiple myeloma patients. In the phase III study ARROW, once-weekly 70 mg/m 2 carfilzomib prolonged the median progression-free survival of relapsed multiple myeloma patients in comparison with twice-weekly 27 mg/m2 carfilzomib, without adding ...

journal_title：Haematologica

authors： Bringhen S,Mina R,Petrucci MT,Gaidano G,Ballanti S,Musto P,Offidani M,Spada S,Benevolo G,Ponticelli E,Galieni P,Cavo M,Di Toritto TC,Di Raimondo F,Montefusco V,Palumbo A,Boccadoro M,Larocca A

更新日期：2019-08-01 00:00:00

abstract：:Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the developmental stages of the hematopoietic system and the molecular bases of malignant and non-malignant blood diseases for the past three decades. Previously, only the genes targeted by expression microarrays could be profiled g...

journal_title：Haematologica

authors： Grassi L,Izuogu OG,Jorge NA,Seyres D,Bustamante M,Burden F,Farrow S,Farahi N,Martin FJ,Frankish A,Mudge JM,Kostadima M,Petersen R,Lambourne JJ,Rowlston S,Martin-Rendon E,Clarke L,Downes K,Estivill X,Flicek P,Marte

更新日期：2020-07-23 00:00:00

abstract：:Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact in the general population are rare. Furthermore, discussions on the optimal definition of anemia have n...

journal_title：Haematologica

authors： Wouters HJCM,van der Klauw MM,de Witte T,Stauder R,Swinkels DW,Wolffenbuttel BHR,Huls G

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Most secreted proteins, including coagulation factor X (FX), are synthesized with a signal peptide, which is necessary for targeting the nascent polypeptide into the endoplasmic reticulum. Characterization of naturally occurring mutations may provide insights into the functional roles of the a...

journal_title：Haematologica

authors： Wang WB,Fu QH,Yin J,Wu WM,Ding QL,Zhou RF,Hu YQ,Wang XF,Wang ZY,Wang HL

更新日期：2005-12-01 00:00:00