Multivariate analysis of Hodgkin's disease prognosis. Fitness and use of a directly predictive equation.

abstract：BACKGROUND:Polymorphic differences between donor and recipient human leukocyte antigen class I molecules can result in graft-versus-host disease due to distinct peptide presentation. As part of the peptide-loading complex, tapasin plays an important role in selecting peptides from the pool of potential ligands. Class I...

journal_title：Haematologica

authors： Badrinath S,Saunders P,Huyton T,Aufderbeck S,Hiller O,Blasczyk R,Bade-Doeding C

更新日期：2012-01-01 00:00:00

abstract：:Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the evidence for stand-alone intrathecal prophylaxis has been perfor...

journal_title：Haematologica

authors： Eyre TA,Djebbari F,Kirkwood AA,Collins GP

更新日期：2020-07-01 00:00:00

abstract：:The coexistence of chronic myeloid leukemia (CML) and B-cell chronic lymphocytic leukemia (CLL) in the same patient is rare. A 71-year-old woman developed a B-lineage lymphoid blast crisis at 18 months after diagnosis of Ph-positive CML. At this time, a lymphoid cell population with morphologic and immunophenotypic fe...

journal_title：Haematologica

authors： Esteve J,Cervantes F,Rives S,Rozman M,Zarco MA,Montserrat E

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Alterations in hemostasis have frequently been observed in patients with leukemia, and thrombotic events are well documented in patients receiving L-asparaginase (ASP) as a single agent or in combination with vincristine, prednisone (sometimes complemented by an anthracycline). The present study was designed...

journal_title：Haematologica

authors： Nowak-Göttl U,Werber G,Ziemann D,Ahlke E,Boos J

更新日期：1996-03-01 00:00:00

abstract：:Shwachman-Diamond syndrome is a congenital bone marrow failure disorder characterized by debilitating neutropenia. The disease is associated with loss-of-function mutations in the SBDS gene, implicated in ribosome biogenesis, but the cellular and molecular events driving cell specific phenotypes in ribosomopathies rem...

journal_title：Haematologica

authors： Zambetti NA,Bindels EM,Van Strien PM,Valkhof MG,Adisty MN,Hoogenboezem RM,Sanders MA,Rommens JM,Touw IP,Raaijmakers MH

更新日期：2015-10-01 00:00:00

abstract：:A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point s...

journal_title：Haematologica

authors： Gallamini A,Barrington SF,Biggi A,Chauvie S,Kostakoglu L,Gregianin M,Meignan M,Mikhaeel GN,Loft A,Zaucha JM,Seymour JF,Hofman MS,Rigacci L,Pulsoni A,Coleman M,Dann EJ,Trentin L,Casasnovas O,Rusconi C,Brice P,Bolis

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Increased levels of microparticles exposing tissue factor circulate in the blood of patients with coronary heart disease, possibly disseminating their pro-thrombotic and pro-inflammatory potential. Because diets rich in n-3 (polyunsaturated) fatty acids have been associated with reduced incidence of coronary...

journal_title：Haematologica

authors： Del Turco S,Basta G,Lazzerini G,Evangelista M,Rainaldi G,Tanganelli P,Christensen JH,Schmidt EB,De Caterina R

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone. DESIGN AND METHODS:In this prospective, multicenter, phase II study, patients with relapsed/refractory mantle cell lymphoma who were not eligible for, or had relap...

journal_title：Haematologica

authors： Zaja F,De Luca S,Vitolo U,Orsucci L,Levis A,Salvi F,Rusconi C,Ravelli E,Tucci A,Bottelli C,Balzarotti M,Brusamolino E,Bonfichi M,Pileri SA,Sabattini E,Volpetti S,Monagheddu C,Vacca A,Ria R,Fanin R

更新日期：2012-03-01 00:00:00

abstract：:To further clarify the role of ribosomal protein S14 (RPS14) in myelodysplastic syndrome, we examined RPS14 transcription in bone marrow derived CD34+ cells from patients with non-5q- myelodysplastic syndrome and found a reduced expression of RPS14 in 51 of 72 (71%) patients. MDS patients with an intermediate-1 risk (...

journal_title：Haematologica

authors： Czibere A,Bruns I,Junge B,Singh R,Kobbe G,Haas R,Germing U

更新日期：2009-10-01 00:00:00

abstract：:Older chronic lymphocytic leukemia patients have poor outcomes with standard treatments and are underrepresented in clinical trials. We retrospectively reviewed outcomes of refractory chronic lymphocytic leukemia patients in two age categories (≥70 and <70 years) treated with single-agent flavopiridol, a drug active i...

journal_title：Haematologica

authors： Stephens DM,Ruppert AS,Blum K,Jones J,Flynn JM,Johnson AJ,Ji J,Phelps MA,Grever MR,Byrd JC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and survival. DESIGN AND ...

journal_title：Haematologica

authors： Stamatopoulos B,Meuleman N,De Bruyn C,Delforge A,Bron D,Lagneaux L

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Although IFN-beta is 30-40% homologous with IFN-alpha, its intrinsic biological properties are not identical. Compared with IFN-alpha, IFN-beta exerts greater in vitro antiproliferative activity on many cell lines, stimulates peripheral blood stem cells of hairy-cell leukemia (HCL) patients to differentiate ...

journal_title：Haematologica

authors： Liberati AM,Schippa M,Portuesi MG,Grazia Proietti M,De Angelis V,Ferrajoli A,Cinieri S,Di Clemente F,Palmisano L,Berruto P

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:All-trans retinoic acid (ATRA) induces growth arrest and apoptosis in acute myeloblastic leukemia (AML) cells. Since cellular redox state regulates these events, we were interested in studying whether it has any role in the responsiveness of AML cells to ATRA. DESIGN AND METHODS:Two human AML ...

journal_title：Haematologica

authors： Mäntymaa P,Guttorm T,Siitonen T,Säily M,Savolainen ER,Levonen AL,Kinnula V,Koistinen P

更新日期：2000-03-01 00:00:00

abstract：:Blackfan-Diamond anemia (BDA) is a rare hypoproliferative anemia occurring in infancy or in early childhood. Patients who fail on usual doses of steroids did not achieve remission with other pharmacological agents. Claims that other molecules such as cyclosporin A (CSA) or antithymocyte globulin (ATG) are effective re...

journal_title：Haematologica

authors： Bejaoui M,Fitouri Z,Sfar MT,Lakhoua R

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The strongest risk factor identified for inhibitor development in people with severe hemophilia A is the type of factor VIII gene mutation. The objective of this study was to evaluate the mutation type dependent concordance rate of inhibitor formation in siblings. DESIGN AND METHODS:The gene ...

journal_title：Haematologica

authors： Astermark J,Oldenburg J,Escobar M,White GC 2nd,Berntorp E,Malmö International Brother Study study group.

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The limited value of qualitative reverse transcription polymerase chain-reaction (RT-PCR) for monitoring chronic myeloid leukemia (CML) patients has prompted the development of quantitative assays. We have developed a quantitative real-time PCR (QC-PCR) method in the LightCycler, based on the ...

journal_title：Haematologica

authors： Bolufer P,Sanz GF,Barragán E,Sanz MA,Cervera J,Lerma E,Senent L,Moreno I,Planelles MD

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:LMO2 is highly expressed at the most immature stages of lymphopoiesis. In T-lymphocytes, aberrant LMO2 expression beyond those stages leads to T-cell acute lymphoblastic leukemia, while in B cells LMO2 is also expressed in germinal center lymphocytes and diffuse large B-cell lymphomas, where it predicts bett...

journal_title：Haematologica

authors： Malumbres R,Fresquet V,Roman-Gomez J,Bobadilla M,Robles EF,Altobelli GG,Calasanz MJ,Smeland EB,Aznar MA,Agirre X,Martin-Palanco V,Prosper F,Lossos IS,Martinez-Climent JA

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The diagnosis of T-cell neoplasia requires the use of immunohistochemistry on tumor sections or molecular genetic analysis of T-cell receptor (TCR) clonality. Multiplex polymerase chain reactions (PCR) offer a sensitive and expeditious approach to determining clonality early in the diagnostic ...

journal_title：Haematologica

authors： Dictor M,Warenholt J,Isinger A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:An effective second-line treatment for intermediate and high grade non-Hodgkin's lymphoma is greatly needed since 30% of patients do not achieved complete remission (CR) and another 20% to 30% of the CRs will eventually relapse. METHODS:A four-drug combination with Mitoxantrone, Etoposide, Cisplatin and Dex...

journal_title：Haematologica

authors： Vitolo U,Orsucci L,Bertini M,Cavallero G,Gallamini A,Ghio R,Levis A,Rota-Scalabrini D,Resegotti L

更新日期：1991-01-01 00:00:00

abstract：:In contrast to well-established hierarchical concepts of tumor stem cells, leukemia-initiating cells in B-cell precursor acute lymphoblastic leukemia have not yet been phenotypically identified. Different subpopulations, as defined by surface markers, have shown equal abilities to reconstitute leukemia upon transplant...

journal_title：Haematologica

authors： Trentin L,Queudeville M,Eckhoff SM,Hasan N,Münch V,Boldrin E,Seyfried F,Enzenmüller S,Debatin KM,Meyer LH

更新日期：2018-06-01 00:00:00

abstract：:The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic...

journal_title：Haematologica

authors： Ross FM,Avet-Loiseau H,Ameye G,Gutiérrez NC,Liebisch P,O'Connor S,Dalva K,Fabris S,Testi AM,Jarosova M,Hodkinson C,Collin A,Kerndrup G,Kuglik P,Ladon D,Bernasconi P,Maes B,Zemanova Z,Michalova K,Michau L,Neben K,

更新日期：2012-08-01 00:00:00

abstract：:Perforin gene (PRF1) mutations cause the primary form of hemophagocytic lymphohistiocytosis (HLH). We report a genetic defect of PRF1 in a 62-year-old Japanese man with recurrent episodes of HLH. Sequencing of PRF1 from both peripheral blood mononuclear cells and nail clippings showed compound heterozygous mutation, i...

journal_title：Haematologica

authors： Nagafuji K,Nonami A,Kumano T,Kikushige Y,Yoshimoto G,Takenaka K,Shimoda K,Ohga S,Yasukawa M,Horiuchi H,Ishii E,Harada M

更新日期：2007-07-01 00:00:00

abstract：:There is emerging consensus that a pro-inflammatory condition contributes to the vaso-occlusive complications of sickle cell disease (SCD). We evaluated the potential value of inflammatory mediators as early markers of severity of painful vaso-occlusive crises (VOC) in SCD. We assayed the plasma levels of cytokines, s...

journal_title：Haematologica

authors： Etienne-Julan M,Belloy MS,Decastel M,Dougaparsad S,Ravion S,Hardy-Dessources MD

更新日期：2004-07-01 00:00:00

abstract：:The introduction of agents inhibiting the BCR-associated kinases such as ibrutinib has dramatically changed treatments algorithms of chronic lymphocytic leukaemia (CLL) as well as the role of different adverse prognosticators. We evaluated the efficacy of ibrutinib as single agent, in a real-life context, on 180 patie...

journal_title：Haematologica

authors： Del Poeta G,Biagi A,Laurenti L,Chiarenza A,Pozzo F,Innocenti I,Postorino M,Rossi FM,Del Principe MI,Bomben R,de Fabritiis P,Bruno A,Cantonetti M,Di Raimondo F,Zucchetto A,Gattei V

更新日期：2020-07-30 00:00:00

abstract：BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS:We studied 23 patients with PNH, before and after five and 11 weeks of treatment with eculizumab. We examined markers of thrombin generation and reactional fibrinolysis...

journal_title：Haematologica

authors： Helley D,de Latour RP,Porcher R,Rodrigues CA,Galy-Fauroux I,Matheron J,Duval A,Schved JF,Fischer AM,Socié G,French Society of Hematology.

更新日期：2010-04-01 00:00:00

abstract：:e tested whether polymorphic variations in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and interleukin-1 (IL-1beta and IL-1RN) genes confer susceptibility to mucosa-associated lymphoid tissue lymphomas (MALT) in a Chinese population. The rates of GSTM1, GSTP1, IL-1beta and IL-1RN genotypes did not differ bet...

journal_title：Haematologica

authors： Wu MS,Shun CT,Huang SP,Cheng AL,Chen LT,Lin JT

更新日期：2004-08-01 00:00:00

abstract：:To date, few mutations associated with a dominant quantitative deficiency of von Willebrand factor (VWF) and a high penetrance have been reported. This phenotype was confirmed in seven unrelated families of several patients diagnosed with von Willebrand's disease out of 70 who requested genetic studies of the VWF gene...

journal_title：Haematologica

authors： Casaña P,Cabrera N,Haya S,Cid AR,Aznar JA

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Antithymocyte globulin or human Jurkat T-cell-line-derived antilymphocyte globulin is used in allogeneic stem cell transplantation to induce in vivo T-cell depletion to facilitate engraftment and lower graft-versus-host disease. In vitro studies suggest that antithymocyte globulin, besides causing T-cell dep...

journal_title：Haematologica

authors： Ayuk F,Perez-Simon JA,Shimoni A,Sureda A,Zabelina T,Schwerdtfeger R,Martino R,Sayer HG,Alegre A,Lahuerta JJ,Atanackovic D,Wolschke C,Nagler A,Zander AR,San Miguel JF,Kröger N

更新日期：2008-09-01 00:00:00

abstract：:Children with immune thrombocytopenia for ≥6 months completing a romiplostim study received weekly subcutaneous romiplostim (1-10 μg/kg targeting platelet counts of 50-200×109/L) in this extension to examine romiplostim's long-term safety and efficacy. Sixty-five children received romiplostim for a median of 2.6 years...

journal_title：Haematologica

authors： Tarantino MD,Bussel JB,Blanchette VS,Beam D,Roy J,Despotovic J,Raj A,Carpenter N,Mehta B,Eisen M

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Patients affected by Hodgkin's disease (HD) in pathologic stage IA-IIA have a strong possibility of remission and long-term survival when treated with radiotherapy to extended fields. However, 20-30% of cases relapse in the five years following treatment and consequently need further therapy. T...

journal_title：Haematologica

authors： Enrici RM,Anselmo AP,Donato V,Falchetto Osti M,Santoro M,Tombolini V,Mandelli F

更新日期：1999-10-01 00:00:00