Abstract:
:Older chronic lymphocytic leukemia patients have poor outcomes with standard treatments and are underrepresented in clinical trials. We retrospectively reviewed outcomes of refractory chronic lymphocytic leukemia patients in two age categories (≥70 and <70 years) treated with single-agent flavopiridol, a drug active in genomically high-risk patients, during two trials. No significant difference between older and younger patients was observed in response rates (43 vs. 47%) or progression-free survival (median 8.7 vs. 9.9 months, P>0.80). Although overall survival was worse in older patients (median 2.1 vs. 2.4 years, P=0.02); when adjusted for other factors this difference was no longer significant (P≥0.10). With the exception of infections (older 29% vs. younger 62%) no significant association with toxicity was observed. These data demonstrate that flavopiridol administration to older chronic lymphocytic leukemia patients is feasible, tolerable, and may have similar efficacy to that in younger patients. Development of treatment approaches including flavopiridol should be considered for these older patients.
journal_name
Haematologicajournal_title
Haematologicaauthors
Stephens DM,Ruppert AS,Blum K,Jones J,Flynn JM,Johnson AJ,Ji J,Phelps MA,Grever MR,Byrd JCdoi
10.3324/haematol.2011.047324subject
Has Abstractpub_date
2012-03-01 00:00:00pages
423-7issue
3eissn
0390-6078issn
1592-8721pii
haematol.2011.047324journal_volume
97pub_type
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