Parvovirus B19 infections in patients with chronic anemia.

abstract：:Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representa...

journal_title：Haematologica

authors： MacKenzie J,Greaves MF,Eden TO,Clayton RA,Perry J,Wilson KS,Jarrett RF

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Treatment of older patients with non-Hodgkin's lymphoma (NHL) is difficult and conflicting. Lower responsiveness to therapy has been reported; however, the high risk of treatment morbidity, drug-dose reduction, and the occurrence of unrelated deaths might account for the poor outcome of NHL in the elderly. ...

journal_title：Haematologica

authors： Orlandi E,Lazzarino M,Brusamolino E,Castelli G,Pagnucco G,Morra E,Bernasconi C

更新日期：1991-05-01 00:00:00

abstract：:BACKGROUND. Hypofibrinogenemia and increased fibrin(ogen) degradation products in acute leukemia have been attributed to intravascular thrombin generation triggered by leukemic cells. However, the strict relationship between fibrinogen catabolism and turnover of fibrinopeptide A (FPA), which is a sensitive and specifi...

journal_title：Haematologica

authors： Castaman G,Galloni E,Dri AV,Rodeghiero F

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...

journal_title：Haematologica

authors： Origa R,Galanello R,Ganz T,Giagu N,Maccioni L,Faa G,Nemeth E

更新日期：2007-05-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and V(H) gene sequencing in a prospective clinical evaluation. The V(H) mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for spec...

journal_title：Haematologica

authors： Méhes G,Kovács G,Kajtár B,Lacza A,Várnai A,Losonczy H,Pajor L

更新日期：2006-10-01 00:00:00

abstract：:Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1 shows clear bimodal expression with high levels in chronic lymph...

journal_title：Haematologica

authors： Plešingerová H,Janovská P,Mishra A,Smyčková L,Poppová L,Libra A,Plevová K,Ovesná P,Radová L,Doubek M,Pavlová Š,Pospíšilová Š,Bryja V

更新日期：2018-02-01 00:00:00

abstract：:As in other malignancies, peripheral blood progenitor cells (PBPC) have almost completely replaced bone marrow as the source of stem cells for autologous transplantation in multiple myeloma. PBPC collection could be optimized either by reducing contamination by the malignant clone or by increasing hematopoietic qualit...

journal_title：Haematologica

authors： Harousseau JL

更新日期：1999-06-01 00:00:00

abstract：:The National Institutes of Health global score for chronic graft-versus-host disease was devised by experts but was not based on empirical data. We hypothesized that analysis of prospectively collected data would enable derivation of a more accurate model for estimating mortality risk. We analyzed 574 adult patients w...

journal_title：Haematologica

authors： Inamoto Y,Martin PJ,Storer BE,Palmer J,Weisdorf DJ,Pidala J,Flowers ME,Arora M,Jagasia M,Arai S,Chai X,Pavletic SZ,Vogelsang GB,Lee SJ,Chronic GVHD Consortium.

更新日期：2014-10-01 00:00:00

abstract：:The role of reduced intensity allogeneic stem cell transplantation for the treatment of relapsed/refractory Hodgkin's lymphoma remains controversial. We retrospectively analyzed 191 patients who underwent reduced intensity allogeneic stem cell transplantation between 1998 and 2008 for relapsed or refractory Hodgkin's ...

journal_title：Haematologica

authors： Marcais A,Porcher R,Robin M,Mohty M,Michalet M,Blaise D,Tabrizi R,Clement L,Ceballos P,Daguindau E,Bilger K,Dhedin N,Lapusan S,Bay JO,Pautas C,Garban F,Ifrah N,Guillerm G,Contentin N,Bourhis JH,Yakoub Agha I,Ber

更新日期：2013-09-01 00:00:00

abstract：:Diagnostic biomarkers can be used to determine relapse risk in acute myeloid leukemia, and certain genetic aberrancies have prognostic relevance. A diagnostic immunophenotypic expression profile, which quantifies the amounts of distinct gene products, not just their presence or absence, was established in order to imp...

journal_title：Haematologica

authors： Voigt AP,Brodersen LE,Alonzo TA,Gerbing RB,Menssen AJ,Wilson ER,Kahwash S,Raimondi SC,Hirsch BA,Gamis AS,Meshinchi S,Wells DA,Loken MR

更新日期：2017-12-01 00:00:00

abstract：:Outcomes after relapse of childhood B-acute lymphoblastic leukemia (B-ALL) are poor, and optimal therapy is unclear. Children's Oncology Group study AALL0433 evaluated a new platform for relapsed ALL. Between March 2007 and October 2013 AALL0433 enrolled 275 participants with late bone marrow or very early isolated ce...

journal_title：Haematologica

authors： Lew G,Chen Y,Lu X,Rheingold SR,Whitlock JA,Devidas M,Hastings CA,Winick NJ,Carroll WL,Wood BL,Borowitz MJ,Pulsipher MA,Hunger SP

更新日期：2021-01-01 00:00:00

abstract：:Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal. Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase. Sequential inhibition of ribonu...

journal_title：Haematologica

authors： Zeidner JF,Karp JE,Blackford AL,Smith BD,Gojo I,Gore SD,Levis MJ,Carraway HE,Greer JM,Ivy SP,Pratz KW,McDevitt MA

更新日期：2014-04-01 00:00:00

abstract：:ALK-positive large B-cell lymphoma is a rare subtype of lymphoma, and most cases follow an aggressive clinical course with a poor prognosis. We examined an ALK-positive large B-cell lymphoma case showing an anti-ALK immunohistochemistry pattern distinct from those of 2 known ALK fusions, CLTC-ALK and NPM-ALK, for the ...

journal_title：Haematologica

authors： Takeuchi K,Soda M,Togashi Y,Ota Y,Sekiguchi Y,Hatano S,Asaka R,Noguchi M,Mano H

更新日期：2011-03-01 00:00:00

abstract：:Iron overload and hepatitis virus C infection cause liver fibrosis in thalassemics. In a monocentric retrospective analysis of liver disease in a cohort of 191 transfusion-dependent thalassemics, in 126 patients who had undergone liver biopsy (mean age 17.2 years; 58 hepatitis virus C-RNA positive and 68 hepatitis vir...

journal_title：Haematologica

authors： Di Marco V,Capra M,Gagliardotto F,Borsellino Z,Cabibi D,Barbaria F,Ferraro D,Cuccia L,Ruffo GB,Bronte F,Di Stefano R,Almasio PL,Craxì A

更新日期：2008-08-01 00:00:00

abstract：:Acquired aplastic anemia is an autoimmune-mediated bone marrow failure syndrome. The mechanism by which such an autoimmune reaction is initiated is unknown. Whether and how the genetic lesions detected in patients cause autoimmune bone marrow failure have not yet been determined. We found that mice with spontaneous de...

journal_title：Haematologica

authors： Xin J,Breslin P,Wei W,Li J,Gutierrez R,Cannova J,Ni A,Ng G,Schmidt R,Chen H,Parini V,Kuo PC,Kini AR,Stiff P,Zhu J,Zhang J

更新日期：2017-02-01 00:00:00

abstract：:Conventional coagulation tests might be inadequate to explore mechanisms regulating thrombin generation in neonates, because they do not allow full activation of the reduced levels of protein C. Therefore, they do not reflect the action of pro- and anti-coagulants as does the endogenous thrombin potential assessed in ...

journal_title：Haematologica

authors： Tripodi A,Ramenghi LA,Chantarangkul V,De Carli A,Clerici M,Groppo M,Mosca F,Mannucci PM

更新日期：2008-08-01 00:00:00

abstract：:MicroRNA-34b down-regulation in acute myeloid leukemia was previously shown to induce CREB overexpression, thereby causing leukemia proliferation in vitro and in vivo. The role of microRNA-34b and CREB in patients with myeloid malignancies has never been evaluated. We examined microRNA-34b expression and the methylati...

journal_title：Haematologica

authors： Pigazzi M,Manara E,Bresolin S,Tregnago C,Beghin A,Baron E,Giarin E,Cho EC,Masetti R,Rao DS,Sakamoto KM,Basso G

更新日期：2013-04-01 00:00:00

abstract：:Peripheral blood lymphoid cell expansions with an unusual CD3+, CD4+, CD8dim+/-, CD11b+, CD57+ immunophenotype have recently been reported. They frequently have the morphology of large granular lymphocytes (LGL) and can be either monoclonal or polyclonal. Their significance is still unclear and no association with hem...

journal_title：Haematologica

authors： Airò P,Rossi G,Facchetti F,Marocolo D,Garza L,Lanfranchi A,Prati E,Brugnoni D,Malacarne F,Cattaneo R

更新日期：1995-03-01 00:00:00

abstract：:New drugs are needed for the treatment of relapsed acute lymphoblastic leukemia and preclinical evaluation of the MEK inhibitor, selumetinib, has shown that this drug has excellent activity in those leukemias with RAS pathway mutations. The proapoptotic protein, BIM is pivotal in the induction of cell death by both se...

journal_title：Haematologica

authors： Matheson EC,Thomas H,Case M,Blair H,Jackson RK,Masic D,Veal G,Halsey C,Newell DR,Vormoor J,Irving JAE

更新日期：2019-09-01 00:00:00

abstract：:Even though alterations in platelet counts are presumed to be detrimental, their impact on the survival of patients has not been studied in large cohorts. The prevalence of thrombocytopenia and thrombocytosis was examined in a large inner city outpatient population of 36,262 individuals aged ≥65 years old. A significa...

journal_title：Haematologica

authors： Msaouel P,Lam AP,Gundabolu K,Chrysofakis G,Yu Y,Mantzaris I,Friedman E,Verma A

更新日期：2014-05-01 00:00:00

abstract：:A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point s...

journal_title：Haematologica

authors： Gallamini A,Barrington SF,Biggi A,Chauvie S,Kostakoglu L,Gregianin M,Meignan M,Mikhaeel GN,Loft A,Zaucha JM,Seymour JF,Hofman MS,Rigacci L,Pulsoni A,Coleman M,Dann EJ,Trentin L,Casasnovas O,Rusconi C,Brice P,Bolis

更新日期：2014-06-01 00:00:00

abstract：:Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the developmental stages of the hematopoietic system and the molecular bases of malignant and non-malignant blood diseases for the past three decades. Previously, only the genes targeted by expression microarrays could be profiled g...

journal_title：Haematologica

authors： Grassi L,Izuogu OG,Jorge NA,Seyres D,Bustamante M,Burden F,Farrow S,Farahi N,Martin FJ,Frankish A,Mudge JM,Kostadima M,Petersen R,Lambourne JJ,Rowlston S,Martin-Rendon E,Clarke L,Downes K,Estivill X,Flicek P,Marte

更新日期：2020-07-23 00:00:00

abstract：:Children with immune thrombocytopenia for ≥6 months completing a romiplostim study received weekly subcutaneous romiplostim (1-10 μg/kg targeting platelet counts of 50-200×109/L) in this extension to examine romiplostim's long-term safety and efficacy. Sixty-five children received romiplostim for a median of 2.6 years...

journal_title：Haematologica

authors： Tarantino MD,Bussel JB,Blanchette VS,Beam D,Roy J,Despotovic J,Raj A,Carpenter N,Mehta B,Eisen M

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Approximately 15% of patients with cancer will experience a thrombotic episode at some time. Some patients are at particularly high risk depending on the histology of the malignant disease. The aim of the study was to determine the actual prevalence of thrombotic episodes in oncohematologic pat...

journal_title：Haematologica

authors： Sgarabotto D,Prandoni P,Stefani PM,Scano F,Vianello F,Sartori R,Pietrogrande F,Caenazzo A,Girolami A

更新日期：1998-05-01 00:00:00

abstract：:We report a family with type I and type III protein S (PS) deficiency, which showed to be phenotypic variants of the same genetic disease. Direct sequencing analysis of the PROS1 gene was performed to establish the genotype. The ratio of protein C antigen and total PS antigen levels (protein C/S ratio) was used to cla...

journal_title：Haematologica

authors： ten Kate MK,Mulder R,Platteel M,Brouwer JL,van der Steege G,van der Meer J

更新日期：2006-08-01 00:00:00

abstract：:Patients with essential thrombocythemia often complain of various subjective neurological symptoms. This prospective study aims to assess their incidence and response to therapy. Among 37 consecutive patients with essential thrombocythemia, 11 presented with neurological symptoms. Among them 4 had thrombotic events, 7...

journal_title：Haematologica

authors： Billot S,Kouroupi EG,Le Guilloux J,Cassinat B,Jardin C,Laperche T,Fenaux P,Carpentier AF,Kiladjian JJ

更新日期：2011-12-01 00:00:00

abstract：:It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. In this study, we analyzed the outcome of 84 patients at 3 years of follow-up ...

journal_title：Haematologica

authors： García-Marco JA,Jiménez JL,Recasens V,Zarzoso MF,González-Barca E,De Marcos NS,Ramírez MJ,Parraga FJP,Yañez L,De La Serna Torroba J,Malo MDG,Ariznavarreta GD,Persona EP,Guinaldo MAR,De Paz Arias R,Llanos EB,Jarque I,Val

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and function has not yet been established. Our study aimed to compare th...

journal_title：Haematologica

authors： Pepe A,Meloni A,Capra M,Cianciulli P,Prossomariti L,Malaventura C,Putti MC,Lippi A,Romeo MA,Bisconte MG,Filosa A,Caruso V,Quarta A,Pitrolo L,Missere M,Midiri M,Rossi G,Positano V,Lombardi M,Maggio A

更新日期：2011-01-01 00:00:00

abstract：:Diabetes insipidus and thrombocytosis were presenting symptoms in a case of adult ANLL-M1. Cytogenetic investigations revealed a typical 3q rearrangement, i.e. inv(3)(q21q26). A subclone with monosomy 7 was also found and documented by FISH analysis. Correlations between clinical/hematological features and cytogenetic...

journal_title：Haematologica

authors： La Starza R,Falzetti D,Fania C,Tabilio A,Martelli MF,Mecucci C

更新日期：1994-07-01 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose immunophenotype remains incompletely characterized, particularly in terms of distinction from reactive plasmacytoid dendritic cells (PDCs). This limitation complicates detection of low-level involvement by BPDCN as well as mini...

journal_title：Haematologica

authors： Wang W,Khoury JD,Miranda RN,Jorgensen JL,Xu J,Loghavi S,Li S,Pemmaraju N,Nguyen T,Medeiros LJ,Wang SA

更新日期：2020-04-02 00:00:00