Abstract:
:Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representational difference analysis (RDA) to examine tumor samples for the presence of exogenous genomes. Twenty RDA experiments were carried out, using four different restriction enzymes, but no exogenous sequences were identified within leukemic cells. These results suggest that it is unlikely that a single, direct transforming agent is involved in the pathogenesis of common acute lymphoblastic leukemia.
journal_name
Haematologicajournal_title
Haematologicaauthors
MacKenzie J,Greaves MF,Eden TO,Clayton RA,Perry J,Wilson KS,Jarrett RFkeywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
240-3issue
2eissn
0390-6078issn
1592-8721journal_volume
91pub_type
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