Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging.

abstract：BACKGROUND AND OBJECTIVES:Rituximab reacts specifically with the CD20 antigen and induces B-cell depletion. This could interfere with the production of autoantibodies in some immune diseases. The objective of this study was to assess the effects of rituximab in autoimmune hemolytic anemia and thrombocytopenia. DESIGN ...

journal_title：Haematologica

authors： Zaja F,Iacona I,Masolini P,Russo D,Sperotto A,Prosdocimo S,Patriarca F,de Vita S,Regazzi M,Baccarani M,Fanin R

更新日期：2002-02-01 00:00:00

abstract：:Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene expression programs. These programs are stabilized by the epigenetic a...

journal_title：Haematologica

authors： Herkt SC,Kuvardina ON,Herglotz J,Schneider L,Meyer A,Pommerenke C,Salinas-Riester G,Seifried E,Bonig H,Lausen J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:We have shown previously that both erythrocyte production rate (EPR) and plasma erythropoietin (EPO) levels in response to hypoxia or to compounds able to stimulate EPO secretion are very much higher in post-hypoxic (PH) than in hypertransfused (HT) polycythemic mice with similar levels of hematocrit. Since ...

journal_title：Haematologica

authors： Alippi RM,Boyer P,Leal T,Barcelò AC,Martinez MP,Bozzini CE

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Relapsing primary central nervous system lymphoma carries a poor prognosis when treated with conventional chemotherapy with a one-year overall survival of 25-40%. Encouraging results have been shown with intensive chemotherapy followed by autologous hematopoietic stem cell rescue. We report the results of a ...

journal_title：Haematologica

authors： Soussain C,Choquet S,Fourme E,Delgadillo D,Bouabdallah K,Ghesquières H,Damaj G,Dupriez B,Vargaftig J,Gonzalez A,Houillier C,Taillandier L,Hoang-Xuan K,Leblond V

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In multiple myeloma (MM), the mechanisms used by plasma cells to invade locally and metastasize are thought to be similar to those developed by solid tumors and include cell proliferation and secretion of extracellular matrix (ECM) degrading enzymes following adhesion to ECM proteins. We studi...

journal_title：Haematologica

authors： Ria R,Vacca A,Ribatti D,Di Raimondo F,Merchionne F,Dammacco F

更新日期：2002-08-01 00:00:00

abstract：:The diversity of the human leukocyte antigen (HLA) class I and II alleles can be simplified by consolidating them into fewer supertypes based on functional or predicted structural similarities in epitope-binding grooves of HLA molecules. We studied the impact of matched and mismatched HLA-A (265 versus 429), -B (230 v...

journal_title：Haematologica

authors： Lazaryan A,Wang T,Spellman SR,Wang HL,Pidala J,Nishihori T,Askar M,Olsson R,Oudshoorn M,Abdel-Azim H,Yong A,Gandhi M,Dandoy C,Savani B,Hale G,Page K,Bitan M,Reshef R,Drobyski W,Marsh SG,Schultz K,Müller CR,Fer

更新日期：2016-10-01 00:00:00

abstract：:As of 1999, the German registry of immune tolerance treatment in hemophilia has received reports on 146 patients who have undergone this therapy from 25 hemophilia centers. In 16 of the reported patients treatment is ongoing. Therapy has been completed in 126 patients of all groups with hemophilia A; most of them are ...

journal_title：Haematologica

authors： Lenk H,ITT Study Group.

更新日期：2000-10-01 00:00:00

abstract：:It is well known that thalassemic patients exhibit an increased frequency of thrombotic events. Most individuals with resistance to activated protein C (APCR) are the result of a point mutation replacing Arg 506 with Gln in the factor V aminoacidic sequence (factor V Leiden). Recently APCR has been shown to account fo...

journal_title：Haematologica

authors： Giordano P,Sabato V,Schettini F,De Mattia D,Iolascon A

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There are several therapeutic options for patients with myeiodysplastic syndrome (MDS) but most of them are poorly effective and the potentially curative ones are available only for a minority of individuals. The aim of this article is to define a rational basis for a patient-oriented approach ...

journal_title：Haematologica

authors： Cazzola M,Anderson JE,Ganser A,Hellström-Lindberg E

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:A D-dimer assay can be helpful to rule out thromboembolism provided it is sensitive, reliable, fast and easy to perform. Tests based on the ELISA methodology have a high diagnostic sensitivity, and are therefore adequate for excluding deep venous thrombosis (DVT). The drawbacks are their long a...

journal_title：Haematologica

authors： Villa P,Ferrando F,Serra J,Faus H,Mira Y,Vayá A,Aznar J

更新日期：2000-05-01 00:00:00

abstract：:Previous studies identified the Ser/Thr protein kinase, AKT, as a therapeutic target in thrombo-inflammatory diseases. Here we report that specific inhibition of AKT with ARQ 092, an orally-available AKT inhibitor currently in phase Ib clinical trials as an anti-cancer drug, attenuates the adhesive function of neutrop...

journal_title：Haematologica

authors： Kim K,Li J,Barazia A,Tseng A,Youn SW,Abbadessa G,Yu Y,Schwartz B,Andrews RK,Gordeuk VR,Cho J

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The incidence of primary gastric non-Hodgkin's lymphoma (NHL) appears to have increased worldwide in recent years, and this seems to be confirmed by large-sample population studies. METHODS AND RESULTS:We derived our data from the Lombardy Cancer Registry, which provides the incidence of cancer in the provi...

journal_title：Haematologica

authors： Pinotti G,Novario R,Berrino F,Bianchi P,Comi MA,Gamba MC,Venco A

更新日期：1992-09-01 00:00:00

abstract：:Transient pancytopenia preceding childhood acute lymphoblastic leukemia (ALL) is an unfrequent but well-known event. The association of this preleukemic syndrome with hepatitis is extremely rare, with only two such cases having been published in the literature. We report the case of a 16-year-old boy who was diagnosed...

journal_title：Haematologica

authors： Rafel M,Cobo F,Cervantes F,Bosch F,Campo E,Montserrat E

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dendritic cells (DC) pulsed with multiple myeloma (MM) patient-specific idiotype (Id) protein can induce MM-specific T-cell responses. DESIGN AND METHODS:We established serum-free culture conditions to generate monocyte-derived DC for clinical use to circumvent anti-xenogenic immune responses...

journal_title：Haematologica

authors： Reichardt VL,Milazzo C,Brugger W,Einsele H,Kanz L,Brossart P

更新日期：2003-10-01 00:00:00

abstract：:Immunoparesis or suppression of polyclonal immunoglobulins is a very common condition in newly diagnosed myeloma patients. However, the recovery of polyclonal immunoglobulins in the setting of immune reconstitution after autologous stem cell transplantation and its effect on outcome has not yet been explored. We condu...

journal_title：Haematologica

authors： González-Calle V,Cerdá S,Labrador J,Sobejano E,González-Mena B,Aguilera C,Ocio EM,Vidriales MB,Puig N,Gutiérrez NC,García-Sanz R,Alonso JM,López R,Aguilar C,de Coca AG,Hernández R,Hernández JM,Escalante F,Mateos MV

更新日期：2017-05-01 00:00:00

abstract：:Adoptive transfer of ex vivo expanded CD4(+)CD25(+)FOXP3(+) regulatory T cells is a successful therapy for autoimmune diseases and transplant rejection in experimental models. In man, equivalent manipulations in bone marrow transplant recipients appear safe, but questions regarding the stability of the transferred reg...

journal_title：Haematologica

authors： Scottà C,Esposito M,Fazekasova H,Fanelli G,Edozie FC,Ali N,Xiao F,Peakman M,Afzali B,Sagoo P,Lechler RI,Lombardi G

更新日期：2013-08-01 00:00:00

abstract：:Disease bulk is an important prognostic factor in early stage Hodgkin lymphoma, but its definition is unclear in the computed tomography era. This retrospective analysis investigated the prognostic significance of bulky disease measured in transverse and coronal planes on computed tomography imaging. Early stage Hodgk...

journal_title：Haematologica

authors： Kumar A,Burger IA,Zhang Z,Drill EN,Migliacci JC,Ng A,LaCasce A,Wall D,Witzig TE,Ristow K,Yahalom J,Moskowitz CH,Zelenetz AD

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:A novel role for shedding of the surface molecule L-selectin has been proposed as an adjunctive phenomenon during cell detachment from marrow stroma or vessel endothelium. We wished to examine whether variations in expression of L-selectin on a lymphoma B cell line were linked to shedding. DES...

journal_title：Haematologica

authors： Po JL,Mak A,Ginsberg D,Huerta P,Manoukian R,Shustik C,Jensen GS

更新日期：1999-09-01 00:00:00

abstract：:Home care (HC) has an increasingly expanding role in the global management of patients affected by hematologic malignancies. Integrated strategies, including causal-targeted and supportive treatments according to hematologic expertise and a holistic approach inspired by the philosophy and practice of palliative medici...

journal_title：Haematologica

authors： Niscola P,de Fabritiis P,Cartoni C,Romani C,Sorrentino F,Dentamaro T,Piccioni D,Scaramucci L,Giovannini M,Amadori S,Mandelli F

更新日期：2006-11-01 00:00:00

abstract：:The detection of iron deficiency anemia is challenged by the paucity of diagnostic tests demonstrating high sensitivity and specificity. Using two biomarkers, zinc-protoporphyrin/heme and hepcidin, we established the diagnostic cut-off values for iron deficiency anemia in preschool children and women. We randomly sele...

journal_title：Haematologica

authors： Kanuri G,Chichula D,Sawhney R,Kuriakose K,De'Souza S,Pais F,Arumugam K,Shet AS

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Serum beta(2)-microglobulin (s beta(2)m) is an established prognostic factor for multiple myeloma and non-Hodgkin's lymphoma, but only limited data suggest an adverse prognostic significance for Hodgkin's lymphoma (HL). This study was undertaken to examine the impact of s beta(2)m on the progn...

journal_title：Haematologica

authors： Vassilakopoulos TP,Nadali G,Angelopoulou MK,Siakantaris MP,Dimopoulou MN,Kontopidou FN,Karkantaris C,Kokoris SI,Kyrtsonis MC,Tsaftaridis P,Pizzolo G,Pangalis GA

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The use of intensive therapy supported by autologous stem cell transplantation (ASCT) is being investigated as treatment for poor-prognosis follicular lymphomas (FL). A single-center experience is herein reported. DESIGN AND METHODS:From September 1990 to October 1997, 30 consecutive patients ...

journal_title：Haematologica

authors： López R,Martino R,Sureda A,Nomdedéu J,Briones J,Martin-Henao G,García J,Brunet S,Sierra J

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We further characterized a novel type of chimeric BCR-ABL mRNA transcript detected in a patient with Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML). DESIGN AND METHODS:We used reverse-transcription polymerase chain reaction (RT-PCR) and sequence analysis of the fusion re...

journal_title：Haematologica

authors： Martinelli G,Terragna C,Amabile M,Montefusco V,Testoni N,Ottaviani E,de Vivo A,Mianulli A,Saglio G,Tura S

更新日期：2000-01-01 00:00:00

abstract：:Pseudomonas aeruginosa is one leading gram-negative organism associated with nosocomial infections. Bacteremia is life-threatening in the immunocompromised host. Increasing frequency of multi-drug-resistant (MDRPA) strains is concerning. We started a retrospective survey in the pediatric hematology oncology Italian ne...

journal_title：Haematologica

authors： Caselli D,Cesaro S,Ziino O,Zanazzo G,Manicone R,Livadiotti S,Cellini M,Frenos S,Milano GM,Cappelli B,Licciardello M,Beretta C,Aricò M,Castagnola E,Infection Study Group of the Associazione Italiana Ematologia Oncologia Pediat

更新日期：2010-09-01 00:00:00

abstract：:Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representa...

journal_title：Haematologica

authors： MacKenzie J,Greaves MF,Eden TO,Clayton RA,Perry J,Wilson KS,Jarrett RF

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Identification of early megakaryocyte (MK) precursors is difficult and conflicting. The prevalence of leukemias with a megakaryocytic component may be underestimated when conventional techniques are utilized. The recent development of immuno-ultrastructural procedures for simultaneous detection of platelet p...

journal_title：Haematologica

authors： Tomasi P,Tallarico A,Vasi V,Scapoli G,Castoldi G

更新日期：1993-03-01 00:00:00

abstract：:n patients with Kasabach-Merritt syndrome (KMS), local activation of coagulation commonly results in disseminated intravascular coagulation (DIC). Progress of DIC is associated with 30-40% mortality as a result of uncontrollable hemorrhage. A 39-year-old woman with an enlarging giant liver hemangioma was diagnosed as ...

journal_title：Haematologica

authors： Ontachi Y,Asakura H,Omote M,Yoshida T,Matsui O,Nakao S

更新日期：2005-11-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role...

journal_title：Haematologica

authors： de Vries AC,Stam RW,Kratz CP,Zenker M,Niemeyer CM,van den Heuvel-Eibrink MM,European Working Group on childhood MDS (EWOG-MDS).

更新日期：2007-11-01 00:00:00

abstract：:In childhood B-cell precursor acute lymphoblastic leukemia, cytogenetics is important in diagnosis and as an indicator of response to therapy, thus playing a key role in risk stratification of patients for treatment. Little is known of the relationship between different cytogenetic subtypes in B-cell precursor acute l...

journal_title：Haematologica

authors： Schwab CJ,Chilton L,Morrison H,Jones L,Al-Shehhi H,Erhorn A,Russell LJ,Moorman AV,Harrison CJ

更新日期：2013-07-01 00:00:00

abstract：:Primary vaginal non-Hodgkin lymphoma is really uncommon and may be misdiagnosed as inflammatory disease or solid cancer, so careful diagnostic procedures are needed, particularly as far as pathological and immunocytochemical evaluation is concerned. Most of these lymphomas present with follicular patterns and limited ...

journal_title：Haematologica

authors： Lonardi F,Ferrari V,Pavanato G,Bonciarelli G,Jirillo A,Balli M

更新日期：1994-03-01 00:00:00