Phenotype in combination with genotype improves outcome prediction in acute myeloid leukemia: a report from Children's Oncology Group protocol AAML0531.

abstract：BACKGROUND AND OBJECTIVE:Approximately 15% of patients with cancer will experience a thrombotic episode at some time. Some patients are at particularly high risk depending on the histology of the malignant disease. The aim of the study was to determine the actual prevalence of thrombotic episodes in oncohematologic pat...

journal_title：Haematologica

authors： Sgarabotto D,Prandoni P,Stefani PM,Scano F,Vianello F,Sartori R,Pietrogrande F,Caenazzo A,Girolami A

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Diamond-Blackfan anemia is a fatal congenital anemia characterized by a specific disruption in erythroid progenitor cell development. Approximately 25% of patients have mutations in the ribosomal protein RPS19 suggesting that Diamond-Blackfan anemia may be caused by a defect in ribosome biogenesis and transl...

journal_title：Haematologica

authors： Rey MA,Duffy SP,Brown JK,Kennedy JA,Dick JE,Dror Y,Tailor CS

更新日期：2008-11-01 00:00:00

abstract：:Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to gran...

journal_title：Haematologica

authors： Drouet M,Delaunay C,Grenier N,Garrigou P,Mayol JF,Hérodin F

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The histone deacetylase inhibitor ITF2357 has potent cytotoxic activity in multiple myeloma in vitro and has entered clinical trials for this disease. DESIGN AND METHODS:In order to gain an overall view of the activity of ITF2357 and identify specific pathways that may be modulated by the drug, we performed...

journal_title：Haematologica

authors： Todoerti K,Barbui V,Pedrini O,Lionetti M,Fossati G,Mascagni P,Rambaldi A,Neri A,Introna M,Lombardi L,Golay J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Treatment of acute myeloid leukemia (AML) in older patients remains unsatisfactory. The BGMT 95 trial for older patients set out to improve the outcome of these patients by adding a third drug (lomustine) to a 5+7 idarubicin and cytarabine schedule at induction and evaluating intermediate-dose...

journal_title：Haematologica

authors： Pigneux A,Perreau V,Jourdan E,Vey N,Dastugue N,Huguet F,Sotto JJ,Salmi LR,Ifrah N,Reiffers J

更新日期：2007-10-01 00:00:00

abstract：:Decidual natural killer cells accumulate at the fetal-maternal interface and play a key role in a successful pregnancy. However, their origin is still unknown. Do they derive from peripheral natural killer cells recruited in decidua or do they represent a distinct population that originates in situ? Here, we identifie...

journal_title：Haematologica

authors： Chiossone L,Vacca P,Orecchia P,Croxatto D,Damonte P,Astigiano S,Barbieri O,Bottino C,Moretta L,Mingari MC

更新日期：2014-03-01 00:00:00

abstract：:We report the findings of the immunophenotypic profile of three cases of nasal T/NK cell lymphoma in leukemic phase. Flow cytometry analysis was carried out using cell suspensions of tumor nasal biopsies and peripheral blood. Tumor samples were composed by a mixture of a predominant subset of medium-size true NK cytCD...

journal_title：Haematologica

authors： Falcão RP,Rizzatti EG,Saggioro FP,Garcia AB,Marinato AF,Rego EM

更新日期：2007-02-01 00:00:00

abstract：:Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall su...

journal_title：Haematologica

authors： Dimopoulos MA,Weisel KC,Song KW,Delforge M,Karlin L,Goldschmidt H,Moreau P,Banos A,Oriol A,Garderet L,Cavo M,Ivanova V,Alegre A,Martinez-Lopez J,Chen C,Spencer A,Knop S,Bahlis NJ,Renner C,Yu X,Hong K,Sternas L,

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The c-Met signaling pathway regulates a variety of biological processes, including proliferation, survival and migration. Deregulated c-Met activation has been implicated in the pathogenesis and prognosis of many human malignancies. We studied the function and prognostic significance of c-Met and hepatocyte ...

journal_title：Haematologica

authors： Xu C,Plattel W,van den Berg A,Rüther N,Huang X,Wang M,de Jong D,Vos H,van Imhoff G,Viardot A,Möller P,Poppema S,Diepstra A,Visser L

更新日期：2012-04-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-autonomous process, which is the focus of another review in the same issue of Haematologica However, studies on the microenvironment that maintains and regulates HSC (HSC niche) over the past 20 years have suggested that microenvironme...

journal_title：Haematologica

authors： Ho YH,Méndez-Ferrer S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor. Hereditary type I protein S deficiency (low total and low free protein S) is a well-established risk factor for venous thrombosis, whereas t...

journal_title：Haematologica

authors： Castoldi E,Maurissen LF,Tormene D,Spiezia L,Gavasso S,Radu C,Hackeng TM,Rosing J,Simioni P

更新日期：2010-09-01 00:00:00

abstract：:In the present work we investigated HDL-C and its subfractions HDL2 and HDL3 as well as total cholesterol (TC), triglycerides (TG), LDL-C, VLDL-C, apolipoproteins A1 (ApoA1) and B (ApoB) and lipoprotein (a) (Lp(a) in 25 patients with newly diagnosed acute lymphocytic leukemia (ALL) before and after induction treatment...

journal_title：Haematologica

authors： Scribano D,Baroni S,Pagano L,Zuppi C,Leone G,Giardina B

更新日期：1996-07-01 00:00:00

abstract：:To our knowledge, there is little information about functional thrombin activatable fibrinolysis inhibitor (TAFI) levels and the risk of acute coronary artery disease (CAD). We investigated the risk of acute CAD related to plasma levels of functional TAFI. We found that functional TAFI levels in plasma (above 126%), i...

journal_title：Haematologica

authors： Santamaría A,Martínez-Rubio A,Borrell M,Mateo J,Ortín R,Fontcuberta J

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We assessed direct health care costs associated with the most commonly prescribed treatments for indolent follicular non-Hodgkin's lymphoma (FL). DESIGN AND METHODS:New and previously diagnosed FL patients (>or=18 years) known during 1997-1998 to 15 Dutch hospitals were selected for inclusion...

journal_title：Haematologica

authors： van Agthoven M,Kramer MH,Sonneveld P,van der Hem KG,Huijgens PC,Wijermans PW,Kluin-Nelemans HC,Schaafsma MR,Biesma DH,Mattijssen V,Uyl-de Groot CA,Hagenbeek A

更新日期：2005-10-01 00:00:00

abstract：:CLLU1, located at chromosome 12q22, encodes a transcript specific to chronic lymphocytic leukemia and has potential prognostic value. We assessed the value of CLLU1 expression in the LRF CLL4 randomized trial. Samples from 515 patients with chronic lymphocytic leukemia were collected immediately before the start of tr...

journal_title：Haematologica

authors： Gonzalez D,Else M,Wren D,Usai M,Buhl AM,Parker A,Oscier D,Morgan G,Catovsky D

更新日期：2013-02-01 00:00:00

abstract：:The development of inhibitors is currently one of the most serious complications in the treatment of hemophilic children. Prospective studies of previously untreated patients (PUP) showed that up to 52% of patients with severe hemophilia A developed inhibitors during the first 50 exposure days (ED) (>100 for outliers)...

journal_title：Haematologica

authors： Kreuz W,Ettingshausen CE,Auerswald G,Saguer IM,Becker S,Funk M,Heller C,Klarmann D,Klingebiel T,GTH PUP Study Group.

更新日期：2003-06-01 00:00:00

abstract：:Heart disease is the leading cause of mortality and one of the main causes of morbidity in beta-thalassemia. The clinical spectrum of the thalassemia syndrome ranges from the severe, transfusion--dependent thalassemia major and the asymptomatic carrier state. Thalassemia intermedia represents a milder form and is usua...

journal_title：Haematologica

authors： Aessopos A,Kati M,Farmakis D

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Polycythemia vera (PV) is a myeloproliferative disorder, characterized by the expansion of the red cell mass. Our purpose was to evaluate the efficacy of pipobroman (PB) in the long-term control of PV and to assess early and late events. DESIGN AND METHODS:From June 1975 to December 1997, 163...

journal_title：Haematologica

authors： Passamonti F,Brusamolino E,Lazzarino M,Baraté C,Klersy C,Orlandi E,Canevari A,Castelli G,Merante S,Bernasconi C

更新日期：2000-10-01 00:00:00

abstract：:The present study reports a method for the easy, rapid and cost effective detection of heterozygous large deletions. As a model gene all exons of the antithrombin gene were amplified in a one tube multiplex polymerase chain reaction (PCR) and the products separated according to their size by reverse-phase ion-pair hig...

journal_title：Haematologica

authors： Pavlova A,El-Maarri O,Luxembourg B,Lindhoff-Last E,Kochhan L,Bruhn HD,Delev D,Watzka M,Seifried E,Oldenburg J

更新日期：2006-09-01 00:00:00

abstract：:Inherited factor VIl (FVII) deficiency is a rare autosomal recessive coagulation disorder characterized by a wide genet-ic heterogeneity and a poor relationship between FVII activity (FVII:C) levels and severity of the hemorrhagic diathesis. Given both the rarity and the heterogeneity of this disorder,genotype-phenoty...

journal_title：Haematologica

authors： Giansily-Blaizot M,Aguilar-Martinez P,Schved JF

更新日期：2002-03-01 00:00:00

abstract：:Evaluation of Anagrelide (Xagrid®) Efficacy and Long-term Safety, a phase IV, prospective, non-interventional study performed in 13 European countries enrolled high-risk essential thrombocythemia patients treated with cytoreductive therapy. The primary objectives were safety and pregnancy outcomes. Of 3721 registered ...

journal_title：Haematologica

authors： Birgegård G,Besses C,Griesshammer M,Gugliotta L,Harrison CN,Hamdani M,Wu J,Achenbach H,Kiladjian JJ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Autologous stem cell transplantation (ASCT) is currently being evaluated as a therapy for patients with multiple sclerosis (MS). We report the results of a phase II trial to evaluate feasibility and toxicity of CD34+ selected ASCT (CD34+/ASCT) and treatment results at one year of follow-up. D...

journal_title：Haematologica

authors： Carreras E,Saiz A,Marín P,Martínez C,Rovira M,Villamor N,Aymerich M,Lozano M,Fernández-Avilés F,Urbano-Izpizua A,Montserrat E,Graus F

更新日期：2003-03-01 00:00:00

abstract：:It is well known that allo-reactive T cells play a crucial role in graft-versus-leukemia and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (alloSCT). Allo-reactive CD4(+) T cells can mediate direct cytolysis, but may also stimulate production of IgG antibodies as helper cells. Immu...

journal_title：Haematologica

authors： Kremer AN,van der Griendt JC,van der Meijden ED,Honders MW,Ayoglu B,Schwenk JM,Nilsson P,Falkenburg JH,Griffioen M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Alterations in hemostasis have frequently been observed in patients with leukemia, and thrombotic events are well documented in patients receiving L-asparaginase (ASP) as a single agent or in combination with vincristine, prednisone (sometimes complemented by an anthracycline). The present study was designed...

journal_title：Haematologica

authors： Nowak-Göttl U,Werber G,Ziemann D,Ahlke E,Boos J

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In recent years, two predictive equations to estimate median expected survival at diagnosis for patients affected with Hodgkin's disease have been developed at the University of Pavia Medical School. The present retrospective work was aimed at testing correlation between mean survival estimated...

journal_title：Haematologica

authors： Bettini R,Tonolini M,Maccianti E

更新日期：1997-05-01 00:00:00

abstract：:Patients with advanced myeloma experience a high symptom burden particularly near the end of life, making timely hospice use crucial. Little is known about the quality and determinants of end-of-life care for this population, including whether potential increases in hospice use are also accompanied by "late" enrollmen...

journal_title：Haematologica

authors： Odejide OO,Li L,Cronin AM,Murillo A,Richardson PG,Anderson KC,Abel GA

更新日期：2018-08-01 00:00:00

abstract：:We report the distribution and clinicopathological characteristics of malignant lymphomas in Taiwan, defined according to the WHO classification. Data including age and gender of the patients, clinical staging and disease courses were collected for 598 cases of malignant lymphomas. The results showed that the epidemio...

journal_title：Haematologica

authors： Lee MY,Tan TD,Feng AC,Liu MC

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Venous thromboembolism includes two closely related clinical manifestations: deep vein thrombosis (DVT), more commonly of the lower limbs, and pulmonary embolism. Pulmonary embolism is the most common cause of preventable death in hospitalized patients. The definition of the risk factors for ve...

journal_title：Haematologica

authors： Agnelli G,Sonaglia F

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Diffuse large B-cell lymphomas (DLBCL) have a variable outcome, and powerful methods of prognostication are needed in order to choose the best treatment for each patient. Immunophenotypic classification of the tumor as germinal center (GC) or non-germinal center-like (nGC) and early response e...

journal_title：Haematologica

authors： Dupuis J,Gaulard P,Hemery F,Itti E,Gisselbrecht C,Rahmouni A,Copie-Bergman C,Brière J,El Gnaoui T,Gaillard I,Meignan M,Haioun C

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Aggressive diffuse large cell non-Hodgkin's lymphoma (DLCL) occurring late after a solid organ transplant fails to regress after discontinuation of immunosuppression. Moreover, chemotherapy treatment is associated with a high mortality rate due to severe toxicity. Since the majority of post-tr...

journal_title：Haematologica

authors： Dotti G,Rambaldi A,Fiocchi R,Motta T,Torre G,Viero P,Gridelli B,Barbui T

更新日期：2001-06-01 00:00:00