Abstract:
:B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and V(H) gene sequencing in a prospective clinical evaluation. The V(H) mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for specific VH gene usage (V(3-21) and V(1-69)). Complex karyotypes were highly indicative of disease progression.
journal_name
Haematologicajournal_title
Haematologicaauthors
Méhes G,Kovács G,Kajtár B,Lacza A,Várnai A,Losonczy H,Pajor Lsubject
Has Abstractpub_date
2006-10-01 00:00:00pages
1430-1issue
10eissn
0390-6078issn
1592-8721pii
03906078_9657journal_volume
91pub_type
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