Abstract:
:Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.
journal_name
Haematologicajournal_title
Haematologicaauthors
Bende RJ,van Maldegem F,van Noesel CJdoi
10.3324/haematol.2009.005983subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1109-23issue
8eissn
0390-6078issn
1592-8721pii
haematol.2009.005983journal_volume
94pub_type
杂志文章,评审相关文献
HAEMATOLOGICA文献大全abstract::The transferability of the T2* technique for measurement of tissue iron between magnetic resonance (MR) scanners is unknown. Heart and liver multi-breath-hold T2* sequences were installed on MR scanners at six different sites. T2* was assessed locally in five or more patients with thalassemia major (n=39), and subject...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion of T cells with suppressive properties. In the current study, we analyzed the potential synergistic effect of bortezomib in conjunction with sirolimus in order to reduce-graft-versus-host disease wit...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2011.058677
更新日期:2012-09-01 00:00:00
abstract::e tested whether polymorphic variations in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and interleukin-1 (IL-1beta and IL-1RN) genes confer susceptibility to mucosa-associated lymphoid tissue lymphomas (MALT) in a Chinese population. The rates of GSTM1, GSTP1, IL-1beta and IL-1RN genotypes did not differ bet...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. DESIGN AND METHODS:The types and subtypes, blood group frequency and its relevance, bleeding sites, response to...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::Proteolysis targeting chimeric molecule ARV 825 causes ubiquitination of bromodomains resulting in their efficient degradation by proteasome activity. Bromodomain degradation down-regulates MYC transcription contributing to growth inhibition of various human cancers. We examined the therapeutic potential of ARV 825 ag...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.201483
更新日期:2019-06-01 00:00:00
abstract::Juvenile hemochromatosis is a severe form of hereditary iron overload. It can be caused by mutations in either hepcidin or hemojuvelin genes. In this study we identified the molecular basis of juvenile hemochromatosis in three Australian families and assessed the role of potential modifying genes in individuals carryi...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Identification of early megakaryocyte (MK) precursors is difficult and conflicting. The prevalence of leukemias with a megakaryocytic component may be underestimated when conventional techniques are utilized. The recent development of immuno-ultrastructural procedures for simultaneous detection of platelet p...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2-4 acute GVHD compared to patients in m...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.10971
更新日期:2007-07-01 00:00:00
abstract::To date, few mutations associated with a dominant quantitative deficiency of von Willebrand factor (VWF) and a high penetrance have been reported. This phenotype was confirmed in seven unrelated families of several patients diagnosed with von Willebrand's disease out of 70 who requested genetic studies of the VWF gene...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). DESIGN AND METHODS:Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusi...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Multiple myeloma causes major morbidity resulting from osteolytic lesions that can be detected by metastatic bone surveys. Magnetic resonance imaging and positron emission tomography can detect bone marrow focal lesions long before development of osteolytic lesions. Using data from patients enrolled in Total Therapy 3...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:10.3324/haematol.2012.066555
更新日期:2013-01-01 00:00:00
abstract::All hematopoietic cells that develop in the bone marrow must cross the endothelial barrier to enter the blood circulation. Blood platelets, however, are released by bigger protrusions of huge progenitor cells, named megakaryocytes, and enter the blood stream as so-called proplatelets before fragmenting into mature pla...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.202010
更新日期:2020-04-01 00:00:00
abstract::It is currently unknown whether immunosuppressive therapy or hematopoietic stem cell transplantation is the most appropriate treatment strategy for children with refractory cytopenia and normal karyotype or trisomy 8. We report on 31 children with hypoplastic refractory cytopenia treated with immunosuppressive therapy...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.10683
更新日期:2007-03-01 00:00:00
abstract::The role of reduced intensity allogeneic stem cell transplantation for the treatment of relapsed/refractory Hodgkin's lymphoma remains controversial. We retrospectively analyzed 191 patients who underwent reduced intensity allogeneic stem cell transplantation between 1998 and 2008 for relapsed or refractory Hodgkin's ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2012.080895
更新日期:2013-09-01 00:00:00
abstract::To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2009.007708
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Human cytomegalovirus infection is the most frequent viral complication in patients undergoing hematopoietic stem cell transplantation. We investigated the development of human cytomegalovirus-specific T cells in adult recipients of hematopoietic stem cell transplants. DESIGN AND METHODS:From May 2003 throu...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.11912
更新日期:2008-02-01 00:00:00
abstract::Even though alterations in platelet counts are presumed to be detrimental, their impact on the survival of patients has not been studied in large cohorts. The prevalence of thrombocytopenia and thrombocytosis was examined in a large inner city outpatient population of 36,262 individuals aged ≥65 years old. A significa...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2013.101949
更新日期:2014-05-01 00:00:00
abstract::Arecent source data meta-analysis of randomized trials in adults assessing the immunoconjugate gemtuzumab ozogamicin combined with standard chemotherapy in acute myeloid leukemia showed a significant survival benefit in patients without an adverse karyotype. It is not clear whether the optimal dose should be 3 mg/m(2)...
journal_title:Haematologica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3324/haematol.2016.141937
更新日期:2016-06-01 00:00:00
abstract::Patients with chronic lymphocytic leukemia and unmutated immunoglobulin heavy-chain variable region gene (IGHV) have inferior survival from time of treatment in clinical studies. We assessed real-world outcomes based on mutational status and treatment regimen in a nationwide population-based cohort, comprising all 4,1...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2019.220194
更新日期:2020-06-01 00:00:00
abstract::The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic myeloid leukemia have been based on company-sponsored trials. Independent confirmations are extremely important. We report an investigator-sponsored study of nilotinib 300 mg twice daily in 130 chronic myeloid leukemia p...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2016.144949
更新日期:2016-10-01 00:00:00
abstract::Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunological cytolytic pathway. Secondary hemophagocytic lymphohistiocytosis i...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.209551
更新日期:2019-10-01 00:00:00
abstract::Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal. Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase. Sequential inhibition of ribonu...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2013.097246
更新日期:2014-04-01 00:00:00
abstract::Granulocyte colony-stimulating factor (G-CSF) can be administered after a peripheral blood stem cell transplantation with the aim of accelerating neutrophil recovery. In a randomized, single-blind study we studied a new administration schedule of G-CSF in this context. ...
journal_title:Haematologica
pub_type: 临床试验,信件,随机对照试验
doi:
更新日期:2004-09-01 00:00:00
abstract::Post-transfusion hepatitis (PTH) is a major problem in patients with acute leukemias requiring blood products during induction or consolidation therapy. In fact, PTH causes delays of chemotherapy with major violations in the timing of protocols. In order to assess the efficacy and safety of a short course of alpha-int...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many physiological processes. Indeed, t...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2019.236901
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Myelodysplastic syndromes (MDS) comprise a group of heterogeneous hematologic disorders with risk of leukemic evolution (LE). The French-American-British (FAB) co-operative group classifies them into five morphologic entities and the International Prognostic Scoring System (IPSS) proposes four...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver er...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.029827
更新日期:2010-12-01 00:00:00
abstract::We report on a patient with relapsed chronic lymphocytic leukemia (CLL) treated with the novel mTOR inhibitor RAD001 within a phase II clinical trial. Although the patient initially responded to therapy, RAD001 was discontinued after 32 weeks due to progression and fludarabine-based chemotherapy was started. The patie...
journal_title:Haematologica
pub_type: 信件
doi:10.3324/haematol.11155
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD). DESIGN AND METHODS:Eight patients from three unrelated families with this mutation were included in the present study who had distinct VWF abnormalities, not descr...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2008.003301
更新日期:2009-05-01 00:00:00
abstract::Older chronic lymphocytic leukemia patients have poor outcomes with standard treatments and are underrepresented in clinical trials. We retrospectively reviewed outcomes of refractory chronic lymphocytic leukemia patients in two age categories (≥70 and <70 years) treated with single-agent flavopiridol, a drug active i...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2011.047324
更新日期:2012-03-01 00:00:00