Alterations of red blood cell metabolome in overhydrated hereditary stomatocytosis.

abstract：BACKGROUND AND OBJECTIVES:The detection of recombinant human erythropoietin (r-HuEPO) abuse by athletes remains problematic. The main aim of this study was to demonstrate that the five indirect markers of altered erythropoiesis identified in our earlier work were reliable evidence of current or recently discontinued r-...

journal_title：Haematologica

authors： Parisotto R,Wu M,Ashenden MJ,Emslie KR,Gore CJ,Howe C,Kazlauskas R,Sharpe K,Trout GJ,Xie M

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Oxidant damage is an important contributor to the premature destruction of erythrocytes and anemia in thalassemias. To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of huma...

journal_title：Haematologica

authors： de Franceschi L,Turrini F,Honczarenko M,Ayi K,Rivera A,Fleming MD,Law T,Mannu F,Kuypers FA,Bast A,van der Vijgh WJ,Brugnara C

更新日期：2004-11-01 00:00:00

abstract：:The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analy...

journal_title：Haematologica

authors： Fuerst D,Frank S,Mueller C,Beelen DW,Schetelig J,Niederwieser D,Finke J,Bunjes D,Kröger N,Neuchel C,Tsamadou C,Schrezenmeier H,Beyersmann J,Mytilineos J

更新日期：2018-09-01 00:00:00

abstract：:ALK-positive large B-cell lymphoma is a rare subtype of lymphoma, and most cases follow an aggressive clinical course with a poor prognosis. We examined an ALK-positive large B-cell lymphoma case showing an anti-ALK immunohistochemistry pattern distinct from those of 2 known ALK fusions, CLTC-ALK and NPM-ALK, for the ...

journal_title：Haematologica

authors： Takeuchi K,Soda M,Togashi Y,Ota Y,Sekiguchi Y,Hatano S,Asaka R,Noguchi M,Mano H

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current Wo...

journal_title：Haematologica

authors： Salaverria I,Zettl A,Beà S,Hartmann EM,Dave SS,Wright GW,Boerma EJ,Kluin PM,Ott G,Chan WC,Weisenburger DD,Lopez-Guillermo A,Gascoyne RD,Delabie J,Rimsza LM,Braziel RM,Jaffe ES,Staudt LM,Müller-Hermelink HK,Campo E,

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia arises from a somatic mutation in a pluripotent stem cell. It generally terminates with a blastic crisis (BC). One third of BC are lymphoid, and most have a pre-B phenotype. Few cases of T-lymphoid BC have been reported. Here we describe a lymph node blast crisis mimicking T-immunobl...

journal_title：Haematologica

authors： Leone G,La Rocca LM,Teofili L,De Candia E,Landolfi R,Sica S,Zini G,Zollino M,Tabilio A

更新日期：1992-07-01 00:00:00

abstract：:Not available. ...

journal_title：Haematologica

authors： Kinder M,Bahlis NJ,Malavasi F,De Goeij B,Babich A,Sendecki J,Rusbuldt J,Bellew K,Kane C,Van de Donk NWCJ

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The mechanisms accounting for the increased risk of thrombosis in patients with essential thrombocythemia (ET) are not well known. The aim of the present study was to ascertain the role of platelet and leukocyte activation in the thrombosis of ET. DESIGN AND METHODS:The activation status of p...

journal_title：Haematologica

authors： Arellano-Rodrigo E,Alvarez-Larrán A,Reverter JC,Villamor N,Colomer D,Cervantes F

更新日期：2006-02-01 00:00:00

abstract：:A new, sensitive method combining seminested polymerase chain reaction (PCR) and heteroduplex analysis was used to detect follicular lymphoma (FL) cells in peripheral blood. Based on the detection of IgH rearrangement in DNA from peripheral blood leukocytes, the method demonstrated the presence of monoclonal B cells i...

journal_title：Haematologica

authors： Oehadian A,Koide N,Mu MM,Hassan F,Yoshida T,Yokochi T

更新日期：2004-10-01 00:00:00

abstract：:This study reports a case of granulocytic sarcoma that developed in the epidural zone 25 days before clinical evidence of an acute promyelocytic leukemia. The case presented the diagnostic difficulties that are common to all aleukemic granulocytic sarcomas. Moreover, it highlights the very rare association between gra...

journal_title：Haematologica

authors： Tosi A,De Paoli A,Fava S,Luoni M,Sironi M,Tocci A,Assi A,Cassi E

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Although several studies have reported on the use of children as donors for peripheral blood progenitor cells (PBPC), no specific characteristics have been identified as predictors of PBPC collection in this population. In this study we analyzed predictive factors for PBPC collection in pediat...

journal_title：Haematologica

authors： Díaz MA,Sevilla J,de la Rubia J,Verdeguer A,Espigado I,Vicent MG,Pascual MJ,Zamora C,Arrieta R,Serrano D,del Cañizo C,Arbona C,de Arriba F,Bargay J,Brunet S,Sanz MA

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology. DESIGN AND METHODS:We studied 65 patients with dyskeratosis congenita and 127 unaffected relatives. Telomere length was measured by automated multicolor flow fluorescence in situ hybridization in...

journal_title：Haematologica

authors： Alter BP,Rosenberg PS,Giri N,Baerlocher GM,Lansdorp PM,Savage SA

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:CD20 has been proposed as a novel suicide gene system for the treatment of graft-versus-host disease (GVHD), a fatal complication of allogeneic bone marrow transplantation: indeed expression of the human non-immunogenic exogenous CD20 protein allows positive immunoselection of transduced cells...

journal_title：Haematologica

authors： Serafini M,Bonamino M,Golay J,Introna M

更新日期：2004-01-01 00:00:00

abstract：:We evaluate the long-term results of a prospective clinical study enrolling more than 100 adult patients with Burkitt lymphoma/leukemia. Depending on extent of disease, treatment consisted of six to eight rituximab infusions and four to six courses of intensive chemotherapy (attenuated in patients aged >55 years) with...

journal_title：Haematologica

authors： Intermesoli T,Rambaldi A,Rossi G,Delaini F,Romani C,Pogliani EM,Pagani C,Angelucci E,Terruzzi E,Levis A,Cassibba V,Mattei D,Gianfaldoni G,Scattolin AM,Di Bona E,Oldani E,Parolini M,Gökbuget N,Bassan R

更新日期：2013-11-01 00:00:00

abstract：:Adoptive transfer of ex vivo expanded CD4(+)CD25(+)FOXP3(+) regulatory T cells is a successful therapy for autoimmune diseases and transplant rejection in experimental models. In man, equivalent manipulations in bone marrow transplant recipients appear safe, but questions regarding the stability of the transferred reg...

journal_title：Haematologica

authors： Scottà C,Esposito M,Fazekasova H,Fanelli G,Edozie FC,Ali N,Xiao F,Peakman M,Afzali B,Sagoo P,Lechler RI,Lombardi G

更新日期：2013-08-01 00:00:00

abstract：:This study aimed at evaluating the effectiveness of alpha interferon (IFN) in chronic myelomonocytic leukemia, a disease for which therapeutic options are still unsatisfactory. Fourteen sequential unselected patients received recombinant alpha-2b IFN (Intron-A, Schering-Essex) 3 megaU/day, progressively elevated to 10...

journal_title：Haematologica

authors： Catalano L,Majolino I,Musto P,Fragrasso A,Molica S,Cirincione S,Selleri C,Luciano L,De Renzo A,Vecchione R

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Polycythemia vera is a clonal hematopoietic stem cell disorder in which the JAK2 V617F mutation is observed in >95% of patients, but an as yet unidentified process appears to initiate the clonal expansion of hematopoiesis. Because microRNA regulate hematopoietic differentiation, we hypothesized that dysregul...

journal_title：Haematologica

authors： Bruchova H,Merkerova M,Prchal JT

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The Hong Kong government is planning to introduce an electronic smart identity card for all seven million citizens in 2003. If the smart card contains the full red cell phenotype/genotype of the individual, it may be possible to transfuse phenotype-matched blood units without pre-transfusion a...

journal_title：Haematologica

authors： Lau FY,Wong R,Chan NP,Chui CH,Ng E,Ng MH,Cheng G

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The diagnosis of myelodysplastic syndromes (MDS) is essentially morphological and based on the presence of dysplastic features in the peripheral blood and bone marrow. The French-American-British (FAB) Cooperative Group proposed a classification based on easily obtainable laboratory information...

journal_title：Haematologica

authors： Vallespí T,Imbert M,Mecucci C,Preudhomme C,Fenaux P

更新日期：1998-03-01 00:00:00

abstract：:Next-generation sequencing (NGS) has transitioned from research to clinical routine, yet the comparability of different technologies for mutation profiling remains an open question. We performed a European multicenter (n=6) evaluation of three amplicon-based NGS assays targeting 11 genes recurrently mutated in chronic...

journal_title：Haematologica

authors： Sutton LA,Ljungström V,Enjuanes A,Cortese D,Skaftason A,Tausch E,Stano Kozubik K,Nadeu F,Armand M,Malcikova J,Pandzic T,Forster J,Davis Z,Oscier D,Rossi D,Ghia P,Strefford JC,Pospisilova S,Stilgenbauer S,Davi F,Ca

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:Specific tumor cell recognition is required for optimal tumor directed therapy. Lymphokine activated killer (LAK) cells are able to recognize tumor targets specifically because LAK cells can distinguish between normal and tumor cells. This study was aimed at analyzing receptor molecules on tumor cells and th...

journal_title：Haematologica

authors： Lefterova P,Negrin R,Neubauer A,Huhn D,Blume K,Schmidt-Wolf I

更新日期：1993-11-01 00:00:00

abstract：:e tested whether polymorphic variations in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and interleukin-1 (IL-1beta and IL-1RN) genes confer susceptibility to mucosa-associated lymphoid tissue lymphomas (MALT) in a Chinese population. The rates of GSTM1, GSTP1, IL-1beta and IL-1RN genotypes did not differ bet...

journal_title：Haematologica

authors： Wu MS,Shun CT,Huang SP,Cheng AL,Chen LT,Lin JT

更新日期：2004-08-01 00:00:00

abstract：:We report on five Caucasian patients with congenital polycythemia and mutations of the von Hipple-Lindau (VHL) gene: a compound heterozygote for the novel exon 1 (VHL 235C->T) and previously reported VHL 562C->G mutations; three homozygotes for Chuvash VHL 598C->T mutation; and a heterozygote for VHL 523->G mutation w...

journal_title：Haematologica

authors： Bento MC,Chang KT,Guan Y,Liu E,Caldas G,Gatti RA,Prchal JT

更新日期：2005-01-01 00:00:00

abstract：:The development of inhibitors is currently one of the most serious complications in the treatment of hemophilic children. Prospective studies of previously untreated patients (PUP) showed that up to 52% of patients with severe hemophilia A developed inhibitors during the first 50 exposure days (ED) (>100 for outliers)...

journal_title：Haematologica

authors： Kreuz W,Ettingshausen CE,Auerswald G,Saguer IM,Becker S,Funk M,Heller C,Klarmann D,Klingebiel T,GTH PUP Study Group.

更新日期：2003-06-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression. Recently, blasts of patients with acute myeloid leukemia were shown to e...

journal_title：Haematologica

authors： Chamuleau ME,van de Loosdrecht AA,Hess CJ,Janssen JJ,Zevenbergen A,Delwel R,Valk PJ,Löwenberg B,Ossenkoppele GJ

更新日期：2008-12-01 00:00:00

abstract：:Allogeneic transplants with PBSC are rapidly expanding, but a number of problems concerning both donors and recipients are still unsolved. GITMO (Italian Bone Marrow Transplant Group) has established a committee for allogeneic PBSC transplants. We present here an analysis of the main aspects of this evolving area and ...

journal_title：Haematologica

authors： Majolino I,Aversa F,Bacigalupo A,Bandini G,Arcese W

更新日期：1996-11-01 00:00:00

abstract：:Decidual natural killer cells accumulate at the fetal-maternal interface and play a key role in a successful pregnancy. However, their origin is still unknown. Do they derive from peripheral natural killer cells recruited in decidua or do they represent a distinct population that originates in situ? Here, we identifie...

journal_title：Haematologica

authors： Chiossone L,Vacca P,Orecchia P,Croxatto D,Damonte P,Astigiano S,Barbieri O,Bottino C,Moretta L,Mingari MC

更新日期：2014-03-01 00:00:00

abstract：:Eight elderly patients with relapsed or refractory acute myeloid leukemia were treated sequentially with recombinant human granulocyte colony-stimulating factor with rhG-CSF and Mylotarg. Priming with rhG-CSF in vivo induced an increase in the proportion of CD33+ cycling blasts. Four patients (50% ) achieved a complet...

journal_title：Haematologica

authors： Leone G,Rutella S,Voso MT,Fianchi L,Scardocci A,Pagano L

更新日期：2004-05-01 00:00:00

abstract：:Diabetes insipidus and thrombocytosis were presenting symptoms in a case of adult ANLL-M1. Cytogenetic investigations revealed a typical 3q rearrangement, i.e. inv(3)(q21q26). A subclone with monosomy 7 was also found and documented by FISH analysis. Correlations between clinical/hematological features and cytogenetic...

journal_title：Haematologica

authors： La Starza R,Falzetti D,Fania C,Tabilio A,Martelli MF,Mecucci C

更新日期：1994-07-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN. However, it is not clear whether NOTCH1 mutations associate with decreased PTEN expression in primary T-ALL. Here, we compared patients with or wi...

journal_title：Haematologica

authors： Silva A,Jotta PY,Silveira AB,Ribeiro D,Brandalise SR,Yunes JA,Barata JT

更新日期：2010-04-01 00:00:00