Tetraploidy or near-tetraploidy clones with double 8;21 translocation: a non-random additional anomaly of acute myeloid leukemia with t(8;21)(q22;q22).

abstract：:Dickkopf-1 (DKK1), broadly expressed by tumor cells from human multiple myeloma (MM) and other cancers but absent from most normal tissues, may be an ideal target for immunotherapy. Our previous studies have shown that DKK1 (peptide)-specific cytotoxic T lymphocytes can effectively lyse primary MM cells in vitro. To d...

journal_title：Haematologica

authors： Li R,Zheng C,Wang Q,Bi E,Yang M,Hou J,Fu W,Yi Q,Qian J

更新日期：2020-02-20 00:00:00

abstract：BACKGROUND:Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and function has not yet been established. Our study aimed to compare th...

journal_title：Haematologica

authors： Pepe A,Meloni A,Capra M,Cianciulli P,Prossomariti L,Malaventura C,Putti MC,Lippi A,Romeo MA,Bisconte MG,Filosa A,Caruso V,Quarta A,Pitrolo L,Missere M,Midiri M,Rossi G,Positano V,Lombardi M,Maggio A

更新日期：2011-01-01 00:00:00

abstract：:About 25-30% of patients with immune thrombocytopenic purpura (ITP) are refractory to corticosteroids, splenectomy and other treatments. It has been suggested that interferon-alpha 2b (IFN-alpha 2b) may be useful in the treatment of chronic refractory ITP patients. We treated 9 chronic refractory ITP patients with IFN...

journal_title：Haematologica

authors： Vianelli N,Tazzari PL,Baravelli S,Ricci F,Valdrè L,Tura S

更新日期：1998-08-01 00:00:00

abstract：:Leukemia stem cells contribute to drug-resistance and relapse in chronic myeloid leukemia (CML) and BCR-ABL1 inhibitor monotherapy fails to eliminate these cells, thereby necessitating alternate therapeutic strategies for patients CML. The peroxisome proliferator-activated receptor-γ (PPARγ) agonist pioglitazone downr...

journal_title：Haematologica

authors： Kumar H,Chattopadhyay S,Das N,Shree S,Patel D,Mohapatra J,Gurjar A,Kushwaha S,Singh AK,Dubey S,Lata K,Kushwaha R,Mohammed R,Dastidar KG,Yadav N,Vishwakarma AL,Gayen JR,Bandyopadhyay S,Chatterjee A,Jain MR,Tripathi

更新日期：2020-04-01 00:00:00

abstract：:The objective of this study was to create a bioclinical model, based on clinical and molecular predictors of event-free and overall survival for relapsed/refractory diffuse large B-cell lymphoma patients treated on the Canadian Cancer Trials Group (CCTG) LY12 prospective study. In 91 cases, sufficient histologic mater...

journal_title：Haematologica

authors： Bosch M,Akhter A,Chen BE,Mansoor A,Lebrun D,Good D,Crump M,Shepherd L,Scott DW,Stewart DA

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Alterations in hemostasis have frequently been observed in patients with leukemia, and thrombotic events are well documented in patients receiving L-asparaginase (ASP) as a single agent or in combination with vincristine, prednisone (sometimes complemented by an anthracycline). The present study was designed...

journal_title：Haematologica

authors： Nowak-Göttl U,Werber G,Ziemann D,Ahlke E,Boos J

更新日期：1996-03-01 00:00:00

abstract：:Immune dysregulation is a mechanism contributing to ineffective hematopoiesis in a subset of myelodysplastic syndrome patients. We report the first US multicenter non-randomized, phase II trial examining the efficacy of rabbit(r)-anti-thymocyte globulin using 2.5 mg/kg/day administered daily for 4 doses. The primary e...

journal_title：Haematologica

authors： Komrokji RS,Mailloux AW,Chen DT,Sekeres MA,Paquette R,Fulp WJ,Sugimori C,Paleveda-Pena J,Maciejewski JP,List AF,Epling-Burnette PK

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Relapsing primary central nervous system lymphoma carries a poor prognosis when treated with conventional chemotherapy with a one-year overall survival of 25-40%. Encouraging results have been shown with intensive chemotherapy followed by autologous hematopoietic stem cell rescue. We report the results of a ...

journal_title：Haematologica

authors： Soussain C,Choquet S,Fourme E,Delgadillo D,Bouabdallah K,Ghesquières H,Damaj G,Dupriez B,Vargaftig J,Gonzalez A,Houillier C,Taillandier L,Hoang-Xuan K,Leblond V

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We tested the principle of local International Normalized Ratio (INR) calibration using INR calibrator plasmas (PT Calibration Plasma Kit, Behring), two thomboplastin reagents (Neoplastin plus, rabbit brain, Stago, and Recombiplastin, recombinant human tissue factor, Ortho Diagnostics) and the...

journal_title：Haematologica

authors： Testa S,Morstabilini G,Fattorini A,Galli L,Denti N,D'Angelo A

更新日期：2002-12-01 00:00:00

abstract：:The aim of this study was to investigate the microRNA (miRNA) expression pattern in neutrophils from rheumatoid arthritis (RA) patients and its contribution to their pathogenic profile and to analyze the effect of specific autoantibodies or inflammatory components in the regulation of miRNA in RA neutrophils and its m...

journal_title：Haematologica

authors： De la Rosa IA,Perez-Sanchez C,Ruiz-Limon P,Patiño-Trives A,Torres-Granados C,Jimenez-Gomez Y,Del Carmen Abalos-Aguilera M,Cecchi I,Ortega R,Caracuel MA,Calvo-Gutierrez J,Escudero-Contreras A,Collantes-Estevez E,Lopez-Pedrera C

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. DESIGN AND METHODS:The types and subtypes, blood group frequency and its relevance, bleeding sites, response to...

journal_title：Haematologica

authors： Woods AI,Meschengieser SS,Blanco AN,Salviú MJ,Farías CE,Kempfer AC,Lazzari MA

更新日期：2001-04-01 00:00:00

abstract：:The occurrence of immunoglobulin heavy chain (IgH) and/or T-cell receptor (TcR) gene rearrangements has been reported in some cases of acute non lymphoid leukemia (ANLL), and variously interpreted as reflecting "aberrant gene expression" or "lineage promiscuity" of the leukemic cell. In an attempt to verify the incide...

journal_title：Haematologica

authors： Leone R,Lo Coco F,De Rossi G,Diverio D,Frontani M,Spadea A,Testi AM,Cordone I,Mandelli F

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The limited value of qualitative reverse transcription polymerase chain-reaction (RT-PCR) for monitoring chronic myeloid leukemia (CML) patients has prompted the development of quantitative assays. We have developed a quantitative real-time PCR (QC-PCR) method in the LightCycler, based on the ...

journal_title：Haematologica

authors： Bolufer P,Sanz GF,Barragán E,Sanz MA,Cervera J,Lerma E,Senent L,Moreno I,Planelles MD

更新日期：2000-12-01 00:00:00

abstract：:Macaques are emerging as a critical animal model in transfusion medicine, because of their evolutionary similarity to humans and perceived utility in discovery and translational science. However, little is known about the metabolism of Rhesus macaque red blood cells (RBC) and how this compares to human RBC metabolism ...

journal_title：Haematologica

authors： Stefanoni D,Shin HKH,Baek JH,Champagne DP,Nemkov T,Thomas T,Francis RO,Zimring JC,Yoshida T,Reisz JA,Spitalnik SL,Buehler PW,D'Alessandro A

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human metabolic disorder in southern China. We investigated the incidence and distribution of mutations, the molecular pathology of affected females and the haplotype association with G6PD deficiency in patients from the Gu...

journal_title：Haematologica

authors： Yan T,Cai R,Mo O,Zhu D,Ouyang H,Huang L,Zhao M,Huang F,Li L,Liang X,Xu X

更新日期：2006-10-01 00:00:00

abstract：:Second-line therapy for corticosteroid-refractory or -dependent acute graft-versus-host disease remains ill-defined, due to limited efficacy of drugs and evolving clinical trial endpoints. Six-month freedom from treatment failure has been proposed as a novel clinical trial endpoint and is defined by the absence of dea...

journal_title：Haematologica

authors： Das-Gupta E,Greinix H,Jacobs R,Zhou L,Savani BN,Engelhardt BG,Kassim A,Worel N,Knobler R,Russell N,Jagasia M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mantle cell lymphoma (MCL) is a separate histological and clinical entity recently recognized in the new revised European-American Lymphoma Classification. Little information exists regarding its therapy. We report the results of a retrospective study of 27 patients affected by MCL evaluating t...

journal_title：Haematologica

authors： Bertini M,Rus C,Freilone R,Botto B,Calvi R,Novero D,Orsucci L,Vitolo U,Palestro G,Resegotti L

更新日期：1998-04-01 00:00:00

abstract：:The availability of reliable and standardizable procedures with low contamination risk and less prominent loss in MNC, would solve the existing perplexities about the systematic use of this passage. We tried to experiment Areman's et al protocol that utilizes the CS 3000 blood cell processor without gradient, making s...

journal_title：Haematologica

authors： Franchini E,Porlezza M

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The expression of CD36 antigen has not been conclusively associated with human B-lymphocytes although CD36 was recently detected in a human B-cell angiotropic lymphoma where it might be involved in lymphoblast-endothelial cell adhesion. We investigated the expression of CD36 in B-cell chronic l...

journal_title：Haematologica

authors： Rutella S,Rumi C,Puggioni P,Barberi T,Di Mario A,Larocca LM,Leone G

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:It has been shown that fludarabine (FLU) is superior to conventional treatment in B-CLL for rate and quality of response, leading to CR even at the molecular level. In this paper we report our preliminary results with this drug in B-CLL patients. METHODS AND PATIENTS:Twenty-seven B-CLL patients (16 refracto...

journal_title：Haematologica

authors： Spriano M,Clavio M,Carrara P,Canepa L,Miglino M,Pierri I,Celesti L,Rossi E,Vimercati R,Bruni R

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver er...

journal_title：Haematologica

authors： Ji P,Yeh V,Ramirez T,Murata-Hori M,Lodish HF

更新日期：2010-12-01 00:00:00

abstract：:Anti-CD20-containing chemotherapy regimens have become the standard of care for patients with follicular lymphoma needing cytotoxic therapy. Four randomized trials demonstrated a clinical benefit for patients treated with rituximab. However, no long-term follow up (i.e. > 5 years) of these trials is yet available. Bet...

journal_title：Haematologica

authors： Bachy E,Houot R,Morschhauser F,Sonet A,Brice P,Belhadj K,Cartron G,Audhuy B,Fermé C,Feugier P,Sebban C,Delwail V,Maisonneuve H,Le Gouill S,Lefort S,Brousse N,Foussard C,Salles G,Groupe d'Etude des Lymphomes de l'Adult

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:There is variability in the outcome of patients with chronic lymphocytic leukemia with apparently the same stage of disease. Identifying genetic variants that influence patients' outcome and response to treatment may provide important insights into the biology of the disease. DESIGN AND METHODS:We investiga...

journal_title：Haematologica

authors： Wade R,Di Bernardo MC,Richards S,Rossi D,Crowther-Swanepoel D,Gaidano G,Oscier DG,Catovsky D,Houlston RS

更新日期：2011-10-01 00:00:00

abstract：:Adoptive transfer of ex vivo expanded CD4(+)CD25(+)FOXP3(+) regulatory T cells is a successful therapy for autoimmune diseases and transplant rejection in experimental models. In man, equivalent manipulations in bone marrow transplant recipients appear safe, but questions regarding the stability of the transferred reg...

journal_title：Haematologica

authors： Scottà C,Esposito M,Fazekasova H,Fanelli G,Edozie FC,Ali N,Xiao F,Peakman M,Afzali B,Sagoo P,Lechler RI,Lombardi G

更新日期：2013-08-01 00:00:00

abstract：:The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric transferrin. As this molecule influences the production of the iron regulatory hormone hepcidin, we hypothesized that erythropoiesis-driven changes in diferric transf...

journal_title：Haematologica

authors： Mirciov CSG,Wilkins SJ,Hung GCC,Helman SL,Anderson GJ,Frazer DM

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Aberrant promoter methylation targets CpG islands causing gene silencing. We explored aberrant promoter methylation of genes potentially involved in B-cell malignancies and encoding proteins implicated in DNA repair (O6-methylguanine-DNA methyltransferase, MGMT), detoxification of environmenta...

journal_title：Haematologica

authors： Rossi D,Capello D,Gloghini A,Franceschetti S,Paulli M,Bhatia K,Saglio G,Vitolo U,Pileri SA,Esteller M,Carbone A,Gaidano G

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The increasing application of multi-color flow cytometry assays for staging and follow-up in mantle cell lymphoma necessitates that the specificity and sensitivity of this technique are evaluated. Data from prospective clinical trials comparing the clinical applicability of flow cytometry to routine diagnost...

journal_title：Haematologica

authors： Böttcher S,Ritgen M,Buske S,Gesk S,Klapper W,Hoster E,Hiddemann W,Unterhalt M,Dreyling M,Siebert R,Kneba M,Pott C,EU MCL MRD Group.

更新日期：2008-04-01 00:00:00

abstract：:This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective International T-cell Project. We analyzed data from 1020 patients with newly diagnosed disease, enrolled between September 2006 and December 2015. Out of 937 pati...

journal_title：Haematologica

authors： Bellei M,Foss FM,Shustov AR,Horwitz SM,Marcheselli L,Kim WS,Cabrera ME,Dlouhy I,Nagler A,Advani RH,Pesce EA,Ko YH,Martinez V,Montoto S,Chiattone C,Moskowitz A,Spina M,Biasoli I,Manni M,Federico M,International T-c

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data. This is also true for immunohistochemical classifiers that are thought to reflect the cell-of-origin subclassification of gene expression stu...

journal_title：Haematologica

authors： Bernd HW,Ziepert M,Thorns C,Klapper W,Wacker HH,Hummel M,Stein H,Hansmann ML,Ott G,Rosenwald A,Müller-Hermelink HK,Barth TF,Möller P,Cogliatti SB,Pfreundschuh M,Schmitz N,Trümper L,Höller S,Löffler M,Feller AC,Ger

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Diffuse large B-cell lymphomas (DLBCL) have a variable outcome, and powerful methods of prognostication are needed in order to choose the best treatment for each patient. Immunophenotypic classification of the tumor as germinal center (GC) or non-germinal center-like (nGC) and early response e...

journal_title：Haematologica

authors： Dupuis J,Gaulard P,Hemery F,Itti E,Gisselbrecht C,Rahmouni A,Copie-Bergman C,Brière J,El Gnaoui T,Gaillard I,Meignan M,Haioun C

更新日期：2007-06-01 00:00:00