Mononuclear cell (MNC) concentration from the marrow harvest by automatic system.

abstract：:Monitoring minimal residual disease is an important way to identify patients with acute myeloid leukemia at high risk of relapse. In this study we investigated the prognostic potential of minimal residual disease monitoring by quantitative real-time polymerase chain reaction analysis of NPM1 mutations in patients trea...

journal_title：Haematologica

authors： Hubmann M,Köhnke T,Hoster E,Schneider S,Dufour A,Zellmeier E,Fiegl M,Braess J,Bohlander SK,Subklewe M,Sauerland MC,Berdel WE,Büchner T,Wörmann B,Hiddemann W,Spiekermann K

更新日期：2014-08-01 00:00:00

abstract：:Distinct expression patterns of pro- and anti-apoptotic proteins may contribute to different prognoses and therapy outcomes in adult versus childhood acute myeloid leukemia (AML). Therefore, we investigated whether expression levels of apoptosis-related proteins CD95, Bcl-2, Bax, Bcl-xL, procaspase-3, XIAP, cIAP-1, an...

journal_title：Haematologica

authors： Wuchter C,Richter S,Oltersdorf D,Karawajew L,Ludwig WD,Tamm I

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not yet been evaluated for a large panel of cancer testis antigens which can be classified by varying expression in normal tissue: restricted to testis, ...

journal_title：Haematologica

authors： van Duin M,Broyl A,de Knegt Y,Goldschmidt H,Richardson PG,Hop WC,van der Holt B,Joseph-Pietras D,Mulligan G,Neuwirth R,Sahota SS,Sonneveld P

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:A phase II study was conducted to investigate the effects of a therapeutic program based on the combination of fludarabine and cytarabine (ARA-C) administered as a sequential continuous infusion in untreated elderly patients with acute myeloid leukemia (AML). DESIGN AND METHODS:Sixty-three pa...

journal_title：Haematologica

authors： Ferrara F,D'Arco AM,De Simone M,Mele G,Califano C,Pocali B,Danise P,Palmieri S

更新日期：2005-06-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) levels have been tested in patients with chronic relative polycythemia (RP), polycythemia vera, and in healthy subjects in order to find a possible underlying pathophysiological mechanism for relative polycythemia. No difference in statistical significance has been found between the me...

journal_title：Haematologica

authors： Cohen AM,Gelvan A,Winaver J,Kahna L,Floru S,Djaldetti M

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:In a study of childhood acute lymphoblastic leukemia (CoALL 06-97 study), the in vitro sensitivity of the patients' cells to prednisolone, vincristine and asparaginase was introduced as a new additional risk parameter for treatment stratification. In parallel in vivo treatment response was assessed by determ...

journal_title：Haematologica

authors： Escherich G,Tröger A,Göbel U,Graubner U,Pekrun A,Jorch N,Kaspers G,Zimmermann M,zur Stadt U,Kazemier K,Pieters R,Den Boer ML,Horstmann M,Janka GE,CoALL study group, Hamburg, Germany.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRbeta (TPbeta, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRalpha (FPalpha) results from a deletion on chromosome 4q12 and ZNF19...

journal_title：Haematologica

authors： Toffalini F,Kallin A,Vandenberghe P,Pierre P,Michaux L,Cools J,Demoulin JB

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The c-Met signaling pathway regulates a variety of biological processes, including proliferation, survival and migration. Deregulated c-Met activation has been implicated in the pathogenesis and prognosis of many human malignancies. We studied the function and prognostic significance of c-Met and hepatocyte ...

journal_title：Haematologica

authors： Xu C,Plattel W,van den Berg A,Rüther N,Huang X,Wang M,de Jong D,Vos H,van Imhoff G,Viardot A,Möller P,Poppema S,Diepstra A,Visser L

更新日期：2012-04-01 00:00:00

abstract：:High levels of HbF were found in patients with myelodysplastic syndrome (MDS), as well as a possible switching of the ratio of the gamma chains from the adult to the newborn type in 25% of our patients. These abnormalities in general were not present in the parents. The possibility of having thalassemia or other hemog...

journal_title：Haematologica

authors： Bourantas KL,Georgiou I,Seferiadis K

更新日期：1991-07-01 00:00:00

abstract：:The National Institutes of Health global score for chronic graft-versus-host disease was devised by experts but was not based on empirical data. We hypothesized that analysis of prospectively collected data would enable derivation of a more accurate model for estimating mortality risk. We analyzed 574 adult patients w...

journal_title：Haematologica

authors： Inamoto Y,Martin PJ,Storer BE,Palmer J,Weisdorf DJ,Pidala J,Flowers ME,Arora M,Jagasia M,Arai S,Chai X,Pavletic SZ,Vogelsang GB,Lee SJ,Chronic GVHD Consortium.

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transplant-related mortality (TRM) following allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be related to disease stage, duratiion of disease and type of donor. Furthermore, the outcome of transplants performed in the 1990s appears to be better than that of tran...

journal_title：Haematologica

authors： Bacigalupo A,Sormani MP,Lamparelli T,Gualandi F,Occhini D,Bregante S,Raiola AM,di Grazia C,Dominietto A,Tedone E,Piaggio G,Podesta M,Bruno B,Oneto R,Lombardi A,Frassoni F,Rolla D,Rollandi G,Viscoli C,Ferro C,Garba

更新日期：2004-10-01 00:00:00

abstract：:Advanced myelodysplastic syndrome harbors a high risk of progression to acute myeloid leukemia and poor prognosis. In children, there is no established treatment to prevent or delay progression to leukemia prior to hematopoietic stem cell transplantation. Azacitidine is a hypomethylating agent, which was shown to slow...

journal_title：Haematologica

authors： Waespe N,Van Den Akker M,Klaassen RJ,Lieberman L,Irwin MS,Ali SS,Abdelhaleem M,Zlateska B,Liebman M,Cada M,Schechter T,Dror Y

更新日期：2016-12-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Our objective was to improve the outcome of cord blood (CB) transplantation in adults, by overcoming the limitations imposed by the low number of stem cells present in CB units. DESIGN AND METHODS:We combined single CB units and co-infusion of third party donor (TPD)-derived peripheral blood ...

journal_title：Haematologica

authors： Magro E,Regidor C,Cabrera R,Sanjuán I,Forès R,Garcia-Marco JA,Ruiz E,Gil S,Bautista G,Millán I,Madrigal A,Fernandez MN

更新日期：2006-05-01 00:00:00

abstract：:The role of reduced intensity allogeneic stem cell transplantation for the treatment of relapsed/refractory Hodgkin's lymphoma remains controversial. We retrospectively analyzed 191 patients who underwent reduced intensity allogeneic stem cell transplantation between 1998 and 2008 for relapsed or refractory Hodgkin's ...

journal_title：Haematologica

authors： Marcais A,Porcher R,Robin M,Mohty M,Michalet M,Blaise D,Tabrizi R,Clement L,Ceballos P,Daguindau E,Bilger K,Dhedin N,Lapusan S,Bay JO,Pautas C,Garban F,Ifrah N,Guillerm G,Contentin N,Bourhis JH,Yakoub Agha I,Ber

更新日期：2013-09-01 00:00:00

abstract：:Ten consecutive patients (pts), suffering from hematological malignancies (5 NHL, 3 ANLL and 2 HD), received high doses of radio-chemotherapy and autologous peripheral blood stem cell (PBSC) transplantation. Seven of them were in 1st CR, two in 3rd CR and one in refractory status. The recruitment of PBSC was performed...

journal_title：Haematologica

authors： Fioritoni G,Iacone A,D'Antonio D,Dragani A,Quaglietta AM,Accorsi P,Angelini A,Spadano A,Natale D,Berardi A

更新日期：1990-01-01 00:00:00

abstract：:The characteristics of 14 HIV-seropositive patients with NHL consecutively observed between 1984 and 1988 at our Institution are described. Patients belonged to a known population of 1242 HIV-seropositive individuals in whom the incidence of NHL was 1.13%, significantly higher than in age-matched controls (P less than...

journal_title：Haematologica

authors： Rossi G,Cadeo G,Stellini R,Zorzi F,Favret M,Sueri L,Carosi G,Mariano M,Marinone G

更新日期：1990-05-01 00:00:00

abstract：:Disease bulk is an important prognostic factor in early stage Hodgkin lymphoma, but its definition is unclear in the computed tomography era. This retrospective analysis investigated the prognostic significance of bulky disease measured in transverse and coronal planes on computed tomography imaging. Early stage Hodgk...

journal_title：Haematologica

authors： Kumar A,Burger IA,Zhang Z,Drill EN,Migliacci JC,Ng A,LaCasce A,Wall D,Witzig TE,Ristow K,Yahalom J,Moskowitz CH,Zelenetz AD

更新日期：2016-10-01 00:00:00

abstract：:Juvenile hemochromatosis is a severe form of hereditary iron overload. It can be caused by mutations in either hepcidin or hemojuvelin genes. In this study we identified the molecular basis of juvenile hemochromatosis in three Australian families and assessed the role of potential modifying genes in individuals carryi...

journal_title：Haematologica

authors： Wallace DF,Dixon JL,Ramm GA,Anderson GJ,Powell LW,Subramaniam N

更新日期：2005-02-01 00:00:00

abstract：:Recent studies indicate that a subset of patients with apparently acquired aplastic anemia (AA) have mutations in genes for telomerase ribonucleoprotein complex components. We looked for mutations in telomerase RNA (TERC) and telomerase reverse transcriptase (TERT) in 96 Japanese children with acquired AA and in 76 he...

journal_title：Haematologica

authors： Liang J,Yagasaki H,Kamachi Y,Hama A,Matsumoto K,Kato K,Kudo K,Kojima S

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Germ cell tumors (GCTs) are very chemosensitive cancers, in which high-dose chemotherapy (HDCT) has been investigated as salvage therapy or as first-line treatment in poor prognosis patients. This paper presents an update of available information in order to define the status of HDCT in GCT pa...

journal_title：Haematologica

authors： De Giorgi U,Rosti G,Papiani G,Marangolo M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Idarubicin (IDA) is relatively immune to the multidrug resistance P-gp mechanism that is frequently expressed in recurrent and refractory hematologic malignancies. Owing to rapid metabolism in vivo, a continuous infusion (CI) of IDA might prolong exposure time to the parent drug rather than its...

journal_title：Haematologica

authors： Bassan R,Chiodini B,Zucchetti M,Lerede T,Cornelli PE,Cortelazzo S,Barbui T

更新日期：1998-01-01 00:00:00

abstract：:Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular pathologies such as atherosclerosis and thrombosis. Here, we sought ...

journal_title：Haematologica

authors： Kurakula K,Koenis DS,Herzik MA Jr,Liu Y,Craft JW Jr,van Loenen PB,Vos M,Tran MK,Versteeg HH,Goumans MTH,Ruf W,de Vries CJM,Şen M

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Whether degree of iron stores influences progression of human immunodeficiency virus (HIV) disease is controversial. We studied the relationship of indirect measures of iron stores with mortality in highly active antiretroviral therapy (HAART)-naive participants from the Women's Interagency HI...

journal_title：Haematologica

authors： Gordeuk VR,Onojobi G,Schneider MF,Dawkins FW,Delapenha R,Voloshin Y,von Wyl V,Bacon M,Minkoff H,Levine A,Cohen M,Greenblatt RM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Persistent mixed chimerism represents a state in which recipient and donor cells stably co-exist after hematopoietic stem cell transplantation. However, since in most of the studies reported in literature the engraftment state was observed in the nucleated cells, in this study we determined the donor origin ...

journal_title：Haematologica

authors： Andreani M,Testi M,Gaziev J,Condello R,Bontadini A,Tazzari PL,Ricci F,De Felice L,Agostini F,Fraboni D,Ferrari G,Battarra M,Troiano M,Sodani P,Lucarelli G

更新日期：2011-01-01 00:00:00

abstract：:A case of Di Guglielmo's syndrome passed through the three stages of chronic erythromyelosis, erythroleukemia and acute myeloid leukemia (AML). According to the FAB classification the subsequent stages of this syndrome were refractory anemia (RA), RA with excess of blasts (RAEB), AML-M6, AML-M2 and undifferentiated AM...

journal_title：Haematologica

authors： Michiels JJ,van der Meulen J,Brederoo P

更新日期：1997-07-01 00:00:00

abstract：:Tumor microenvironment (TME) and limited immune surveillance play important roles in lymphoma pathogenesis. Here, we aimed to characterize immunological profiles of diffuse large B-cell lymphoma (DLBCL), and predict the outcome in response to immunochemotherapy. We profiled the expression of 730 immune-related genes i...

journal_title：Haematologica

authors： Autio M,Leivonen SK,Brück O,Mustjoki S,Jørgensen JM,Karjalainen-Lindsberg ML,Beiske K,Holte H,Pellinen T,Leppä S

更新日期：2020-02-20 00:00:00

abstract：BACKGROUND:We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/progenitor cells overexpressing miR-125b is able to induce l...

journal_title：Haematologica

authors： Bousquet M,Nguyen D,Chen C,Shields L,Lodish HF

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Light chain amyloidosis is a rare plasma cell dyscrasia. Interphase fluorescence in situ hybridization (FISH) coupled to cytoplasmic staining of specific Ig (cIg-FISH) on bone marrow plasma cells has become well established in the initial evaluation of multiple myeloma, a related disorder. Little, however, i...

journal_title：Haematologica

authors： Bryce AH,Ketterling RP,Gertz MA,Lacy M,Knudson RA,Zeldenrust S,Kumar S,Hayman S,Buadi F,Kyle RA,Greipp PR,Lust JA,Russell S,Rajkumar SV,Fonseca R,Dispenzieri A

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Folate deficiency in the general population is associated with a risk of cardiovascular disease and various cancers. The aim of this study was to evaluate folate status in Italian blood donors and its relationship with gender and smoking habit. DESIGN AND METHODS:A prospective study of 201 fi...

journal_title：Haematologica

authors： Cafolla A,Dragoni F,Girelli G,Tosti ME,Costante A,Pastorelli D,Bedogni G,Scott S

更新日期：2000-07-01 00:00:00