Identification of an immunogenic DKK1 long peptide for immunotherapy of human multiple myeloma.

abstract：:With the deaths of Janet Rowley and John Goldman in December 2013, the world lost two pioneers in the field of chronic myeloid leukemia. In 1973, Janet Rowley, unraveled the cytogenetic anatomy of the Philadelphia chromosome, which subsequently led to the identification of the BCR-ABL1 fusion gene and its principal pa...

journal_title：Haematologica

authors： Mughal TI,Radich JP,Deininger MW,Apperley JF,Hughes TP,Harrison CJ,Gambacorti-Passerini C,Saglio G,Cortes J,Daley GQ

更新日期：2016-05-01 00:00:00

abstract：:The transferability of the T2* technique for measurement of tissue iron between magnetic resonance (MR) scanners is unknown. Heart and liver multi-breath-hold T2* sequences were installed on MR scanners at six different sites. T2* was assessed locally in five or more patients with thalassemia major (n=39), and subject...

journal_title：Haematologica

authors： Tanner MA,He T,Westwood MA,Firmin DN,Pennell DJ,Thalassemia International Federation Heart T2* Investigators.

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In multiple myeloma (MM), the mechanisms used by plasma cells to invade locally and metastasize are thought to be similar to those developed by solid tumors and include cell proliferation and secretion of extracellular matrix (ECM) degrading enzymes following adhesion to ECM proteins. We studi...

journal_title：Haematologica

authors： Ria R,Vacca A,Ribatti D,Di Raimondo F,Merchionne F,Dammacco F

更新日期：2002-08-01 00:00:00

abstract：:Adoptive transfer of ex vivo expanded CD4(+)CD25(+)FOXP3(+) regulatory T cells is a successful therapy for autoimmune diseases and transplant rejection in experimental models. In man, equivalent manipulations in bone marrow transplant recipients appear safe, but questions regarding the stability of the transferred reg...

journal_title：Haematologica

authors： Scottà C,Esposito M,Fazekasova H,Fanelli G,Edozie FC,Ali N,Xiao F,Peakman M,Afzali B,Sagoo P,Lechler RI,Lombardi G

更新日期：2013-08-01 00:00:00

abstract：:This phase Ib/II trial combined the pan-deacetylase inhibitor panobinostat with chemotherapy followed by panobinostat maintenance in elderly patients with newly diagnosed acute myeloid leukemia. Patients with prior history of myelodysplastic syndrome were excluded and 38 evaluable patients were included in the study (...

journal_title：Haematologica

authors： Ocio EM,Herrera P,Olave MT,Castro N,Pérez-Simón JA,Brunet S,Oriol A,Mateo M,Sanz MÁ,López J,Montesinos P,Chillón MC,Prieto-Conde MI,Díez-Campelo M,González M,Vidriales MB,Mateos MV,San Miguel JF,PETHEMA Group.

更新日期：2015-10-01 00:00:00

abstract：:Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact in the general population are rare. Furthermore, discussions on the optimal definition of anemia have n...

journal_title：Haematologica

authors： Wouters HJCM,van der Klauw MM,de Witte T,Stauder R,Swinkels DW,Wolffenbuttel BHR,Huls G

更新日期：2019-03-01 00:00:00

abstract：:Mucormycosis is an emerging cause of infectious morbidity and mortality in patients with hematologic malignancies. However, there are no recommendations to guide diagnosis and management. The European Conference on Infections in Leukemia assigned experts in hematology and infectious diseases to develop evidence-based ...

journal_title：Haematologica

authors： Skiada A,Lanternier F,Groll AH,Pagano L,Zimmerli S,Herbrecht R,Lortholary O,Petrikkos GL,European Conference on Infections in Leukemia.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Persistent mixed chimerism represents a state in which recipient and donor cells stably co-exist after hematopoietic stem cell transplantation. However, since in most of the studies reported in literature the engraftment state was observed in the nucleated cells, in this study we determined the donor origin ...

journal_title：Haematologica

authors： Andreani M,Testi M,Gaziev J,Condello R,Bontadini A,Tazzari PL,Ricci F,De Felice L,Agostini F,Fraboni D,Ferrari G,Battarra M,Troiano M,Sodani P,Lucarelli G

更新日期：2011-01-01 00:00:00

abstract：:Extramedullary (EM) disease in patients with acute myeloid leukemia (AML) is a known phenomenon. Since the prevalence of EM AML has so far only been clinically determined on examination, we performed a prospective study in patients with AML. The aim of the study was to determine the prevalence of metabolically active ...

journal_title：Haematologica

authors： Stölzel F,Lüer T,Löck S,Parmentier S,Kuithan F,Kramer M,Alakel NS,Sockel K,Taube F,Middeke JM,Schetelig J,Röllig C,Paulus T,Kotzerke J,Ehninger G,Bornhäuser M,Schaich M,Zoephel K

更新日期：2020-06-01 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates phosphatidylinositol 3-kinase (PI3K)-AKT signaling and is often inactivated by mutations (including deletions) in a variety of cancer types, including T-cell acute lymphoblastic leukemia. Here we review mutation-associated mechanisms that ...

journal_title：Haematologica

authors： Mendes RD,Canté-Barrett K,Pieters R,Meijerink JP

更新日期：2016-09-01 00:00:00

abstract：:Whole blood donors, especially frequently donating donors, have a risk of iron deficiency and low hemoglobin levels, which may affect their health and eligibility to donate. Lifestyle behaviors, such as dietary iron intake and physical activity, may influence iron stores and thereby hemoglobin levels. We aimed to inve...

journal_title：Haematologica

authors： Timmer TC,de Groot R,Rijnhart JJM,Lakerveld J,Brug J,Perenboom CWM,Baart MA,Prinsze FJ,Zalpuri S,van der Schoot EC,de Kort WLAM,van den Hurk K

更新日期：2020-10-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-autonomous process, which is the focus of another review in the same issue of Haematologica However, studies on the microenvironment that maintains and regulates HSC (HSC niche) over the past 20 years have suggested that microenvironme...

journal_title：Haematologica

authors： Ho YH,Méndez-Ferrer S

更新日期：2020-01-01 00:00:00

abstract：:The control of mRNA stability plays a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation and tumorigenesis. HNRNPA0, which encodes an RNA-binding protein shown to regulate transcript stability via binding to the AU-rich elements of mRNAs, is located within the commonly...

journal_title：Haematologica

authors： Young DJ,Stoddart A,Nakitandwe J,Chen SC,Qian Z,Downing JR,Le Beau MM

更新日期：2014-06-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome is a rare genetic disorder characterized by defective FAS-mediated apoptosis, autoimmune disease, accumulation of mature T-cell receptor alpha/beta positive, CD4 and CD8 double-negative T cells and increased risk of lymphoma. Despite frequent hematologic abnormalities, literatur...

journal_title：Haematologica

authors： Xie Y,Pittaluga S,Price S,Raffeld M,Hahn J,Jaffe ES,Rao VK,Maric I

更新日期：2017-02-01 00:00:00

abstract：:Differentiation of erythroblasts to mature red blood cells involves dynamic changes of the membrane and cytoskeleton networks that are not fully characterized. Using a mouse fetal liver erythroblast culture system and a targeted shRNA functional screening strategy, we identified a critical role of pleckstrin-2 in acti...

journal_title：Haematologica

authors： Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

更新日期：2014-07-01 00:00:00

abstract：:Transient pancytopenia preceding childhood acute lymphoblastic leukemia (ALL) is an unfrequent but well-known event. The association of this preleukemic syndrome with hepatitis is extremely rare, with only two such cases having been published in the literature. We report the case of a 16-year-old boy who was diagnosed...

journal_title：Haematologica

authors： Rafel M,Cobo F,Cervantes F,Bosch F,Campo E,Montserrat E

更新日期：1998-06-01 00:00:00

abstract：:Granulocyte activation parameters have been described in patients with myeloproliferative disorders (MPD). We have evaluated the accuracy of leukocyte alkaline phosphatase (LAP) score to predict JAK2 V617F mutation. LAP score was obtained using a cytochemical reaction in granulocytes of patients' peripheral blood with...

journal_title：Haematologica

authors： Basquiera AL,Fassetta F,Soria N,Barral JM,Ricchi B,García JJ

更新日期：2007-05-01 00:00:00

abstract：:To date, few mutations associated with a dominant quantitative deficiency of von Willebrand factor (VWF) and a high penetrance have been reported. This phenotype was confirmed in seven unrelated families of several patients diagnosed with von Willebrand's disease out of 70 who requested genetic studies of the VWF gene...

journal_title：Haematologica

authors： Casaña P,Cabrera N,Haya S,Cid AR,Aznar JA

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:How to reach the correct diagnosis of a lymph node enlargement is still a problem which strongly challenges the knowledge and experience of the clinician. Organized and specifically oriented literature on the right sequential steps and the logical criteria that should guide this diagnostic appr...

journal_title：Haematologica

authors： Ghirardelli ML,Jemos V,Gobbi PG

更新日期：1999-03-01 00:00:00

abstract：:Systemic AL amyloidosis, a disease with improving outcomes using novel therapies, is increasingly recognized in the elderly but treatment and outcomes have not been systematically studied in this group of patients in whom comorbidities and frailty may compound morbidity and mortality. We report the outcomes of 295 pat...

journal_title：Haematologica

authors： Sachchithanantham S,Offer M,Venner C,Mahmood SA,Foard D,Rannigan L,Lane T,Gillmore JD,Lachmann HJ,Hawkins PN,Wechalekar AD

更新日期：2015-11-01 00:00:00

abstract：:Diagnostic biomarkers can be used to determine relapse risk in acute myeloid leukemia, and certain genetic aberrancies have prognostic relevance. A diagnostic immunophenotypic expression profile, which quantifies the amounts of distinct gene products, not just their presence or absence, was established in order to imp...

journal_title：Haematologica

authors： Voigt AP,Brodersen LE,Alonzo TA,Gerbing RB,Menssen AJ,Wilson ER,Kahwash S,Raimondi SC,Hirsch BA,Gamis AS,Meshinchi S,Wells DA,Loken MR

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Myeloid leukemia of Down's syndrome (ML-DS) has characteristic biological features (e.g. expression of the truncated GATA1s), which are different from those of non-DS childhood acute myeloid leukemias (AML). The objective of this study was to investigate factors predisposing to the development...

journal_title：Haematologica

authors： Langebrake C,Klusmann JH,Wortmann K,Kolar M,Puhlmann U,Reinhardt D

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Perceiving the need for rigorous recommendations to facilitate decisions concerning the management of patients with multiple myeloma (MM), the Italian Society of Hematology (SIE) and the two affiliate societies (SIES and GITMO) commissioned a project to develop guidelines for the therapy of MM using evidence...

journal_title：Haematologica

authors： Barosi G,Boccadoro M,Cavo M,Corradini P,Marchetti M,Massaia M,Merlini G,Tosi P,Tura S,Italian Society of Hematology.,Italian Society of Experimental Hematology.,Italian Group for Bone Marrow Transplantation.

更新日期：2004-06-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunological cytolytic pathway. Secondary hemophagocytic lymphohistiocytosis i...

journal_title：Haematologica

authors： Tsuboi I,Harada T,Hirabayashi Y,Aizawa S

更新日期：2019-10-01 00:00:00

abstract：:The total number of children with incident cancer in Italy has never been specifically estimated. Specialized population-based Childhood Cancer Registries have only been operating in Piedmont (CCRP) and in the Marche region, while general population cancer registries cover about 20% of the Italian population. The numb...

journal_title：Haematologica

authors： Baussano I,Maule MM,Dama E,Dalmasso P,Mosso ML,Galzerano M,Merletti F,Magnani C,Pastore G

更新日期：2007-09-01 00:00:00

abstract：:We describe the case of a 12-year old boy with Hoyeraal-Hreidarsson Syndrome (HHS). This syndrome includes intrauterine growth retardation, microcephaly, mental retardation, cerebellar malformation, and pancytopenia. HHS is a severe multisystem disorder associated with premature mortality, due to bone marrow failure. ...

journal_title：Haematologica

authors： Ozdemir MA,Karakukcu M,Kose M,Kumandas S,Gumus H

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Whether human mesenchymal stem cells (MSC) can be transplanted is controversial and their presence in peripheral blood is not fully accepted. In the present study we have analyzed whether, within the allogeneic transplantation setting, MSC are of host or donor origin. DESIGN AND METHODS:Bone ...

journal_title：Haematologica

authors： Villaron EM,Almeida J,López-Holgado N,Alcoceba M,Sánchez-Abarca LI,Sanchez-Guijo FM,Alberca M,Pérez-Simon JA,San Miguel JF,Del Cañizo MC

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not yet been evaluated for a large panel of cancer testis antigens which can be classified by varying expression in normal tissue: restricted to testis, ...

journal_title：Haematologica

authors： van Duin M,Broyl A,de Knegt Y,Goldschmidt H,Richardson PG,Hop WC,van der Holt B,Joseph-Pietras D,Mulligan G,Neuwirth R,Sahota SS,Sonneveld P

更新日期：2011-11-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role...

journal_title：Haematologica

authors： de Vries AC,Stam RW,Kratz CP,Zenker M,Niemeyer CM,van den Heuvel-Eibrink MM,European Working Group on childhood MDS (EWOG-MDS).

更新日期：2007-11-01 00:00:00

abstract：:Clinical and hematologic characteristics of beta(β)-thalassemia are determined by several factors resulting in a wide spectrum of severity. Phenotype modulators are: HBB mutations, HBA defects and fetal hemoglobin production modulators (HBG2:g.-158C>T polymorphism, HBS1L-MYB intergenic region and the BCL11A). We chara...

journal_title：Haematologica

authors： Danjou F,Francavilla M,Anni F,Satta S,Demartis FR,Perseu L,Manca M,Sollaino MC,Manunza L,Mereu E,Marceddu G,Pissard S,Joly P,Thuret I,Origa R,Borg J,Forni GL,Piga A,Lai ME,Badens C,Moi P,Galanello R

更新日期：2015-04-01 00:00:00