当前位置： SCI文献检索 > HAEMATOLOGICA期刊下所有文献 > Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice.

Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice.

Abstract：

:Acquired aplastic anemia is an autoimmune-mediated bone marrow failure syndrome. The mechanism by which such an autoimmune reaction is initiated is unknown. Whether and how the genetic lesions detected in patients cause autoimmune bone marrow failure have not yet been determined. We found that mice with spontaneous deletion of the TGFβ-activated kinase-1 gene in a small subset of hematopoietic cells developed bone marrow failure which resembled the clinical manifestations of acquired aplastic anemia patients. Bone marrow failure in such mice could be reversed by depletion of CD4+ T lymphocytes or blocked by knockout of interferon-γ, suggesting a Th1-cell-mediated autoimmune mechanism. The onset and progression of bone marrow failure in such mice were significantly accelerated by the inactivation of tumor necrosis factor-α signaling. Tumor necrosis factor-α restricts autoimmune bone marrow failure by inhibiting type-1 T-cell responses and maintaining the function of myeloid-derived suppressor cells. Furthermore, we determined that necroptosis among a small subset of mutant hematopoietic cells is the cause of autoimmune bone marrow failure because such bone marrow failure can be prevented by deletion of receptor interacting protein kinase-3 Our study suggests a novel mechanism to explain the pathogenesis of autoimmune bone marrow failure.

journal_name

Haematologica

journal_title

Haematologica

authors

Xin J,Breslin P,Wei W,Li J,Gutierrez R,Cannova J,Ni A,Ng G,Schmidt R,Chen H,Parini V,Kuo PC,Kini AR,Stiff P,Zhu J,Zhang J

doi

10.3324/haematol.2016.151514

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

295-307

issue

2

eissn

0390-6078

issn

1592-8721

pii

haematol.2016.151514

journal_volume

102

pub_type

杂志文章

相关文献

HAEMATOLOGICA文献大全
  • The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms.

    abstract：BACKGROUND:Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features such as acquired mutations in the JAK2, TET2, CBL and MPL genes. There are recent reports that a JAK2 gene haplotype (GGCC or 46/1) confers susceptibility to JAK2 mutation-positive myeloprol...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2010.034488

    authors： Olcaydu D,Rumi E,Harutyunyan A,Passamonti F,Pietra D,Pascutto C,Berg T,Jäger R,Hammond E,Cazzola M,Kralovics R

    更新日期：2011-03-01 00:00:00

  • The association of cyclophosphamide and dexamethasone in advanced refractory multiple myeloma patients.

    abstract：:VAD is the most active regimen in refractory myeloma patients; however, the role of vincristine and doxorubicin remains unclear. Relatively high doses of cyclophosphamide (3.6 g/sqm) increased the response rate and survival in resistant MM. Cyclophosphamide and dexamethasone were administered to 28 patients with advan...

    journal_title：Haematologica

    pub_type： 临床试验,杂志文章,多中心研究

    doi：

    authors： Celesti L,Clavio M,Poggi A,Casciaro S,Vallebella E,Gobbi M

    更新日期：1997-05-01 00:00:00

  • Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis.

    abstract：:Perforin gene (PRF1) mutations cause the primary form of hemophagocytic lymphohistiocytosis (HLH). We report a genetic defect of PRF1 in a 62-year-old Japanese man with recurrent episodes of HLH. Sequencing of PRF1 from both peripheral blood mononuclear cells and nail clippings showed compound heterozygous mutation, i...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.11233

    authors： Nagafuji K,Nonami A,Kumano T,Kikushige Y,Yoshimoto G,Takenaka K,Shimoda K,Ohga S,Yasukawa M,Horiuchi H,Ishii E,Harada M

    更新日期：2007-07-01 00:00:00

  • Aberrant expression of microRNA in polycythemia vera.

    abstract：BACKGROUND:Polycythemia vera is a clonal hematopoietic stem cell disorder in which the JAK2 V617F mutation is observed in >95% of patients, but an as yet unidentified process appears to initiate the clonal expansion of hematopoiesis. Because microRNA regulate hematopoietic differentiation, we hypothesized that dysregul...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.12706

    authors： Bruchova H,Merkerova M,Prchal JT

    更新日期：2008-07-01 00:00:00

  • Cryoprecipitate versus commercial fibrinogen concentrate in patients who occasionally require a therapeutic supply of fibrinogen: risk comparison in the case of an emerging transfusion-transmitted infection.

    abstract：:A probabilistic model was used to compare cryoprecipitate to viral inactivated, commercial fibrinogen concentrate to evaluate with regard to the recipient's risk of exposure to an emergent AIDS-like epidemic. In patients who occasionally need a therapeutic dose of fibrinogen, commercial fibrinogen would be marginally ...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.11072

    authors： Pereira A

    更新日期：2007-06-01 00:00:00

  • Comparison of CD38 antibodies in vitro and ex vivo mechanisms of action in multiple myeloma.

    abstract：:Not available. ...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2020.268656

    authors： Kinder M,Bahlis NJ,Malavasi F,De Goeij B,Babich A,Sendecki J,Rusbuldt J,Bellew K,Kane C,Van de Donk NWCJ

    更新日期：2021-01-14 00:00:00

  • CD34+ selected autologous peripheral blood stem cell transplantation for multiple sclerosis: report of toxicity and treatment results at one year of follow-up in 15 patients.

    abstract：BACKGROUND AND OBJECTIVES:Autologous stem cell transplantation (ASCT) is currently being evaluated as a therapy for patients with multiple sclerosis (MS). We report the results of a phase II trial to evaluate feasibility and toxicity of CD34+ selected ASCT (CD34+/ASCT) and treatment results at one year of follow-up. D...

    journal_title：Haematologica

    pub_type： 临床试验,杂志文章

    doi：

    authors： Carreras E,Saiz A,Marín P,Martínez C,Rovira M,Villamor N,Aymerich M,Lozano M,Fernández-Avilés F,Urbano-Izpizua A,Montserrat E,Graus F

    更新日期：2003-03-01 00:00:00

  • A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms.

    abstract：:Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal. Triapine is a novel inhibitor of the M2 subunit of ribonucleotide reductase. Sequential inhibition of ribonu...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2013.097246

    authors： Zeidner JF,Karp JE,Blackford AL,Smith BD,Gojo I,Gore SD,Levis MJ,Carraway HE,Greer JM,Ivy SP,Pratz KW,McDevitt MA

    更新日期：2014-04-01 00:00:00

  • The TMPRSS6 variant (SNP rs855791) affects iron metabolism and oral iron absorption - a stable iron isotope study in Taiwanese women.

    abstract：:Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. In nonanemic Taiwanese women (n=79, 44 TT variant, 35 CC variant), we administered standardized rice-based test meals containing 4 mg of labeled 57Fe or 58Fe a...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2020.264556

    authors： Buerkli S,Pei SN,Hsiao SC,Lee CT,Zeder C,Zimmermann MB,Moretti D

    更新日期：2020-10-05 00:00:00

  • Molecular basis for therapeutic decisions in chronic myeloid leukemia patients after allogeneic bone marrow transplantation.

    abstract：BACKGROUND AND OBJECTIVES:Recent progress in the development of diagnostic techniques has greatly facilitated the monitoring of minimal residual disease (MRD) in patients with chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT), the only curative treatment for this disease. The presence of...

    journal_title：Haematologica

    pub_type： 杂志文章,评审

    doi：

    authors： Román J,Alvarez MA,Torres A

    更新日期：2000-10-01 00:00:00

  • Impaired killing of Candida albicans by granulocytes mobilized for transfusion purposes: a role for granule components.

    abstract：:Granulocyte transfusions are used to treat neutropenic patients with life-threatening bacterial or fungal infections that do not respond to anti-microbial drugs. Donor neutrophils that have been mobilized with granulocyte-colony stimulating factor (G-CSF) and dexamethasone are functional in terms of antibacterial acti...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2015.136630

    authors： Gazendam RP,van de Geer A,van Hamme JL,Tool AT,van Rees DJ,Aarts CE,van den Biggelaar M,van Alphen F,Verkuijlen P,Meijer AB,Janssen H,Roos D,van den Berg TK,Kuijpers TW

    更新日期：2016-05-01 00:00:00

  • Monoclonal expansion of large granular lymphocytes with a CD4+ CD8dim+/- phenotype associated with hairy cell leukemia.

    abstract：:Peripheral blood lymphoid cell expansions with an unusual CD3+, CD4+, CD8dim+/-, CD11b+, CD57+ immunophenotype have recently been reported. They frequently have the morphology of large granular lymphocytes (LGL) and can be either monoclonal or polyclonal. Their significance is still unclear and no association with hem...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：

    authors： Airò P,Rossi G,Facchetti F,Marocolo D,Garza L,Lanfranchi A,Prati E,Brugnoni D,Malacarne F,Cattaneo R

    更新日期：1995-03-01 00:00:00

  • Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo.

    abstract：:Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear ...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2008.000034

    authors： Heringer-Walther S,Eckert K,Schumacher SM,Uharek L,Wulf-Goldenberg A,Gembardt F,Fichtner I,Schultheiss HP,Rodgers K,Walther T

    更新日期：2009-06-01 00:00:00

  • The German Registry of immune tolerance treatment in hemophilia--1999 update.

    abstract：:As of 1999, the German registry of immune tolerance treatment in hemophilia has received reports on 146 patients who have undergone this therapy from 25 hemophilia centers. In 16 of the reported patients treatment is ongoing. Therapy has been completed in 126 patients of all groups with hemophilia A; most of them are ...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：

    authors： Lenk H,ITT Study Group.

    更新日期：2000-10-01 00:00:00

  • Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A.

    abstract：:Prostacyclin (PGI2) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for reasons that are unclear. Using both pharmacological and genetic approaches we describe a mechanism by...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2018.213348

    authors： Berger M,Raslan Z,Aburima A,Magwenzi S,Wraith KS,Spurgeon BEJ,Hindle MS,Law R,Febbraio M,Naseem KM

    更新日期：2020-03-01 00:00:00

  • Double versus single autotransplantation in multiple myeloma; a single center experience of 100 patients.

    abstract：:One hundred patients with newly diagnosed multiple myeloma (MM) were treated with high-dose chemotherapy followed by single or double autologous stem cell transplantation (ASCT). Up-front treatment with a double ASCT tended to prolong progression-free and overall survival. ...

    journal_title：Haematologica

    pub_type： 信件

    doi：

    authors： Putkonen M,Rauhala A,Itälä M,Kauppila M,Pelliniemi TT,Remes K

    更新日期：2005-04-01 00:00:00

  • A case of adult T cell leukemia and lymphoma in an Italian woman showing different malignant clones in tumor mass and in blood.

    abstract：:HTLV-1 infections and their associated diseases are very rare in Italy, as well as in most parts of Europe, occurring prevalently in subjects related to endemic areas. The HTLV-1-associated leukemia/lymphoma, ATLL, is a very aggressive T-cell non-Hodgkin's lymphoma which can be difficult to recognize in non-endemic ar...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：

    authors： Menin C,Bulian P,Filippi F,Buttarello M,Casado C,Lopez-Galindez C,De Rossi A,Chieco-Bianchi L,Del Mistro A

    更新日期：2003-07-01 00:00:00

  • A sequential approach with imatinib, chemotherapy and transplant for adult Ph+ acute lymphoblastic leukemia: final results of the GIMEMA LAL 0904 study.

    abstract：:In the GIMEMA LAL 0904 protocol, adult Philadelphia positive acute lymphoblastic leukemia patients were treated with chemotherapy for induction and consolidation, followed by maintenance with imatinib. The protocol was subsequently amended and imatinib was incorporated in the induction and post-remission phase togethe...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2016.144535

    authors： Chiaretti S,Vitale A,Vignetti M,Piciocchi A,Fazi P,Elia L,Falini B,Ronco F,Ferrara F,De Fabritiis P,Luppi M,La Nasa G,Tedeschi A,Califano C,Fanin R,Dore F,Mandelli F,Meloni G,Foà R

    更新日期：2016-12-01 00:00:00

  • Bone marrow transplantation for severe aplastic anemia: the Barcelona Hospital Clinic experience.

    abstract：BACKGROUND AND OBJECTIVE:The outcome of patients with severe aplastic anemia (SAA) has improved considerably over the last decades. Bone marrow transplantation (BMT) is the treatment of choice in young patients who have an HLA-identical sibling donor. This study analyzes the outcome and factors related to survival in p...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：

    authors： Hernández-Boluda JC,Marín P,Carreras E,Aguilar JL,Grañena A,Rozman C,Montserrat E

    更新日期：1999-01-01 00:00:00

  • Rapamycin is highly effective in murine models of immune-mediated bone marrow failure.

    abstract：:Acquired aplastic anemia, the prototypical bone marrow failure disease, is characterized by pancytopenia and marrow hypoplasia. Most aplastic anemia patients respond to immunosuppressive therapy, usually with anti-thymocyte globulin and cyclosporine, but some relapse on cyclosporine withdrawal or require long-term adm...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2017.163675

    authors： Feng X,Lin Z,Sun W,Hollinger MK,Desierto MJ,Keyvanfar K,Malide D,Muranski P,Chen J,Young NS

    更新日期：2017-10-01 00:00:00

  • Immunoglobulin genes in multiple myeloma: expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases.

    abstract：BACKGROUND AND OBJECTIVES:The available data on the immunoglobulin gene (IG) repertoire in multiple myeloma (MM) derive mainly from heavy chains; considerably less is known about light chains. We assessed in parallel IGH and IGK/IGL rearrangements in 101 MM patients so as to gain insight into: (i) IG repertoires; (ii) ...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：

    authors： Hadzidimitriou A,Stamatopoulos K,Belessi C,Lalayianni C,Stavroyianni N,Smilevska T,Hatzi K,Laoutaris N,Anagnostopoulos A,Kollia P,Fassas A

    更新日期：2006-06-01 00:00:00

  • Lenalidomide plus cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab is safe and effective in untreated, elderly patients with diffuse large B-cell lymphoma: a phase I study by the Fondazione Italiana Linfomi.

    abstract：:Despite improvements in standard therapy with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone for patients with untreated, diffuse large B-cell lymphoma, up to 40% of these patients relapse. Lenalidomide alone or in combination with rituximab has been shown to be active in relapsed/refractory aggr...

    journal_title：Haematologica

    pub_type： 杂志文章,多中心研究

    doi：10.3324/haematol.2013.085134

    authors： Chiappella A,Tucci A,Castellino A,Pavone V,Baldi I,Carella AM,Orsucci L,Zanni M,Salvi F,Liberati AM,Gaidano G,Bottelli C,Rossini B,Perticone S,De Masi P,Ladetto M,Ciccone G,Palumbo A,Rossi G,Vitolo U,Fondazione It

    更新日期：2013-11-01 00:00:00

  • Epidoxorubicin vs idarubicin containing regimens in intermediate and high grade non-Hodgkin's lymphoma: preliminary results of a multicentric randomized trial.

    abstract：BACKGROUND:In recent years many therapeutic regimens have been designed in order to improve response rate and response duration in non-Hodgkin's lymphoma (NHL). In 1991 the Italian Lymphoma Study Group (GISL) started a prospective randomized trial on treatment of aggressive and advanced NHL, focused on the efficacy of ...

    journal_title：Haematologica

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Brugiatelli M,Federico M,Gobbi PG,Avanzini P,Callea V,Cavanna L,De Pasquale A,Di Prisco AU,Di Rienzo N,Silingardi V

    更新日期：1993-09-01 00:00:00

  • The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy.

    abstract：:We performed a dose-escalation study of bendamustine in 31 patients with multiple myeloma that had progressed after high-dose chemotherapy. Bendamustine 100 mg/m2 on days 1 and 2 per cycle was found to be the maximal tolerated dose. The overall response rate was 55% with a median progression-free survival of 26 (0-61)...

    journal_title：Haematologica

    pub_type： 信件

    doi：

    authors： Knop S,Straka C,Haen M,Schwedes R,Hebart H,Einsele H

    更新日期：2005-09-01 00:00:00

  • Granulocyte colony-stimulating factor after autologous CD34+ immunoselected peripheral blood stem cell transplantation.

    abstract：:Granulocyte colony-stimulating factor (G-CSF) can be administered after a peripheral blood stem cell transplantation with the aim of accelerating neutrophil recovery. In a randomized, single-blind study we studied a new administration schedule of G-CSF in this context. ...

    journal_title：Haematologica

    pub_type： 临床试验,信件,随机对照试验

    doi：

    authors： Piccirillo N,De Matteis S,Sorà F,d'Onofrio G,Leone G,Sica S

    更新日期：2004-09-01 00:00:00

  • Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells.

    abstract：:Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene expression programs. These programs are stabilized by the epigenetic a...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.2017.174516

    authors： Herkt SC,Kuvardina ON,Herglotz J,Schneider L,Meyer A,Pommerenke C,Salinas-Riester G,Seifried E,Bonig H,Lausen J

    更新日期：2018-01-01 00:00:00

  • Red cell aplasia and autoimmune hemolytic anemia following immunosuppression with alemtuzumab, mycophenolate, and daclizumab in pancreas transplant recipients.

    abstract：BACKGROUND AND OBJECTIVES:Acquired red cell aplasia (RCA) is a rare disorder and can be either idiopathic or associated with certain diseases, pregnancy, or drugs. In exceptionally rare cases, it has been reported to co-exist with other autoimmune cytopenias. We report a high incidence of RCA and autoimmune hemolytic a...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.10733

    authors： Elimelakh M,Dayton V,Park KS,Gruessner AC,Sutherland D,Howe RB,Reding MT,Eastlund T,van Burik JA,Singleton TP,Gruessner RW,Key NS

    更新日期：2007-08-01 00:00:00

  • Italian blood donors with anti-HBc and occult hepatitis B virus infection.

    abstract：BACKGROUND AND OBJECTIVES:Occult hepatitis B virus (HBV) infection might allow the release of viremic units into the blood supply network if blood is tested only for hepatitis B surface antigen (HBsAg). The aim of our study was to evaluate the actual prevalence, viral load and genotype of occult HBV infections among fi...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：10.3324/haematol.11224

    authors： Manzini P,Girotto M,Borsotti R,Giachino O,Guaschino R,Lanteri M,Testa D,Ghiazza P,Vacchini M,Danielle F,Pizzi A,Valpreda C,Castagno F,Curti F,Magistroni P,Abate ML,Smedile A,Rizzetto M

    更新日期：2007-12-01 00:00:00

  • Acute cholestatic Hodgkin's lymphoma: an unusual clinical picture.

    abstract：:Hodgkin's lymphoma (HL) simulating acute cholestatic hepatitis is a very unusual clinical picture. Massive liver infiltration with conspicuous acute cholestatic symptoms, in fact, suggests more aggressive systemic diseases such as non Hodgkin's lymphomas or acute leukemias. Nevertheless, we observed two cases of mixed...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：

    authors： Marinone G,Lazzari R,Pellizzari F,Marinone MG

    更新日期：1989-05-01 00:00:00

  • Elongation factor 1 (EF1alpha) promoter in a lentiviral backbone improves expression of the CD20 suicide gene in primary T lymphocytes allowing efficient rituximab-mediated lysis.

    abstract：BACKGROUND AND OBJECTIVES:CD20 has been proposed as a novel suicide gene system for the treatment of graft-versus-host disease (GVHD), a fatal complication of allogeneic bone marrow transplantation: indeed expression of the human non-immunogenic exogenous CD20 protein allows positive immunoselection of transduced cells...

    journal_title：Haematologica

    pub_type： 杂志文章

    doi：

    authors： Serafini M,Bonamino M,Golay J,Introna M

    更新日期：2004-01-01 00:00:00