Double versus single autotransplantation in multiple myeloma; a single center experience of 100 patients.

abstract：BACKGROUND:Vgamma9Vdelta2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vgamma9Vdelta2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers ...

journal_title：Haematologica

authors： Gomes AQ,Correia DV,Grosso AR,Lança T,Ferreira C,Lacerda JF,Barata JT,Silva MG,Silva-Santos B

更新日期：2010-08-01 00:00:00

abstract：:Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. In nonanemic Taiwanese women (n=79, 44 TT variant, 35 CC variant), we administered standardized rice-based test meals containing 4 mg of labeled 57Fe or 58Fe a...

journal_title：Haematologica

authors： Buerkli S,Pei SN,Hsiao SC,Lee CT,Zeder C,Zimmermann MB,Moretti D

更新日期：2020-10-05 00:00:00

abstract：:Comparative analyses of the leukocyte differential counting were performed using a Coulter VCS Hematology Flow Cytometer and direct microscopic observation on 547 unselected individuals analyzed at the outpatient clinic of the Institute of Hematology "L. e A. Seràgnoli" of Bologna. The Coulter VCS is able to provide l...

journal_title：Haematologica

authors： Zaccaria A,Celso B,Raspadori D,Motta MR,Testoni N,Rizzi S

更新日期：1990-09-01 00:00:00

abstract：:The regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique combining electron paramagnetic resonance spectroscopy and turbidimetry, which has been utilized...

journal_title：Haematologica

authors： Vara D,Cifuentes-Pagano E,Pagano PJ,Pula G

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:It has been shown that fludarabine (FLU) is superior to conventional treatment in B-CLL for rate and quality of response, leading to CR even at the molecular level. In this paper we report our preliminary results with this drug in B-CLL patients. METHODS AND PATIENTS:Twenty-seven B-CLL patients (16 refracto...

journal_title：Haematologica

authors： Spriano M,Clavio M,Carrara P,Canepa L,Miglino M,Pierri I,Celesti L,Rossi E,Vimercati R,Bruni R

更新日期：1994-05-01 00:00:00

abstract：:We conducted a phase I/II multicenter trial using 6 cycles of brentuximab vedotin (BV) in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for treatment of patients with CD30-positive (+) B-cell lymphomas. Thirty-one patients were evaluable for toxicity and 29 for efficacy including 22...

journal_title：Haematologica

authors： Svoboda J,Bair SM,Landsburg DJ,Nasta SD,Nagle SJ,Barta SK,Khan N,Filicko-O'Hara J,Gaballa S,Strelec L,Chong E,Mitnick S,Waite TS,King C,Ballard H,Youngman M,Gerson J,Plastaras JP,Maity A,Bogusz AM,Hung SS,Nakamu

更新日期：2020-05-15 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Abnormalities in the expression of cell adhesion molecules (CAM) are thought to influence the patterns of intranodal growth and hematogeneous spread of malignant cells in chronic lymphoproliferative disorders (LPD). Therefore, the characterization of CAM phenotypic profiles of the neoplastic cl...

journal_title：Haematologica

authors： Lúcio PJ,Faria MT,Pinto AM,da Silva MR,Correia Júnior ME,da Costa RJ,Parreira AB

更新日期：1998-02-01 00:00:00

abstract：:In S. Camillo Hospital, Rome, the Apheresis Center (CNTS-CRI) and the Haematological Division, Authors treated 17 patients affected by haematologic malignances and solid tumours with leukoapheresis procedures for PBSC collection. Nine patients were treated with continuous-flow cell separator Dideco Vivacell, performin...

journal_title：Haematologica

authors： Del Monte C,Basso P,Consoli P,Cossutta M,Morara R,Pescarollo A,Lanti T

更新日期：1990-01-01 00:00:00

abstract：:Even though alterations in platelet counts are presumed to be detrimental, their impact on the survival of patients has not been studied in large cohorts. The prevalence of thrombocytopenia and thrombocytosis was examined in a large inner city outpatient population of 36,262 individuals aged ≥65 years old. A significa...

journal_title：Haematologica

authors： Msaouel P,Lam AP,Gundabolu K,Chrysofakis G,Yu Y,Mantzaris I,Friedman E,Verma A

更新日期：2014-05-01 00:00:00

abstract：:In the eighties there has been an enormous increase in our knowledge about erythropoietin, previously defined as "an elusive hormone". In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the ...

journal_title：Haematologica

authors： Liberato NL,Costa A,Barosi G

更新日期：1990-07-01 00:00:00

abstract：:Outcome of patients with primary refractory acute myeloid leukemia remains unsatisfactory. We conducted a prospective phase II clinical trial with gemtuzumab ozogamicin (3 mg/m(2) intravenously on day 1), all-trans retinoic acid (45 mg/m(2) orally on days 4-6 and 15 mg/m(2) orally on days 7-28), high-dose cytarabine (...

journal_title：Haematologica

authors： Hütter-Krönke ML,Benner A,Döhner K,Krauter J,Weber D,Moessner M,Köhne CH,Horst HA,Schmidt-Wolf IG,Rummel M,Götze K,Koller E,Petzer AL,Salwender H,Fiedler W,Kirchen H,Haase D,Kremers S,Theobald M,Matzdorff AC,Ganse

更新日期：2016-07-01 00:00:00

abstract：:Chronic lymphocytic leukemia is frequently associated with immune disturbances. The relationship between chronic lymphocytic leukemia and autoimmune cytopenias, particularly autoimmune hemolytic anemia and immune thrombocytopenia, is well established. The responsible mechanisms, particularly the role of leukemic cells...

journal_title：Haematologica

authors： Hodgson K,Ferrer G,Montserrat E,Moreno C

更新日期：2011-05-01 00:00:00

abstract：:Plasma transfusion is indicated for replenishment of coagulative proteins to stop or prevent bleeding. In 2014, the Netherlands switched from using ~300mL fresh frozen plasma (FFP) units to using 200mL Omniplasma, a solvent/detergent treated pooled plasma (SD plasma), units. We evaluated the effect of the introduction...

journal_title：Haematologica

authors： Saadah NH,Schipperus MR,Wiersum-Osselton JC,van Kraaij MG,Caram-Deelder C,Beckers EAM,Leyte A,Rondeel JMM,de Vooght KMK,Weerkamp F,Zwaginga JJ,van der Bom JG

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dendritic cells (DC) pulsed with multiple myeloma (MM) patient-specific idiotype (Id) protein can induce MM-specific T-cell responses. DESIGN AND METHODS:We established serum-free culture conditions to generate monocyte-derived DC for clinical use to circumvent anti-xenogenic immune responses...

journal_title：Haematologica

authors： Reichardt VL,Milazzo C,Brugger W,Einsele H,Kanz L,Brossart P

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Dyskeratosis congenita is a cancer-prone bone marrow failure syndrome caused by aberrations in telomere biology. DESIGN AND METHODS:We studied 65 patients with dyskeratosis congenita and 127 unaffected relatives. Telomere length was measured by automated multicolor flow fluorescence in situ hybridization in...

journal_title：Haematologica

authors： Alter BP,Rosenberg PS,Giri N,Baerlocher GM,Lansdorp PM,Savage SA

更新日期：2012-03-01 00:00:00

abstract：:Lenalidomide is a very active drug in myelodysplastic syndrome with del (5q). We report such a patient treated with this drug who developed unusual complex cytogenetic abnormalities, which were elucidated by multi-FISH and FISH analysis as jumping translocations involving the long arm of chromosome 5, that resulted in...

journal_title：Haematologica

authors： Eclache V,Da Rocha A,Le Roux G,Fenaux P

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). DESIGN AND METHODS:Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusi...

journal_title：Haematologica

authors： Cesana C,Nosari AM,Klersy C,Miqueleiz S,Rossi V,Ferrando P,Valentini M,Barbarano L,Morra E

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The treatment of acquired aplastic anemia (AA) is based on allogeneic bone marrow transplantation (BMT) and immunosuppressive therapy. The aim of this study was to assess the outcome of children and adults with AA treated in the last decade, and to determine whether results have improved in tw...

journal_title：Haematologica

authors： Locasciulli A,Oneto R,Bacigalupo A,Socié G,Korthof E,Bekassy A,Schrezenmeier H,Passweg J,Führer M,Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplant Group.

更新日期：2007-01-01 00:00:00

abstract：:Decidual natural killer cells accumulate at the fetal-maternal interface and play a key role in a successful pregnancy. However, their origin is still unknown. Do they derive from peripheral natural killer cells recruited in decidua or do they represent a distinct population that originates in situ? Here, we identifie...

journal_title：Haematologica

authors： Chiossone L,Vacca P,Orecchia P,Croxatto D,Damonte P,Astigiano S,Barbieri O,Bottino C,Moretta L,Mingari MC

更新日期：2014-03-01 00:00:00

abstract：:Differentiation of erythroblasts to mature red blood cells involves dynamic changes of the membrane and cytoskeleton networks that are not fully characterized. Using a mouse fetal liver erythroblast culture system and a targeted shRNA functional screening strategy, we identified a critical role of pleckstrin-2 in acti...

journal_title：Haematologica

authors： Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

更新日期：2014-07-01 00:00:00

abstract：:The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the development of experimental models to probe mechanisms and evaluate new therapies, and the development of more efficacious treatment stratification. Genomic analyse...

journal_title：Haematologica

authors： Inaba H,Mullighan CG

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Venous thromboembolism includes two closely related clinical manifestations: deep vein thrombosis (DVT), more commonly of the lower limbs, and pulmonary embolism. Pulmonary embolism is the most common cause of preventable death in hospitalized patients. The definition of the risk factors for ve...

journal_title：Haematologica

authors： Agnelli G,Sonaglia F

更新日期：1997-07-01 00:00:00

abstract：:Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated whether BM MM endothelial cells (MMECs) control disease progression vi...

journal_title：Haematologica

authors： Solimando AG,Da Vià MC,Leone P,Borrelli P,Croci GA,Tabares P,Brandl A,Di Lernia G,Bianchi FP,Tafuri S,Steinbrunn T,Balduini A,Melaccio A,De Summa S,Argentiero A,Rauert-Wunderlich H,Frassanito MA,Ditonno P,Henke E,Kl

更新日期：2020-04-30 00:00:00

abstract：:We studied the impact of comorbidities on survival and evaluated the prognostic utility of comorbidity scores in MDS patients, who received best supportive care and were assessable according to the Charlson Comorbidity Index (CCI) and the Hematopoietic Stem Cell Transplantation Comorbidity Index (HCTCI): 171 patients ...

journal_title：Haematologica

authors： Zipperer E,Pelz D,Nachtkamp K,Kuendgen A,Strupp C,Gattermann N,Haas R,Germing U

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The expression of CD36 antigen has not been conclusively associated with human B-lymphocytes although CD36 was recently detected in a human B-cell angiotropic lymphoma where it might be involved in lymphoblast-endothelial cell adhesion. We investigated the expression of CD36 in B-cell chronic l...

journal_title：Haematologica

authors： Rutella S,Rumi C,Puggioni P,Barberi T,Di Mario A,Larocca LM,Leone G

更新日期：1999-05-01 00:00:00

abstract：:We quantified Wilm's tumor gene (WT1) using a real time quantitative polymerase chain reaction in 20 adult patients with acute lymphoblastic leukemia at presentation. A WT1 level greater than 906 (median value for the whole series) was a significant predictor of a poor disease-free and overall survival in uni- and mul...

journal_title：Haematologica

authors： Chiusa L,Francia di Celle P,Campisi P,Ceretto C,Marmont F,Pich A

更新日期：2006-02-01 00:00:00

abstract：:The present study reports a method for the easy, rapid and cost effective detection of heterozygous large deletions. As a model gene all exons of the antithrombin gene were amplified in a one tube multiplex polymerase chain reaction (PCR) and the products separated according to their size by reverse-phase ion-pair hig...

journal_title：Haematologica

authors： Pavlova A,El-Maarri O,Luxembourg B,Lindhoff-Last E,Kochhan L,Bruhn HD,Delev D,Watzka M,Seifried E,Oldenburg J

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia is characterized by a reciprocal translocation between chromosomes 9 and 22, creating the fusion gene BCR-ABL. The clinical significance of the type of BCR-ABL transcript in newly diagnosed patients in chronic phase treated with imatinib 400 mg from initial diagnosis remains unknown....

journal_title：Haematologica

authors： Lucas CM,Harris RJ,Giannoudis A,Davies A,Knight K,Watmough SJ,Wang L,Clark RE

更新日期：2009-10-01 00:00:00

abstract：:The recent identification of acquired mutations in key components of the spliceosome machinery strongly implicates abnormalities of mRNA splicing in the pathogenesis of myelodysplastic syndromes. However, questions remain as to how these aberrations functionally combine with the growing list of mutations in genes invo...

journal_title：Haematologica

authors： Mian SA,Smith AE,Kulasekararaj AG,Kizilors A,Mohamedali AM,Lea NC,Mitsopoulos K,Ford K,Nasser E,Seidl T,Mufti GJ

更新日期：2013-07-01 00:00:00

abstract：:The occurrence of immunoglobulin heavy chain (IgH) and/or T-cell receptor (TcR) gene rearrangements has been reported in some cases of acute non lymphoid leukemia (ANLL), and variously interpreted as reflecting "aberrant gene expression" or "lineage promiscuity" of the leukemic cell. In an attempt to verify the incide...

journal_title：Haematologica

authors： Leone R,Lo Coco F,De Rossi G,Diverio D,Frontani M,Spadea A,Testi AM,Cordone I,Mandelli F

更新日期：1990-03-01 00:00:00