The TMPRSS6 variant (SNP rs855791) affects iron metabolism and oral iron absorption - a stable iron isotope study in Taiwanese women.

Abstract:

:Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. In nonanemic Taiwanese women (n=79, 44 TT variant, 35 CC variant), we administered standardized rice-based test meals containing 4 mg of labeled 57Fe or 58Fe as FeSO4 on alternate days. Fractional iron absorption was measured by erythrocyte incorporation of the tracers 14 days after administration. Compared to the CC variant, in the TT variant serum iron and transferrin saturation were lower (P=0.001; P<0.001, respectively) and serum hepcidin/transferrin saturation and serum hepcidin/serum iron ratios were higher (P=0.042; P=0.088, respectively). Serum hepcidin did not differ between groups (P=0.862). Geometric mean (95% CI) fractional iron absorption, corrected to a serum ferritin of 15 μg/L, was 26.6% (24.0, 29.5) in the CC variant and 18.5% (16.2, 21.1) in the TT variant (P=0.002). Overall, predictors of iron absorption were: serum ferritin (P<0.001); genetic variant (P=0.032); and hepcidin (P<0.001). In the models by variant, in the CC variant the model explained 67-71% of variability in absorption and serum ferritin was the only significant predictor (P<0.001); in the TT variant, the model explained only 35-43% of variability, and hemoglobin (P=0.032), soluble transferrin receptor (P=0.004) and hepcidin (P<0.001) were significant predictors. Women with the TMPRSS6 rs855791 (2321 C>T) polymorphism show altered iron homeostasis which affects oral iron absorption and may increase their risk for iron deficiency. The trial was registered at www.clinicaltrials.gov as NCT03317873, and funded by the Kaohsiung Chang-Gung Memorial Hospital, Kaohsiung, Taiwan, (grant CMRPG8F0721) and ETH Zurich, Switzerland.

journal_name

Haematologica

journal_title

Haematologica

authors

Buerkli S,Pei SN,Hsiao SC,Lee CT,Zeder C,Zimmermann MB,Moretti D

doi

10.3324/haematol.2020.264556

subject

Has Abstract

pub_date

2020-10-05 00:00:00

eissn

0390-6078

issn

1592-8721

journal_volume

Online ahead of print

pub_type

杂志文章
  • MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation.

    abstract::The balance between self-renewal and differentiation is crucial to ensure the homeostasis of the hematopoietic system, and is a hallmark of hematopoietic stem cells. However, the underlying molecular pathways, including the role of micro-RNA, are not completely understood. To assess the contribution of micro-RNA, we p...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.198499

    authors: Crisafulli L,Muggeo S,Uva P,Wang Y,Iwasaki M,Locatelli S,Anselmo A,Colombo FS,Carlo-Stella C,Cleary ML,Villa A,Gentner B,Ficara F

    更新日期:2019-09-01 00:00:00

  • Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor.

    abstract::Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to macrophages independently of this receptor under static conditions, suggesting the existence ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2017.175216

    authors: Wohner N,Muczynski V,Mohamadi A,Legendre P,Proulle V,Aymé G,Christophe OD,Lenting PJ,Denis CV,Casari C

    更新日期:2018-04-01 00:00:00

  • Age is a prognostic factor even among patients with multiple myeloma younger than 66 years treated with high-dose melphalan: the IFM experience on 2316 patients.

    abstract::Age is a strong prognostic factor in multiple myeloma. The overall survival is shorter in patients older than 66 years, and even shorter in those older than 75 years. Whether age is also a prognostic parameter in patients younger than 66 years treated homogeneously with intensive approaches is unknown. To address this...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2013.098608

    authors: Chretien ML,Hebraud B,Cances-Lauwers V,Hulin C,Marit G,Leleu X,Karlin L,Roussel M,Stoppa AM,Guilhot F,Lamy T,Garderet L,Pegourie B,Dib M,Sebban C,Lenain P,Brechignac S,Royer B,Wetterwald M,Legros L,Orsini-Piocelle

    更新日期:2014-07-01 00:00:00

  • Non-Hodgkin's lymphoma in the elderly: the impact of advanced age on therapeutic options and clinical results.

    abstract:BACKGROUND:Treatment of older patients with non-Hodgkin's lymphoma (NHL) is difficult and conflicting. Lower responsiveness to therapy has been reported; however, the high risk of treatment morbidity, drug-dose reduction, and the occurrence of unrelated deaths might account for the poor outcome of NHL in the elderly. ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Orlandi E,Lazzarino M,Brusamolino E,Castelli G,Pagnucco G,Morra E,Bernasconi C

    更新日期:1991-05-01 00:00:00

  • Liver iron concentrations and urinary hepcidin in beta-thalassemia.

    abstract:BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.10842

    authors: Origa R,Galanello R,Ganz T,Giagu N,Maccioni L,Faa G,Nemeth E

    更新日期:2007-05-01 00:00:00

  • Stiff-man syndrome in a patient with Hodgkin's disease. An unusual paraneoplastic syndrome.

    abstract::A case of stiff-man syndrome (SMS), a rare and dramatic CNS disease characterized by continuous muscle activity and painful spasms resembling a chronic form of tetanus, occurring in a patient with Hodgkin's disease (HD) is reported. The patient developed the clinical features of SMS at the same time as the HD relapse....

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Ferrari P,Federico M,Grimaldi LM,Silingardi V

    更新日期:1990-11-01 00:00:00

  • Effect of the administration of n-3 polyunsaturated fatty acids on circulating levels of microparticles in patients with a previous myocardial infarction.

    abstract:BACKGROUND:Increased levels of microparticles exposing tissue factor circulate in the blood of patients with coronary heart disease, possibly disseminating their pro-thrombotic and pro-inflammatory potential. Because diets rich in n-3 (polyunsaturated) fatty acids have been associated with reduced incidence of coronary...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.11845

    authors: Del Turco S,Basta G,Lazzerini G,Evangelista M,Rainaldi G,Tanganelli P,Christensen JH,Schmidt EB,De Caterina R

    更新日期:2008-06-01 00:00:00

  • Rapamycin is highly effective in murine models of immune-mediated bone marrow failure.

    abstract::Acquired aplastic anemia, the prototypical bone marrow failure disease, is characterized by pancytopenia and marrow hypoplasia. Most aplastic anemia patients respond to immunosuppressive therapy, usually with anti-thymocyte globulin and cyclosporine, but some relapse on cyclosporine withdrawal or require long-term adm...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2017.163675

    authors: Feng X,Lin Z,Sun W,Hollinger MK,Desierto MJ,Keyvanfar K,Malide D,Muranski P,Chen J,Young NS

    更新日期:2017-10-01 00:00:00

  • Immobilized fibrinogen activates human platelets through glycoprotein VI.

    abstract::Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon platelet adhesion to fibrinogen. Full spreading of human platelets on fibrinogen was abolished in platelets f...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2017.182972

    authors: Mangin PH,Onselaer MB,Receveur N,Le Lay N,Hardy AT,Wilson C,Sanchez X,Loyau S,Dupuis A,Babar AK,Miller JL,Philippou H,Hughes CE,Herr AB,Ariëns RA,Mezzano D,Jandrot-Perrus M,Gachet C,Watson SP

    更新日期:2018-05-01 00:00:00

  • The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation.

    abstract:BACKGROUND:Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRbeta (TPbeta, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRalpha (FPalpha) results from a deletion on chromosome 4q12 and ZNF19...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2008.001149

    authors: Toffalini F,Kallin A,Vandenberghe P,Pierre P,Michaux L,Cools J,Demoulin JB

    更新日期:2009-08-01 00:00:00

  • Comparative flow cytometric evaluation of bcl-2 oncoprotein in CD5+ and CD5- B-cell lymphoid chronic leukemias.

    abstract:BACKGROUND AND OBJECTIVES:Levels of intracellular bcl-2 oncoprotein have been found to be increased in leukemic cells of CD5+ B-chronic lymphocytic leukemia (CLL) patients. However, it is not clear whether bcl-2 overexpression is a peculiar feature of CD5+ B-CLL. Based on this background we carried out a quantitative f...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Molica S,Mannella A,Crispino G,Dattilo A,Levato D

    更新日期:1997-09-01 00:00:00

  • Immunoglobulin genes in multiple myeloma: expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases.

    abstract:BACKGROUND AND OBJECTIVES:The available data on the immunoglobulin gene (IG) repertoire in multiple myeloma (MM) derive mainly from heavy chains; considerably less is known about light chains. We assessed in parallel IGH and IGK/IGL rearrangements in 101 MM patients so as to gain insight into: (i) IG repertoires; (ii) ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Hadzidimitriou A,Stamatopoulos K,Belessi C,Lalayianni C,Stavroyianni N,Smilevska T,Hatzi K,Laoutaris N,Anagnostopoulos A,Kollia P,Fassas A

    更新日期:2006-06-01 00:00:00

  • Long-term follow up of tandem autologous-allogeneic hematopoietic cell transplantation for multiple myeloma.

    abstract::We previously reported initial results in 102 multiple myeloma (MM) patients treated with sequential high-dose melphalan and autologous hematopoietic cell transplantation followed by 200 cGy total body irradiation with or without fludarabine 90 mg/m2 and allogeneic hematopoietic cell transplantation. Here we present l...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.200253

    authors: Maffini E,Storer BE,Sandmaier BM,Bruno B,Sahebi F,Shizuru JA,Chauncey TR,Hari P,Lange T,Pulsipher MA,McSweeney PA,Holmberg L,Becker PS,Green DJ,Mielcarek M,Maloney DG,Storb R

    更新日期:2019-02-01 00:00:00

  • Factors predicting peripheral blood progenitor cell collection from pediatric donors for allogeneic transplantation.

    abstract:BACKGROUND AND OBJECTIVES:Although several studies have reported on the use of children as donors for peripheral blood progenitor cells (PBPC), no specific characteristics have been identified as predictors of PBPC collection in this population. In this study we analyzed predictive factors for PBPC collection in pediat...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Díaz MA,Sevilla J,de la Rubia J,Verdeguer A,Espigado I,Vicent MG,Pascual MJ,Zamora C,Arrieta R,Serrano D,del Cañizo C,Arbona C,de Arriba F,Bargay J,Brunet S,Sanz MA

    更新日期:2003-08-01 00:00:00

  • Natural killer cell lines preferentially kill clonogenic multiple myeloma cells and decrease myeloma engraftment in a bioluminescent xenograft mouse model.

    abstract:BACKGROUND:Novel therapies capable of targeting drug resistant clonogenic MM cells are required for more effective treatment of multiple myeloma. This study investigates the cytotoxicity of natural killer cell lines against bulk and clonogenic multiple myeloma and evaluates the tumor burden after NK cell therapy in a b...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2011.054254

    authors: Swift BE,Williams BA,Kosaka Y,Wang XH,Medin JA,Viswanathan S,Martinez-Lopez J,Keating A

    更新日期:2012-07-01 00:00:00

  • Long-term results of treatment of childhood and adolescent Hodgkin's disease in 73 patients: the experience of the Departments of Radiology and Hematology of the University of Rome "La Sapienza".

    abstract:PURPOSE:Various experiences show no substantial differences between children and adults in the treatment of Hodgkin's disease. In consideration of some peculiar characteristics of these cases which might influence the therapeutical choice, particularly regarding long-term survival and therapeutical complications, we re...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Enrici RM,Anselmo AP,Osti MF,Sbarbati S,Tombolini V,Cartoni C,Mandelli F,Biagini C

    更新日期:1996-05-01 00:00:00

  • Epidoxorubicin vs idarubicin containing regimens in intermediate and high grade non-Hodgkin's lymphoma: preliminary results of a multicentric randomized trial.

    abstract:BACKGROUND:In recent years many therapeutic regimens have been designed in order to improve response rate and response duration in non-Hodgkin's lymphoma (NHL). In 1991 the Italian Lymphoma Study Group (GISL) started a prospective randomized trial on treatment of aggressive and advanced NHL, focused on the efficacy of ...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Brugiatelli M,Federico M,Gobbi PG,Avanzini P,Callea V,Cavanna L,De Pasquale A,Di Prisco AU,Di Rienzo N,Silingardi V

    更新日期:1993-09-01 00:00:00

  • Cutaneous T-cell lymphomas (including rare subtypes). Current concepts. II.

    abstract:BACKGROUND:Cutaneous T-cell lymphomas (CTCL) represent about the 80% of skin lymphomas and comprise a heterogeneous group of diseases with respect to clinical presentation, outcome, histologic and immunophenotypic features. In the recent years, data have been accumulated indicating that clinical and biological differen...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Paulli M,Berti E

    更新日期:2004-11-01 00:00:00

  • Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials.

    abstract:BACKGROUND:Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data. This is also true for immunohistochemical classifiers that are thought to reflect the cell-of-origin subclassification of gene expression stu...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2009.008862

    authors: Bernd HW,Ziepert M,Thorns C,Klapper W,Wacker HH,Hummel M,Stein H,Hansmann ML,Ott G,Rosenwald A,Müller-Hermelink HK,Barth TF,Möller P,Cogliatti SB,Pfreundschuh M,Schmitz N,Trümper L,Höller S,Löffler M,Feller AC,Ger

    更新日期:2009-11-01 00:00:00

  • Osteonecrosis after allogeneic stem cell transplantation in childhood. A case-control study in Italy.

    abstract::A case-control study was conducted among Italian children treated with a stem cell transplant (SCT). Cases (n = 43) were allogeneic recipients with osteonecrosis, and the controls (n = 129) were matched to the corresponding cases on the basis of survival, SCT center and date of transplant. Univariate analysis showed t...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Faraci M,Calevo MG,Lanino E,Caruso S,Messina C,Favr C,Iori A,Santaron S,Bonanomi S,Rondelli R,Dini G,Haupt R,AIEOP-SCT Group.

    更新日期:2006-08-01 00:00:00

  • Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines.

    abstract::We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent...

    journal_title:Haematologica

    pub_type: 信件

    doi:10.3324/haematol.10874

    authors: Jácomo RH,Melo RA,Souto FR,de Mattos ER,de Oliveira CT,Fagundes EM,Bittencourt HN,Bittencourt RI,Bortolheiro TC,Paton EJ,Bendlin R,Ismael S,Chauffaille Mde L,Silva D,Pagnano KB,Ribeiro R,Rego EM

    更新日期:2007-10-01 00:00:00

  • LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome.

    abstract:BACKGROUND:LMO2 is highly expressed at the most immature stages of lymphopoiesis. In T-lymphocytes, aberrant LMO2 expression beyond those stages leads to T-cell acute lymphoblastic leukemia, while in B cells LMO2 is also expressed in germinal center lymphocytes and diffuse large B-cell lymphomas, where it predicts bett...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2011.040568

    authors: Malumbres R,Fresquet V,Roman-Gomez J,Bobadilla M,Robles EF,Altobelli GG,Calasanz MJ,Smeland EB,Aznar MA,Agirre X,Martin-Palanco V,Prosper F,Lossos IS,Martinez-Climent JA

    更新日期:2011-07-01 00:00:00

  • HIV-related Hodgkin's disease. Report of nine cases.

    abstract:BACKGROUND:The association between lymphoproliferative disease and AIDS is now well known, but only non-Hodgkin's lymphomas (LNH) are surely related to HIV infection. Hodgkin's disease (HD) occurs rarely in HIV seropositives, so it is impossible to establish a connection between AIDS and this neoplasm. METHODS AND RES...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Novati S,Malfitano A,Sacchi P,Patruno SF,Tornari PM,Rondanelli EG

    更新日期:1993-01-01 00:00:00

  • t(X;14)(p11.4;q32.33) is recurrent in marginal zone lymphoma and up-regulates GPR34.

    abstract::Genetic events underlying pathogenesis of nodal and extranodal marginal zone lymphoma are not completely understood. We report here a novel t(X;14)(p11.4;q32.33) identified in 4 lymphoma cases: 2 with a mucosa-associated lymphoid tissue lymphoma, one with a nodal marginal zone lymphoma and one with gastric diffuse lar...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2011.052639

    authors: Baens M,Finalet Ferreiro J,Tousseyn T,Urbankova H,Michaux L,de Leval L,Dierickx D,Wolter P,Sagaert X,Vandenberghe P,De Wolf-Peeters C,Wlodarska I

    更新日期:2012-02-01 00:00:00

  • Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia.

    abstract::Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearranged leukemia by CRISPR-Cas9 mediated deletion of MN1. MN1 was require...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.211201

    authors: Sharma A,Jyotsana N,Gabdoulline R,Heckl D,Kuchenbauer F,Slany RK,Ganser A,Heuser M

    更新日期:2020-05-01 00:00:00

  • CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL.

    abstract:UNLABELLED:BACKGROUND Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34(+) stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem cells has previously been impractical because of the sca...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2011.056705

    authors: Fischer U,Ruckert C,Hubner B,Eckermann O,Binder V,Bakchoul T,Schuster FR,Merk S,Klein HU,Führer M,Dugas M,Borkhardt A

    更新日期:2012-09-01 00:00:00

  • Outcomes after late bone marrow and very early central nervous system relapse of childhood B-acute lymphoblastic leukemia: a report from the Children's Oncology Group phase III study AALL0433.

    abstract::Outcomes after relapse of childhood B-acute lymphoblastic leukemia (B-ALL) are poor, and optimal therapy is unclear. Children's Oncology Group study AALL0433 evaluated a new platform for relapsed ALL. Between March 2007 and October 2013 AALL0433 enrolled 275 participants with late bone marrow or very early isolated ce...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.237230

    authors: Lew G,Chen Y,Lu X,Rheingold SR,Whitlock JA,Devidas M,Hastings CA,Winick NJ,Carroll WL,Wood BL,Borowitz MJ,Pulsipher MA,Hunger SP

    更新日期:2021-01-01 00:00:00

  • Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study.

    abstract::Cough mixture abuse has been reported to cause severe folate deficiency and neurological defects. We carried out a prospective case-controlled survey to confirm this association and define the incidence and severity of the problem. A total of 57 cough mixture abusers and 47 other substance abusers (controls) were stud...

    journal_title:Haematologica

    pub_type: 信件

    doi:10.3324/haematol.10859

    authors: Au WY,Tsang SK,Cheung BK,Siu TS,Ma ES,Tam S

    更新日期:2007-04-01 00:00:00

  • Multilineage engraftment of refrozen cord blood hematopoietic progenitors in NOD/SCID mice.

    abstract::Seven cord blood (CB) units were tested for their capacity to repopulate irradiated NOD/SCID mice after one or two successive cryopreservation procedures. In primary transplants with frozen or refrozen CB cells we observed equivalent human colonies and percentages of human CD45+ cells, with multilineage engraftment. I...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Timeus F,Crescenzio N,Sanavio F,Fazio L,Doria A,Foglia L,Pignochino Y,Berger M,Piacibello W,Madon E,Cordero di Montezemolo L,Fagioli F

    更新日期:2006-03-01 00:00:00

  • Efficacy of anti-CD20 monoclonal antibodies (Mabthera) in patients with progressed hairy cell leukemia.

    abstract:BACKGROUND AND OBJECTIVES:Recently, a chimeric monoclonal antibody (MoAb) directed against the CD20 antigen (rituximab) has been successfully introduced in the treatment of several CD20-positive B-cell neoplasias and particularly of follicular lymphomas. Based on these premises we evaluated the efficacy and the toxicit...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Lauria F,Lenoci M,Annino L,Raspadori D,Marotta G,Bocchia M,Forconi F,Gentili S,La Manda M,Marconcini S,Tozzi M,Baldini L,Zinzani PL,Foà R

    更新日期:2001-10-01 00:00:00