The association of cyclophosphamide and dexamethasone in advanced refractory multiple myeloma patients.

abstract：:Plasma transfusion is indicated for replenishment of coagulative proteins to stop or prevent bleeding. In 2014, the Netherlands switched from using ~300mL fresh frozen plasma (FFP) units to using 200mL Omniplasma, a solvent/detergent treated pooled plasma (SD plasma), units. We evaluated the effect of the introduction...

journal_title：Haematologica

authors： Saadah NH,Schipperus MR,Wiersum-Osselton JC,van Kraaij MG,Caram-Deelder C,Beckers EAM,Leyte A,Rondeel JMM,de Vooght KMK,Weerkamp F,Zwaginga JJ,van der Bom JG

更新日期：2020-04-01 00:00:00

abstract：:Systemic anaplastic large cell lymphoma is a category of T-cell non-Hodgkin's lymphoma which can be further subdivided into two distinct entities (ALK(+) and ALK(-)) based on the presence or absence of ALK gene rearrangements. Among several pathways triggered by ALK signaling, constitutive activation of STAT3 is stric...

journal_title：Haematologica

authors： Spaccarotella E,Pellegrino E,Ferracin M,Ferreri C,Cuccuru G,Liu C,Iqbal J,Cantarella D,Taulli R,Provero P,Di Cunto F,Medico E,Negrini M,Chan WC,Inghirami G,Piva R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Thrombopoietin has been established as the major regulator of megakaryocyte and platelet production. In this study we evaluated the effects of PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), a pegylated and truncated form of thrombopoietin, on the growth and dif...

journal_title：Haematologica

authors： Catani L,Gugliotta L,Motta M,Tazzari P,Baravelli S,Tura S

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients affected by hereditary bleeding disorders and treated with non-virus inactivated clotting factor concentrates during the 1970s. INFORMATION SOURCES:In this review, we briefly report the present know...

journal_title：Haematologica

authors： Franchini M,Capra F,Tagliaferri A,Rossetti G,De Gironcoli M,Rocca P,Aprili G,Gandini G

更新日期：2002-05-01 00:00:00

abstract：:The success story of hemophilia care first began in the 1970s, when the availability of plasma-derived concentrates of coagulation factor VIII (FVIII) and factor IX (FIX) provided efficacious treatment of bleeding in patients with hemophilia A and B. This positive scenario was consolidated in terms of greater safety a...

journal_title：Haematologica

authors： Mannucci PM

更新日期：2020-03-01 00:00:00

abstract：:Five patients with lymphoid blastic transformation of chronic myeloid leukemia have been treated with IL2 associated with Vincristine (VCR) plus Prednisone (PDN). Our study indicates that IL2 may be employed in the management of this disease without excessive toxicity at the higher doses in hospitalized patients and a...

journal_title：Haematologica

authors： Meloni G,Foà R,Tosti S,Vignetti M,Gavosto F,Mandelli F

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Transcription factors play essential roles in both normal and malignant hematopoiesis. This is the case for the growth factor independent 1b (GFI1B) transcription factor, which is required for erythroid and megakaryocytic differentiation and over-expressed in leukemic patients and cell lines. DESIGN AND MET...

journal_title：Haematologica

authors： Anguita E,Villegas A,Iborra F,Hernández A

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall survival when applied ...

journal_title：Haematologica

authors： Buyse M,Michiels S,Squifflet P,Lucchesi KJ,Hellstrand K,Brune ML,Castaigne S,Rowe JM

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The threshold for prophylactic platelet transfusions has been classically established at 20,000/microL. In 48 patients with de novo acute myeloblastic leukemia (AML) we analyzed the effect of reducing the threshold for prophylactic platelet transfusion from 20,000/microL (group A) to 10,000/mic...

journal_title：Haematologica

authors： Navarro JT,Hernández JA,Ribera JM,Sancho JM,Oriol A,Pujol M,Millá F,Feliu E

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Diamond-Blackfan anemia is a rare, clinically heterogeneous, congenital red cell aplasia: 40% of patients have congenital abnormalities. Recent studies have shown that in western countries, the disease is associated with heterozygous mutations in the ribosomal protein (RP) genes in about 50% of patients. The...

journal_title：Haematologica

authors： Konno Y,Toki T,Tandai S,Xu G,Wang R,Terui K,Ohga S,Hara T,Hama A,Kojima S,Hasegawa D,Kosaka Y,Yanagisawa R,Koike K,Kanai R,Imai T,Hongo T,Park MJ,Sugita K,Ito E

更新日期：2010-08-01 00:00:00

abstract：:Although myelodysplastic syndromes are heterogeneous disorders comprising a benign subset of bone marrow failure similar to aplastic anemia, no laboratory test has been established to distinguish it from bone marrow failures that can evolve into acute myeloid leukemia. Plasma thrombopoietin levels were measured in 120...

journal_title：Haematologica

authors： Seiki Y,Sasaki Y,Hosokawa K,Saito C,Sugimori N,Yamazaki H,Takami A,Nakao S

更新日期：2013-06-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：:Comparative analyses of the leukocyte differential counting were performed using a Coulter VCS Hematology Flow Cytometer and direct microscopic observation on 547 unselected individuals analyzed at the outpatient clinic of the Institute of Hematology "L. e A. Seràgnoli" of Bologna. The Coulter VCS is able to provide l...

journal_title：Haematologica

authors： Zaccaria A,Celso B,Raspadori D,Motta MR,Testoni N,Rizzi S

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Alterations in hemostasis have frequently been observed in patients with leukemia, and thrombotic events are well documented in patients receiving L-asparaginase (ASP) as a single agent or in combination with vincristine, prednisone (sometimes complemented by an anthracycline). The present study was designed...

journal_title：Haematologica

authors： Nowak-Göttl U,Werber G,Ziemann D,Ahlke E,Boos J

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not yet been evaluated for a large panel of cancer testis antigens which can be classified by varying expression in normal tissue: restricted to testis, ...

journal_title：Haematologica

authors： van Duin M,Broyl A,de Knegt Y,Goldschmidt H,Richardson PG,Hop WC,van der Holt B,Joseph-Pietras D,Mulligan G,Neuwirth R,Sahota SS,Sonneveld P

更新日期：2011-11-01 00:00:00

abstract：:Leukemia stem cells contribute to drug-resistance and relapse in chronic myeloid leukemia (CML) and BCR-ABL1 inhibitor monotherapy fails to eliminate these cells, thereby necessitating alternate therapeutic strategies for patients CML. The peroxisome proliferator-activated receptor-γ (PPARγ) agonist pioglitazone downr...

journal_title：Haematologica

authors： Kumar H,Chattopadhyay S,Das N,Shree S,Patel D,Mohapatra J,Gurjar A,Kushwaha S,Singh AK,Dubey S,Lata K,Kushwaha R,Mohammed R,Dastidar KG,Yadav N,Vishwakarma AL,Gayen JR,Bandyopadhyay S,Chatterjee A,Jain MR,Tripathi

更新日期：2020-04-01 00:00:00

abstract：:Diseases with clonal hematopoiesis such as myelodysplastic syndrome and acute myeloid leukemia have high rates of relapse. Only a small subset of acute myeloid leukemia patients are cured with chemotherapy alone. Relapse in these diseases occurs at least in part due to the failure to eradicate leukemic stem cells or h...

journal_title：Haematologica

authors： Mani R,Goswami S,Gopalakrishnan B,Ramaswamy R,Wasmuth R,Tran M,Mo X,Gordon A,Bucci D,Lucas DM,Mims A,Brooks C,Dorrance A,Walker A,Blum W,Byrd JC,Lozanski G,Vasu S,Muthusamy N

更新日期：2018-08-01 00:00:00

abstract：:Distinct expression patterns of pro- and anti-apoptotic proteins may contribute to different prognoses and therapy outcomes in adult versus childhood acute myeloid leukemia (AML). Therefore, we investigated whether expression levels of apoptosis-related proteins CD95, Bcl-2, Bax, Bcl-xL, procaspase-3, XIAP, cIAP-1, an...

journal_title：Haematologica

authors： Wuchter C,Richter S,Oltersdorf D,Karawajew L,Ludwig WD,Tamm I

更新日期：2004-03-01 00:00:00

abstract：:A case of acute adult T-cell leukemia-lymphoma (ATLL) was observed in northeast Italy, presenting with fever, lymphadenomegaly, splenomegaly, hypercalcemia and renal failure. Leukaemic cells were morphologically typical, expressed a T-cell CD4+ phenotype, did not display any helper functions, and grew in vitro under s...

journal_title：Haematologica

authors： Fanin R,Minutillo S,D'Agaro P,Raspadori D,Tassinari A,Tazzari P,Testoni N,Damiani D,Gallizia C,Michieli M

更新日期：1990-07-01 00:00:00

abstract：:β-thalassemia and sickle cell disease are widespread fatal genetic diseases. None of the existing clinical treatments provides a solution for all patients. Two main strategies for treatment are currently being investigated: (i) gene transfer of a normal β-globin gene; (ii) reactivation of the endogenous γ-globin gene....

journal_title：Haematologica

authors： Manchinu MF,Marongiu MF,Poddie D,Casu C,Latini V,Simbula M,Galanello R,Moi P,Cao A,Porcu S,Ristaldi MS

更新日期：2014-01-01 00:00:00

abstract：:A prospective longitudinal study was conducted to determine whether single-donor fresh frozen plasma (FFP) substitution was able to influence L-asparaginase-associated hypoproteinemia. Within a 36-month period, 20 of 42 children with ALL received a total of 42 prophylactic FFP doses at a median of 10 (5-20) mliter/kg ...

journal_title：Haematologica

authors： Nowak-Göttl U,Rath B,Binder M,Hassel JU,Wolff J,Husemann S,Ritter J

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Treatment of acute myeloid leukemia (AML) in older patients remains unsatisfactory. The BGMT 95 trial for older patients set out to improve the outcome of these patients by adding a third drug (lomustine) to a 5+7 idarubicin and cytarabine schedule at induction and evaluating intermediate-dose...

journal_title：Haematologica

authors： Pigneux A,Perreau V,Jourdan E,Vey N,Dastugue N,Huguet F,Sotto JJ,Salmi LR,Ifrah N,Reiffers J

更新日期：2007-10-01 00:00:00

abstract：:Reduction in minimal residual disease, measured by real-time quantitative PCR or flow cytometry, predicts prognosis in childhood B-cell precursor acute lymphoblastic leukemia. We explored whether cells reported as minimal residual disease by flow cytometry represent the malignant clone harboring clone-specific genomic...

journal_title：Haematologica

authors： Øbro NF,Ryder LP,Madsen HO,Andersen MK,Lausen B,Hasle H,Schmiegelow K,Marquart HV

更新日期：2012-01-01 00:00:00

abstract：:Granulocyte transfusions are used to treat neutropenic patients with life-threatening bacterial or fungal infections that do not respond to anti-microbial drugs. Donor neutrophils that have been mobilized with granulocyte-colony stimulating factor (G-CSF) and dexamethasone are functional in terms of antibacterial acti...

journal_title：Haematologica

authors： Gazendam RP,van de Geer A,van Hamme JL,Tool AT,van Rees DJ,Aarts CE,van den Biggelaar M,van Alphen F,Verkuijlen P,Meijer AB,Janssen H,Roos D,van den Berg TK,Kuijpers TW

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transplant-related mortality (TRM) following allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be related to disease stage, duratiion of disease and type of donor. Furthermore, the outcome of transplants performed in the 1990s appears to be better than that of tran...

journal_title：Haematologica

authors： Bacigalupo A,Sormani MP,Lamparelli T,Gualandi F,Occhini D,Bregante S,Raiola AM,di Grazia C,Dominietto A,Tedone E,Piaggio G,Podesta M,Bruno B,Oneto R,Lombardi A,Frassoni F,Rolla D,Rollandi G,Viscoli C,Ferro C,Garba

更新日期：2004-10-01 00:00:00

abstract：:Next generation sequencing technologies have provided insights into the molecular heterogeneity of various myeloid neoplasms, revealing previously unknown somatic genetic events. In our cohort of 1444 cases analyzed by next generation sequencing, somatic mutations in the gene BRCA1-BRCA2-containing complex 3 (BRCC3) w...

journal_title：Haematologica

authors： Huang D,Nagata Y,Grossmann V,Radivoyevitch T,Okuno Y,Nagae G,Hosono N,Schnittger S,Sanada M,Przychodzen B,Kon A,Polprasert C,Shen W,Clemente MJ,Phillips JG,Alpermann T,Yoshida K,Nadarajah N,Sekeres MA,Oakley K,Ngu

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Telomerase is the enzyme that stabilizes and elongates the telomeric ends of chromosomes. It is expressed in germline and malignant cells and absent in most human somatic cells. The selective expression of telomerase has thus been proposed to be a basis for the immortality of germline and malig...

journal_title：Haematologica

authors： Hohaus S,Voso MT,Orta-La Barbera E,Cavallo S,Bellacosa A,Rutella S,Rumi C,Genuardi M,Neri G,Leone G

更新日期：1997-05-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression. Recently, blasts of patients with acute myeloid leukemia were shown to e...

journal_title：Haematologica

authors： Chamuleau ME,van de Loosdrecht AA,Hess CJ,Janssen JJ,Zevenbergen A,Delwel R,Valk PJ,Löwenberg B,Ossenkoppele GJ

更新日期：2008-12-01 00:00:00

abstract：:Home care (HC) has an increasingly expanding role in the global management of patients affected by hematologic malignancies. Integrated strategies, including causal-targeted and supportive treatments according to hematologic expertise and a holistic approach inspired by the philosophy and practice of palliative medici...

journal_title：Haematologica

authors： Niscola P,de Fabritiis P,Cartoni C,Romani C,Sorrentino F,Dentamaro T,Piccioni D,Scaramucci L,Giovannini M,Amadori S,Mandelli F

更新日期：2006-11-01 00:00:00

abstract：:Over the past 20 years we have studied 1781 patients with beta-thalassemia syndromes of which 1481 Yugoslav, 166 Bulgarian, 102 Turkish and 32 Albanian. In this paper we summarize the data on the heterogeneity and molecular basis of beta-thal, delta beta-thal and Lepore hemoglobinopathy in these four nationalities liv...

journal_title：Haematologica

authors： Efremov GD

更新日期：1990-09-01 00:00:00