FLU-ID (fludarabine and idarubicin) regimen as salvage therapy in pretreated low-grade non-Hodgkin's lymphoma.

abstract：:We report on a patient with relapsed chronic lymphocytic leukemia (CLL) treated with the novel mTOR inhibitor RAD001 within a phase II clinical trial. Although the patient initially responded to therapy, RAD001 was discontinued after 32 weeks due to progression and fludarabine-based chemotherapy was started. The patie...

journal_title：Haematologica

authors： Götze KS,Hoffmann D,Schätzl HM,Peschel C,Fend F,Decker T

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with acute myeloblastic leukemia (AML) with features of myelodysplastic syndrome and abnormalities of megakaryocytopoiesis often have cytogenetic aberrations of 3q21 and 3q26 bands involving the paracentric inversion [inv(3) (q21q26)] or a reciprocal translocation [t(3;3) (q21;q26)]. ...

journal_title：Haematologica

authors： Martinelli G,Ottaviani E,Buonamici S,Isidori A,Borsaru G,Visani G,Piccaluga PP,Malagola M,Testoni N,Rondoni M,Nucifora G,Tura S,Baccarani M

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The outcome of patients with severe aplastic anemia (SAA) has improved considerably over the last decades. Bone marrow transplantation (BMT) is the treatment of choice in young patients who have an HLA-identical sibling donor. This study analyzes the outcome and factors related to survival in p...

journal_title：Haematologica

authors： Hernández-Boluda JC,Marín P,Carreras E,Aguilar JL,Grañena A,Rozman C,Montserrat E

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Graft-versus-host disease (GVHD) presents an important complication of allogeneic bone marrow transplantation. A method to predict GVHD might be the analysis of cytotoxic T lymphocyte precursors, but the technique requires the use of radioactive elements not suitable in all laboratories. DESIG...

journal_title：Haematologica

authors： Maiocchi MA,Nano R,Capelli E,Bonfichi M,Alessandrino EP,Bernasconi P

更新日期：1998-08-01 00:00:00

abstract：:We conducted a phase I/II multicenter trial using 6 cycles of brentuximab vedotin (BV) in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for treatment of patients with CD30-positive (+) B-cell lymphomas. Thirty-one patients were evaluable for toxicity and 29 for efficacy including 22...

journal_title：Haematologica

authors： Svoboda J,Bair SM,Landsburg DJ,Nasta SD,Nagle SJ,Barta SK,Khan N,Filicko-O'Hara J,Gaballa S,Strelec L,Chong E,Mitnick S,Waite TS,King C,Ballard H,Youngman M,Gerson J,Plastaras JP,Maity A,Bogusz AM,Hung SS,Nakamu

更新日期：2020-05-15 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy derived from plasmacytoid dendritic cells. There is currently no accepted standard of care for treating this neoplasm, and therapeutic strategies have never been prospectively evaluated. Since blastic plasmacytoid dendritic cell neoplasm cells ex...

journal_title：Haematologica

authors： Angelot-Delettre F,Roggy A,Frankel AE,Lamarthee B,Seilles E,Biichle S,Royer B,Deconinck E,Rowinsky EK,Brooks C,Bardet V,Benet B,Bennani H,Benseddik Z,Debliquis A,Lusina D,Roussel M,Solly F,Ticchioni M,Saas P,Garna

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Although acquired aplastic anemia is usually a chronic disorder, a small proportion of patients with aplastic anemia was reported to recover spontaneously without specific therapy such as allogeneic bone marrow transplantation or immunosuppressive treatment. We attempted to determine the rate ...

journal_title：Haematologica

authors： Lee JH,Lee JH,Shin YR,Lee JS,Kim WK,Chi HS,Park CJ,Lee KH

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The mdr-1 gene, which codes for a 170-kd transmembrane glycoprotein (P170), is frequently overexpressed in multidrug resistant (MDR) tumor cell lines and in spontaneous tumors, including leukemia and lymphoma. However, it is also constitutively expressed as a normal gene in normal tissues. METHODS:We used h...

journal_title：Haematologica

authors： Damiani D,Michieli M,Michelutti A,Geromin A,Raspadori D,Fanin R,Savignano C,Giacca M,Pileri S,Mallardi F

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation. The effect of donor lymphocyte infusion is mediated by donor T cells recognizing minor histocompatibility antigens. T cells recognizing hemat...

journal_title：Haematologica

authors： Griffioen M,Honders MW,van der Meijden ED,van Luxemburg-Heijs SA,Lurvink EG,Kester MG,van Bergen CA,Falkenburg JH

更新日期：2012-08-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Recent progress in the development of diagnostic techniques has greatly facilitated the monitoring of minimal residual disease (MRD) in patients with chronic myeloid leukemia (CML) after allogeneic bone marrow transplantation (BMT), the only curative treatment for this disease. The presence of...

journal_title：Haematologica

authors： Román J,Alvarez MA,Torres A

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia arises from a somatic mutation in a pluripotent stem cell. It generally terminates with a blastic crisis (BC). One third of BC are lymphoid, and most have a pre-B phenotype. Few cases of T-lymphoid BC have been reported. Here we describe a lymph node blast crisis mimicking T-immunobl...

journal_title：Haematologica

authors： Leone G,La Rocca LM,Teofili L,De Candia E,Landolfi R,Sica S,Zini G,Zollino M,Tabilio A

更新日期：1992-07-01 00:00:00

abstract：:Multiple myeloma management has undergone profound changes in the past thanks to advances in our understanding of the disease biology and improvements in treatment and supportive care approaches. This article presents recommendations of the European Myeloma Network for newly diagnosed patients based on the GRADE syste...

journal_title：Haematologica

authors： Engelhardt M,Terpos E,Kleber M,Gay F,Wäsch R,Morgan G,Cavo M,van de Donk N,Beilhack A,Bruno B,Johnsen HE,Hajek R,Driessen C,Ludwig H,Beksac M,Boccadoro M,Straka C,Brighen S,Gramatzki M,Larocca A,Lokhorst H,Magar

更新日期：2014-02-01 00:00:00

abstract：:We quantified Wilm's tumor gene (WT1) using a real time quantitative polymerase chain reaction in 20 adult patients with acute lymphoblastic leukemia at presentation. A WT1 level greater than 906 (median value for the whole series) was a significant predictor of a poor disease-free and overall survival in uni- and mul...

journal_title：Haematologica

authors： Chiusa L,Francia di Celle P,Campisi P,Ceretto C,Marmont F,Pich A

更新日期：2006-02-01 00:00:00

abstract：:A significant proportion of hematopoietic stem cell transplants are performed with ABO-mismatched donors. The impact of ABO mismatch on outcome following transplantation remains controversial and there are no published data regarding the impact of ABO mismatch in acute myeloid leukemia patients receiving haploidentica...

journal_title：Haematologica

authors： Canaani J,Savani BN,Labopin M,Huang XJ,Ciceri F,Arcese W,Tischer J,Koc Y,Bruno B,Gülbas Z,Blaise D,Maertens J,Ehninger G,Mohty M,Nagler A

更新日期：2017-06-01 00:00:00

abstract：:Systemic AL amyloidosis, a disease with improving outcomes using novel therapies, is increasingly recognized in the elderly but treatment and outcomes have not been systematically studied in this group of patients in whom comorbidities and frailty may compound morbidity and mortality. We report the outcomes of 295 pat...

journal_title：Haematologica

authors： Sachchithanantham S,Offer M,Venner C,Mahmood SA,Foard D,Rannigan L,Lane T,Gillmore JD,Lachmann HJ,Hawkins PN,Wechalekar AD

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Abnormalities in the expression of cell adhesion molecules (CAM) are thought to influence the patterns of intranodal growth and hematogeneous spread of malignant cells in chronic lymphoproliferative disorders (LPD). Therefore, the characterization of CAM phenotypic profiles of the neoplastic cl...

journal_title：Haematologica

authors： Lúcio PJ,Faria MT,Pinto AM,da Silva MR,Correia Júnior ME,da Costa RJ,Parreira AB

更新日期：1998-02-01 00:00:00

abstract：:Drug resistance impedes the long-term effect of targeted therapies in acute myeloid leukemia (AML), necessitating the identification of mechanisms underlying resistance. Approximately 25% of AML patients carry FLT3 mutations and develop post-treatment insensitivity to FLT3 inhibitors, including sorafenib. Using a geno...

journal_title：Haematologica

authors： Damnernsawad A,Bottomly D,Kurtz SE,Eide CA,McWeeney SK,Tyner JW,Nechiporuk T

更新日期：2020-12-30 00:00:00

abstract：:In contrast to well-established hierarchical concepts of tumor stem cells, leukemia-initiating cells in B-cell precursor acute lymphoblastic leukemia have not yet been phenotypically identified. Different subpopulations, as defined by surface markers, have shown equal abilities to reconstitute leukemia upon transplant...

journal_title：Haematologica

authors： Trentin L,Queudeville M,Eckhoff SM,Hasan N,Münch V,Boldrin E,Seyfried F,Enzenmüller S,Debatin KM,Meyer LH

更新日期：2018-06-01 00:00:00

abstract：:It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. In this study, we analyzed the outcome of 84 patients at 3 years of follow-up ...

journal_title：Haematologica

authors： García-Marco JA,Jiménez JL,Recasens V,Zarzoso MF,González-Barca E,De Marcos NS,Ramírez MJ,Parraga FJP,Yañez L,De La Serna Torroba J,Malo MDG,Ariznavarreta GD,Persona EP,Guinaldo MAR,De Paz Arias R,Llanos EB,Jarque I,Val

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Imatinib induces complete cytogenetic responses (CCR) in the majority of patients with chronic myeloid leukemia (CML) in chronic phase (CP). However, a subgroup of patients is refractory at the cytogenetic level. Clinically, it would be advantageous to identify such patients a priori, since th...

journal_title：Haematologica

authors： Crossman LC,Mori M,Hsieh YC,Lange T,Paschka P,Harrington CA,Krohn K,Niederwieser DW,Hehlmann R,Hochhaus A,Druker BJ,Deininger MW

更新日期：2005-04-01 00:00:00

abstract：:The main purpose of this work is to give methodologic details and further verification regarding the predictive system recently elaborated for Hodgkin's disease (HD) patients, by which, under standard accuracy and conventional treatment, patient survival can be directly estimated (within a given confidence interval) w...

journal_title：Haematologica

authors： Gobbi PG,Gobbi PG,Mazza P,Zinzani PL

更新日期：1989-01-01 00:00:00

abstract：:Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). The aim of this study was to define the prevalence and clinical characteristics of pediatric thrombosis in subjects with inherite...

journal_title：Haematologica

authors： de la Morena-Barrio B,Orlando C,de la Morena-Barrio ME,Vicente V,Jochmans K,Corral J

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The threshold for prophylactic platelet transfusions has been classically established at 20,000/microL. In 48 patients with de novo acute myeloblastic leukemia (AML) we analyzed the effect of reducing the threshold for prophylactic platelet transfusion from 20,000/microL (group A) to 10,000/mic...

journal_title：Haematologica

authors： Navarro JT,Hernández JA,Ribera JM,Sancho JM,Oriol A,Pujol M,Millá F,Feliu E

更新日期：1998-11-01 00:00:00

abstract：:Our objectives were to evaluate thrombotic complications in patients with lupus anticoagulant fulfilling Sapporo criteria, anticoagulated with an intended INR 2.0-3.0 due to venous and arterial thrombosis. In our series standard anticoagulation was safe and efficacious in preventing recurrences in patients with system...

journal_title：Haematologica

authors： Casais P,Alberto MF,Gennari LC,Grosso SH,Meschengieser SS,Lazzari MA

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Whether degree of iron stores influences progression of human immunodeficiency virus (HIV) disease is controversial. We studied the relationship of indirect measures of iron stores with mortality in highly active antiretroviral therapy (HAART)-naive participants from the Women's Interagency HI...

journal_title：Haematologica

authors： Gordeuk VR,Onojobi G,Schneider MF,Dawkins FW,Delapenha R,Voloshin Y,von Wyl V,Bacon M,Minkoff H,Levine A,Cohen M,Greenblatt RM

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Pediatric acute myeloid leukemia is a heterogeneous disease characterized by non-random genetic aberrations related to outcome. The genetic subtype is currently detected by different diagnostic procedures which differ in success rate and/or specificity. DESIGN AND METHODS:We examined the potential of gene e...

journal_title：Haematologica

authors： Balgobind BV,Van den Heuvel-Eibrink MM,De Menezes RX,Reinhardt D,Hollink IH,Arentsen-Peters ST,van Wering ER,Kaspers GJ,Cloos J,de Bont ES,Cayuela JM,Baruchel A,Meyer C,Marschalek R,Trka J,Stary J,Beverloo HB,Pieters R

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Loss of heterozygosity (LOH) on the long arm of chromosome 7 (7q) has been frequently reported in several types of human cancer including hematologic malignancies. Moreover, monosomy of chromosome 7 and 7q deletions have been associated in acute myeloid leukemia (AML) with aggressive disease a...

journal_title：Haematologica

authors： Basiricò R,Pirrotta R,Fabbiano F,Mirto S,Cascio L,Pagano M,Cammarata G,Magrin S,Santoro A

更新日期：2003-04-01 00:00:00

abstract：:The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates phosphatidylinositol 3-kinase (PI3K)-AKT signaling and is often inactivated by mutations (including deletions) in a variety of cancer types, including T-cell acute lymphoblastic leukemia. Here we review mutation-associated mechanisms that ...

journal_title：Haematologica

authors： Mendes RD,Canté-Barrett K,Pieters R,Meijerink JP

更新日期：2016-09-01 00:00:00

abstract：:Aplastic anemia is usually treated with immunosuppression or allogeneic transplant, depending on patient and disease characteristics. Syngeneic transplant offers a rare treatment opportunity with minimal transplant-related mortality, and offers an insight into disease mechanisms. We present here a retrospective analys...

journal_title：Haematologica

authors： Gerull S,Stern M,Apperley J,Beelen D,Brinch L,Bunjes D,Butler A,Ganser A,Ghavamzadeh A,Koh MB,Komarnicki M,Kröger N,Maertens J,Maschan A,Peters C,Rovira M,Sengeløv H,Socié G,Tischer J,Oneto R,Passweg J,Marsh J

更新日期：2013-11-01 00:00:00