Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study.

abstract：:Umbilical cord blood stem cell transplants are commonly used in adults lacking HLA-identical donors. Delays in hematopoietic recovery contribute to mortality and morbidity. To hasten recovery, we used co-infusion of progenitor cells from a partially matched related donor and from an umbilical cord blood graft (haplo-c...

journal_title：Haematologica

authors： van Besien K,Hari P,Zhang MJ,Liu HT,Stock W,Godley L,Odenike O,Larson R,Bishop M,Wickrema A,Gergis U,Mayer S,Shore T,Tsai S,Rhodes J,Cushing MM,Korman S,Artz A

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Transplant-related mortality (TRM) following allogeneic hematopoietic stem cell transplantation (HSCT) has been reported to be related to disease stage, duratiion of disease and type of donor. Furthermore, the outcome of transplants performed in the 1990s appears to be better than that of tran...

journal_title：Haematologica

authors： Bacigalupo A,Sormani MP,Lamparelli T,Gualandi F,Occhini D,Bregante S,Raiola AM,di Grazia C,Dominietto A,Tedone E,Piaggio G,Podesta M,Bruno B,Oneto R,Lombardi A,Frassoni F,Rolla D,Rollandi G,Viscoli C,Ferro C,Garba

更新日期：2004-10-01 00:00:00

abstract：:Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated whether BM MM endothelial cells (MMECs) control disease progression vi...

journal_title：Haematologica

authors： Solimando AG,Da Vià MC,Leone P,Borrelli P,Croci GA,Tabares P,Brandl A,Di Lernia G,Bianchi FP,Tafuri S,Steinbrunn T,Balduini A,Melaccio A,De Summa S,Argentiero A,Rauert-Wunderlich H,Frassanito MA,Ditonno P,Henke E,Kl

更新日期：2020-04-30 00:00:00

abstract：:We previously reported initial results in 102 multiple myeloma (MM) patients treated with sequential high-dose melphalan and autologous hematopoietic cell transplantation followed by 200 cGy total body irradiation with or without fludarabine 90 mg/m2 and allogeneic hematopoietic cell transplantation. Here we present l...

journal_title：Haematologica

authors： Maffini E,Storer BE,Sandmaier BM,Bruno B,Sahebi F,Shizuru JA,Chauncey TR,Hari P,Lange T,Pulsipher MA,McSweeney PA,Holmberg L,Becker PS,Green DJ,Mielcarek M,Maloney DG,Storb R

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:There is little published information on the everyday clinical management of myelodysplastic syndromes in real world practice. DESIGN AND METHODS:We conducted a cross-sectional study of all patients with myelodysplastic syndromes attending 74 French centers in a 1-week period for inpatient admission, day-ho...

journal_title：Haematologica

authors： Kelaidi C,Stamatoullas A,Beyne-Rauzy O,Raffoux E,Quesnel B,Guerci A,Dreyfus F,Brechignac S,Berthou C,Prebet T,Hicheri Y,Hacini M,Delaunay J,Gourin MP,Camo JM,Zerazhi H,Taksin AL,Legros L,Choufi B,Fenaux P,Groupe F

更新日期：2010-06-01 00:00:00

abstract：:Acquired aplastic anemia is an immune-mediated disease characterized by severe defects in stem cell number resulting in hypocellular marrow and peripheral blood cytopenias. Minor paroxysmal nocturnal hemoglobinuria populations and a short telomere length were identified as predictive biomarkers of immunosuppressive th...

journal_title：Haematologica

authors： Narita A,Muramatsu H,Sekiya Y,Okuno Y,Sakaguchi H,Nishio N,Yoshida N,Wang X,Xu Y,Kawashima N,Doisaki S,Hama A,Takahashi Y,Kudo K,Moritake H,Kobayashi M,Kobayashi R,Ito E,Yabe H,Ohga S,Ohara A,Kojima S,Japan Ch

更新日期：2015-12-01 00:00:00

abstract：:Heart disease is the leading cause of mortality and one of the main causes of morbidity in beta-thalassemia. The clinical spectrum of the thalassemia syndrome ranges from the severe, transfusion--dependent thalassemia major and the asymptomatic carrier state. Thalassemia intermedia represents a milder form and is usua...

journal_title：Haematologica

authors： Aessopos A,Kati M,Farmakis D

更新日期：2007-05-01 00:00:00

abstract：:Adults with relapsed/refractory acute lymphoblastic leukemia have an unfavourable prognosis, which is influenced by disease and patient characteristics. To further evaluate these characteristics, a retrospective analysis of 1,706 adult patients with Ph-negative relapsed/refractory B-precursor acute lymphoblastic leuke...

journal_title：Haematologica

authors： Gökbuget N,Dombret H,Ribera JM,Fielding AK,Advani A,Bassan R,Chia V,Doubek M,Giebel S,Hoelzer D,Ifrah N,Katz A,Kelsh M,Martinelli G,Morgades M,O'Brien S,Rowe JM,Stieglmaier J,Wadleigh M,Kantarjian H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features such as acquired mutations in the JAK2, TET2, CBL and MPL genes. There are recent reports that a JAK2 gene haplotype (GGCC or 46/1) confers susceptibility to JAK2 mutation-positive myeloprol...

journal_title：Haematologica

authors： Olcaydu D,Rumi E,Harutyunyan A,Passamonti F,Pietra D,Pascutto C,Berg T,Jäger R,Hammond E,Cazzola M,Kralovics R

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Somatic hypermutation of the BCL6 gene and its expression in lymphoma represent specific markers for B-cell transit through the germinal center. Thus, analysis of BCL6 may aid in clarifying the relationship between primary mediastinal B-cell lymphoma (PMBL) and other non-thymic diffuse large c...

journal_title：Haematologica

authors： Malpeli G,Barbi S,Moore PS,Scardoni M,Chilosi M,Scarpa A,Menestrina F

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Pediatric acute myeloid leukemia is a heterogeneous disease characterized by non-random genetic aberrations related to outcome. The genetic subtype is currently detected by different diagnostic procedures which differ in success rate and/or specificity. DESIGN AND METHODS:We examined the potential of gene e...

journal_title：Haematologica

authors： Balgobind BV,Van den Heuvel-Eibrink MM,De Menezes RX,Reinhardt D,Hollink IH,Arentsen-Peters ST,van Wering ER,Kaspers GJ,Cloos J,de Bont ES,Cayuela JM,Baruchel A,Meyer C,Marschalek R,Trka J,Stary J,Beverloo HB,Pieters R

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Most secreted proteins, including coagulation factor X (FX), are synthesized with a signal peptide, which is necessary for targeting the nascent polypeptide into the endoplasmic reticulum. Characterization of naturally occurring mutations may provide insights into the functional roles of the a...

journal_title：Haematologica

authors： Wang WB,Fu QH,Yin J,Wu WM,Ding QL,Zhou RF,Hu YQ,Wang XF,Wang ZY,Wang HL

更新日期：2005-12-01 00:00:00

abstract：:Over the past 20 years we have studied 1781 patients with beta-thalassemia syndromes of which 1481 Yugoslav, 166 Bulgarian, 102 Turkish and 32 Albanian. In this paper we summarize the data on the heterogeneity and molecular basis of beta-thal, delta beta-thal and Lepore hemoglobinopathy in these four nationalities liv...

journal_title：Haematologica

authors： Efremov GD

更新日期：1990-09-01 00:00:00

abstract：:A case of acute adult T-cell leukemia-lymphoma (ATLL) was observed in northeast Italy, presenting with fever, lymphadenomegaly, splenomegaly, hypercalcemia and renal failure. Leukaemic cells were morphologically typical, expressed a T-cell CD4+ phenotype, did not display any helper functions, and grew in vitro under s...

journal_title：Haematologica

authors： Fanin R,Minutillo S,D'Agaro P,Raspadori D,Tassinari A,Tazzari P,Testoni N,Damiani D,Gallizia C,Michieli M

更新日期：1990-07-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) levels have been tested in patients with chronic relative polycythemia (RP), polycythemia vera, and in healthy subjects in order to find a possible underlying pathophysiological mechanism for relative polycythemia. No difference in statistical significance has been found between the me...

journal_title：Haematologica

authors： Cohen AM,Gelvan A,Winaver J,Kahna L,Floru S,Djaldetti M

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Preclinical studies have highlighted the activity of lenalidomide in mantle cell lymphoma and its anti-proliferative synergy with dexamethasone. DESIGN AND METHODS:In this prospective, multicenter, phase II study, patients with relapsed/refractory mantle cell lymphoma who were not eligible for, or had relap...

journal_title：Haematologica

authors： Zaja F,De Luca S,Vitolo U,Orsucci L,Levis A,Salvi F,Rusconi C,Ravelli E,Tucci A,Bottelli C,Balzarotti M,Brusamolino E,Bonfichi M,Pileri SA,Sabattini E,Volpetti S,Monagheddu C,Vacca A,Ria R,Fanin R

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There are no widely accepted criteria for the definition of hematopoietic stem cell transplant -associated microangiopathy (TAM). An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM. DESIGN AND METHODS:The particip...

journal_title：Haematologica

authors： Ruutu T,Barosi G,Benjamin RJ,Clark RE,George JN,Gratwohl A,Holler E,Iacobelli M,Kentouche K,Lämmle B,Moake JL,Richardson P,Socié G,Zeigler Z,Niederwieser D,Barbui T,European Group for Blood and Marrow Transplantation.,E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia has a variable clinical course. Genomic aberrations identify prognostic subgroups, pointing towards distinct underlying biological mechanisms that are poorly understood. In particular it remains unclear whether the prognostic subgroups of chronic lymphocytic leukemia are characte...

journal_title：Haematologica

authors： Winkler D,Schneider C,Zucknick M,Bögelein D,Schulze K,Zenz T,Mohr J,Philippen A,Huber H,Bühler A,Habermann A,Benner A,Döhner H,Stilgenbauer S,Mertens D

更新日期：2010-11-01 00:00:00

abstract：:The assessment of clinical probability represents an important step in the diagnostic strategy of patients with suspected deep vein thrombosis. The recently derived LEFt clinical prediction rule for pregnant women combines three variables: symptoms in the left leg (L), calf circumference difference of 2 centimeters or...

journal_title：Haematologica

authors： Righini M,Jobic C,Boehlen F,Broussaud J,Becker F,Jaffrelot M,Blondon M,Guias B,Le Gal G,EDVIGE study group.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Storage pool diseases (SPD) are heterogeneous disorders associated with an abnormal presence of intraplatelet granules, which cause mild to moderate bleeding diathesis. We investigated signaling through tyrosine phosphorylation of proteins occurring in platelets with total or partial absence o...

journal_title：Haematologica

authors： Arderiu G,Díaz-Ricart M,Domenech P,Escolar G,Ordinas A,Pujol-Moix N

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:31D8 monoclonal antibody (mAb) has been shown to bind heterogeneously to human neutrophils, identifying subsets of cells which differ in their functional response to chemotactic stimuli. In this study we used 31D8 mAb to determine whether differences in neutrophil subpopulations might explain the long-lastin...

journal_title：Haematologica

authors： Capsoni F,Minonzio F,Carbonelli V,Ongari AM,Mocellin MC,Soligo D,Annaloro C,Della Volpe A,Lambertenghi Dliliers G

更新日期：1995-03-01 00:00:00

abstract：:Diabetes insipidus and thrombocytosis were presenting symptoms in a case of adult ANLL-M1. Cytogenetic investigations revealed a typical 3q rearrangement, i.e. inv(3)(q21q26). A subclone with monosomy 7 was also found and documented by FISH analysis. Correlations between clinical/hematological features and cytogenetic...

journal_title：Haematologica

authors： La Starza R,Falzetti D,Fania C,Tabilio A,Martelli MF,Mecucci C

更新日期：1994-07-01 00:00:00

abstract：:We report on the data collected in the Italian Registry of acquired haemophilia (AH) in 2001. Recombinant activated factor VII (rFVIIa) was selected as first-line therapy in 19 bleeding episodes because of their severity and as salvage in one case. Bleeding was controlled in 90% of the episodes, indicating the efficac...

journal_title：Haematologica

authors： Baudo F,de Cataldo F,Gaidano G,Italian registry of acquired hemophilia.

更新日期：2004-06-01 00:00:00

abstract：:Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular pathologies such as atherosclerosis and thrombosis. Here, we sought ...

journal_title：Haematologica

authors： Kurakula K,Koenis DS,Herzik MA Jr,Liu Y,Craft JW Jr,van Loenen PB,Vos M,Tran MK,Versteeg HH,Goumans MTH,Ruf W,de Vries CJM,Şen M

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...

journal_title：Haematologica

authors： Origa R,Galanello R,Ganz T,Giagu N,Maccioni L,Faa G,Nemeth E

更新日期：2007-05-01 00:00:00

abstract：:A commercial multiplex reverse transcription polymerase chain reaction screening assay, covering 28 leukemic fusion transcripts, was applied in 143 samples obtained from patients with acute myeloid leukemia at primary diagnosis. In five patients, a cytogenetically unrevealed fusion gene of prognostic importance was de...

journal_title：Haematologica

authors： Hutchings Hoffmann M,Wirenfeldt Klausen T,Hasle H,Schmiegelow K,Brondum-Nielsen K,Johnsen HE

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:High-dose melphalan with autologous peripheral blood stem cell transplantation (ASCT) is an effective treatment for systemic primary amyloidosis. This procedure is, however, associated with substantial toxicity and mortality, particularly if the heart is involved. Refined selection of patients...

journal_title：Haematologica

authors： Perfetti V,Siena S,Palladini G,Bregni M,Di Nicola M,Obici L,Magni M,Brunetti L,Gianni AM,Merlini G

更新日期：2006-12-01 00:00:00

abstract：:A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point s...

journal_title：Haematologica

authors： Gallamini A,Barrington SF,Biggi A,Chauvie S,Kostakoglu L,Gregianin M,Meignan M,Mikhaeel GN,Loft A,Zaucha JM,Seymour JF,Hofman MS,Rigacci L,Pulsoni A,Coleman M,Dann EJ,Trentin L,Casasnovas O,Rusconi C,Brice P,Bolis

更新日期：2014-06-01 00:00:00

abstract：:The aim of the study was to define the minimal effective dose (MED) of granulocyte colony-stimulating factor (G-CSF) among five daily doses following chemotherapy for peripheral blood stem cell (PBSC) collection. Twenty-five patients were included in this double-blind dose-finding phase II study conducted according to...

journal_title：Haematologica

authors： Lefrère F,Zohar S,Bresson JL,Chevret S,Mogenet A,Audat F,Durand-Zaleski I,Ghez D,Dal Cortivo L,Piesvaux P,Cavazzana-Calvo M,Varet B

更新日期：2006-04-01 00:00:00

abstract：:The main purpose of this work is to give methodologic details and further verification regarding the predictive system recently elaborated for Hodgkin's disease (HD) patients, by which, under standard accuracy and conventional treatment, patient survival can be directly estimated (within a given confidence interval) w...

journal_title：Haematologica

authors： Gobbi PG,Gobbi PG,Mazza P,Zinzani PL

更新日期：1989-01-01 00:00:00