Abstract:
:A case of acute adult T-cell leukemia-lymphoma (ATLL) was observed in northeast Italy, presenting with fever, lymphadenomegaly, splenomegaly, hypercalcemia and renal failure. Leukaemic cells were morphologically typical, expressed a T-cell CD4+ phenotype, did not display any helper functions, and grew in vitro under supply of exogenous interleukin-2. Antibodies to human T-cell lymphotropic virus (HTLV-I) were found in the serum, and the virus was isolated from leukaemic cells. The family members who could be tested were seronegative. The patient had never travelled outside Italy, had never received blood transfusions and did not belong to any known categories at risk of viral disease transmission. Present knowledge of the epidemiology of HTLV-I infection warns that other cases of HTLV-I induced disease are expected to occur outside already recognised endemic areas. This case suggests that untraceable, presumably short-term exposures can also account for HTLV-I transmission.
journal_name
Haematologicajournal_title
Haematologicaauthors
Fanin R,Minutillo S,D'Agaro P,Raspadori D,Tassinari A,Tazzari P,Testoni N,Damiani D,Gallizia C,Michieli Msubject
Has Abstract,Author List Incompletepub_date
1990-07-01 00:00:00pages
375-80issue
4eissn
0390-6078issn
1592-8721journal_volume
75pub_type
杂志文章相关文献
HAEMATOLOGICA文献大全abstract:BACKGROUND:Transplantation from an HLA-matched sibling is the treatment of choice for young patients with acquired severe aplastic anemia. For older patients, the acceptable upper age limit for transplantation as first-line treatment varies. The current analysis, therefore, sought to identify age or ages at transplanta...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.026682
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:With the development and refinement of guidance modalities for percutaneous biopsies, many investigators have reported studies supporting the role of guided core needle biopsy in the diagnosis of mediastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core need...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract::Sixteen autologous stem cell transplant recipients received three vaccinations with conjugated haemophilus influenzae type b vaccine. Quantitative and qualitative aspects of the antibody response were studied. The vaccination schedule resulted in high antibody response rates and functional maturation of antibodies, as...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2005-11-01 00:00:00
abstract::Extramedullary (EM) disease in patients with acute myeloid leukemia (AML) is a known phenomenon. Since the prevalence of EM AML has so far only been clinically determined on examination, we performed a prospective study in patients with AML. The aim of the study was to determine the prevalence of metabolically active ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2019.223032
更新日期:2020-06-01 00:00:00
abstract::The aim of this study was to investigate the microRNA (miRNA) expression pattern in neutrophils from rheumatoid arthritis (RA) patients and its contribution to their pathogenic profile and to analyze the effect of specific autoantibodies or inflammatory components in the regulation of miRNA in RA neutrophils and its m...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.205047
更新日期:2020-09-01 00:00:00
abstract::Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...
journal_title:Haematologica
pub_type: 信件
doi:
更新日期:2006-05-01 00:00:00
abstract::Chronic graft-versus-host disease is a serious complication in long-term survivors of allogeneic hematopoietic stem cell transplantation, with several organ systems affected. Chronic graft-versus-host disease is an important cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation. This a...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.13311
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Thrombopoietin has been established as the major regulator of megakaryocyte and platelet production. In this study we evaluated the effects of PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF), a pegylated and truncated form of thrombopoietin, on the growth and dif...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Hydroxyurea (HU) is known to increase gamma-globin chain expression in postnatal life. The efficacy of HU treatment in thalassemia patients is still unclear. The aim of this study was to monitor treatment of a large cohort of patients with beta-thalassemia major in order to establish the respo...
journal_title:Haematologica
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2004-10-01 00:00:00
abstract::Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To date, the role played by T-cell receptor in the oncogenic transformation of developing T cells remains unclear. Here we...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.188359
更新日期:2018-06-01 00:00:00
abstract::Since HA-1-specific T cells have been shown to make a significant contribution to the clinical responses in patients with relapsed leukemia, we investigated the feasibility of adoptive transfer of in vitro induced HA-1-specific CD8 positive T cells to patients with relapsed leukemia after allogeneic stem cell transpla...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2011.053371
更新日期:2012-08-01 00:00:00
abstract::ALK-positive large B-cell lymphoma is a rare subtype of lymphoma, and most cases follow an aggressive clinical course with a poor prognosis. We examined an ALK-positive large B-cell lymphoma case showing an anti-ALK immunohistochemistry pattern distinct from those of 2 known ALK fusions, CLTC-ALK and NPM-ALK, for the ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2010.033514
更新日期:2011-03-01 00:00:00
abstract::The aim of this study was to identify new pathogenic variations of the UGT1A1 gene in 11 patients diagnosed with neonatal unconjugated hyperbilirubinemia. We describe two cases in which clinically unapparent heterozygotic mutations in the UGT1A1 gene may become evident in combination with certain environmental conditi...
journal_title:Haematologica
pub_type: 信件
doi:10.3324/haematol.10585
更新日期:2007-01-01 00:00:00
abstract::The erythropoietin (Epo)-erythroferrone (ERFE)-hepcidin axis coordinates erythropoiesis and iron homeostasis. While mouse studies have established that Epo-induced ERFE production represses hepcidin synthesis by inhibiting hepatic BMP/SMAD signaling, evidence for the role of ERFE in humans is limited. To investigate t...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2019.233874
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Autologous peripheral stem cell transplantation (APSCT) is increasingly used for various hematologic malignancies and solid tumors. The objective of this study was to analyze the immune reconstitution after APSCT and see if there was any correlation with diagnosis, age, type of high-dose thera...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract::The majority of responses produced in patients with low-grade lymphomas are unique among non-Hodgkin's lymphomas (NHL), and even with a more intensive chemotherapy regimen, they are only partial; the very few complete responses which are induced are usually of short duration and do not influence overall survival. Ther...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
abstract::Next-generation sequencing (NGS) has transitioned from research to clinical routine, yet the comparability of different technologies for mutation profiling remains an open question. We performed a European multicenter (n=6) evaluation of three amplicon-based NGS assays targeting 11 genes recurrently mutated in chronic...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2019.234716
更新日期:2020-04-09 00:00:00
abstract:BACKGROUND AND OBJECTIVES:A progressively growing number of peripheral blood stem cell transplants (PBSCTs) are being performed in patients with newly diagnosed multiple myeloma (MM) since they are ever more frequently being offered as up-front therapy. Furthermore, there are considerable concerns regarding the appropr...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:It has been shown that fludarabine (FLU) is superior to conventional treatment in B-CLL for rate and quality of response, leading to CR even at the molecular level. In this paper we report our preliminary results with this drug in B-CLL patients. METHODS AND PATIENTS:Twenty-seven B-CLL patients (16 refracto...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Here we critically evaluate the role of elevated hematocrit as the principal determinant of thrombotic risk in polycythemia and erythrocytosis, defined by an expansion of red cell mass. Since red cell volume determination is no longer readily available, in clinical practice, polycythemia and erythrocytosis are defined...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2018.210732
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:Perceiving the need for rigorous recommendations to facilitate decisions concerning the management of patients with multiple myeloma (MM), the Italian Society of Hematology (SIE) and the two affiliate societies (SIES and GITMO) commissioned a project to develop guidelines for the therapy of MM using evidence...
journal_title:Haematologica
pub_type: 杂志文章,实务指引,评审
doi:
更新日期:2004-06-01 00:00:00
abstract::The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic...
journal_title:Haematologica
pub_type: 共识发展会议,杂志文章
doi:10.3324/haematol.2011.056176
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Storage pool diseases (SPD) are heterogeneous disorders associated with an abnormal presence of intraplatelet granules, which cause mild to moderate bleeding diathesis. We investigated signaling through tyrosine phosphorylation of proteins occurring in platelets with total or partial absence o...
journal_title:Haematologica
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:The genetic characterization of chronic lymphocytic leukemia cells correlates with the behavior, progression and response to treatment of the disease. DESIGN AND METHODS:Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progressi...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2011.049270
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Patients with beta-thalassemia, like those with genetic hemochromatosis, develop iron overload due to increased iron absorption, and their iron burden is further exacerbated by transfusion therapy. Hepcidin, a hepatic hormone, regulates systemic iron homeostasis by inhibiting the absorption of...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.10842
更新日期:2007-05-01 00:00:00
abstract::Overhydrated hereditary stomatocytosis, clinically characterized by hemolytic anemia, is a rare disorder of the erythrocyte membrane permeability to monovalent cations, associated with mutations in the Rh-associated glycoprotein gene. We assessed the red blood cell metabolome of 4 patients with this disorder and showe...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:10.3324/haematol.2011.045179
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The nucleoside analogue fludarabine is used in the treatment of chronic lymphocytic leukemia. It triggers p53-mediated apoptosis, although the mutational status of p53 does not fully account for heterogeneity in responsiveness to treatment. The aim of this study was to identify new genes implicated in fludar...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.13186
更新日期:2008-12-01 00:00:00
abstract::Disease bulk is an important prognostic factor in early stage Hodgkin lymphoma, but its definition is unclear in the computed tomography era. This retrospective analysis investigated the prognostic significance of bulky disease measured in transverse and coronal planes on computed tomography imaging. Early stage Hodgk...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2016.141846
更新日期:2016-10-01 00:00:00
abstract::Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). The aim of this study was to define the prevalence and clinical characteristics of pediatric thrombosis in subjects with inherite...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.210666
更新日期:2019-12-01 00:00:00
abstract::Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection. Thrombocytopenia is a major and sometimes fatal complication in patients with acute leukemia. However, the mechanisms underlying defective thrombo...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.214593
更新日期:2019-10-01 00:00:00