New insights into the pathophysiology of gastrointestinal graft-versus-host disease using capsule endoscopy.

Abstract:

:We investigated gastrointestinal graft-versus-host-disease using capsule endoscopy in patients with abdominal pain and/or diarrhea. We found severe pathology involving most of the gut including loss of villi, ulcerations, narrowing, bleeding and fistula formation. In 2 patients, capsule endoscopy alone established the diagnosis of graft-versus-host-disease. Some ulcerations were associated with cytomegalovirus infection.

journal_name

Haematologica

journal_title

Haematologica

authors

Shapira M,Adler SN,Jacob H,Resnick IB,Slavin S,Or R

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

1003-4

issue

7

eissn

0390-6078

issn

1592-8721

journal_volume

90

pub_type

信件
  • Discrepant sensitivity of thromboplastin reagents to clotting factor levels explored by the prothrombin time in patients on stable oral anticoagulant treatment: impact on the international normalized ratio system.

    abstract:BACKGROUND AND OBJECTIVES:We tested the principle of local International Normalized Ratio (INR) calibration using INR calibrator plasmas (PT Calibration Plasma Kit, Behring), two thomboplastin reagents (Neoplastin plus, rabbit brain, Stago, and Recombiplastin, recombinant human tissue factor, Ortho Diagnostics) and the...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Testa S,Morstabilini G,Fattorini A,Galli L,Denti N,D'Angelo A

    更新日期:2002-12-01 00:00:00

  • Phenotype in combination with genotype improves outcome prediction in acute myeloid leukemia: a report from Children's Oncology Group protocol AAML0531.

    abstract::Diagnostic biomarkers can be used to determine relapse risk in acute myeloid leukemia, and certain genetic aberrancies have prognostic relevance. A diagnostic immunophenotypic expression profile, which quantifies the amounts of distinct gene products, not just their presence or absence, was established in order to imp...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3324/haematol.2017.169029

    authors: Voigt AP,Brodersen LE,Alonzo TA,Gerbing RB,Menssen AJ,Wilson ER,Kahwash S,Raimondi SC,Hirsch BA,Gamis AS,Meshinchi S,Wells DA,Loken MR

    更新日期:2017-12-01 00:00:00

  • Competing-risk outcomes after hematopoietic stem cell transplantation from the perspective of time-dependent effects.

    abstract::The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analy...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2017.183012

    authors: Fuerst D,Frank S,Mueller C,Beelen DW,Schetelig J,Niederwieser D,Finke J,Bunjes D,Kröger N,Neuchel C,Tsamadou C,Schrezenmeier H,Beyersmann J,Mytilineos J

    更新日期:2018-09-01 00:00:00

  • Cytokines in combination to treat radiation-induced myelosuppresssion: evaluation of SCF + glycosylated EPO + pegylated G-CSF as an emergency treatment in highly irradiated monkeys.

    abstract::Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to gran...

    journal_title:Haematologica

    pub_type: 信件

    doi:10.3324/haematol.12183

    authors: Drouet M,Delaunay C,Grenier N,Garrigou P,Mayol JF,Hérodin F

    更新日期:2008-03-01 00:00:00

  • High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura.

    abstract::To evaluate the effects of high-dose dexamethasone (HD-DXM) on the balance of interleukin-18 (IL-18) and its endogenous antagonist IL-18 binding protein (IL-18BP) in ITP patients, IL-18, IL-18BP as well as IFN-gamma, IL-4 plasma levels and platelet counts were determined in 17 ITP patients receiving DXM 40 mg/day for ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2009.007708

    authors: Shan NN,Zhu XJ,Wang Q,Wang CY,Qin P,Peng J,Hou M

    更新日期:2009-11-01 00:00:00

  • Treosulfan-based conditioning regimen for children and adolescents with hemophagocytic lymphohistiocytosis.

    abstract::In hematopoietic stem cell transplantation for hemophagocytic lymphohistiocytosis, high transplant-related mortality after busulfan-based myeloablative regimens has been observed. Conditioning regimens with reduced toxicity based on melphalan or treosulfan are promising alternatives. We retrospectively analyzed hemato...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:10.3324/haematol.2013.094730

    authors: Lehmberg K,Albert MH,Beier R,Beutel K,Gruhn B,Kröger N,Meisel R,Schulz A,Stachel D,Woessmann W,Janka G,Müller I

    更新日期:2014-01-01 00:00:00

  • The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells.

    abstract:BACKGROUND:Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and survival. DESIGN AND ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2009.013847

    authors: Stamatopoulos B,Meuleman N,De Bruyn C,Delforge A,Bron D,Lagneaux L

    更新日期:2010-07-01 00:00:00

  • Cost analysis of common treatment options for indolent follicular non-Hodgkin's lymphoma.

    abstract:BACKGROUND AND OBJECTIVES:We assessed direct health care costs associated with the most commonly prescribed treatments for indolent follicular non-Hodgkin's lymphoma (FL). DESIGN AND METHODS:New and previously diagnosed FL patients (>or=18 years) known during 1997-1998 to 15 Dutch hospitals were selected for inclusion...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: van Agthoven M,Kramer MH,Sonneveld P,van der Hem KG,Huijgens PC,Wijermans PW,Kluin-Nelemans HC,Schaafsma MR,Biesma DH,Mattijssen V,Uyl-de Groot CA,Hagenbeek A

    更新日期:2005-10-01 00:00:00

  • Aberrant expression of microRNA in polycythemia vera.

    abstract:BACKGROUND:Polycythemia vera is a clonal hematopoietic stem cell disorder in which the JAK2 V617F mutation is observed in >95% of patients, but an as yet unidentified process appears to initiate the clonal expansion of hematopoiesis. Because microRNA regulate hematopoietic differentiation, we hypothesized that dysregul...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.12706

    authors: Bruchova H,Merkerova M,Prchal JT

    更新日期:2008-07-01 00:00:00

  • Interferon alpha plus intermittent oral Ara-C ocfosfate (YNK-01) in chronic myeloid leukemia primarily resistant or with minimal cytogenetic response to interferon.

    abstract:BACKGROUND AND OBJECTIVES:Subcutaneous Ara-C plus interferon (IFN) produces more cytogenetic responses than IFN in chronic myeloid leukemia (CML) but a greater toxicity. The objective of this study was to determine the efficacy and tolerance of IFN plus oral Ara-C ocfosfate (YNK-01) in IFN-resistant CML patients. DESI...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Cervantes F,Sureda A,Hernández-Boluda JC,Martino R,Brunet S,Borrego D,Antich JL,Montserrat E

    更新日期:2001-12-01 00:00:00

  • Treatment of childhood acute lymphoblastic leukemia. Long-term results of the AIEOP-ALL 87 study.

    abstract:BACKGROUND AND OBJECTIVES:In March 1987 AIEOP started the AIEOP-ALL-87 study, based on the previous AIEOP-ALL-82. The aim of this new study was to evaluate, for all risk groups: a) the efficacy of treatment intensification achieved by adding a fourth drug (daunomycin) in the induction phase and a 3-drug reinduction pha...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Paolucci G,Vecchi V,Favre C,Miniero R,Madon E,Pession A,Rondelli R,De Rossi G,Lo Nigro L,Porta F,Santoro N,Indolfi P,Basso G,Conter V,Aricò M,Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP).

    更新日期:2001-05-01 00:00:00

  • HTLV-I positive adult T-cell leukaemia-lymphoma: report of a typical case from Italy.

    abstract::A case of acute adult T-cell leukemia-lymphoma (ATLL) was observed in northeast Italy, presenting with fever, lymphadenomegaly, splenomegaly, hypercalcemia and renal failure. Leukaemic cells were morphologically typical, expressed a T-cell CD4+ phenotype, did not display any helper functions, and grew in vitro under s...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Fanin R,Minutillo S,D'Agaro P,Raspadori D,Tassinari A,Tazzari P,Testoni N,Damiani D,Gallizia C,Michieli M

    更新日期:1990-07-01 00:00:00

  • Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study.

    abstract::Cough mixture abuse has been reported to cause severe folate deficiency and neurological defects. We carried out a prospective case-controlled survey to confirm this association and define the incidence and severity of the problem. A total of 57 cough mixture abusers and 47 other substance abusers (controls) were stud...

    journal_title:Haematologica

    pub_type: 信件

    doi:10.3324/haematol.10859

    authors: Au WY,Tsang SK,Cheung BK,Siu TS,Ma ES,Tam S

    更新日期:2007-04-01 00:00:00

  • In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia.

    abstract:BACKGROUND AND OBJECTIVES:Oxidant damage is an important contributor to the premature destruction of erythrocytes and anemia in thalassemias. To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of huma...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: de Franceschi L,Turrini F,Honczarenko M,Ayi K,Rivera A,Fleming MD,Law T,Mannu F,Kuypers FA,Bast A,van der Vijgh WJ,Brugnara C

    更新日期:2004-11-01 00:00:00

  • Autologous transplantation in multiple myeloma: a GITMO retrospective analysis on 290 patients. Gruppo Italiano Trapianti di Midollo Osseo.

    abstract:BACKGROUND AND OBJECTIVE:Autologous transplantation is a better treatment for multiple myeloma (MM) than chemotherapy, but uncertainty remains about patient selection, optimal timing of autograft, conditioning regimen, need for a second autograft, and role of maintenance. To provide partial answers to these questions w...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Majolino I,Vignetti M,Meloni G,Vegna ML,Scimè R,Tringali S,Amaddii G,Coser P,Tribalto M,Raimondi R,Bergonzi C,Sajeva MR,Sica S,Ferrando F,Messina G,Mandelli F

    更新日期:1999-09-01 00:00:00

  • Comparison of CD38 antibodies in vitro and ex vivo mechanisms of action in multiple myeloma.

    abstract::Not available. ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2020.268656

    authors: Kinder M,Bahlis NJ,Malavasi F,De Goeij B,Babich A,Sendecki J,Rusbuldt J,Bellew K,Kane C,Van de Donk NWCJ

    更新日期:2021-01-14 00:00:00

  • Mantle cell lymphoma: a retrospective study on 27 patients. Clinical features and natural history.

    abstract:BACKGROUND AND OBJECTIVE:Mantle cell lymphoma (MCL) is a separate histological and clinical entity recently recognized in the new revised European-American Lymphoma Classification. Little information exists regarding its therapy. We report the results of a retrospective study of 27 patients affected by MCL evaluating t...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Bertini M,Rus C,Freilone R,Botto B,Calvi R,Novero D,Orsucci L,Vitolo U,Palestro G,Resegotti L

    更新日期:1998-04-01 00:00:00

  • In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent.

    abstract::Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy derived from plasmacytoid dendritic cells. There is currently no accepted standard of care for treating this neoplasm, and therapeutic strategies have never been prospectively evaluated. Since blastic plasmacytoid dendritic cell neoplasm cells ex...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2014.111740

    authors: Angelot-Delettre F,Roggy A,Frankel AE,Lamarthee B,Seilles E,Biichle S,Royer B,Deconinck E,Rowinsky EK,Brooks C,Bardet V,Benet B,Bennani H,Benseddik Z,Debliquis A,Lusina D,Roussel M,Solly F,Ticchioni M,Saas P,Garna

    更新日期:2015-02-01 00:00:00

  • Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone.

    abstract:BACKGROUND AND OBJECTIVES:The efficacy and safety of added dexamethasone were assessed in patients with relapsed and/or refractory multiple myeloma who had a suboptimal response to bortezomib alone. DESIGN AND METHODS:In two previously reported, open-label, multicenter phase 2 studies, bortezomib 1.0 or 1.3 mg/m2 was ...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Jagannath S,Richardson PG,Barlogie B,Berenson JR,Singhal S,Irwin D,Srkalovic G,Schenkein DP,Esseltine DL,Anderson KC,SUMMIT\/CREST Investigators.

    更新日期:2006-07-01 00:00:00

  • Mitoxantrone, etoposide, cisplatin and dexamethasone (MEPD) as salvage chemotherapy in resistant non-Hodgkin's lymphoma.

    abstract:BACKGROUND:An effective second-line treatment for intermediate and high grade non-Hodgkin's lymphoma is greatly needed since 30% of patients do not achieved complete remission (CR) and another 20% to 30% of the CRs will eventually relapse. METHODS:A four-drug combination with Mitoxantrone, Etoposide, Cisplatin and Dex...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Vitolo U,Orsucci L,Bertini M,Cavallero G,Gallamini A,Ghio R,Levis A,Rota-Scalabrini D,Resegotti L

    更新日期:1991-01-01 00:00:00

  • Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia.

    abstract::Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearranged leukemia by CRISPR-Cas9 mediated deletion of MN1. MN1 was require...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.211201

    authors: Sharma A,Jyotsana N,Gabdoulline R,Heckl D,Kuchenbauer F,Slany RK,Ganser A,Heuser M

    更新日期:2020-05-01 00:00:00

  • Concomitant aberrant overexpression of RUNX1 and NCAM in regenerating bone marrow of myeloid leukemia of Down's syndrome.

    abstract:BACKGROUND AND OBJECTIVES:Myeloid leukemia of Down's syndrome (ML-DS) has characteristic biological features (e.g. expression of the truncated GATA1s), which are different from those of non-DS childhood acute myeloid leukemias (AML). The objective of this study was to investigate factors predisposing to the development...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Langebrake C,Klusmann JH,Wortmann K,Kolar M,Puhlmann U,Reinhardt D

    更新日期:2006-11-01 00:00:00

  • CAV chemotherapy (CCNU, melphalan, etoposide) as salvage treatment for relapsing or resistant Hodgkin's disease.

    abstract::Twenty-five adult patients with resistant or early relapsing Hodgkin's disease have been treated with CAV combination chemotherapy (CCNU, melphalan and etoposide). All patients had previously received both MOPP and ABVD regimens (23 patients as primary therapy and two as first salvage). High-energy radiotherapy had be...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Brusamolino E,Castelli G,Pagnucco G,Orlandi E,Malagó D,Lazzarino M,Bernasconi C

    更新日期:1990-07-01 00:00:00

  • Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines.

    abstract::We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent...

    journal_title:Haematologica

    pub_type: 信件

    doi:10.3324/haematol.10874

    authors: Jácomo RH,Melo RA,Souto FR,de Mattos ER,de Oliveira CT,Fagundes EM,Bittencourt HN,Bittencourt RI,Bortolheiro TC,Paton EJ,Bendlin R,Ismael S,Chauffaille Mde L,Silva D,Pagnano KB,Ribeiro R,Rego EM

    更新日期:2007-10-01 00:00:00

  • Primary lymphoma of the vagina. A case report.

    abstract::Primary vaginal non-Hodgkin lymphoma is really uncommon and may be misdiagnosed as inflammatory disease or solid cancer, so careful diagnostic procedures are needed, particularly as far as pathological and immunocytochemical evaluation is concerned. Most of these lymphomas present with follicular patterns and limited ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Lonardi F,Ferrari V,Pavanato G,Bonciarelli G,Jirillo A,Balli M

    更新日期:1994-03-01 00:00:00

  • Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis.

    abstract::Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deformability and there is marked heterogeneity in disease severity among patients. To ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.188151

    authors: Huisjes R,Makhro A,Llaudet-Planas E,Hertz L,Petkova-Kirova P,Verhagen LP,Pignatelli S,Rab MAE,Schiffelers RM,Seiler E,van Solinge WW,Corrons JV,Kaestner L,Mañú-Pereira M,Bogdanova A,van Wijk R

    更新日期:2020-01-31 00:00:00

  • Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features.

    abstract::In childhood B-cell precursor acute lymphoblastic leukemia, cytogenetics is important in diagnosis and as an indicator of response to therapy, thus playing a key role in risk stratification of patients for treatment. Little is known of the relationship between different cytogenetic subtypes in B-cell precursor acute l...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3324/haematol.2013.085175

    authors: Schwab CJ,Chilton L,Morrison H,Jones L,Al-Shehhi H,Erhorn A,Russell LJ,Moorman AV,Harrison CJ

    更新日期:2013-07-01 00:00:00

  • CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL.

    abstract:UNLABELLED:BACKGROUND Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34(+) stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem cells has previously been impractical because of the sca...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2011.056705

    authors: Fischer U,Ruckert C,Hubner B,Eckermann O,Binder V,Bakchoul T,Schuster FR,Merk S,Klein HU,Führer M,Dugas M,Borkhardt A

    更新日期:2012-09-01 00:00:00

  • Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia.

    abstract::Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection. Thrombocytopenia is a major and sometimes fatal complication in patients with acute leukemia. However, the mechanisms underlying defective thrombo...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.214593

    authors: Gao A,Gong Y,Zhu C,Yang W,Li Q,Zhao M,Ma S,Li J,Hao S,Cheng H,Cheng T

    更新日期:2019-10-01 00:00:00

  • CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting.

    abstract::Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the leukemic stem cells responsible for disease maintenance and relapse upon drug cessation. Herein, we p...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2017.169946

    authors: Landberg N,von Palffy S,Askmyr M,Lilljebjörn H,Sandén C,Rissler M,Mustjoki S,Hjorth-Hansen H,Richter J,Ågerstam H,Järås M,Fioretos T

    更新日期:2018-03-01 00:00:00