Resolution of bone marrow fibrosis in a patient receiving JAK1/JAK2 inhibitor treatment with ruxolitinib.

abstract：BACKGROUND:MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma. DESIGN AND METHODS:MicroRNA profiles of enriched follicular lymphoma tumor cells from 16 patients were generated by assaying 851 human micr...

journal_title：Haematologica

authors： Wang W,Corrigan-Cummins M,Hudson J,Maric I,Simakova O,Neelapu SS,Kwak LW,Janik JE,Gause B,Jaffe ES,Calvo KR

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Alterations in hemostasis have frequently been observed in patients with leukemia, and thrombotic events are well documented in patients receiving L-asparaginase (ASP) as a single agent or in combination with vincristine, prednisone (sometimes complemented by an anthracycline). The present study was designed...

journal_title：Haematologica

authors： Nowak-Göttl U,Werber G,Ziemann D,Ahlke E,Boos J

更新日期：1996-03-01 00:00:00

abstract：:We describe the case of a 12-year old boy with Hoyeraal-Hreidarsson Syndrome (HHS). This syndrome includes intrauterine growth retardation, microcephaly, mental retardation, cerebellar malformation, and pancytopenia. HHS is a severe multisystem disorder associated with premature mortality, due to bone marrow failure. ...

journal_title：Haematologica

authors： Ozdemir MA,Karakukcu M,Kose M,Kumandas S,Gumus H

更新日期：2004-09-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) patients frequently display NOTCH1 activating mutations and Notch can transcriptionally down-regulate the tumor suppressor PTEN. However, it is not clear whether NOTCH1 mutations associate with decreased PTEN expression in primary T-ALL. Here, we compared patients with or wi...

journal_title：Haematologica

authors： Silva A,Jotta PY,Silveira AB,Ribeiro D,Brandalise SR,Yunes JA,Barata JT

更新日期：2010-04-01 00:00:00

abstract：:Interleukin-10 failed to modify either the percentage of bcl-2+ cells or the number of bcl-2 molecules, or to reduce 2-chlorodeoxyadenosine- and fludarabine-induced apoptosis. The cytokine at 0.1 ng/mL induced an increase of cell survival both in the absence or in the presence of 2-chlorodeoxyadenosine, while no diffe...

journal_title：Haematologica

authors： Morabito F,Filangeri M,Sculli G,Oliva B

更新日期：1998-11-01 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) complex 1 is a central integrator of nutrient and growth factor inputs that controls cell growth in eukaryotes. The second generation of mTOR kinase inhibitors (TORKi), directly targeting the mTOR catalytic site, are more effective than rapamycin and its analogs in cancer treatme...

journal_title：Haematologica

authors： Bi C,Zhang X,Lu T,Zhang X,Wang X,Meng B,Zhang H,Wang P,Vose JM,Chan WC,McKeithan TW,Fu K

更新日期：2017-04-01 00:00:00

abstract：:We studied the immune function of 33 long-term survivors of thalassemia after hematopoietic stem cell transplantation. Lymphocyte subsets, lymphoproliferative response and immunoglobulin were normal but the level of natural killer cells was low. Five and seven patients had suboptimal antibody response at 4 week after ...

journal_title：Haematologica

authors： Li CK,Leung TF,Chan PK,Chick KW,Lee V,Cheung AY

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:All-trans retinoic acid (ATRA) induces growth arrest and apoptosis in acute myeloblastic leukemia (AML) cells. Since cellular redox state regulates these events, we were interested in studying whether it has any role in the responsiveness of AML cells to ATRA. DESIGN AND METHODS:Two human AML ...

journal_title：Haematologica

authors： Mäntymaa P,Guttorm T,Siitonen T,Säily M,Savolainen ER,Levonen AL,Kinnula V,Koistinen P

更新日期：2000-03-01 00:00:00

abstract：:Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated whether BM MM endothelial cells (MMECs) control disease progression vi...

journal_title：Haematologica

authors： Solimando AG,Da Vià MC,Leone P,Borrelli P,Croci GA,Tabares P,Brandl A,Di Lernia G,Bianchi FP,Tafuri S,Steinbrunn T,Balduini A,Melaccio A,De Summa S,Argentiero A,Rauert-Wunderlich H,Frassanito MA,Ditonno P,Henke E,Kl

更新日期：2020-04-30 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Parvovirus B19 has a marked tropism for erythroid progenitor cells and this may lead to chronic anemia in predisposed individuals. It was the purpose of the present study to investigate prospectively the frequency of parvovirus B19 infections in patients with a diagnosis of chronic anemia. MET...

journal_title：Haematologica

authors： Heegaard ED,Myhre J,Hornsleth A,Gundestrup M,Boye H

更新日期：1997-07-01 00:00:00

abstract：:Ten consecutive patients (pts), suffering from hematological malignancies (5 NHL, 3 ANLL and 2 HD), received high doses of radio-chemotherapy and autologous peripheral blood stem cell (PBSC) transplantation. Seven of them were in 1st CR, two in 3rd CR and one in refractory status. The recruitment of PBSC was performed...

journal_title：Haematologica

authors： Fioritoni G,Iacone A,D'Antonio D,Dragani A,Quaglietta AM,Accorsi P,Angelini A,Spadano A,Natale D,Berardi A

更新日期：1990-01-01 00:00:00

abstract：:We report results of a phase II trial of combination of melphalan, lenalidomide, and dexamethasone for the treatment of immunoglobulin light chain (AL) amyloidosis. The primary objectives were tolerability and hematologic response rate; secondary objectives were organ responses and survival. Treatment protocol consist...

journal_title：Haematologica

authors： Sanchorawala V,Patel JM,Sloan JM,Shelton AC,Zeldis JB,Seldin DC

更新日期：2013-05-01 00:00:00

abstract：:A case of acute adult T-cell leukemia-lymphoma (ATLL) was observed in northeast Italy, presenting with fever, lymphadenomegaly, splenomegaly, hypercalcemia and renal failure. Leukaemic cells were morphologically typical, expressed a T-cell CD4+ phenotype, did not display any helper functions, and grew in vitro under s...

journal_title：Haematologica

authors： Fanin R,Minutillo S,D'Agaro P,Raspadori D,Tassinari A,Tazzari P,Testoni N,Damiani D,Gallizia C,Michieli M

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Allogeneic stem cell transplantation is a potentially curative treatment for myelofibrosis, although its use is limited by a high rate of transplant-related mortality. In this study, we evaluated the outcome of patients with myelofibrosis who underwent allogeneic stem cell transplantation, and the impact of ...

journal_title：Haematologica

authors： Patriarca F,Bacigalupo A,Sperotto A,Isola M,Soldano F,Bruno B,van Lint MT,Iori AP,Santarone S,Porretto F,Pioltelli P,Visani G,Iacopino P,Fanin R,Bosi A,GITMO.

更新日期：2008-10-01 00:00:00

abstract：:The characteristics of 14 HIV-seropositive patients with NHL consecutively observed between 1984 and 1988 at our Institution are described. Patients belonged to a known population of 1242 HIV-seropositive individuals in whom the incidence of NHL was 1.13%, significantly higher than in age-matched controls (P less than...

journal_title：Haematologica

authors： Rossi G,Cadeo G,Stellini R,Zorzi F,Favret M,Sueri L,Carosi G,Mariano M,Marinone G

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:The purpose of our cooperative trial was to investigate whether epirubicin (EPI) at 90 mg/m2 in a CHOP-like combination (called CEOP) could increase complete response (CR) and survival rates in non-Hodgkin lymphoma (NHL) patients while maintaining a tolerable degree of toxicity. METHODS:Between September 19...

journal_title：Haematologica

authors： Lambertenghi Deliliers G,Butti C,Baldini L,Ceriani A,Lombardi F,Luoni M,Montalbetti L,Pavia G,Pinotti G,Pogliani E

更新日期：1995-07-01 00:00:00

abstract：:One hundred patients with newly diagnosed multiple myeloma (MM) were treated with high-dose chemotherapy followed by single or double autologous stem cell transplantation (ASCT). Up-front treatment with a double ASCT tended to prolong progression-free and overall survival. ...

journal_title：Haematologica

authors： Putkonen M,Rauhala A,Itälä M,Kauppila M,Pelliniemi TT,Remes K

更新日期：2005-04-01 00:00:00

abstract：:Diffuse large B-cell lymphoma can be classified by gene expression profiling into germinal center and activated B-cell subtypes with different prognoses after rituximab-CHOP. The importance of previously recognized prognostic markers, such as Bcl-2 protein expression and BCL2 gene abnormalities, has been questioned in...

journal_title：Haematologica

authors： Visco C,Tzankov A,Xu-Monette ZY,Miranda RN,Tai YC,Li Y,Liu WM,d'Amore ES,Li Y,Montes-Moreno S,Dybkær K,Chiu A,Orazi A,Zu Y,Bhagat G,Wang HY,Dunphy CH,His ED,Zhao XF,Choi WW,Zhao X,van Krieken JH,Huang Q,Ai W

更新日期：2013-02-01 00:00:00

abstract：:The mammalian target of rapamycin plays an important role in multiple myeloma. The allosteric mammalian target of rapamycin inhibitor everolimus has long been approved for immunosuppression and has shown activity in certain cancers. This investigator-initiated phase I trial explored the use of everolimus in relapsed a...

journal_title：Haematologica

authors： Günther A,Baumann P,Burger R,Kellner C,Klapper W,Schmidmaier R,Gramatzki M

更新日期：2015-04-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) levels have been tested in patients with chronic relative polycythemia (RP), polycythemia vera, and in healthy subjects in order to find a possible underlying pathophysiological mechanism for relative polycythemia. No difference in statistical significance has been found between the me...

journal_title：Haematologica

authors： Cohen AM,Gelvan A,Winaver J,Kahna L,Floru S,Djaldetti M

更新日期：1989-07-01 00:00:00

abstract：:Perforin gene (PRF1) mutations cause the primary form of hemophagocytic lymphohistiocytosis (HLH). We report a genetic defect of PRF1 in a 62-year-old Japanese man with recurrent episodes of HLH. Sequencing of PRF1 from both peripheral blood mononuclear cells and nail clippings showed compound heterozygous mutation, i...

journal_title：Haematologica

authors： Nagafuji K,Nonami A,Kumano T,Kikushige Y,Yoshimoto G,Takenaka K,Shimoda K,Ohga S,Yasukawa M,Horiuchi H,Ishii E,Harada M

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:How to reach the correct diagnosis of a lymph node enlargement is still a problem which strongly challenges the knowledge and experience of the clinician. Organized and specifically oriented literature on the right sequential steps and the logical criteria that should guide this diagnostic appr...

journal_title：Haematologica

authors： Ghirardelli ML,Jemos V,Gobbi PG

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Most minimal residual disease-directed treatment interventions in current treatment protocols for acute lymphoblastic leukemia are based on bone marrow testing, which is a consequence of previous studies showing the superiority of bone marrow over peripheral blood as an investigational material. Those studie...

journal_title：Haematologica

authors： Volejnikova J,Mejstrikova E,Valova T,Reznickova L,Hodonska L,Mihal V,Sterba J,Jabali Y,Prochazkova D,Blazek B,Hak J,Cerna Z,Hrusak O,Stary J,Trka J,Fronkova E

更新日期：2011-12-01 00:00:00

abstract：:We conducted a phase I/II multicenter trial using 6 cycles of brentuximab vedotin (BV) in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for treatment of patients with CD30-positive (+) B-cell lymphomas. Thirty-one patients were evaluable for toxicity and 29 for efficacy including 22...

journal_title：Haematologica

authors： Svoboda J,Bair SM,Landsburg DJ,Nasta SD,Nagle SJ,Barta SK,Khan N,Filicko-O'Hara J,Gaballa S,Strelec L,Chong E,Mitnick S,Waite TS,King C,Ballard H,Youngman M,Gerson J,Plastaras JP,Maity A,Bogusz AM,Hung SS,Nakamu

更新日期：2020-05-15 00:00:00

abstract：:Interactions between chronic lymphocytic leukemia (CLL) B cells and the bone marrow (BM) microenvironment play a major function in the physiopathology of CLL. Extracellular vesicles (EVs), which are composed of exosomes and microparticles, play an important role in cell communication. However, little is known about th...

journal_title：Haematologica

authors： Crompot E,Van Damme M,Pieters K,Vermeersch M,Perez-Morga D,Mineur P,Maerevoet M,Meuleman N,Bron D,Lagneaux L,Stamatopoulos B

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Diffuse large B-cell lymphomas (DLBCL) have a variable outcome, and powerful methods of prognostication are needed in order to choose the best treatment for each patient. Immunophenotypic classification of the tumor as germinal center (GC) or non-germinal center-like (nGC) and early response e...

journal_title：Haematologica

authors： Dupuis J,Gaulard P,Hemery F,Itti E,Gisselbrecht C,Rahmouni A,Copie-Bergman C,Brière J,El Gnaoui T,Gaillard I,Meignan M,Haioun C

更新日期：2007-06-01 00:00:00

abstract：:The prognosis of patients with acute myeloid leukemia in whom primary treatment fails remains very poor. In order to improve such patients' outcome, we conducted a phase 2, prospective, multicenter trial to test the feasibility of a new sequential regimen, combining a short course of intensive chemotherapy and a reduc...

journal_title：Haematologica

authors： Mohty M,Malard F,Blaise D,Milpied N,Socié G,Huynh A,Reman O,Yakoub-Agha I,Furst S,Guillaume T,Tabrizi R,Vigouroux S,Peterlin P,El-Cheikh J,Moreau P,Labopin M,Chevallier P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS:We studied 23 patients with PNH, before and after five and 11 weeks of treatment with eculizumab. We examined markers of thrombin generation and reactional fibrinolysis...

journal_title：Haematologica

authors： Helley D,de Latour RP,Porcher R,Rodrigues CA,Galy-Fauroux I,Matheron J,Duval A,Schved JF,Fischer AM,Socié G,French Society of Hematology.

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Assays to evaluate platelet function are often interchangeably used to assess "resistance" to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin. DESIGN AND METHODS:Platelet function was evaluated in 162 subjects, 85 of whom were not being treated with any ...

journal_title：Haematologica

authors： Renda G,Zurro M,Malatesta G,Ruggieri B,De Caterina R

更新日期：2010-12-01 00:00:00

abstract：:Histone methylation and demethylation regulate B-cell development, and their deregulation correlates with tumor chemoresistance in diffuse large B-cell lymphoma, limiting cure rates. Since histone methylation status correlates with disease aggressiveness and relapse, we investigated the therapeutic potential of inhibi...

journal_title：Haematologica

authors： Mathur R,Sehgal L,Havranek O,Köhrer S,Khashab T,Jain N,Burger JA,Neelapu SS,Davis RE,Samaniego F

更新日期：2017-02-01 00:00:00