Cytokines in combination to treat radiation-induced myelosuppresssion: evaluation of SCF + glycosylated EPO + pegylated G-CSF as an emergency treatment in highly irradiated monkeys.

abstract：BACKGROUND AND OBJECTIVES:Autologous stem cell transplantation (ASCT) is currently being evaluated as a therapy for patients with multiple sclerosis (MS). We report the results of a phase II trial to evaluate feasibility and toxicity of CD34+ selected ASCT (CD34+/ASCT) and treatment results at one year of follow-up. D...

journal_title：Haematologica

authors： Carreras E,Saiz A,Marín P,Martínez C,Rovira M,Villamor N,Aymerich M,Lozano M,Fernández-Avilés F,Urbano-Izpizua A,Montserrat E,Graus F

更新日期：2003-03-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) can be administered after a peripheral blood stem cell transplantation with the aim of accelerating neutrophil recovery. In a randomized, single-blind study we studied a new administration schedule of G-CSF in this context. ...

journal_title：Haematologica

authors： Piccirillo N,De Matteis S,Sorà F,d'Onofrio G,Leone G,Sica S

更新日期：2004-09-01 00:00:00

abstract：:Not available. ...

journal_title：Haematologica

authors： Tanaka Y,Yeoh AEJ,Moriyama T,Li CK,Kudo K,Arakawa Y,Buaboonnam J,Zhang H,Liu HC,Ariffin H,Chen Z,Kham SKY,Nishii R,Hasegawa D,Fujimura J,Keino D,Kondoh K,Sato A,Ueda T,Yamamoto M,Taneyama Y,Hino M,Takagi M,O

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND AND OBJECTIVE:A prospective study to evaluate the role of fludarabine alone or in combination with idarubicin in untreated patients with mantle cell lymphoma (MCL). DESIGN AND METHODS:Twenty-nine untreated patients with mantle cell lymphoma were stochastically treated with intravenous fludarabine at a dose ...

journal_title：Haematologica

authors： Zinzani PL,Magagnoli M,Moretti L,Battista R,Ronconi F,De Renzo A,Zaccaria A,Gentilini P,Guardigni L,Gherlinzoni F,Cellini C,Fattori PP,Bendandi M,Bocchia M,Aitini E,Tura S

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T)...

journal_title：Haematologica

authors： Kracht T,Schrappe M,Strehl S,Reiter A,Elsner HA,Trka J,Cario G,Viehmann S,Harbott J,Borkhardt A,Metzler M,Langer T,Repp R,Marschalek R,Welte K,Haas OA,Stanulla M

更新日期：2004-12-01 00:00:00

abstract：:Plasma transfusion is indicated for replenishment of coagulative proteins to stop or prevent bleeding. In 2014, the Netherlands switched from using ~300mL fresh frozen plasma (FFP) units to using 200mL Omniplasma, a solvent/detergent treated pooled plasma (SD plasma), units. We evaluated the effect of the introduction...

journal_title：Haematologica

authors： Saadah NH,Schipperus MR,Wiersum-Osselton JC,van Kraaij MG,Caram-Deelder C,Beckers EAM,Leyte A,Rondeel JMM,de Vooght KMK,Weerkamp F,Zwaginga JJ,van der Bom JG

更新日期：2020-04-01 00:00:00

abstract：:The erythropoietin (Epo)-erythroferrone (ERFE)-hepcidin axis coordinates erythropoiesis and iron homeostasis. While mouse studies have established that Epo-induced ERFE production represses hepcidin synthesis by inhibiting hepatic BMP/SMAD signaling, evidence for the role of ERFE in humans is limited. To investigate t...

journal_title：Haematologica

authors： Robach P,Gammella E,Recalcati S,Girelli D,Castagna A,Roustit M,Lundby C,Lundby AK,Bouzat P,Vergès S,Séchaud G,Banco P,Uhr M,Cornu C,Sallet P,Cairo G

更新日期：2021-02-01 00:00:00

abstract：:Multiple myeloma causes major morbidity resulting from osteolytic lesions that can be detected by metastatic bone surveys. Magnetic resonance imaging and positron emission tomography can detect bone marrow focal lesions long before development of osteolytic lesions. Using data from patients enrolled in Total Therapy 3...

journal_title：Haematologica

authors： Waheed S,Mitchell A,Usmani S,Epstein J,Yaccoby S,Nair B,van Hemert R,Angtuaco E,Brown T,Bartel T,McDonald J,Anaissie E,van Rhee F,Crowley J,Barlogie B

更新日期：2013-01-01 00:00:00

abstract：:The diversity of the human leukocyte antigen (HLA) class I and II alleles can be simplified by consolidating them into fewer supertypes based on functional or predicted structural similarities in epitope-binding grooves of HLA molecules. We studied the impact of matched and mismatched HLA-A (265 versus 429), -B (230 v...

journal_title：Haematologica

authors： Lazaryan A,Wang T,Spellman SR,Wang HL,Pidala J,Nishihori T,Askar M,Olsson R,Oudshoorn M,Abdel-Azim H,Yong A,Gandhi M,Dandoy C,Savani B,Hale G,Page K,Bitan M,Reshef R,Drobyski W,Marsh SG,Schultz K,Müller CR,Fer

更新日期：2016-10-01 00:00:00

abstract：:To date, few mutations associated with a dominant quantitative deficiency of von Willebrand factor (VWF) and a high penetrance have been reported. This phenotype was confirmed in seven unrelated families of several patients diagnosed with von Willebrand's disease out of 70 who requested genetic studies of the VWF gene...

journal_title：Haematologica

authors： Casaña P,Cabrera N,Haya S,Cid AR,Aznar JA

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The diagnosis of T-cell neoplasia requires the use of immunohistochemistry on tumor sections or molecular genetic analysis of T-cell receptor (TCR) clonality. Multiplex polymerase chain reactions (PCR) offer a sensitive and expeditious approach to determining clonality early in the diagnostic ...

journal_title：Haematologica

authors： Dictor M,Warenholt J,Isinger A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To assess the efficacy and the toxic profile of gemcitabine, a novel pyrimidine antimetabolite active against several solid tumors, we carried out a study in heavily pretreated Hodgkin's disease (HD) patients. DESIGN AND METHODS:From May 1997 to January 1999, 14 pretreated patients (10 relaps...

journal_title：Haematologica

authors： Zinzani PL,Bendandi M,Stefoni V,Albertini P,Gherlinzoni F,Tani M,Piccaluga PP,Tura S

更新日期：2000-09-01 00:00:00

abstract：:Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene expression programs. These programs are stabilized by the epigenetic a...

journal_title：Haematologica

authors： Herkt SC,Kuvardina ON,Herglotz J,Schneider L,Meyer A,Pommerenke C,Salinas-Riester G,Seifried E,Bonig H,Lausen J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The association between lymphoproliferative disease and AIDS is now well known, but only non-Hodgkin's lymphomas (LNH) are surely related to HIV infection. Hodgkin's disease (HD) occurs rarely in HIV seropositives, so it is impossible to establish a connection between AIDS and this neoplasm. METHODS AND RES...

journal_title：Haematologica

authors： Novati S,Malfitano A,Sacchi P,Patruno SF,Tornari PM,Rondanelli EG

更新日期：1993-01-01 00:00:00

abstract：:Granulocyte activation parameters have been described in patients with myeloproliferative disorders (MPD). We have evaluated the accuracy of leukocyte alkaline phosphatase (LAP) score to predict JAK2 V617F mutation. LAP score was obtained using a cytochemical reaction in granulocytes of patients' peripheral blood with...

journal_title：Haematologica

authors： Basquiera AL,Fassetta F,Soria N,Barral JM,Ricchi B,García JJ

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis. DESIGN AND METHODS:We reviewed the outcome of thrombolytic therapy for p...

journal_title：Haematologica

authors： Araten DJ,Notaro R,Thaler HT,Kernan N,Boulad F,Castro-Malaspina H,Small T,Scaradavou A,Magnan H,Prockop S,Chaffee S,Gonsky J,Thertulien R,Tarquini R,Luzzatto L

更新日期：2012-03-01 00:00:00

abstract：:Allogeneic transplants with PBSC are rapidly expanding, but a number of problems concerning both donors and recipients are still unsolved. GITMO (Italian Bone Marrow Transplant Group) has established a committee for allogeneic PBSC transplants. We present here an analysis of the main aspects of this evolving area and ...

journal_title：Haematologica

authors： Majolino I,Aversa F,Bacigalupo A,Bandini G,Arcese W

更新日期：1996-11-01 00:00:00

abstract：:The success story of hemophilia care first began in the 1970s, when the availability of plasma-derived concentrates of coagulation factor VIII (FVIII) and factor IX (FIX) provided efficacious treatment of bleeding in patients with hemophilia A and B. This positive scenario was consolidated in terms of greater safety a...

journal_title：Haematologica

authors： Mannucci PM

更新日期：2020-03-01 00:00:00

abstract：:Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmun...

journal_title：Haematologica

authors： Bende RJ,van Maldegem F,van Noesel CJ

更新日期：2009-08-01 00:00:00

abstract：:We describe the case of a 12-year old boy with Hoyeraal-Hreidarsson Syndrome (HHS). This syndrome includes intrauterine growth retardation, microcephaly, mental retardation, cerebellar malformation, and pancytopenia. HHS is a severe multisystem disorder associated with premature mortality, due to bone marrow failure. ...

journal_title：Haematologica

authors： Ozdemir MA,Karakukcu M,Kose M,Kumandas S,Gumus H

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Routine electrophoretic analysis fails to detect a monoclonal component (MC) in a considerable portion of AL amyloidosis patients. We investigated whether the combination of immunofixation (IF) on agarose gel electrophoresis and bone marrow plasma cell (BMPC) light chain kappa/lambda ratio analysis could con...

journal_title：Haematologica

authors： Perfetti V,Garini P,Vignarelli MC,Marinone MG,Zorzoli I,Merlini G

更新日期：1995-09-01 00:00:00

abstract：:Since its first description in Hodgkin's disease, alcohol-induced pain has subsequently been described both in other neoplasms and in various non-malignant conditions. There seems little doubt that ethyl alcohol itself is responsible, although the mechanism for producing pain remains elusive. We report a case of alcoh...

journal_title：Haematologica

authors： Custodi P,Cerutti A,Bagnato R,Cassani P

更新日期：1993-11-01 00:00:00

abstract：:The mammalian target of rapamycin plays an important role in multiple myeloma. The allosteric mammalian target of rapamycin inhibitor everolimus has long been approved for immunosuppression and has shown activity in certain cancers. This investigator-initiated phase I trial explored the use of everolimus in relapsed a...

journal_title：Haematologica

authors： Günther A,Baumann P,Burger R,Kellner C,Klapper W,Schmidmaier R,Gramatzki M

更新日期：2015-04-01 00:00:00

abstract：:Children with immune thrombocytopenia for ≥6 months completing a romiplostim study received weekly subcutaneous romiplostim (1-10 μg/kg targeting platelet counts of 50-200×109/L) in this extension to examine romiplostim's long-term safety and efficacy. Sixty-five children received romiplostim for a median of 2.6 years...

journal_title：Haematologica

authors： Tarantino MD,Bussel JB,Blanchette VS,Beam D,Roy J,Despotovic J,Raj A,Carpenter N,Mehta B,Eisen M

更新日期：2019-11-01 00:00:00

abstract：:Peripheral cytopenia has been reported in a number of patients with the acquired immunodeficiency syndrome (AIDS), but the mechanism of bone marrow (BM) failure is unclear. We have examined the BM morphology and cytokinetics of 16 untreated HIV-positive patients whose clinical condition ranged from asymptomatic (stage...

journal_title：Haematologica

authors： Danova M,Riccardi A,Brugnatelli S,Maserati R,Comolli G,Mazzini G,Castello A,Ascari E,Rondanelli EG

更新日期：1989-07-01 00:00:00

abstract：:We describe the behavior of hemostatic variables in children with portal vein thrombosis (PVT) and in a control pediatric population. Hereditary protein C (PC) or protein S (PS) deficiency was not a etiologic factor for PVT in children. Minor signs of consumption of coagulation factors II, V, fibrinogen and hyperfibri...

journal_title：Haematologica

authors： Seixas CA,Hessel G,Siqueira LH,Machado TF,Gallizoni AM,Annichino-Bizzacchi JM

更新日期：1998-10-01 00:00:00

abstract：:The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analy...

journal_title：Haematologica

authors： Fuerst D,Frank S,Mueller C,Beelen DW,Schetelig J,Niederwieser D,Finke J,Bunjes D,Kröger N,Neuchel C,Tsamadou C,Schrezenmeier H,Beyersmann J,Mytilineos J

更新日期：2018-09-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role...

journal_title：Haematologica

authors： de Vries AC,Stam RW,Kratz CP,Zenker M,Niemeyer CM,van den Heuvel-Eibrink MM,European Working Group on childhood MDS (EWOG-MDS).

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The risk for donors of allogeneic hematopoietic stem cells transplants is generally considered negligible. Scattered reports of severe complications and a recent controversy on hematopoietic malignancies after granulocyte colony-stimulating factor administration have challenged this opinion. DESIGN AND METH...

journal_title：Haematologica

authors： Halter J,Kodera Y,Ispizua AU,Greinix HT,Schmitz N,Favre G,Baldomero H,Niederwieser D,Apperley JF,Gratwohl A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Transplantation from an HLA-matched sibling is the treatment of choice for young patients with acquired severe aplastic anemia. For older patients, the acceptable upper age limit for transplantation as first-line treatment varies. The current analysis, therefore, sought to identify age or ages at transplanta...

journal_title：Haematologica

authors： Gupta V,Eapen M,Brazauskas R,Carreras J,Aljurf M,Gale RP,Hale GA,Ilhan O,Passweg JR,Ringdén O,Sabloff M,Schrezenmeier H,Socié G,Marsh JC

更新日期：2010-12-01 00:00:00