Competing-risk outcomes after hematopoietic stem cell transplantation from the perspective of time-dependent effects.

abstract：BACKGROUND AND OBJECTIVE:A novel role for shedding of the surface molecule L-selectin has been proposed as an adjunctive phenomenon during cell detachment from marrow stroma or vessel endothelium. We wished to examine whether variations in expression of L-selectin on a lymphoma B cell line were linked to shedding. DES...

journal_title：Haematologica

authors： Po JL,Mak A,Ginsberg D,Huerta P,Manoukian R,Shustik C,Jensen GS

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Rituximab reacts specifically with the CD20 antigen and induces B-cell depletion. This could interfere with the production of autoantibodies in some immune diseases. The objective of this study was to assess the effects of rituximab in autoimmune hemolytic anemia and thrombocytopenia. DESIGN ...

journal_title：Haematologica

authors： Zaja F,Iacona I,Masolini P,Russo D,Sperotto A,Prosdocimo S,Patriarca F,de Vita S,Regazzi M,Baccarani M,Fanin R

更新日期：2002-02-01 00:00:00

abstract：:Diagnostic biomarkers can be used to determine relapse risk in acute myeloid leukemia, and certain genetic aberrancies have prognostic relevance. A diagnostic immunophenotypic expression profile, which quantifies the amounts of distinct gene products, not just their presence or absence, was established in order to imp...

journal_title：Haematologica

authors： Voigt AP,Brodersen LE,Alonzo TA,Gerbing RB,Menssen AJ,Wilson ER,Kahwash S,Raimondi SC,Hirsch BA,Gamis AS,Meshinchi S,Wells DA,Loken MR

更新日期：2017-12-01 00:00:00

abstract：:The European Myeloma Network has organized two workshops on fluorescence in situ hybridization in multiple myeloma. The first aimed to identify specific indications and consensus technical approaches of current practice. A second workshop followed a quality control exercise in which 21 laboratories analyzed diagnostic...

journal_title：Haematologica

authors： Ross FM,Avet-Loiseau H,Ameye G,Gutiérrez NC,Liebisch P,O'Connor S,Dalva K,Fabris S,Testi AM,Jarosova M,Hodkinson C,Collin A,Kerndrup G,Kuglik P,Ladon D,Bernasconi P,Maes B,Zemanova Z,Michalova K,Michau L,Neben K,

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features such as acquired mutations in the JAK2, TET2, CBL and MPL genes. There are recent reports that a JAK2 gene haplotype (GGCC or 46/1) confers susceptibility to JAK2 mutation-positive myeloprol...

journal_title：Haematologica

authors： Olcaydu D,Rumi E,Harutyunyan A,Passamonti F,Pietra D,Pascutto C,Berg T,Jäger R,Hammond E,Cazzola M,Kralovics R

更新日期：2011-03-01 00:00:00

abstract：:Double cord blood transplantation extends the use of cord blood to adults for whom a single unit is not available, but the procedure is limited by its cost. To evaluate outcomes and cost-effectiveness of double compared to single cord blood transplantation, we analyzed 134 transplants in adults with acute leukemia in ...

journal_title：Haematologica

authors： Labopin M,Ruggeri A,Gorin NC,Gluckman E,Blaise D,Mannone L,Milpied N,Yakoub-Agha I,Deconinck E,Michallet M,Fegueux N,Socié G,Nguyen S,Cahn JY,de Revel T,Garnier F,Faucher C,Taright N,Kenzey C,Volt F,Bertrand D,M

更新日期：2014-03-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase degrades the amino acid tryptophan which is essential for T cells. Tryptophan depletion causes T-cell cycle arrest and solid tumors that express high levels of indoleamine 2,3-dioxygenase can create immune suppression. Recently, blasts of patients with acute myeloid leukemia were shown to e...

journal_title：Haematologica

authors： Chamuleau ME,van de Loosdrecht AA,Hess CJ,Janssen JJ,Zevenbergen A,Delwel R,Valk PJ,Löwenberg B,Ossenkoppele GJ

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Allogeneic stem cell transplantation is a potentially curative treatment for myelofibrosis, although its use is limited by a high rate of transplant-related mortality. In this study, we evaluated the outcome of patients with myelofibrosis who underwent allogeneic stem cell transplantation, and the impact of ...

journal_title：Haematologica

authors： Patriarca F,Bacigalupo A,Sperotto A,Isola M,Soldano F,Bruno B,van Lint MT,Iori AP,Santarone S,Porretto F,Pioltelli P,Visani G,Iacopino P,Fanin R,Bosi A,GITMO.

更新日期：2008-10-01 00:00:00

abstract：:Next-generation sequencing (NGS) has transitioned from research to clinical routine, yet the comparability of different technologies for mutation profiling remains an open question. We performed a European multicenter (n=6) evaluation of three amplicon-based NGS assays targeting 11 genes recurrently mutated in chronic...

journal_title：Haematologica

authors： Sutton LA,Ljungström V,Enjuanes A,Cortese D,Skaftason A,Tausch E,Stano Kozubik K,Nadeu F,Armand M,Malcikova J,Pandzic T,Forster J,Davis Z,Oscier D,Rossi D,Ghia P,Strefford JC,Pospisilova S,Stilgenbauer S,Davi F,Ca

更新日期：2020-04-09 00:00:00

abstract：:We report a novel alpha2-globin gene allele with the mutation cod 117 TTC>TCC or alpha 117(GH5)Phe>Ser detected in three carriers with alpha-thalassemia phenotype. The mutated mRNA was present in the reticulocytes in the same amount as the normal one, but no chain or hemoglobin variant were detected. Most likely the a...

journal_title：Haematologica

authors： Lacerra G,Scarano C,Musollino G,Flagiello A,Pucci P,Carestia C

更新日期：2008-01-01 00:00:00

abstract：:A pilot study, testing two different chemotherapeutic schedules in CML patients, was carried out in order to verify the possibility of Ph1 clone disappearance. Both therapeutic regimens, though able to induce severe marrow aplasia, determined only a reduction of Ph1 positive metaphases in two patients, while in one ca...

journal_title：Haematologica

authors： Centurioni R,Leoni P,Russo D,Brianzoni MF,Montillo M,Baccarani M,Tura S

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Loss of heterozygosity (LOH) on the long arm of chromosome 7 (7q) has been frequently reported in several types of human cancer including hematologic malignancies. Moreover, monosomy of chromosome 7 and 7q deletions have been associated in acute myeloid leukemia (AML) with aggressive disease a...

journal_title：Haematologica

authors： Basiricò R,Pirrotta R,Fabbiano F,Mirto S,Cascio L,Pagano M,Cammarata G,Magrin S,Santoro A

更新日期：2003-04-01 00:00:00

abstract：:We studied the immune function of 33 long-term survivors of thalassemia after hematopoietic stem cell transplantation. Lymphocyte subsets, lymphoproliferative response and immunoglobulin were normal but the level of natural killer cells was low. Five and seven patients had suboptimal antibody response at 4 week after ...

journal_title：Haematologica

authors： Li CK,Leung TF,Chan PK,Chick KW,Lee V,Cheung AY

更新日期：2003-10-01 00:00:00

abstract：:Interactions of malignant multiple myeloma (MM) plasma cells (MM-cells) with the microenvironment control MM-cell growth, survival, drug-resistance and dissemination. As in MM microvascular density increases in the bone marrow (BM), we investigated whether BM MM endothelial cells (MMECs) control disease progression vi...

journal_title：Haematologica

authors： Solimando AG,Da Vià MC,Leone P,Borrelli P,Croci GA,Tabares P,Brandl A,Di Lernia G,Bianchi FP,Tafuri S,Steinbrunn T,Balduini A,Melaccio A,De Summa S,Argentiero A,Rauert-Wunderlich H,Frassanito MA,Ditonno P,Henke E,Kl

更新日期：2020-04-30 00:00:00

abstract：:The use of minimal residual disease (MRD) measurement as a surrogate marker of molecular response to treatment can potentially improve the evaluation of treatment response and enable estimates of the residual leukemic cell burden during clinical remission, thereby improving the selection of therapeutic strategies and,...

journal_title：Haematologica

authors： Cazzaniga G,Biondi A

更新日期：2005-03-01 00:00:00

abstract：:A prospective neurological and electroencephalographic (EEG) study was performed in sixteen leukemia patients receiving busulfan (BU) and cyclophosphamide before autologous bone marrow transplantation. All patients were given anticonvulsant prophylaxis with a combination of phenobarbital (PB) and clonazepam (CLZ). Neu...

journal_title：Haematologica

authors： Meloni G,Nasta L,Pinto RM,Spalice A,Raucci U,Iannetti P

更新日期：1995-11-01 00:00:00

abstract：:Chronic graft-versus-host disease is a serious complication in long-term survivors of allogeneic hematopoietic stem cell transplantation, with several organ systems affected. Chronic graft-versus-host disease is an important cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation. This a...

journal_title：Haematologica

authors： Kapur R,Ebeling S,Hagenbeek A

更新日期：2008-11-01 00:00:00

abstract：:We report on the likely mechanism of an exacerbation of neurological symptoms developed during immune reconstitution after autologous non-myeloablative hematopoietic stem cell transplantation in a 33-year-old man with systemic lupus erythematosus- associated recurrent transverse myelitis. Cerebrospinal fluid examinati...

journal_title：Haematologica

authors： Muraro PA,Nikolov NP,Butman JA,Abati A,Gea-Banacloche J,Gress R,Lipsky P,Illei G,Pavletic S

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Pathogen-derived molecules are danger signals and are able to activate innate immunity that in turn controls and regulates generation of adaptive immune responses. Mycobacterium tuberculosis heat shock protein 70 (myc HSP70) has been shown to exert a potent adjuvant effect in vaccination again...

journal_title：Haematologica

authors： Liso A,Benedetti R,Fagioli M,Mariano A,Falini B

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The functional activity of the organic cation transporter 1 (OCT-1) protein (OCT-1 activity) is an excellent predictor of molecular response and progression-free survival in patients with newly diagnosed chronic phase chronic myeloid leukemia treated with imatinib as front-line therapy. DESIGN AND METHODS:I...

journal_title：Haematologica

authors： White DL,Radich J,Soverini S,Saunders VA,Frede AK,Dang P,Cilloni D,Lin P,Mongay L,Woodman R,Manley P,Slader C,Kim DW,Pane F,Martinelli G,Saglio G,Hughes TP

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Hematocrit above the normal range for the population, such as in primary or secondary erythrocytosis, predisposes to both arterial and venous thrombosis. However, little is known about the association between hematocrit and risk of venous thromboembolism in a general population. DESIGN AND METHODS:Hematocri...

journal_title：Haematologica

authors： Braekkan SK,Mathiesen EB,Njølstad I,Wilsgaard T,Hansen JB

更新日期：2010-02-01 00:00:00

abstract：:The National Institutes of Health global score for chronic graft-versus-host disease was devised by experts but was not based on empirical data. We hypothesized that analysis of prospectively collected data would enable derivation of a more accurate model for estimating mortality risk. We analyzed 574 adult patients w...

journal_title：Haematologica

authors： Inamoto Y,Martin PJ,Storer BE,Palmer J,Weisdorf DJ,Pidala J,Flowers ME,Arora M,Jagasia M,Arai S,Chai X,Pavletic SZ,Vogelsang GB,Lee SJ,Chronic GVHD Consortium.

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current Wo...

journal_title：Haematologica

authors： Salaverria I,Zettl A,Beà S,Hartmann EM,Dave SS,Wright GW,Boerma EJ,Kluin PM,Ott G,Chan WC,Weisenburger DD,Lopez-Guillermo A,Gascoyne RD,Delabie J,Rimsza LM,Braziel RM,Jaffe ES,Staudt LM,Müller-Hermelink HK,Campo E,

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Chronic graft-versus-host disease is a common late complication of allogeneic hematopoietic stem cell transplantation. Corticosteroids are the standard initial treatment. Second-line treatment has not been well defined. We evaluated the effectiveness and safety of low doses of alemtuzumab plus low doses of r...

journal_title：Haematologica

authors： Gutiérrez-Aguirre CH,Cantú-Rodríguez OG,Borjas-Almaguer OD,González-Llano O,Jaime-Pérez JC,Solano-Genesta M,Gómez-Guijosa M,Mancias-Guerra C,Tarin L,Gómez-Almaguer D

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The genetic characterization of chronic lymphocytic leukemia cells correlates with the behavior, progression and response to treatment of the disease. DESIGN AND METHODS:Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progressi...

journal_title：Haematologica

authors： Guarini A,Marinelli M,Tavolaro S,Bellacchio E,Magliozzi M,Chiaretti S,De Propris MS,Peragine N,Santangelo S,Paoloni F,Nanni M,Del Giudice I,Mauro FR,Torrente I,Foà R

更新日期：2012-01-01 00:00:00

abstract：:The lupus anticoagulant (LAC) and anticardiolipin antibody (ACA) syndromes require particular therapeutic approaches: thrombotic accidents are an indication for oral anticoagulant therapy (OAT), whereas severe thrombocytopenia may require the special treatments used for immunologic thrombocytopenic purpura (ITP). We d...

journal_title：Haematologica

authors： Ballerini G,Gemmati D,Moratelli S,Morelli P,Serino ML

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:To compare the clinical results of two consecutive therapeutic protocols including autologous blood stem cell transplantation (ABSCT) for patients with de novo acute myeloblastic leukemia (AML) in first complete remission (CR1). DESIGN AND METHODS:Between November 1989 and January 1997, 50 pat...

journal_title：Haematologica

authors： de la Rubia J,Sanz GF,Martín G,Martínez J,Cervera J,Solves P,Jiménez C,Arnao M,Vicente A,Jarque I,Sempere A,Sanz MA

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin. In the plas...

journal_title：Haematologica

authors： Marro S,Chiabrando D,Messana E,Stolte J,Turco E,Tolosano E,Muckenthaler MU

更新日期：2010-08-01 00:00:00

abstract：:A parent whose child affected by hemophilia develops an inhibitor has to cope with strong emotions and anxieties related to the acceptance of this second diagnosis when just having severe hemophilia seems nothing compared to having antibodies that neutralize factor infusions and the possibility of uncontrolled hemorrh...

journal_title：Haematologica

authors： Gargallo B

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The degree of globin chain imbalance and tissue hypoxia are important determinants of clinical severity in thalassemia syndromes. Thus phenotypic expression may be modified by interaction of alpha- and beta-thalassemia defects, level and type of hemoglobin synthesized and oxygen release to the...

journal_title：Haematologica

authors： Traeger-Synodinos J,Papassotiriou I,Vrettou C,Skarmoutsou C,Stamoulakatou A,Kanavakis E

更新日期：2001-04-01 00:00:00