Effectiveness of subcutaneous low-dose alemtuzumab and rituximab combination therapy for steroid-resistant chronic graft-versus-host disease.

abstract：:Interactions between chronic lymphocytic leukemia (CLL) B cells and the bone marrow (BM) microenvironment play a major function in the physiopathology of CLL. Extracellular vesicles (EVs), which are composed of exosomes and microparticles, play an important role in cell communication. However, little is known about th...

journal_title：Haematologica

authors： Crompot E,Van Damme M,Pieters K,Vermeersch M,Perez-Morga D,Mineur P,Maerevoet M,Meuleman N,Bron D,Lagneaux L,Stamatopoulos B

更新日期：2017-09-01 00:00:00

abstract：:We report on a case of acute myeloid leukemia in a 17-year old boy affected by Shwachman Diamond syndrome (SDS). Conventional cytogenetics at diagnosis revealed an abnormal clone with complex karyotypic changes including typical myeloid aberrations, such as monosomy 5, tetrasomy of chromosome 8, trisomy 9, and deletio...

journal_title：Haematologica

authors： Spirito FR,Crescenzi B,Matteucci C,Martelli MF,Mecucci C

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Treatment of acute myeloid leukemia (AML) in older patients remains unsatisfactory. The BGMT 95 trial for older patients set out to improve the outcome of these patients by adding a third drug (lomustine) to a 5+7 idarubicin and cytarabine schedule at induction and evaluating intermediate-dose...

journal_title：Haematologica

authors： Pigneux A,Perreau V,Jourdan E,Vey N,Dastugue N,Huguet F,Sotto JJ,Salmi LR,Ifrah N,Reiffers J

更新日期：2007-10-01 00:00:00

abstract：:We report on the data collected in the Italian Registry of acquired haemophilia (AH) in 2001. Recombinant activated factor VII (rFVIIa) was selected as first-line therapy in 19 bleeding episodes because of their severity and as salvage in one case. Bleeding was controlled in 90% of the episodes, indicating the efficac...

journal_title：Haematologica

authors： Baudo F,de Cataldo F,Gaidano G,Italian registry of acquired hemophilia.

更新日期：2004-06-01 00:00:00

abstract：:Double umbilical cord blood transplantation is increasingly applied in the treatment of adult patients with high-risk hematological malignancies and has been associated with improved engraftment as compared to that provided by single unit cord blood transplantation. The mechanism of improved engraftment is, however, s...

journal_title：Haematologica

authors： Somers JA,Braakman E,van der Holt B,Petersen EJ,Marijt EW,Huisman C,Sintnicolaas K,Oudshoorn M,Groenendijk-Sijnke ME,Brand A,Cornelissen JJ

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Paroxysmal nocturnal hemoglobinuria (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS:We studied 23 patients with PNH, before and after five and 11 weeks of treatment with eculizumab. We examined markers of thrombin generation and reactional fibrinolysis...

journal_title：Haematologica

authors： Helley D,de Latour RP,Porcher R,Rodrigues CA,Galy-Fauroux I,Matheron J,Duval A,Schved JF,Fischer AM,Socié G,French Society of Hematology.

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Bone lesions often occur in multiple myeloma (MM), but no tests have proven useful in identifying patients with increased risk. Bone marker assays and bone densitometry are non-invasive methods that can be used repeatedly at low cost. This study was performed to evaluate these methods in predi...

journal_title：Haematologica

authors： Abildgaard N,Brixen K,Eriksen EF,Kristensen JE,Nielsen JL,Heickendorff L

更新日期：2004-05-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphoma originates from a background of diverse chronic inflammatory disorders at various anatomic sites. The genetics underlying its development, particularly in those associated with autoimmune disorders, is poorly characterized. By whole exome sequencing of 21 cases of MALT...

journal_title：Haematologica

authors： Moody S,Thompson JS,Chuang SS,Liu H,Raderer M,Vassiliou G,Wlodarska I,Wu F,Cogliatti S,Robson A,Ashton-Key M,Bi Y,Goodlad J,Du MQ

更新日期：2018-08-01 00:00:00

abstract：:We report on five Caucasian patients with congenital polycythemia and mutations of the von Hipple-Lindau (VHL) gene: a compound heterozygote for the novel exon 1 (VHL 235C->T) and previously reported VHL 562C->G mutations; three homozygotes for Chuvash VHL 598C->T mutation; and a heterozygote for VHL 523->G mutation w...

journal_title：Haematologica

authors： Bento MC,Chang KT,Guan Y,Liu E,Caldas G,Gatti RA,Prchal JT

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There are no widely accepted criteria for the definition of hematopoietic stem cell transplant -associated microangiopathy (TAM). An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM. DESIGN AND METHODS:The particip...

journal_title：Haematologica

authors： Ruutu T,Barosi G,Benjamin RJ,Clark RE,George JN,Gratwohl A,Holler E,Iacobelli M,Kentouche K,Lämmle B,Moake JL,Richardson P,Socié G,Zeigler Z,Niederwieser D,Barbui T,European Group for Blood and Marrow Transplantation.,E

更新日期：2007-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia is a disease with up-regulated expression of the transmembrane tyrosine-protein kinase ROR1, a member of the Wnt/planar cell polarity pathway. In this study, we identified COBLL1 as a novel interaction partner of ROR1. COBLL1 shows clear bimodal expression with high levels in chronic lymph...

journal_title：Haematologica

authors： Plešingerová H,Janovská P,Mishra A,Smyčková L,Poppová L,Libra A,Plevová K,Ovesná P,Radová L,Doubek M,Pavlová Š,Pospíšilová Š,Bryja V

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:The mdr-1 gene, which codes for a 170-kd transmembrane glycoprotein (P170), is frequently overexpressed in multidrug resistant (MDR) tumor cell lines and in spontaneous tumors, including leukemia and lymphoma. However, it is also constitutively expressed as a normal gene in normal tissues. METHODS:We used h...

journal_title：Haematologica

authors： Damiani D,Michieli M,Michelutti A,Geromin A,Raspadori D,Fanin R,Savignano C,Giacca M,Pileri S,Mallardi F

更新日期：1993-01-01 00:00:00

abstract：:Forty-six patients with chronic myeloid leukemia receiving imatinib mesylate (39 in chronic phase, one in accelerated phase, and six in blastic crisis), were studied for a 20-62 month follow-up period by cytogenetics and fluorescence in situ hybridization using dual-color, dual-fusion BCR and ABL probes. This approach...

journal_title：Haematologica

authors： Calabrese G,Fantasia D,Di Gianfilippo R,Stuppia L,Di Lorenzo R,Palka G

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In multiple myeloma (MM), the mechanisms used by plasma cells to invade locally and metastasize are thought to be similar to those developed by solid tumors and include cell proliferation and secretion of extracellular matrix (ECM) degrading enzymes following adhesion to ECM proteins. We studi...

journal_title：Haematologica

authors： Ria R,Vacca A,Ribatti D,Di Raimondo F,Merchionne F,Dammacco F

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Routine electrophoretic analysis fails to detect a monoclonal component (MC) in a considerable portion of AL amyloidosis patients. We investigated whether the combination of immunofixation (IF) on agarose gel electrophoresis and bone marrow plasma cell (BMPC) light chain kappa/lambda ratio analysis could con...

journal_title：Haematologica

authors： Perfetti V,Garini P,Vignarelli MC,Marinone MG,Zorzoli I,Merlini G

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that protects cells against mutagenicity from free radicals and toxic oxygen metabolites. The gene coding for NQO1 is subject to a genetic polymorphism at nucleotide position 609 (C-->T) of the human NQO1 cDNA. Heterozygous individuals (C/T)...

journal_title：Haematologica

authors： Kracht T,Schrappe M,Strehl S,Reiter A,Elsner HA,Trka J,Cario G,Viehmann S,Harbott J,Borkhardt A,Metzler M,Langer T,Repp R,Marschalek R,Welte K,Haas OA,Stanulla M

更新日期：2004-12-01 00:00:00

abstract：:Not available. ...

journal_title：Haematologica

authors： Tanaka Y,Yeoh AEJ,Moriyama T,Li CK,Kudo K,Arakawa Y,Buaboonnam J,Zhang H,Liu HC,Ariffin H,Chen Z,Kham SKY,Nishii R,Hasegawa D,Fujimura J,Keino D,Kondoh K,Sato A,Ueda T,Yamamoto M,Taneyama Y,Hino M,Takagi M,O

更新日期：2021-01-28 00:00:00

abstract：:Rituximab use in severe auto-immune diseases has recently increased. Scattered reports of opportunistic infections were the only reported serious side effects related to rituximab in pediatric patients .Here, we report transient severe acute thrombocytopenia and neutropenia respectively a few days after rituximab infu...

journal_title：Haematologica

authors： Larrar S,Guitton C,Willems M,Bader-Meunier B

更新日期：2006-08-01 00:00:00

abstract：:Multiple myeloma management has undergone profound changes in the past thanks to advances in our understanding of the disease biology and improvements in treatment and supportive care approaches. This article presents recommendations of the European Myeloma Network for newly diagnosed patients based on the GRADE syste...

journal_title：Haematologica

authors： Engelhardt M,Terpos E,Kleber M,Gay F,Wäsch R,Morgan G,Cavo M,van de Donk N,Beilhack A,Bruno B,Johnsen HE,Hajek R,Driessen C,Ludwig H,Beksac M,Boccadoro M,Straka C,Brighen S,Gramatzki M,Larocca A,Lokhorst H,Magar

更新日期：2014-02-01 00:00:00

abstract：:The total number of children with incident cancer in Italy has never been specifically estimated. Specialized population-based Childhood Cancer Registries have only been operating in Piedmont (CCRP) and in the Marche region, while general population cancer registries cover about 20% of the Italian population. The numb...

journal_title：Haematologica

authors： Baussano I,Maule MM,Dama E,Dalmasso P,Mosso ML,Galzerano M,Merletti F,Magnani C,Pastore G

更新日期：2007-09-01 00:00:00

abstract：:Treatment of adults with acute myeloblastic leukemia has changed substantially over the past two decades. Currently available estimates of survival do not reflect results from present state-of-the-art treatment due to a lag between the availability of new treatments and data concerning their effect on survival on the ...

journal_title：Haematologica

authors： Pulte D,Gondos A,Brenner H

更新日期：2008-04-01 00:00:00

abstract：:Transient pancytopenia preceding childhood acute lymphoblastic leukemia (ALL) is an unfrequent but well-known event. The association of this preleukemic syndrome with hepatitis is extremely rare, with only two such cases having been published in the literature. We report the case of a 16-year-old boy who was diagnosed...

journal_title：Haematologica

authors： Rafel M,Cobo F,Cervantes F,Bosch F,Campo E,Montserrat E

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is a clonal hematopoietic malignant disease; about 45-50% of cases do not have detectable chromosomal abnormalities. Here, we identified hidden genomic alterations and novel disease-related regions in normal karyotype acute myeloid leukemia/myelodysplastic syndrome samples. DESIGN AND...

journal_title：Haematologica

authors： Akagi T,Ogawa S,Dugas M,Kawamata N,Yamamoto G,Nannya Y,Sanada M,Miller CW,Yung A,Schnittger S,Haferlach T,Haferlach C,Koeffler HP

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Storage pool diseases (SPD) are heterogeneous disorders associated with an abnormal presence of intraplatelet granules, which cause mild to moderate bleeding diathesis. We investigated signaling through tyrosine phosphorylation of proteins occurring in platelets with total or partial absence o...

journal_title：Haematologica

authors： Arderiu G,Díaz-Ricart M,Domenech P,Escolar G,Ordinas A,Pujol-Moix N

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:To assess the efficacy and the toxic profile of gemcitabine, a novel pyrimidine antimetabolite active against several solid tumors, we carried out a study in heavily pretreated Hodgkin's disease (HD) patients. DESIGN AND METHODS:From May 1997 to January 1999, 14 pretreated patients (10 relaps...

journal_title：Haematologica

authors： Zinzani PL,Bendandi M,Stefoni V,Albertini P,Gherlinzoni F,Tani M,Piccaluga PP,Tura S

更新日期：2000-09-01 00:00:00

abstract：:One hundred thirty-three febrile episodes in 115 neutropenic patients with hematologic malignancies were empirically treated with ceftriaxone and amikacin in a single daily dose. An indwelling central venous catheter (CVC) was present in 44 cases. Septicemia was documented in 18 (41%) patients with CVC (13 gram-positi...

journal_title：Haematologica

authors： Martino P,Girmenia C,Raccah R,Micozzi A,Cimino G,Mandelli F

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Classical Hodgkin's lymphoma is characterized by a minority of neoplastic cells surrounded by a heterogeneous background population of non-neoplastic cells including lymphoma-associated macrophages. High levels of expression of both the monocyte/macrophage lineage-associated antigens CD68 and CD163 have been...

journal_title：Haematologica

authors： Kamper P,Bendix K,Hamilton-Dutoit S,Honoré B,Nyengaard JR,d'Amore F

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Patients with chronic renal failure show signs of accelerated atherosclerosis and high cardiovascular morbidity and mortality. Recent investigations indicate that uremia is associated with endothelial dysfunction and a microinflammatory state. We assessed changes in the expression of adhesion ...

journal_title：Haematologica

authors： Serradell M,Díaz-Ricart M,Cases A,Zurbano MJ,López-Pedret J,Arranz O,Ordinas A,Escolar G

更新日期：2002-10-01 00:00:00

abstract：:BACKGROUND. Hypofibrinogenemia and increased fibrin(ogen) degradation products in acute leukemia have been attributed to intravascular thrombin generation triggered by leukemic cells. However, the strict relationship between fibrinogen catabolism and turnover of fibrinopeptide A (FPA), which is a sensitive and specifi...

journal_title：Haematologica

authors： Castaman G,Galloni E,Dri AV,Rodeghiero F

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In recent years, two predictive equations to estimate median expected survival at diagnosis for patients affected with Hodgkin's disease have been developed at the University of Pavia Medical School. The present retrospective work was aimed at testing correlation between mean survival estimated...

journal_title：Haematologica

authors： Bettini R,Tonolini M,Maccianti E

更新日期：1997-05-01 00:00:00