Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition.

Abstract:

BACKGROUND:Non-Hodgkin's lymphomas are a heterogeneous group of neoplasms arising from the lymphopoietic system including a wide range of subtypes of either B-cell or T-cell lymphomas. The few established risk factors for the development of these neoplasms include viral infections and immunological abnormalities, but their etiology remains largely unknown. Evidence suggests that certain medical conditions may be linked, through immunosuppression, to the risk of non-Hodgkin's lymphoma. Multiple myeloma is a neoplasm of plasma cells that accounts for approximately 15% of lymphopoietic cancers. Increases in the incidence of non-Hodgkin's lymphoma and multiple myeloma in the past implicate environmental factors as potential causal agents. DESIGN AND METHODS:In the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,213 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma (594 men; 619 women) were identified during a follow-up of 8.5 years. Cox proportional hazard models were used to explore the association between self-reported diabetes, diagnosed after 30 years of age, and the risk of non-Hodgkin's lymphoma overall and multiple myeloma and various lymphoma subtypes. RESULTS:We found no association between a personal history of diabetes and the risk of non-Hodgkin's lymphoma overall in men (HR: 1.28, 95% CI: 0.89-1.84), in women (HR: 0.71, 95% CI: 0.41- 1.24), or in men and women combined (HR: 1.09, 95% CI: 0.80-1.47). Among the B-non-Hodgkin's lymphoma subtypes, we observed a statistically significant increased risk of B-cell chronic lymphocytic leukemia (HR: 2.0, 95% CI: 1.04-3.86) in men, but not in women (HR: 1.07, 95% CI: 0.33-3.43). CONCLUSIONS:This prospective study did not provide evidence for a role of self-reported diabetes in the etiology of non-Hodgkin's lymphoma overall or multiple myeloma. We found an increased risk of B-cell chronic lymphocytic leukemia among men with diabetes, but not among women. We hypothesize that diabetes may not play a causal role in the etiology of B-cell chronic lymphocytic leukemia, though the underlying pathogenic mechanisms of both disorders may include shared genetic, host and/or environmental susceptibility factors.

journal_name

Haematologica

journal_title

Haematologica

authors

Khan AE,Gallo V,Linseisen J,Kaaks R,Rohrmann S,Raaschou-Nielsen O,Tjønneland A,Johnsen HE,Overvad K,Bergmann MM,Boeing H,Benetou V,Psaltopoulou T,Trichopoulou A,Masala G,Mattiello A,Grioni S,Tumino R,Vermeulen RC,Pe

doi

10.3324/haematol.12297

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

842-50

issue

6

eissn

0390-6078

issn

1592-8721

pii

haematol.12297

journal_volume

93

pub_type

杂志文章
  • Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice.

    abstract:BACKGROUND:beta-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate beta-globin chain production. The excessive unbound alpha-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis. DESIGN AND METHODS:I...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2009.005827

    authors: Srinoun K,Svasti S,Chumworathayee W,Vadolas J,Vattanaviboon P,Fucharoen S,Winichagoon P

    更新日期:2009-09-01 00:00:00

  • Primary lymphoma of the vagina. A case report.

    abstract::Primary vaginal non-Hodgkin lymphoma is really uncommon and may be misdiagnosed as inflammatory disease or solid cancer, so careful diagnostic procedures are needed, particularly as far as pathological and immunocytochemical evaluation is concerned. Most of these lymphomas present with follicular patterns and limited ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Lonardi F,Ferrari V,Pavanato G,Bonciarelli G,Jirillo A,Balli M

    更新日期:1994-03-01 00:00:00

  • Collection of peripheral blood stem cells by apheresis with continuous flow blood cell separator Dideco Vivacell.

    abstract::In S. Camillo Hospital, Rome, the Apheresis Center (CNTS-CRI) and the Haematological Division, Authors treated 17 patients affected by haematologic malignances and solid tumours with leukoapheresis procedures for PBSC collection. Nine patients were treated with continuous-flow cell separator Dideco Vivacell, performin...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Del Monte C,Basso P,Consoli P,Cossutta M,Morara R,Pescarollo A,Lanti T

    更新日期:1990-01-01 00:00:00

  • Association of anemia with health-related quality of life and survival: a large population-based cohort study.

    abstract::Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact in the general population are rare. Furthermore, discussions on the optimal definition of anemia have n...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.195552

    authors: Wouters HJCM,van der Klauw MM,de Witte T,Stauder R,Swinkels DW,Wolffenbuttel BHR,Huls G

    更新日期:2019-03-01 00:00:00

  • Effect of interleukin-1beta and glutathione S-transferase genotypes on the development of gastric mucosa-associated lymphoid tissue lymphoma.

    abstract::e tested whether polymorphic variations in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and interleukin-1 (IL-1beta and IL-1RN) genes confer susceptibility to mucosa-associated lymphoid tissue lymphomas (MALT) in a Chinese population. The rates of GSTM1, GSTP1, IL-1beta and IL-1RN genotypes did not differ bet...

    journal_title:Haematologica

    pub_type: 信件

    doi:

    authors: Wu MS,Shun CT,Huang SP,Cheng AL,Chen LT,Lin JT

    更新日期:2004-08-01 00:00:00

  • Long-term follow up of the FL2000 study comparing CHVP-interferon to CHVP-interferon plus rituximab in follicular lymphoma.

    abstract::Anti-CD20-containing chemotherapy regimens have become the standard of care for patients with follicular lymphoma needing cytotoxic therapy. Four randomized trials demonstrated a clinical benefit for patients treated with rituximab. However, no long-term follow up (i.e. > 5 years) of these trials is yet available. Bet...

    journal_title:Haematologica

    pub_type: 杂志文章,随机对照试验

    doi:10.3324/haematol.2012.082412

    authors: Bachy E,Houot R,Morschhauser F,Sonet A,Brice P,Belhadj K,Cartron G,Audhuy B,Fermé C,Feugier P,Sebban C,Delwail V,Maisonneuve H,Le Gouill S,Lefort S,Brousse N,Foussard C,Salles G,Groupe d'Etude des Lymphomes de l'Adult

    更新日期:2013-07-01 00:00:00

  • Long-term outcome after immunosuppressive therapy with horse or rabbit antithymocyte globulin and cyclosporine for severe aplastic anemia in children.

    abstract::Some prospective studies showed that rabbit antithymocyte globulin was inferior to horse antithymocyte globulin as first-line therapy for patients with severe aplastic anemia. We retrospectively analyzed the clinical outcome of 455 children with severe aplastic anemia who received horse antithymocyte globulin (n=297) ...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:10.3324/haematol.2013.089268

    authors: Jeong DC,Chung NG,Cho B,Zou Y,Ruan M,Takahashi Y,Muramatsu H,Ohara A,Kosaka Y,Yang W,Kim HK,Zhu X,Kojima S

    更新日期:2014-04-01 00:00:00

  • The predictive role of interim positron emission tomography for Hodgkin lymphoma treatment outcome is confirmed using the interpretation criteria of the Deauville five-point scale.

    abstract::A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point s...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2013.103218

    authors: Gallamini A,Barrington SF,Biggi A,Chauvie S,Kostakoglu L,Gregianin M,Meignan M,Mikhaeel GN,Loft A,Zaucha JM,Seymour JF,Hofman MS,Rigacci L,Pulsoni A,Coleman M,Dann EJ,Trentin L,Casasnovas O,Rusconi C,Brice P,Bolis

    更新日期:2014-06-01 00:00:00

  • Serine protease detection in mixed lymphocyte cultures: a histochemical method for possible prediction of graft-versus-host disease.

    abstract:BACKGROUND AND OBJECTIVE:Graft-versus-host disease (GVHD) presents an important complication of allogeneic bone marrow transplantation. A method to predict GVHD might be the analysis of cytotoxic T lymphocyte precursors, but the technique requires the use of radioactive elements not suitable in all laboratories. DESIG...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Maiocchi MA,Nano R,Capelli E,Bonfichi M,Alessandrino EP,Bernasconi P

    更新日期:1998-08-01 00:00:00

  • IGHV mutational status and outcome for patients with chronic lymphocytic leukemia upon treatment: a Danish nationwide population-based study.

    abstract::Patients with chronic lymphocytic leukemia and unmutated immunoglobulin heavy-chain variable region gene (IGHV) have inferior survival from time of treatment in clinical studies. We assessed real-world outcomes based on mutational status and treatment regimen in a nationwide population-based cohort, comprising all 4,1...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.220194

    authors: Rotbain EC,Frederiksen H,Hjalgrim H,Rostgaard K,Egholm GJ,Zahedi B,Poulsen CB,Enggard L,da Cunha-Bang C,Niemann CU

    更新日期:2020-06-01 00:00:00

  • Granulocyte colony-stimulating factor after autologous CD34+ immunoselected peripheral blood stem cell transplantation.

    abstract::Granulocyte colony-stimulating factor (G-CSF) can be administered after a peripheral blood stem cell transplantation with the aim of accelerating neutrophil recovery. In a randomized, single-blind study we studied a new administration schedule of G-CSF in this context. ...

    journal_title:Haematologica

    pub_type: 临床试验,信件,随机对照试验

    doi:

    authors: Piccirillo N,De Matteis S,Sorà F,d'Onofrio G,Leone G,Sica S

    更新日期:2004-09-01 00:00:00

  • Targeting CD47/TNFAIP8 by miR-155 overcomes drug resistance and inhibits tumor growth through induction of phagocytosis and apoptosis in multiple myeloma.

    abstract::The mechanisms of drug resistance in multiple myeloma are poorly understood. Here we show that CD47, an integrin-associated receptor, is significantly upregulated in drug resistant myeloma cells in comparison with parental cells, and that high expression of CD47 detected by immunohistochemistry is associated with shor...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.227579

    authors: Rastgoo N,Wu J,Liu A,Pourabdollah M,Atenafu EG,Reece D,Chen W,Chang H

    更新日期:2020-12-01 00:00:00

  • Karyotype at diagnosis is the major prognostic factor predicting relapse-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy.

    abstract::To identify factors associated with relapse-free survival (RFS), 80 patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia, enrolled in a phase II study of imatinib-combined chemotherapy, were analyzed. The median follow-up of surviving patients was 26.7 months (maximum, 52.5 month...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:10.3324/haematol.11891

    authors: Yanada M,Takeuchi J,Sugiura I,Akiyama H,Usui N,Yagasaki F,Nishii K,Ueda Y,Takeuchi M,Miyawaki S,Maruta A,Narimatsu H,Miyazaki Y,Ohtake S,Jinnai I,Matsuo K,Naoe T,Ohno R,Japan Adult Leukemia Study Group.

    更新日期:2008-02-01 00:00:00

  • Cutaneous T-cell lymphomas (including rare subtypes). Current concepts. II.

    abstract:BACKGROUND:Cutaneous T-cell lymphomas (CTCL) represent about the 80% of skin lymphomas and comprise a heterogeneous group of diseases with respect to clinical presentation, outcome, histologic and immunophenotypic features. In the recent years, data have been accumulated indicating that clinical and biological differen...

    journal_title:Haematologica

    pub_type: 杂志文章,评审

    doi:

    authors: Paulli M,Berti E

    更新日期:2004-11-01 00:00:00

  • GFI1B controls its own expression binding to multiple sites.

    abstract:BACKGROUND:Transcription factors play essential roles in both normal and malignant hematopoiesis. This is the case for the growth factor independent 1b (GFI1B) transcription factor, which is required for erythroid and megakaryocytic differentiation and over-expressed in leukemic patients and cell lines. DESIGN AND MET...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2009.012351

    authors: Anguita E,Villegas A,Iborra F,Hernández A

    更新日期:2010-01-01 00:00:00

  • Seven novel mutations of the UGT1A1 gene in patients with unconjugated hyperbilirubinemia.

    abstract::The aim of this study was to identify new pathogenic variations of the UGT1A1 gene in 11 patients diagnosed with neonatal unconjugated hyperbilirubinemia. We describe two cases in which clinically unapparent heterozygotic mutations in the UGT1A1 gene may become evident in combination with certain environmental conditi...

    journal_title:Haematologica

    pub_type: 信件

    doi:10.3324/haematol.10585

    authors: D'Apolito M,Marrone A,Servedio V,Vajro P,De Falco L,Iolascon A

    更新日期:2007-01-01 00:00:00

  • The broad spectrum of autoimmune lymphoproliferative disease: molecular bases, clinical features and long-term follow-up in 31 patients.

    abstract::Autoimmune lymphoproliferative disorders, including autoimmune lymphoproliferative syndrome (ALPS) and Dianzani autoimmune lymphoproliferative disease (DALD), are inherited defects of the Fas apoptotic pathway characterized by lymphoid accumulation and autoimmune manifestations. We report the molecular, clinical, immu...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Campagnoli MF,Garbarini L,Quarello P,Garelli E,Carando A,Baravalle V,Doria A,Biava A,Chiocchetti A,Rosolen A,Dufour C,Dianzani U,Ramenghi U

    更新日期:2006-04-01 00:00:00

  • Influence of two different Escherichia coli asparaginase preparations on fibrinolytic proteins in childhood ALL.

    abstract:BACKGROUND:Alterations in hemostasis have frequently been observed in patients with leukemia, and thrombotic events are well documented in patients receiving L-asparaginase (ASP) as a single agent or in combination with vincristine, prednisone (sometimes complemented by an anthracycline). The present study was designed...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Nowak-Göttl U,Werber G,Ziemann D,Ahlke E,Boos J

    更新日期:1996-03-01 00:00:00

  • Differentiation of monoclonal gammopathy of undetermined significance and multiple myeloma using flow cytometric characteristics of plasma cells.

    abstract:BACKGROUND AND OBJECTIVES:The differential diagnosis between multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) may be uncertain in some cases; this problem is reflected by discrepancies between different classification systems with an accordance in only 2/3 of cases. We studied whether...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Sezer O,Heider U,Zavrski I,Possinger K

    更新日期:2001-08-01 00:00:00

  • Using quantification of the PML-RARalpha transcript to stratify the risk of relapse in patients with acute promyelocytic leukemia.

    abstract:BACKGROUND AND OBJECTIVES:The detection of PML-RARalpha by real-time polymerase chain reaction (RQ-PCR) is becoming an important tool for monitoring minimal residual disease (MRD) in patients with acute promyelocytic leukemia (APL). However, its clinical value remains to be determined. Our aim was to analyze any associ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.10734

    authors: Santamaría C,Chillón MC,Fernández C,Martín-Jiménez P,Balanzategui A,García Sanz R,San Miguel JF,González MG

    更新日期:2007-03-01 00:00:00

  • Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia.

    abstract::Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection. Thrombocytopenia is a major and sometimes fatal complication in patients with acute leukemia. However, the mechanisms underlying defective thrombo...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2018.214593

    authors: Gao A,Gong Y,Zhu C,Yang W,Li Q,Zhao M,Ma S,Li J,Hao S,Cheng H,Cheng T

    更新日期:2019-10-01 00:00:00

  • Resolution of bone marrow fibrosis in a patient receiving JAK1/JAK2 inhibitor treatment with ruxolitinib.

    abstract:UNLABELLED:Ruxolitinib, a JAK1/JAK2 inhibitor, is currently the only pharmacological agent approved for the treatment of myelofibrosis. Approval was based on findings from two phase 3 trials comparing ruxolitinib with placebo (COMFORT-I) and with best available therapy (COMFORT-II) for the treatment of primary or secon...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3324/haematol.2013.095109

    authors: Wilkins BS,Radia D,Woodley C,Farhi SE,Keohane C,Harrison CN

    更新日期:2013-12-01 00:00:00

  • Core needle biopsy is effective in the initial diagnosis of mediastinal lymphoma.

    abstract:BACKGROUND AND OBJECTIVE:With the development and refinement of guidance modalities for percutaneous biopsies, many investigators have reported studies supporting the role of guided core needle biopsy in the diagnosis of mediastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core need...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Zinzani PL,Corneli G,Cancellieri A,Magagnoli M,Lacava N,Gherlinzoni F,Bendandi M,Albertini P,Baruzzi G,Tura S,Boaron M

    更新日期:1999-07-01 00:00:00

  • Effect of hematologic response on outcome of patients undergoing transplantation for primary amyloidosis: importance of achieving a complete response.

    abstract::Our objective was to determine whether the goal of high-dose therapy should be a partial hematologic response or a complete response. We analyzed 282 consecutive stem cell transplant patients. A partial hematologic response was achieved in 108 patients (38%), and 93 (33%) achieved a complete hematologic response. Surv...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.11413

    authors: Gertz MA,Lacy MQ,Dispenzieri A,Hayman SR,Kumar SK,Leung N,Gastineau DA

    更新日期:2007-10-01 00:00:00

  • Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation.

    abstract::Pseudomonas aeruginosa is one leading gram-negative organism associated with nosocomial infections. Bacteremia is life-threatening in the immunocompromised host. Increasing frequency of multi-drug-resistant (MDRPA) strains is concerning. We started a retrospective survey in the pediatric hematology oncology Italian ne...

    journal_title:Haematologica

    pub_type: 杂志文章,多中心研究

    doi:10.3324/haematol.2009.020867

    authors: Caselli D,Cesaro S,Ziino O,Zanazzo G,Manicone R,Livadiotti S,Cellini M,Frenos S,Milano GM,Cappelli B,Licciardello M,Beretta C,Aricò M,Castagnola E,Infection Study Group of the Associazione Italiana Ematologia Oncologia Pediat

    更新日期:2010-09-01 00:00:00

  • Prognostic and biologic significance of long non-coding RNA profiling in younger adults with cytogenetically normal acute myeloid leukemia.

    abstract::Long non-coding ribonucleic acids (RNAs) are a novel class of RNA molecules, which are increasingly recognized as important molecular players in solid and hematologic malignancies. Herein we investigated whether long non-coding RNA expression is associated with clinical and molecular features, as well as outcome of yo...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:10.3324/haematol.2017.166215

    authors: Papaioannou D,Nicolet D,Volinia S,Mrózek K,Yan P,Bundschuh R,Carroll AJ,Kohlschmidt J,Blum W,Powell BL,Uy GL,Kolitz JE,Wang ES,Eisfeld AK,Orwick SJ,Lucas DM,Caligiuri MA,Stone RM,Byrd JC,Garzon R,Bloomfield CD

    更新日期:2017-08-01 00:00:00

  • The German Registry of immune tolerance treatment in hemophilia--1999 update.

    abstract::As of 1999, the German registry of immune tolerance treatment in hemophilia has received reports on 146 patients who have undergone this therapy from 25 hemophilia centers. In 16 of the reported patients treatment is ongoing. Therapy has been completed in 126 patients of all groups with hemophilia A; most of them are ...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Lenk H,ITT Study Group.

    更新日期:2000-10-01 00:00:00

  • Molecular diagnosis of A gamma hereditary persistence of fetal hemoglobin using polymerase chain reaction and oligonucleotide analysis.

    abstract::By combining the polymerase chain reaction (PCR) of the gamma globin gene promoters with synthetic oligonucleotide analysis we have diagnosed the -196 C----T and the -117 G----A substitutions in heterozygous carriers of non deletional A gamma HPFH from two unrelated Italian families. The identification of the beta-tha...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:

    authors: Gottardi E,Alfarano A,Serra A,Sciarratta G,Bertero MT,Saglio G,Camaschella C

    更新日期:1990-01-01 00:00:00

  • Cell type specific novel lncRNAs and circRNAs in the BLUEPRINT haematopoietic transcriptomes atlas.

    abstract::Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the developmental stages of the hematopoietic system and the molecular bases of malignant and non-malignant blood diseases for the past three decades. Previously, only the genes targeted by expression microarrays could be profiled g...

    journal_title:Haematologica

    pub_type: 杂志文章

    doi:10.3324/haematol.2019.238147

    authors: Grassi L,Izuogu OG,Jorge NA,Seyres D,Bustamante M,Burden F,Farrow S,Farahi N,Martin FJ,Frankish A,Mudge JM,Kostadima M,Petersen R,Lambourne JJ,Rowlston S,Martin-Rendon E,Clarke L,Downes K,Estivill X,Flicek P,Marte

    更新日期:2020-07-23 00:00:00

  • Idiotype vaccination of multiple myeloma patients using monocyte-derived dendritic cells.

    abstract:BACKGROUND AND OBJECTIVES:Dendritic cells (DC) pulsed with multiple myeloma (MM) patient-specific idiotype (Id) protein can induce MM-specific T-cell responses. DESIGN AND METHODS:We established serum-free culture conditions to generate monocyte-derived DC for clinical use to circumvent anti-xenogenic immune responses...

    journal_title:Haematologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Reichardt VL,Milazzo C,Brugger W,Einsele H,Kanz L,Brossart P

    更新日期:2003-10-01 00:00:00