Abstract:
:This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2-4 acute GVHD compared to patients in mixed TCC (cumulative-incidence, 61% vs. 35%; p=0.01). The delayed establishment of full donor TCC in myeloid malignancies was associated with a higher incidence of relapse (40% vs. 0; p=0.002), suggesting that monitoring of the kinetics of TCC is mandatory after RIC-allo-SCT.
journal_name
Haematologicajournal_title
Haematologicaauthors
Mohty M,Avinens O,Faucher C,Viens P,Blaise D,Eliaou JFdoi
10.3324/haematol.10971subject
Has Abstractpub_date
2007-07-01 00:00:00pages
1004-6issue
7eissn
0390-6078issn
1592-8721journal_volume
92pub_type
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