Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods.

abstract：BACKGROUND AND OBJECTIVES:We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). DESIGN AND METHODS:Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusi...

journal_title：Haematologica

authors： Cesana C,Nosari AM,Klersy C,Miqueleiz S,Rossi V,Ferrando P,Valentini M,Barbarano L,Morra E

更新日期：2003-09-01 00:00:00

abstract：:Effects of concurrent inhibition of mTORC1/2 and Bcl-2/Bcl-xL in human acute myeloid leukemia cells were examined. Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo. Moreover, INK128 co-administered with ...

journal_title：Haematologica

authors： Rahmani M,Aust MM,Hawkins E,Parker RE,Ross M,Kmieciak M,Reshko LB,Rizzo KA,Dumur CI,Ferreira-Gonzalez A,Grant S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation. The effect of donor lymphocyte infusion is mediated by donor T cells recognizing minor histocompatibility antigens. T cells recognizing hemat...

journal_title：Haematologica

authors： Griffioen M,Honders MW,van der Meijden ED,van Luxemburg-Heijs SA,Lurvink EG,Kester MG,van Bergen CA,Falkenburg JH

更新日期：2012-08-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) levels have been tested in patients with chronic relative polycythemia (RP), polycythemia vera, and in healthy subjects in order to find a possible underlying pathophysiological mechanism for relative polycythemia. No difference in statistical significance has been found between the me...

journal_title：Haematologica

authors： Cohen AM,Gelvan A,Winaver J,Kahna L,Floru S,Djaldetti M

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma. DESIGN AND METHODS:MicroRNA profiles of enriched follicular lymphoma tumor cells from 16 patients were generated by assaying 851 human micr...

journal_title：Haematologica

authors： Wang W,Corrigan-Cummins M,Hudson J,Maric I,Simakova O,Neelapu SS,Kwak LW,Janik JE,Gause B,Jaffe ES,Calvo KR

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We assessed direct health care costs associated with the most commonly prescribed treatments for indolent follicular non-Hodgkin's lymphoma (FL). DESIGN AND METHODS:New and previously diagnosed FL patients (>or=18 years) known during 1997-1998 to 15 Dutch hospitals were selected for inclusion...

journal_title：Haematologica

authors： van Agthoven M,Kramer MH,Sonneveld P,van der Hem KG,Huijgens PC,Wijermans PW,Kluin-Nelemans HC,Schaafsma MR,Biesma DH,Mattijssen V,Uyl-de Groot CA,Hagenbeek A

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:The genetic characterization of chronic lymphocytic leukemia cells correlates with the behavior, progression and response to treatment of the disease. DESIGN AND METHODS:Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progressi...

journal_title：Haematologica

authors： Guarini A,Marinelli M,Tavolaro S,Bellacchio E,Magliozzi M,Chiaretti S,De Propris MS,Peragine N,Santangelo S,Paoloni F,Nanni M,Del Giudice I,Mauro FR,Torrente I,Foà R

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to investigate the microRNA (miRNA) expression pattern in neutrophils from rheumatoid arthritis (RA) patients and its contribution to their pathogenic profile and to analyze the effect of specific autoantibodies or inflammatory components in the regulation of miRNA in RA neutrophils and its m...

journal_title：Haematologica

authors： De la Rosa IA,Perez-Sanchez C,Ruiz-Limon P,Patiño-Trives A,Torres-Granados C,Jimenez-Gomez Y,Del Carmen Abalos-Aguilera M,Cecchi I,Ortega R,Caracuel MA,Calvo-Gutierrez J,Escudero-Contreras A,Collantes-Estevez E,Lopez-Pedrera C

更新日期：2020-09-01 00:00:00

abstract：:Arecent source data meta-analysis of randomized trials in adults assessing the immunoconjugate gemtuzumab ozogamicin combined with standard chemotherapy in acute myeloid leukemia showed a significant survival benefit in patients without an adverse karyotype. It is not clear whether the optimal dose should be 3 mg/m(2)...

journal_title：Haematologica

authors： Burnett A,Cavenagh J,Russell N,Hills R,Kell J,Jones G,Nielsen OJ,Khwaja A,Thomas I,Clark R,UK NCRI AML Study Group.

更新日期：2016-06-01 00:00:00

abstract：:High levels of HbF were found in patients with myelodysplastic syndrome (MDS), as well as a possible switching of the ratio of the gamma chains from the adult to the newborn type in 25% of our patients. These abnormalities in general were not present in the parents. The possibility of having thalassemia or other hemog...

journal_title：Haematologica

authors： Bourantas KL,Georgiou I,Seferiadis K

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:With the development and refinement of guidance modalities for percutaneous biopsies, many investigators have reported studies supporting the role of guided core needle biopsy in the diagnosis of mediastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core need...

journal_title：Haematologica

authors： Zinzani PL,Corneli G,Cancellieri A,Magagnoli M,Lacava N,Gherlinzoni F,Bendandi M,Albertini P,Baruzzi G,Tura S,Boaron M

更新日期：1999-07-01 00:00:00

abstract：:The introduction and the extended clinical use of nilotinib in the first-line treatment of chronic myeloid leukemia have been based on company-sponsored trials. Independent confirmations are extremely important. We report an investigator-sponsored study of nilotinib 300 mg twice daily in 130 chronic myeloid leukemia p...

journal_title：Haematologica

authors： Castagnetti F,Breccia M,Gugliotta G,Martino B,D'Adda M,Stagno F,Carella AM,Avanzini P,Tiribelli M,Trabacchi E,Visani G,Gobbi M,Salvucci M,Levato L,Binotto G,Capalbo SF,Bochicchio MT,Soverini S,Cavo M,Martinelli G,

更新日期：2016-10-01 00:00:00

abstract：:Second central nervous system (CNS) relapses represent about 7.3% of subsequent recurrences of childhood acute lymphoblastic leukemia (ALL). In most children these subsequent CNS relapses occur during the first 18 months after diagnosis of the first relapse (mean 1.42 +/- 0.73 years). We present a patient who suffered...

journal_title：Haematologica

authors： Eckert C,Einsiedel HG,Hartmann R,von Stackelberg A,Völpel S,Guggemos A,Hanzsch N,Kawan L,Seeger K,Henze G

更新日期：2004-07-01 00:00:00

abstract：:Ten consecutive patients (pts), suffering from hematological malignancies (5 NHL, 3 ANLL and 2 HD), received high doses of radio-chemotherapy and autologous peripheral blood stem cell (PBSC) transplantation. Seven of them were in 1st CR, two in 3rd CR and one in refractory status. The recruitment of PBSC was performed...

journal_title：Haematologica

authors： Fioritoni G,Iacone A,D'Antonio D,Dragani A,Quaglietta AM,Accorsi P,Angelini A,Spadano A,Natale D,Berardi A

更新日期：1990-01-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role...

journal_title：Haematologica

authors： de Vries AC,Stam RW,Kratz CP,Zenker M,Niemeyer CM,van den Heuvel-Eibrink MM,European Working Group on childhood MDS (EWOG-MDS).

更新日期：2007-11-01 00:00:00

abstract：:Inherited bone marrow failure syndromes are experiments of nature characterized by impaired hematopoiesis with cancer and leukemia predisposition. The mutations associated with inherited bone marrow failure syndromes affect fundamental cellular pathways, such as DNA repair, telomere maintenance, or proteostasis. How t...

journal_title：Haematologica

authors： Oyarbide U,Topczewski J,Corey SJ

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is the second most common leukemia among United States adults with a median age of 69 years. We investigated recent clinical practices related to treatments and disease outcomes in older patients with acute myeloid leukemia in the United States. DESIGN AND METHODS:In this retrospectiv...

journal_title：Haematologica

authors： Oran B,Weisdorf DJ

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Thrombosis is the major risk factor for death in patients with paroxysmal nocturnal hemoglobinuria. Previous case reports indicate that venous thrombosis in patients with paroxysmal nocturnal hemoglobinuria is amenable to thrombolysis. DESIGN AND METHODS:We reviewed the outcome of thrombolytic therapy for p...

journal_title：Haematologica

authors： Araten DJ,Notaro R,Thaler HT,Kernan N,Boulad F,Castro-Malaspina H,Small T,Scaradavou A,Magnan H,Prockop S,Chaffee S,Gonsky J,Thertulien R,Tarquini R,Luzzatto L

更新日期：2012-03-01 00:00:00

abstract：:We report a family with type I and type III protein S (PS) deficiency, which showed to be phenotypic variants of the same genetic disease. Direct sequencing analysis of the PROS1 gene was performed to establish the genotype. The ratio of protein C antigen and total PS antigen levels (protein C/S ratio) was used to cla...

journal_title：Haematologica

authors： ten Kate MK,Mulder R,Platteel M,Brouwer JL,van der Steege G,van der Meer J

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We previously found a high-level amplification in chromosomal region 21q22 in two children with acute lymphoblastic leukemia (ALL) using comparative genomic hybridization. The same region harbors the AML1 gene. The aim of the present study was to investigate whether AML1 is a target gene in the...

journal_title：Haematologica

authors： Niini T,Kanerva J,Vettenranta K,Saarinen-Pihkala UM,Knuutila S

更新日期：2000-04-01 00:00:00

abstract：:A retrospective, international, multicenter study was undertaken to assess: (i) the prognostic role of 'interim' positron emission tomography performed during treatment with doxorubicin, bleomycin, vinblastine and dacarbazine in patients with Hodgkin lymphoma; and (ii) the reproducibility of the Deauville five-point s...

journal_title：Haematologica

authors： Gallamini A,Barrington SF,Biggi A,Chauvie S,Kostakoglu L,Gregianin M,Meignan M,Mikhaeel GN,Loft A,Zaucha JM,Seymour JF,Hofman MS,Rigacci L,Pulsoni A,Coleman M,Dann EJ,Trentin L,Casasnovas O,Rusconi C,Brice P,Bolis

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Allogeneic stem cell transplantation is a potentially curative treatment for myelofibrosis, although its use is limited by a high rate of transplant-related mortality. In this study, we evaluated the outcome of patients with myelofibrosis who underwent allogeneic stem cell transplantation, and the impact of ...

journal_title：Haematologica

authors： Patriarca F,Bacigalupo A,Sperotto A,Isola M,Soldano F,Bruno B,van Lint MT,Iori AP,Santarone S,Porretto F,Pioltelli P,Visani G,Iacopino P,Fanin R,Bosi A,GITMO.

更新日期：2008-10-01 00:00:00

abstract：:We investigated gastrointestinal graft-versus-host-disease using capsule endoscopy in patients with abdominal pain and/or diarrhea. We found severe pathology involving most of the gut including loss of villi, ulcerations, narrowing, bleeding and fistula formation. In 2 patients, capsule endoscopy alone established the...

journal_title：Haematologica

authors： Shapira M,Adler SN,Jacob H,Resnick IB,Slavin S,Or R

更新日期：2005-07-01 00:00:00

abstract：:A prospective longitudinal study was conducted to determine whether single-donor fresh frozen plasma (FFP) substitution was able to influence L-asparaginase-associated hypoproteinemia. Within a 36-month period, 20 of 42 children with ALL received a total of 42 prophylactic FFP doses at a median of 10 (5-20) mliter/kg ...

journal_title：Haematologica

authors： Nowak-Göttl U,Rath B,Binder M,Hassel JU,Wolff J,Husemann S,Ritter J

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:The nucleoside analogue fludarabine is used in the treatment of chronic lymphocytic leukemia. It triggers p53-mediated apoptosis, although the mutational status of p53 does not fully account for heterogeneity in responsiveness to treatment. The aim of this study was to identify new genes implicated in fludar...

journal_title：Haematologica

authors： López-Guerra M,Trigueros-Motos L,Molina-Arcas M,Villamor N,Casado FJ,Montserrat E,Campo E,Colomer D,Pastor-Anglada M

更新日期：2008-12-01 00:00:00

abstract：:Proteolysis targeting chimeric molecule ARV 825 causes ubiquitination of bromodomains resulting in their efficient degradation by proteasome activity. Bromodomain degradation down-regulates MYC transcription contributing to growth inhibition of various human cancers. We examined the therapeutic potential of ARV 825 ag...

journal_title：Haematologica

authors： Lim SL,Damnernsawad A,Shyamsunder P,Chng WJ,Han BC,Xu L,Pan J,Pravin DP,Alkan S,Tyner JW,Koeffler HP

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Hemoglobin sickle cell disease is one of the most frequent hemoglobinopathies. Surprisingly, few studies have been dedicated to this disease, currently considered to be a mild variant of homozygous sickle cell disease. The aim of this study was to update our knowledge about hemoglobin sickle cell disease. D...

journal_title：Haematologica

authors： Lionnet F,Hammoudi N,Stojanovic KS,Avellino V,Grateau G,Girot R,Haymann JP

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Autologous peripheral stem cell transplantation (APSCT) is increasingly used for various hematologic malignancies and solid tumors. The objective of this study was to analyze the immune reconstitution after APSCT and see if there was any correlation with diagnosis, age, type of high-dose thera...

journal_title：Haematologica

authors： Steingrimsdottir H,Gruber A,Björkholm M,Svensson A,Hansson M

更新日期：2000-08-01 00:00:00

abstract：:The assessment of clinical probability represents an important step in the diagnostic strategy of patients with suspected deep vein thrombosis. The recently derived LEFt clinical prediction rule for pregnant women combines three variables: symptoms in the left leg (L), calf circumference difference of 2 centimeters or...

journal_title：Haematologica

authors： Righini M,Jobic C,Boehlen F,Broussaud J,Becker F,Jaffrelot M,Blondon M,Guias B,Le Gal G,EDVIGE study group.

更新日期：2013-04-01 00:00:00

abstract：:This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective International T-cell Project. We analyzed data from 1020 patients with newly diagnosed disease, enrolled between September 2006 and December 2015. Out of 937 pati...

journal_title：Haematologica

authors： Bellei M,Foss FM,Shustov AR,Horwitz SM,Marcheselli L,Kim WS,Cabrera ME,Dlouhy I,Nagler A,Advani RH,Pesce EA,Ko YH,Martinez V,Montoto S,Chiattone C,Moskowitz A,Spina M,Biasoli I,Manni M,Federico M,International T-c

更新日期：2018-07-01 00:00:00