IL-2 in the treatment of chronic myeloid leukemia after lymphoid blast crisis: a pilot study.

abstract：:About 25-30% of patients with immune thrombocytopenic purpura (ITP) are refractory to corticosteroids, splenectomy and other treatments. It has been suggested that interferon-alpha 2b (IFN-alpha 2b) may be useful in the treatment of chronic refractory ITP patients. We treated 9 chronic refractory ITP patients with IFN...

journal_title：Haematologica

authors： Vianelli N,Tazzari PL,Baravelli S,Ricci F,Valdrè L,Tura S

更新日期：1998-08-01 00:00:00

abstract：:As of 1999, the German registry of immune tolerance treatment in hemophilia has received reports on 146 patients who have undergone this therapy from 25 hemophilia centers. In 16 of the reported patients treatment is ongoing. Therapy has been completed in 126 patients of all groups with hemophilia A; most of them are ...

journal_title：Haematologica

authors： Lenk H,ITT Study Group.

更新日期：2000-10-01 00:00:00

abstract：:The deregulated activity of BCR-ABL tyrosine kinase originating from the t(9;22) chromosomal translocation has been shown to be necessary and sufficient for the transformed phenotype of chronic myeloid leukemia (CML) cells. This peculiarity has paved the way for the development of novel therapies specifically targetin...

journal_title：Haematologica

authors： Martinelli G,Soverini S,Rosti G,Cilloni D,Baccarani M

更新日期：2005-04-01 00:00:00

abstract：:Epidemiological evidence suggests that infection is involved in the etiology of common acute lymphoblastic leukemia, either by stimulating an inappropriate immune response or in the form of a classical transforming agent. In an attempt to elucidate the role that infection is playing in this disease, we used representa...

journal_title：Haematologica

authors： MacKenzie J,Greaves MF,Eden TO,Clayton RA,Perry J,Wilson KS,Jarrett RF

更新日期：2006-02-01 00:00:00

abstract：:We report on five Caucasian patients with congenital polycythemia and mutations of the von Hipple-Lindau (VHL) gene: a compound heterozygote for the novel exon 1 (VHL 235C->T) and previously reported VHL 562C->G mutations; three homozygotes for Chuvash VHL 598C->T mutation; and a heterozygote for VHL 523->G mutation w...

journal_title：Haematologica

authors： Bento MC,Chang KT,Guan Y,Liu E,Caldas G,Gatti RA,Prchal JT

更新日期：2005-01-01 00:00:00

abstract：:BACKGROUND. Hypofibrinogenemia and increased fibrin(ogen) degradation products in acute leukemia have been attributed to intravascular thrombin generation triggered by leukemic cells. However, the strict relationship between fibrinogen catabolism and turnover of fibrinopeptide A (FPA), which is a sensitive and specifi...

journal_title：Haematologica

authors： Castaman G,Galloni E,Dri AV,Rodeghiero F

更新日期：1993-11-01 00:00:00

abstract：:Imatinib mesylate is a tyrosine kinase inhibitor used as first line treatment in chronic myeloid leukemia and gastrointestinal stromal tumor patients. Although several in vitro and animal studies demonstrated that imatinib affects immune response, few immune alterations are described in humans. We retrospectively stud...

journal_title：Haematologica

authors： Santachiara R,Maffei R,Martinelli S,Arcari A,Piacentini F,Trabacchi E,Alfieri P,Ferrari A,Leonardi G,Luppi G,Longo G,Vallisa D,Marasca R,Torelli G

更新日期：2008-08-01 00:00:00

abstract：:Monitoring minimal residual disease is an important way to identify patients with acute myeloid leukemia at high risk of relapse. In this study we investigated the prognostic potential of minimal residual disease monitoring by quantitative real-time polymerase chain reaction analysis of NPM1 mutations in patients trea...

journal_title：Haematologica

authors： Hubmann M,Köhnke T,Hoster E,Schneider S,Dufour A,Zellmeier E,Fiegl M,Braess J,Bohlander SK,Subklewe M,Sauerland MC,Berdel WE,Büchner T,Wörmann B,Hiddemann W,Spiekermann K

更新日期：2014-08-01 00:00:00

abstract：:High levels of HbF were found in patients with myelodysplastic syndrome (MDS), as well as a possible switching of the ratio of the gamma chains from the adult to the newborn type in 25% of our patients. These abnormalities in general were not present in the parents. The possibility of having thalassemia or other hemog...

journal_title：Haematologica

authors： Bourantas KL,Georgiou I,Seferiadis K

更新日期：1991-07-01 00:00:00

abstract：:Seven cord blood (CB) units were tested for their capacity to repopulate irradiated NOD/SCID mice after one or two successive cryopreservation procedures. In primary transplants with frozen or refrozen CB cells we observed equivalent human colonies and percentages of human CD45+ cells, with multilineage engraftment. I...

journal_title：Haematologica

authors： Timeus F,Crescenzio N,Sanavio F,Fazio L,Doria A,Foglia L,Pignochino Y,Berger M,Piacibello W,Madon E,Cordero di Montezemolo L,Fagioli F

更新日期：2006-03-01 00:00:00

abstract：:Hematopoietic differentiation is driven by transcription factors, which orchestrate a finely tuned transcriptional network. At bipotential branching points lineage decisions are made, where key transcription factors initiate cell type-specific gene expression programs. These programs are stabilized by the epigenetic a...

journal_title：Haematologica

authors： Herkt SC,Kuvardina ON,Herglotz J,Schneider L,Meyer A,Pommerenke C,Salinas-Riester G,Seifried E,Bonig H,Lausen J

更新日期：2018-01-01 00:00:00

abstract：:We analyzed the clinical outcome of 146 adult patients receiving an HLA-identical sibling donor stem cell transplant depending on HA-8 matching status. The presence of an HA-8 mismatch was associated with an increased risk of severe acute graft-versus-host disease and with a worse overall survival. ...

journal_title：Haematologica

authors： Pérez-García A,De la Cámara R,Torres A,González M,Jiménez A,Gallardo D

更新日期：2005-12-01 00:00:00

abstract：:Outcome of patients with primary refractory acute myeloid leukemia remains unsatisfactory. We conducted a prospective phase II clinical trial with gemtuzumab ozogamicin (3 mg/m(2) intravenously on day 1), all-trans retinoic acid (45 mg/m(2) orally on days 4-6 and 15 mg/m(2) orally on days 7-28), high-dose cytarabine (...

journal_title：Haematologica

authors： Hütter-Krönke ML,Benner A,Döhner K,Krauter J,Weber D,Moessner M,Köhne CH,Horst HA,Schmidt-Wolf IG,Rummel M,Götze K,Koller E,Petzer AL,Salwender H,Fiedler W,Kirchen H,Haase D,Kremers S,Theobald M,Matzdorff AC,Ganse

更新日期：2016-07-01 00:00:00

abstract：:We report on a case of acute myeloid leukemia in a 17-year old boy affected by Shwachman Diamond syndrome (SDS). Conventional cytogenetics at diagnosis revealed an abnormal clone with complex karyotypic changes including typical myeloid aberrations, such as monosomy 5, tetrasomy of chromosome 8, trisomy 9, and deletio...

journal_title：Haematologica

authors： Spirito FR,Crescenzi B,Matteucci C,Martelli MF,Mecucci C

更新日期：2000-11-01 00:00:00

abstract：:Hodgkin's lymphoma (HL) simulating acute cholestatic hepatitis is a very unusual clinical picture. Massive liver infiltration with conspicuous acute cholestatic symptoms, in fact, suggests more aggressive systemic diseases such as non Hodgkin's lymphomas or acute leukemias. Nevertheless, we observed two cases of mixed...

journal_title：Haematologica

authors： Marinone G,Lazzari R,Pellizzari F,Marinone MG

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:In March 1987 AIEOP started the AIEOP-ALL-87 study, based on the previous AIEOP-ALL-82. The aim of this new study was to evaluate, for all risk groups: a) the efficacy of treatment intensification achieved by adding a fourth drug (daunomycin) in the induction phase and a 3-drug reinduction pha...

journal_title：Haematologica

authors： Paolucci G,Vecchi V,Favre C,Miniero R,Madon E,Pession A,Rondelli R,De Rossi G,Lo Nigro L,Porta F,Santoro N,Indolfi P,Basso G,Conter V,Aricò M,Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP).

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Hepatitis C virus (HCV) infection is an important cause of morbidity and mortality in patients affected by hereditary bleeding disorders and treated with non-virus inactivated clotting factor concentrates during the 1970s. INFORMATION SOURCES:In this review, we briefly report the present know...

journal_title：Haematologica

authors： Franchini M,Capra F,Tagliaferri A,Rossetti G,De Gironcoli M,Rocca P,Aprili G,Gandini G

更新日期：2002-05-01 00:00:00

abstract：:Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder which is due to a mutation in the gene encoding for platelet glycoprotein Ibalpha (GPIbalpha) resulting in enhanced affinity for von Willebrand factor (VWF). PT-VWD is often mistakenly diagnosed as type 2B VWD for the similari...

journal_title：Haematologica

authors： Giannini S,Cecchetti L,Mezzasoma AM,Gresele P

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:With the development and refinement of guidance modalities for percutaneous biopsies, many investigators have reported studies supporting the role of guided core needle biopsy in the diagnosis of mediastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core need...

journal_title：Haematologica

authors： Zinzani PL,Corneli G,Cancellieri A,Magagnoli M,Lacava N,Gherlinzoni F,Bendandi M,Albertini P,Baruzzi G,Tura S,Boaron M

更新日期：1999-07-01 00:00:00

abstract：:Perforin gene (PRF1) mutations cause the primary form of hemophagocytic lymphohistiocytosis (HLH). We report a genetic defect of PRF1 in a 62-year-old Japanese man with recurrent episodes of HLH. Sequencing of PRF1 from both peripheral blood mononuclear cells and nail clippings showed compound heterozygous mutation, i...

journal_title：Haematologica

authors： Nagafuji K,Nonami A,Kumano T,Kikushige Y,Yoshimoto G,Takenaka K,Shimoda K,Ohga S,Yasukawa M,Horiuchi H,Ishii E,Harada M

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of Drosophila diaphanous 2 (mDia2), are required for enucleation of in vitro cultured mouse fetal liver er...

journal_title：Haematologica

authors： Ji P,Yeh V,Ramirez T,Murata-Hori M,Lodish HF

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD). DESIGN AND METHODS:Eight patients from three unrelated families with this mutation were included in the present study who had distinct VWF abnormalities, not descr...

journal_title：Haematologica

authors： Pérez-Rodríguez A,García-Rivero A,Lourés E,López-Fernández MF,Rodríguez-Trillo A,Batlle J

更新日期：2009-05-01 00:00:00

abstract：:We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 de...

journal_title：Haematologica

authors： Morkbak AL,Hvas AM,Milman N,Nexo E

更新日期：2007-12-01 00:00:00

abstract：:The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analy...

journal_title：Haematologica

authors： Fuerst D,Frank S,Mueller C,Beelen DW,Schetelig J,Niederwieser D,Finke J,Bunjes D,Kröger N,Neuchel C,Tsamadou C,Schrezenmeier H,Beyersmann J,Mytilineos J

更新日期：2018-09-01 00:00:00

abstract：:Relapsed/refractory multiple myeloma represents a major challenge in multiple myeloma therapy. For patients with relapsed/refractory multiple myeloma, we developed a treatment schema of metronomically scheduled drug therapy. We identified 186 patients who had been treated with metronomic therapy between March 2004 and...

journal_title：Haematologica

authors： Papanikolaou X,Szymonifka J,Rosenthal A,Heuck CJ,Mitchell A,Johann D Jr,Keller J,Waheed S,Usmani SZ,Van Rhee F,Bailey C,Petty N,Hoering A,Crowley J,Barlogie B

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The relative efficacy of high-dose chemotherapy (HDC) compared to standard treatment for high-risk primary (HRPBC) or metastatic breast cancer (MBC) constitutes an area of intense controversy among the medical oncology community. A number of randomized trials have been conducted to address this issue. In mos...

journal_title：Haematologica

authors： Nieto Y

更新日期：2003-02-01 00:00:00

abstract：:This study reports a case of granulocytic sarcoma that developed in the epidural zone 25 days before clinical evidence of an acute promyelocytic leukemia. The case presented the diagnostic difficulties that are common to all aleukemic granulocytic sarcomas. Moreover, it highlights the very rare association between gra...

journal_title：Haematologica

authors： Tosi A,De Paoli A,Fava S,Luoni M,Sironi M,Tocci A,Assi A,Cassi E

更新日期：1995-01-01 00:00:00

abstract：:Thrombosis occurs in 20 to 30% of patients with Behçet's disease (BD), but the precise pathogenic mechanism underlying the thrombotic tendency in these patients is not well known. Venous thromboses are commonly located in the lower extremities, but right intracardiac thrombi are extremely rare. We report for the first...

journal_title：Haematologica

authors： Vayá A,Forner MJ,Estellés A,Villa P,Mira Y,Ferrando F,García Fuster JM,Oliver V,Aznar J

更新日期：2000-04-01 00:00:00

abstract：:The development of inhibitors is currently one of the most serious complications in the treatment of hemophilic children. Prospective studies of previously untreated patients (PUP) showed that up to 52% of patients with severe hemophilia A developed inhibitors during the first 50 exposure days (ED) (>100 for outliers)...

journal_title：Haematologica

authors： Kreuz W,Ettingshausen CE,Auerswald G,Saguer IM,Becker S,Funk M,Heller C,Klarmann D,Klingebiel T,GTH PUP Study Group.

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Detection of minimal residual disease (MRD) by multiparameter flow cytometry is an emerging prognostic factor in patients with acute myeloid leukemia (AML). The present analysis aimed at improving the applicability of this approach to more patients with AML. DESIGN AND METHODS:Bone marrow sam...

journal_title：Haematologica

authors： Kern W,Danhauser-Riedl S,Ratei R,Schnittger S,Schoch C,Kolb HJ,Ludwig WD,Hiddemann W,Haferlach T

更新日期：2003-06-01 00:00:00