Undifferentiated granulocytic sarcoma: a case with epidural onset preceding acute promyelocytic leukemia.

abstract：:A new method, combining seminested polymerase chain reaction (PCR) with heteroduplex analysis, was utilized to detect follicular lymphoma (FL) cells in peripheral blood. The method, based on the detection of IgH rearrangements in DNA, detected the presence of monoclonal B cells in FL patients with a high frequency. ...

journal_title：Haematologica

authors： Oehadian A,Koide N,Mu MM,Hassan F,Yoshida T,Yokochi T

更新日期：2005-02-01 00:00:00

abstract：:Spontaneous Rh blood group changes are a striking sign, reported to occur mainly in patients with hematologic disorders. Upon routine blood grouping, 2 unrelated individuals showed unexplained mixed red cell phenotype regarding the highly immunogenic c antigen (RH4), clinically relevant for blood transfusion and fetom...

journal_title：Haematologica

authors： Dauber EM,Mayr WR,Hustinx H,Schönbacher M,Budde H,Legler TJ,König M,Haas OA,Fritsch G,Körmöczi GF

更新日期：2019-03-01 00:00:00

abstract：:It is well known that thalassemic patients exhibit an increased frequency of thrombotic events. Most individuals with resistance to activated protein C (APCR) are the result of a point mutation replacing Arg 506 with Gln in the factor V aminoacidic sequence (factor V Leiden). Recently APCR has been shown to account fo...

journal_title：Haematologica

authors： Giordano P,Sabato V,Schettini F,De Mattia D,Iolascon A

更新日期：1997-11-01 00:00:00

abstract：:Seven cord blood (CB) units were tested for their capacity to repopulate irradiated NOD/SCID mice after one or two successive cryopreservation procedures. In primary transplants with frozen or refrozen CB cells we observed equivalent human colonies and percentages of human CD45+ cells, with multilineage engraftment. I...

journal_title：Haematologica

authors： Timeus F,Crescenzio N,Sanavio F,Fazio L,Doria A,Foglia L,Pignochino Y,Berger M,Piacibello W,Madon E,Cordero di Montezemolo L,Fagioli F

更新日期：2006-03-01 00:00:00

abstract：:In hematopoietic stem cell transplantation for hemophagocytic lymphohistiocytosis, high transplant-related mortality after busulfan-based myeloablative regimens has been observed. Conditioning regimens with reduced toxicity based on melphalan or treosulfan are promising alternatives. We retrospectively analyzed hemato...

journal_title：Haematologica

authors： Lehmberg K,Albert MH,Beier R,Beutel K,Gruhn B,Kröger N,Meisel R,Schulz A,Stachel D,Woessmann W,Janka G,Müller I

更新日期：2014-01-01 00:00:00

abstract：:Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 days. With fibrin, produced by thrombin-mediated cleavage, fibrinogen plays important roles in many physiological processes. Indeed, t...

journal_title：Haematologica

authors： Vilar R,Fish RJ,Casini A,Neerman-Arbez M

更新日期：2020-01-31 00:00:00

abstract：:Disease bulk is an important prognostic factor in early stage Hodgkin lymphoma, but its definition is unclear in the computed tomography era. This retrospective analysis investigated the prognostic significance of bulky disease measured in transverse and coronal planes on computed tomography imaging. Early stage Hodgk...

journal_title：Haematologica

authors： Kumar A,Burger IA,Zhang Z,Drill EN,Migliacci JC,Ng A,LaCasce A,Wall D,Witzig TE,Ristow K,Yahalom J,Moskowitz CH,Zelenetz AD

更新日期：2016-10-01 00:00:00

abstract：:Adults with relapsed/refractory acute lymphoblastic leukemia have an unfavourable prognosis, which is influenced by disease and patient characteristics. To further evaluate these characteristics, a retrospective analysis of 1,706 adult patients with Ph-negative relapsed/refractory B-precursor acute lymphoblastic leuke...

journal_title：Haematologica

authors： Gökbuget N,Dombret H,Ribera JM,Fielding AK,Advani A,Bassan R,Chia V,Doubek M,Giebel S,Hoelzer D,Ifrah N,Katz A,Kelsh M,Martinelli G,Morgades M,O'Brien S,Rowe JM,Stieglmaier J,Wadleigh M,Kantarjian H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data. This is also true for immunohistochemical classifiers that are thought to reflect the cell-of-origin subclassification of gene expression stu...

journal_title：Haematologica

authors： Bernd HW,Ziepert M,Thorns C,Klapper W,Wacker HH,Hummel M,Stein H,Hansmann ML,Ott G,Rosenwald A,Müller-Hermelink HK,Barth TF,Möller P,Cogliatti SB,Pfreundschuh M,Schmitz N,Trümper L,Höller S,Löffler M,Feller AC,Ger

更新日期：2009-11-01 00:00:00

abstract：:Double umbilical cord blood transplantation is increasingly applied in the treatment of adult patients with high-risk hematological malignancies and has been associated with improved engraftment as compared to that provided by single unit cord blood transplantation. The mechanism of improved engraftment is, however, s...

journal_title：Haematologica

authors： Somers JA,Braakman E,van der Holt B,Petersen EJ,Marijt EW,Huisman C,Sintnicolaas K,Oudshoorn M,Groenendijk-Sijnke ME,Brand A,Cornelissen JJ

更新日期：2014-11-01 00:00:00

abstract：:The present study reports a method for the easy, rapid and cost effective detection of heterozygous large deletions. As a model gene all exons of the antithrombin gene were amplified in a one tube multiplex polymerase chain reaction (PCR) and the products separated according to their size by reverse-phase ion-pair hig...

journal_title：Haematologica

authors： Pavlova A,El-Maarri O,Luxembourg B,Lindhoff-Last E,Kochhan L,Bruhn HD,Delev D,Watzka M,Seifried E,Oldenburg J

更新日期：2006-09-01 00:00:00

abstract：:We evaluate the long-term results of a prospective clinical study enrolling more than 100 adult patients with Burkitt lymphoma/leukemia. Depending on extent of disease, treatment consisted of six to eight rituximab infusions and four to six courses of intensive chemotherapy (attenuated in patients aged >55 years) with...

journal_title：Haematologica

authors： Intermesoli T,Rambaldi A,Rossi G,Delaini F,Romani C,Pogliani EM,Pagani C,Angelucci E,Terruzzi E,Levis A,Cassibba V,Mattei D,Gianfaldoni G,Scattolin AM,Di Bona E,Oldani E,Parolini M,Gökbuget N,Bassan R

更新日期：2013-11-01 00:00:00

abstract：:Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated b...

journal_title：Haematologica

authors： Al-Sharea A,Lee MKS,Whillas A,Michell DL,Shihata WA,Nicholls AJ,Cooney OD,Kraakman MJ,Veiga CB,Jefferis AM,Jackson K,Nagareddy PR,Lambert G,Wong CHY,Andrews KL,Head GA,Chin-Dusting J,Murphy AJ

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD). DESIGN AND METHODS:Eight patients from three unrelated families with this mutation were included in the present study who had distinct VWF abnormalities, not descr...

journal_title：Haematologica

authors： Pérez-Rodríguez A,García-Rivero A,Lourés E,López-Fernández MF,Rodríguez-Trillo A,Batlle J

更新日期：2009-05-01 00:00:00

abstract：:Dickkopf-1 (DKK1), broadly expressed by tumor cells from human multiple myeloma (MM) and other cancers but absent from most normal tissues, may be an ideal target for immunotherapy. Our previous studies have shown that DKK1 (peptide)-specific cytotoxic T lymphocytes can effectively lyse primary MM cells in vitro. To d...

journal_title：Haematologica

authors： Li R,Zheng C,Wang Q,Bi E,Yang M,Hou J,Fu W,Yi Q,Qian J

更新日期：2020-02-20 00:00:00

abstract：:Eleven patients with advanced APL were treated with ATO (0.15 mg/Kg daily). Eight (73%) achieved molecular CR, but 5 relapsed, 1 died in molecular CR, 1 was lost to follow-up and 1 is still alive in CR after allogeneic transplantation. We suggest that ATO may be effective also in advanced APL, but given the short CR, ...

journal_title：Haematologica

authors： Carmosino I,Latagliata R,Avvisati G,Breccia M,Finolezzi E,Lo Coco F,Petti MC

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. DESIGN AND METHODS:The types and subtypes, blood group frequency and its relevance, bleeding sites, response to...

journal_title：Haematologica

authors： Woods AI,Meschengieser SS,Blanco AN,Salviú MJ,Farías CE,Kempfer AC,Lazzari MA

更新日期：2001-04-01 00:00:00

abstract：:About 25-30% of patients with immune thrombocytopenic purpura (ITP) are refractory to corticosteroids, splenectomy and other treatments. It has been suggested that interferon-alpha 2b (IFN-alpha 2b) may be useful in the treatment of chronic refractory ITP patients. We treated 9 chronic refractory ITP patients with IFN...

journal_title：Haematologica

authors： Vianelli N,Tazzari PL,Baravelli S,Ricci F,Valdrè L,Tura S

更新日期：1998-08-01 00:00:00

abstract：:Over the last decades, incrementally improved xenograft mouse models, supporting the engraftment and development of a human hemato-lymphoid system, have been developed and now represent an important research tool in the field. The most significant contributions made by means of humanized mice are the identification of...

journal_title：Haematologica

authors： Theocharides AP,Rongvaux A,Fritsch K,Flavell RA,Manz MG

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Parvovirus B19 has a marked tropism for erythroid progenitor cells and this may lead to chronic anemia in predisposed individuals. It was the purpose of the present study to investigate prospectively the frequency of parvovirus B19 infections in patients with a diagnosis of chronic anemia. MET...

journal_title：Haematologica

authors： Heegaard ED,Myhre J,Hornsleth A,Gundestrup M,Boye H

更新日期：1997-07-01 00:00:00

abstract：:A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subsequently, two courses of chemotherapy for resistant ANLL were administered without achieving complete remissio...

journal_title：Haematologica

authors： Bigazzi C,Galieni P,Scarinci R,Vivarelli R,Bucalossi A,Biancolini G,Falbo R,Vessichelli F,Dispensa E

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor. Hereditary type I protein S deficiency (low total and low free protein S) is a well-established risk factor for venous thrombosis, whereas t...

journal_title：Haematologica

authors： Castoldi E,Maurissen LF,Tormene D,Spiezia L,Gavasso S,Radu C,Hackeng TM,Rosing J,Simioni P

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:We evaluated bacterial infections (BIs) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). DESIGN AND METHODS:Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusi...

journal_title：Haematologica

authors： Cesana C,Nosari AM,Klersy C,Miqueleiz S,Rossi V,Ferrando P,Valentini M,Barbarano L,Morra E

更新日期：2003-09-01 00:00:00

abstract：:Pathological erythropoiesis with consequent anemia is a leading cause of symptomatic morbidity in internal medicine. The etiologies of anemia are complex and include reactive as well as neoplastic conditions. Clonal expansion of erythroid cells in the bone marrow may result in peripheral erythrocytosis and polycythemi...

journal_title：Haematologica

authors： Valent P,Büsche G,Theurl I,Uras IZ,Germing U,Stauder R,Sotlar K,Füreder W,Bettelheim P,Pfeilstöcker M,Oberbauer R,Sperr WR,Geissler K,Schwaller J,Moriggl R,Béné MC,Jäger U,Horny HP,Hermine O

更新日期：2018-10-01 00:00:00

abstract：:Although myelodysplastic syndromes are heterogeneous disorders comprising a benign subset of bone marrow failure similar to aplastic anemia, no laboratory test has been established to distinguish it from bone marrow failures that can evolve into acute myeloid leukemia. Plasma thrombopoietin levels were measured in 120...

journal_title：Haematologica

authors： Seiki Y,Sasaki Y,Hosokawa K,Saito C,Sugimori N,Yamazaki H,Takami A,Nakao S

更新日期：2013-06-01 00:00:00

abstract：:We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent...

journal_title：Haematologica

authors： Jácomo RH,Melo RA,Souto FR,de Mattos ER,de Oliveira CT,Fagundes EM,Bittencourt HN,Bittencourt RI,Bortolheiro TC,Paton EJ,Bendlin R,Ismael S,Chauffaille Mde L,Silva D,Pagnano KB,Ribeiro R,Rego EM

更新日期：2007-10-01 00:00:00

abstract：:Rituximab plus CHOP (R-CHOP) has been proven to increase overall survival in aggressive bcl-2-positive lymphoma patients. Using competing risk analysis, we studied the long-term impact of this treatment in patients from a GELA trial: R-CHOP prevented from progression or relapse in both bcl-2-positive and bcl-2-negativ...

journal_title：Haematologica

authors： Mounier N,Briere J,Gisselbrecht C,Reyes F,Gaulard P,Coiffier B,Groupe d'Etude des Lymphomes de l'Adulte.

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:beta-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate beta-globin chain production. The excessive unbound alpha-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis. DESIGN AND METHODS:I...

journal_title：Haematologica

authors： Srinoun K,Svasti S,Chumworathayee W,Vadolas J,Vattanaviboon P,Fucharoen S,Winichagoon P

更新日期：2009-09-01 00:00:00

abstract：:Plasma levels of several soluble factors were assayed in 31 untreated patients with high-grade non-Hodgkin's lymphomas (NHL). The results showed statistically significant higher average levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-2 receptor (IL-2r) and transferrin receptor (...

journal_title：Haematologica

authors： Stasi R,Conforti M,Del Poeta G,Simone MD,Coppetelli U,Tribalto M,Cantonetti M,Perrotti A,Venditti A,Papa G

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not yet been evaluated for a large panel of cancer testis antigens which can be classified by varying expression in normal tissue: restricted to testis, ...

journal_title：Haematologica

authors： van Duin M,Broyl A,de Knegt Y,Goldschmidt H,Richardson PG,Hop WC,van der Holt B,Joseph-Pietras D,Mulligan G,Neuwirth R,Sahota SS,Sonneveld P

更新日期：2011-11-01 00:00:00